Molecular Evolutionary Models In Drug Discovery

Molecular Evolutionary Models In Drug Discovery Book PDF
✏Book Title : Molecular Evolutionary Models in Drug Discovery
✏Author : Juan Bueno
✏Publisher : Academic Press
✏Release Date : 2020-01-22
✏Pages : 192
✏ISBN : 9780128189290
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Molecular Evolutionary Models in Drug Discovery Book Summary : Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies

Molecular Modelling And Drug Design Book PDF
✏Book Title : Molecular Modelling and Drug Design
✏Author : K Anand Solomon
✏Publisher : MJP Publisher
✏Release Date : 2019-06-05
✏Pages : 242
✏ISBN :
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Molecular Modelling and Drug Design Book Summary : Molecular modelling is the scientific art of simulating chemicalor biological systems, so that computational methods can beapplied to understand the process concerned. Models usingcomputers are generated using mathematical equations and areevolved based on experimental information that is taken intoconsideration during model building. This book is anintroduction to the field of molecular modelling and drug designin which biological molecules effective in treating diseases arediscovered using in silico methods.

📒Adaptive Systems In Drug Design ✍ Gisbert Schneider

Adaptive Systems In Drug Design Book PDF
✏Book Title : Adaptive Systems in Drug Design
✏Author : Gisbert Schneider
✏Publisher : CRC Press
✏Release Date : 2002-10-01
✏Pages : 169
✏ISBN : 9781498713702
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Adaptive Systems in Drug Design Book Summary : A brief history of drug design presented to make clear that there are fashions in this important field and that they change rather rapidly. This is due in part to the fact that the way that a new paradigm is accepted in a drug company often does not depend on its scientific merit alone.

Preclinical Evaluation Of Antimicrobial Nanodrugs Book PDF
✏Book Title : Preclinical Evaluation of Antimicrobial Nanodrugs
✏Author : Juan Bueno
✏Publisher : Springer Nature
✏Release Date : 2020-05-08
✏Pages : 117
✏ISBN : 9783030438555
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Preclinical Evaluation of Antimicrobial Nanodrugs Book Summary : Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome. Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use. This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.

📒Drug Discovery And Development ✍ Izet Kapetanović

Drug Discovery And Development Book PDF
✏Book Title : Drug Discovery and Development
✏Author : Izet Kapetanović
✏Publisher : BoD – Books on Demand
✏Release Date : 2011-12-16
✏Pages : 542
✏ISBN : 9789533076157
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Drug Discovery and Development Book Summary : Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.

Pathway Analysis For Drug Discovery Book PDF
✏Book Title : Pathway Analysis for Drug Discovery
✏Author : Anton Yuryev
✏Publisher : John Wiley & Sons
✏Release Date : 2008-09-17
✏Pages : 304
✏ISBN : 9780470399262
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Pathway Analysis for Drug Discovery Book Summary : This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

Bioinformatics Methods And Applications Genomics Proteomics And Drug Discovery 3rd Ed  Book PDF
✏Book Title : Bioinformatics Methods And Applications Genomics Proteomics And Drug Discovery 3Rd Ed
✏Author : S. C. Rastogi
✏Publisher : PHI Learning Pvt. Ltd.
✏Release Date : 2008
✏Pages : 524
✏ISBN : 9788120335950
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Bioinformatics Methods And Applications Genomics Proteomics And Drug Discovery 3Rd Ed Book Summary :

Sourcebook Of Models For Biomedical Research Book PDF
✏Book Title : Sourcebook of Models for Biomedical Research
✏Author : P. Michael Conn
✏Publisher : Springer Science & Business Media
✏Release Date : 2008
✏Pages : 778
✏ISBN : 9781588299338
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Sourcebook of Models for Biomedical Research Book Summary : The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

📒In Vivo Models For Drug Discovery ✍ José Miguel Vela

In Vivo Models For Drug Discovery Book PDF
✏Book Title : In vivo Models for Drug Discovery
✏Author : José Miguel Vela
✏Publisher : John Wiley & Sons
✏Release Date : 2014-07-31
✏Pages : 594
✏ISBN : 9783527679362
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏In vivo Models for Drug Discovery Book Summary : This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.

📒Rational Drug Design ✍ Donald G. Truhlar

Rational Drug Design Book PDF
✏Book Title : Rational Drug Design
✏Author : Donald G. Truhlar
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-12-06
✏Pages : 213
✏ISBN : 9781461214809
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Rational Drug Design Book Summary : Drug research and discovery are of critical importance in human health care. Computational approaches for drug lead discovery and optimization have proven successful in many recent research programs. These methods have grown in their effectiveness not only because of improved understanding of the basic science - the biological events and molecular interactions that define a target for therapeutic intervention - but also because of advances in algorithms, representations, and mathematical procedures for studying such processes. This volume surveys some of those advances. A broad landscape of high-profile topics in computer-assisted molecular design (CAMD) directed to drug design are included. Subject areas represented in the volume include receptor-based applications such as binding energy approximations, molecular docking, and de novo design; non-receptor-based applications such as molecular similarity; molecular dynamics simulations; solvation and partitioning of a solute between aqueous and nonpolar media; graph theory; non-linear multidimensional optimization, processing of information obtained from simulation studies, global optimization and search strategies, and performance enhancement through parallel computing.

📒Drug Discovery Handbook ✍ Shayne Cox Gad

Drug Discovery Handbook Book PDF
✏Book Title : Drug Discovery Handbook
✏Author : Shayne Cox Gad
✏Publisher : John Wiley & Sons
✏Release Date : 2005-07-08
✏Pages : 1496
✏ISBN : 9780471728771
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Drug Discovery Handbook Book Summary : The Drug Discovery Handbook gives professionals a tool tofacilitate drug discovery by bringing together, for the first timein one resource, a compendium of methods and techniques that needto be considered when developing new drugs. This comprehensive, practical guide presents an explanation of thelatest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systemsbiology Summaries of how these techniques and methods are used todiscover new central nervous system agents, antiviral agents,respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems thatare encountered, solutions to these problems, and limitations ofvarious methods and techniques The thorough coverage and practical, scientifically validproblem-solving approach of Drug Discovery Handbook will serve asan invaluable aid in the complex task of developing new drugs.

📒Molecular Genetic Medicine ✍ Theodore Friedmann

Molecular Genetic Medicine Book PDF
✏Book Title : Molecular Genetic Medicine
✏Author : Theodore Friedmann
✏Publisher : Elsevier
✏Release Date : 2013-10-22
✏Pages : 254
✏ISBN : 9781483262055
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Molecular Genetic Medicine Book Summary : Molecular Genetic Medicine, Volume I, provides an overview of the progress in several of the most important areas of modern molecular genetics and medicine. The aim is to present a technical and historical picture of the concept that it is through a thorough understanding of genetics of all kinds of human diseases, even infectious diseases, that effective treatments will finally come. The book opens with a discussion of the origins and development of the Human Genome Project. This is followed by separate chapters on the development of immune-deficient mice as models for human hematopoietic disease; the application of genetic techniques for testing identity and relatedness of persons; and advances in recombinant DNA technology and their applications in drug discovery. The final chapter discusses the impact of molecular biology and molecular evolution on debates about the origin of humans, and about the origins both of the characteristics that they share with other animals and of those that make humans unique.

Handbook Of Human Molecular Evolution Book PDF
✏Book Title : Handbook of Human Molecular Evolution
✏Author : David Neil Cooper
✏Publisher :
✏Release Date : 2008
✏Pages : 1717
✏ISBN : STANFORD:36105210669136
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Handbook of Human Molecular Evolution Book Summary :

Genetic Algorithms In Molecular Modeling Book PDF
✏Book Title : Genetic Algorithms in Molecular Modeling
✏Author : James Devillers
✏Publisher : Academic Press
✏Release Date : 1996-06-07
✏Pages : 327
✏ISBN : 9780080532387
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Genetic Algorithms in Molecular Modeling Book Summary : Genetic Algorithms in Molecular Modeling is the first book available on the use of genetic algorithms in molecular design. This volume marks the beginning of an ew series of books, Principles in Qsar and Drug Design, which will be an indispensible reference for students and professionals involved in medicinal chemistry, pharmacology, (eco)toxicology, and agrochemistry. Each comprehensive chapter is written by a distinguished researcher in the field. Through its up to the minute content, extensive bibliography, and essential information on software availability, this book leads the reader from the theoretical aspects to the practical applications. It enables the uninitiated reader to apply genetic algorithms for modeling the biological activities and properties of chemicals, and provides the trained scientist with the most up to date information on the topic. . Extremely topical and timely . Sets the foundations for the development of computer-aided tools for solving numerous problems in QSAR and drug design . Written to be accessible without prior direct experience in genetic algorithms

Transformative Concepts For Drug Design Target Wrapping Book PDF
✏Book Title : Transformative Concepts for Drug Design Target Wrapping
✏Author : Ariel Fernandez
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-04-28
✏Pages : 230
✏ISBN : 3642117929
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Transformative Concepts for Drug Design Target Wrapping Book Summary : In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of genomic studies to make safer drugs has proven to be much more difficult than anticipated. More than ever, the lead in the pharmaceutical industry depends on the ability to harness innovative research, and this type of innovation can only come from one source: fundamental knowledge. This book squarely addresses this crucial problem since it introduces fundamental discoveries in basic biomolecular research that hold potential to broaden the technological base of the pharmaceutical industry. The book takes a fresh and fundamental look at the problem of how to design an effective drug with controlled specificity. Since the novel transformative concepts are unfamiliar to most practitioners, the first part of this book explains matters very carefully starting from a fairly elementary physico-chemical level. The second part of the book is devoted to practical applications, aiming at nothing less than a paradigm shift in drug design. This book is addressed to scientists working at the cutting edge of research in the pharmaceutical industry, but the material is at the same time accessible to senior undergraduates or graduate students interested in drug discovery and molecular design.

Protein Protein And Domain Domain Interactions Book PDF
✏Book Title : Protein Protein and Domain Domain Interactions
✏Author : Pandjassarame Kangueane
✏Publisher : Springer
✏Release Date : 2018-02-16
✏Pages : 207
✏ISBN : 9789811073472
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Protein Protein and Domain Domain Interactions Book Summary : This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.

📒Protein Protein Complexes ✍ Martin Zacharias

Protein Protein Complexes Book PDF
✏Book Title : Protein protein Complexes
✏Author : Martin Zacharias
✏Publisher : World Scientific
✏Release Date : 2010
✏Pages : 390
✏ISBN : 9781848163409
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Protein protein Complexes Book Summary : The book consists of 13 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes, theory of protein-protein binding, prediction of interfaces and prediction of protein-protein complex structures. It serves as a bridge between analyzing protein-protein complexes and the prediction and design of interactions. --Résumé de l'éditeur.

Computational Medicinal Chemistry For Drug Discovery Book PDF
✏Book Title : Computational Medicinal Chemistry for Drug Discovery
✏Author : Patrick Bultinck
✏Publisher : CRC Press
✏Release Date : 2003-12-17
✏Pages : 1169
✏ISBN : 9780824758639
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Computational Medicinal Chemistry for Drug Discovery Book Summary : Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure computation, intermolecular behavior, ligand-receptor interaction, and modeling responding to market demands in its selection and authoritative treatment of topics. The book examines molecular mechanics, semi-empirical methods, wave function-based quantum chemistry, density functional theory, 3-D structure generation, and hybrid methods.

Pharmacophore Perception Development And Use In Drug Design Book PDF
✏Book Title : Pharmacophore Perception Development and Use in Drug Design
✏Author : Osman F. Güner
✏Publisher : Internat'l University Line
✏Release Date : 2000
✏Pages : 537
✏ISBN : 0963681761
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Pharmacophore Perception Development and Use in Drug Design Book Summary : In the early 1900s, Paul Ehrlich first defined pharmacophores as molecule frameworks that carry the essential features responsible for a drug's biological activity, and the modern definition is little changed. The 27 studies here begin by tracing the evolution of the concept in pharmaceutical research, then cover analog-based and receptor-based varieties, new algorithms, and the future of research. Among the specific topics: pharmacophores based on multiple common-feature alignments; modeling programs including HypoGen, DISCO, Catalyst, HipHop, GASP, Chem-X, Apex-3D, CoMFA; pharmacophore-based molecular docking, a technique for developing a pharmacophore model that accommodates inherent protein flexibility; and the effect of variable weights and tolerances on predictive model generation. Books in Print lists only one other book on the topic of pharmacophores. Annotation copyrighted by Book News, Inc., Portland, OR

Physico Chemical Methods In Drug Discovery And Development Book PDF
✏Book Title : Physico Chemical Methods in Drug Discovery and Development
✏Author : Zoran Mandic
✏Publisher : IAPC Publishing
✏Release Date : 2012
✏Pages : 482
✏ISBN : 9789535694205
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Physico Chemical Methods in Drug Discovery and Development Book Summary :

Molecular Imaging For Integrated Medical Therapy And Drug Development Book PDF
✏Book Title : Molecular Imaging for Integrated Medical Therapy and Drug Development
✏Author : Nagara Tamaki
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-12-10
✏Pages : 303
✏ISBN : 4431980741
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Molecular Imaging for Integrated Medical Therapy and Drug Development Book Summary : Molecular imaging plays an important role in drug discovery and advanced medical practice. A symposium of world leaders in drug research and development, molecular imaging, and medical therapy including regenerative treatment and radiation therapy has led to the publication of this book. Based on the proceedings of the symposium, many excellent ideas and valuable discussions are introduced that will guide the reader toward new advances in photon detection and protein modification as well as new developments in molecular imaging itself. Both protein modification and photon detection are emerging technologies that hold forth the promise of innovative strategies for drug discovery and medical care. The publication of these proceedings is a timely means of sharing significant experience and knowledge with many specialists all over the world. This book will be of great value to a wide variety of researchers in the fields of drug development and molecular imaging technologies, leading to integrated medical therapy and progress in human health.

Frontiers In Drug Design And Discovery Book PDF
✏Book Title : Frontiers in Drug Design and Discovery
✏Author : Atta-ur- Rahman
✏Publisher : Bentham Science Publishers
✏Release Date : 2010-12-13
✏Pages : 360
✏ISBN : 9781608051991
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Frontiers in Drug Design and Discovery Book Summary : "Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu

Molecular Basis Of Drug Design And Resistance Book PDF
✏Book Title : Molecular Basis of Drug Design and Resistance
✏Author : G. H. Coombs
✏Publisher : Cambridge University Press
✏Release Date : 1997
✏Pages : 151
✏ISBN : 0521626692
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Molecular Basis of Drug Design and Resistance Book Summary : This volume is the specially commissioned supplement to the journal Parasitology, volume 114.

Genetic And Evolutionary Computation Gecco 2004 Book PDF
✏Book Title : Genetic and Evolutionary Computation GECCO 2004
✏Author : Kalyanmoy Deb
✏Publisher : Springer Science & Business Media
✏Release Date : 2004-10-12
✏Pages : 1448
✏ISBN : 9783540223443
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Genetic and Evolutionary Computation GECCO 2004 Book Summary : The two volume set LNCS 3102/3103 constitutes the refereed proceedings of the Genetic and Evolutionary Computation Conference, GECCO 2004, held in Seattle, WA, USA, in June 2004. The 230 revised full papers and 104 poster papers presented were carefully reviewed and selected from 460 submissions. The papers are organized in topical sections on artificial life, adaptive behavior, agents, and ant colony optimization; artificial immune systems, biological applications; coevolution; evolutionary robotics; evolution strategies and evolutionary programming; evolvable hardware; genetic algorithms; genetic programming; learning classifier systems; real world applications; and search-based software engineering.

Quantitative Structure Activity Relationships In Drug Design Predictive Toxicology And Risk Assessment Book PDF
✏Book Title : Quantitative Structure Activity Relationships in Drug Design Predictive Toxicology and Risk Assessment
✏Author : Roy, Kunal
✏Publisher : IGI Global
✏Release Date : 2015-02-28
✏Pages : 727
✏ISBN : 9781466681378
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Quantitative Structure Activity Relationships in Drug Design Predictive Toxicology and Risk Assessment Book Summary : Quantitative structure-activity relationships (QSARs) represent predictive models derived from the application of statistical tools correlating biological activity or other properties of chemicals with descriptors representative of molecular structure and/or property. Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis. Focusing on emerging research in the field, this book is an ideal reference source for industry professionals, students, and academicians in the fields of medicinal chemistry and toxicology.

Annual Reports In Combinatorial Chemistry And Molecular Diversity Book PDF
✏Book Title : Annual Reports in Combinatorial Chemistry and Molecular Diversity
✏Author : W.H. Moos
✏Publisher : Springer Science & Business Media
✏Release Date : 1997-04-30
✏Pages : 354
✏ISBN : 9780306469046
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Annual Reports in Combinatorial Chemistry and Molecular Diversity Book Summary : Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date.

Computational And Structural Approaches To Drug Discovery Book PDF
✏Book Title : Computational and Structural Approaches to Drug Discovery
✏Author : Robert M. Stroud
✏Publisher : Royal Society of Chemistry
✏Release Date : 2008
✏Pages : 382
✏ISBN : 9780854043651
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Computational and Structural Approaches to Drug Discovery Book Summary : This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the physiological factors of pharmacology, a key area, is explored.

📒Breakthrough Business Models ✍ Institute of Medicine

Breakthrough Business Models Book PDF
✏Book Title : Breakthrough Business Models
✏Author : Institute of Medicine
✏Publisher : National Academies Press
✏Release Date : 2009-03-17
✏Pages : 150
✏ISBN : 9780309120883
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Breakthrough Business Models Book Summary : The process for developing new drug and biologic products is extraordinarily expensive and time-consuming. Although large pharmaceutical companies may be able to afford the cost of development because they can expect a large return on investment, organizations developing drugs to treat rare and neglected diseases are unable to rely on such returns. On June 23, 2008, the Institute of Medicine's Forum on Drug Discovery, Development, and Translation held a public workshop, "Breakthrough Business Models: Drug Development for Rare and Neglected Diseases and Individualized Therapies," which sought to explore new and innovative strategies for developing drugs for rare and neglected diseases.

Case Studies In Modern Drug Discovery And Development Book PDF
✏Book Title : Case Studies in Modern Drug Discovery and Development
✏Author : Xianhai Huang
✏Publisher : John Wiley & Sons
✏Release Date : 2012-04-19
✏Pages : 472
✏ISBN : 9781118219676
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Case Studies in Modern Drug Discovery and Development Book Summary : Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining: All phases of drug discovery and development from initial idea to commercialization Some of today's most important and life-saving medications Drugs designed for different therapeutic areas such as cardiovascular disease, infection, inflammation, cancer, metabolic syndrome, and allergies Examples of prodrugs and inhaled drugs Reasons why certain drugs failed to advance to market despite major research investments Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies. Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects.

📒Protein Structure ✍ Daniel Chasman

Protein Structure Book PDF
✏Book Title : Protein Structure
✏Author : Daniel Chasman
✏Publisher : CRC Press
✏Release Date : 2003-03-18
✏Pages : 576
✏ISBN : 9780824748166
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Protein Structure Book Summary : This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.