Molecular Biological Markers for Toxicology and Risk Assessment

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  • Author : Bruce A. Fowler
  • Publisher : Academic Press
  • Pages : 164 pages
  • ISBN : 0128019018
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Molecular Biological Markers for Toxicology and Risk Assessment

Download or Read online Molecular Biological Markers for Toxicology and Risk Assessment full in PDF, ePub and kindle. this book written by Bruce A. Fowler and published by Academic Press which was released on 10 June 2016 with total page 164 pages. We cannot guarantee that Molecular Biological Markers for Toxicology and Risk Assessment book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

Molecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment
  • Author : Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 10 June 2016
GET THIS BOOK Molecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced

Genetic Toxicology and Cancer Risk Assessment

Genetic Toxicology and Cancer Risk Assessment
  • Author : Wai Nang Choy
  • Publisher : CRC Press
  • Release : 31 August 2001
GET THIS BOOK Genetic Toxicology and Cancer Risk Assessment

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and

Computational Toxicology

Computational Toxicology
  • Author : Hong Fang,Huixiao Hong,Zhichao Liu,Roger Perkins,Reagan Kelly,John Beresney,Weida Tong,Bruce A. Fowler
  • Publisher : Elsevier Inc. Chapters
  • Release : 04 June 2013
GET THIS BOOK Computational Toxicology

Current advances in genomics, proteomics, and metabolomics are widely anticipated to translate in the future to a constellation of benefits in human health. However, few biomarkers for risk assessment using “omics” technologies have been reported in the last decade. Nevertheless, the potential application for omics technologies is tremendous. The use of biomarker-based monitoring approaches as a tool for environmental risk assessment is often critically limited by a lack of integrated bioinformatics approaches, statistical analyses, and predictive models. In this chapter

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
  • Publisher : National Academies Press
  • Release : 21 December 2000
GET THIS BOOK Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances,

Risk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures
  • Author : Gunnar F. Nordberg,Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 21 August 2018
GET THIS BOOK Risk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods

Computational Toxicology

Computational Toxicology
  • Author : Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 04 June 2013
GET THIS BOOK Computational Toxicology

Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided

Electronic Waste

Electronic Waste
  • Author : Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 13 April 2017
GET THIS BOOK Electronic Waste

Electronic Waste: Toxicology and Public Health Issues discusses the major public health concerns due to the presence of toxic chemicals that are generated from improper recycling and disposal practices of electronic waste (e-waste). This book highlights hazardous inorganic chemicals found in e-waste, including arsenic, cadmium, lead, mercury, gallium, iridium, and nanomaterials, also focusing on health issues related to the presence of BPA, styrene, and other plastic components and combustion products, while also identifying populations at special risk. To provide readers

Directory of Pathology Training Programs in the United States and Canada

Directory of Pathology Training Programs in the United States and Canada
  • Author : Anonim
  • Publisher : Unknown
  • Release : 16 June 2021
GET THIS BOOK Directory of Pathology Training Programs in the United States and Canada

Directory intended to give "medical students and graduate physicians a timely source of detailed information about the many options for pathology training in the United States and Canada." Geographical arrangement. Entries give in narrative such information as programs offered, facilities, community environment, stipends, staff, and application. Training staff index.

Biological Concepts and Techniques in Toxicology

Biological Concepts and Techniques in Toxicology
  • Author : Jim E. Riviere
  • Publisher : CRC Press
  • Release : 06 March 2006
GET THIS BOOK Biological Concepts and Techniques in Toxicology

Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicol

Introduction to Ecotoxicology

Introduction to Ecotoxicology
  • Author : Des W. Connell,Paul Lam,Bruce Richardson,Rudolf Wu
  • Publisher : John Wiley & Sons
  • Release : 17 July 2009
GET THIS BOOK Introduction to Ecotoxicology

Environmental pollution is one of the most serious threats to the future health of our planet. A wide and ever increasing range of chemicals from industry, agriculture, medicine and a host of other sources continue to contribute to the earth's chemical load. Governments have encountered great difficulties responding to the crucial and immediate need for effective management. As a result, the new science of ecotoxicology has developed, which provides a broad conceptual framework for evaluating the effects of chemicals in

Carcinogen Risk Assessment

Carcinogen Risk Assessment
  • Author : Ronald W. Hart,Fred D. Hoerger
  • Publisher : Cold Spring Harbor Laboratory Press
  • Release : 16 June 1988
GET THIS BOOK Carcinogen Risk Assessment

Papers and discussions from a conference, date and place unspecified. This volume is in a series on carcinogen and health-related topics. Discussion is centered on structure-activity relationship data, pharmacokinetic and metabolic activity data, molecular biological data, approaches toward integrat

Drug Discovery Toxicology

Drug Discovery Toxicology
  • Author : Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy
  • Publisher : John Wiley & Sons
  • Release : 22 March 2016
GET THIS BOOK Drug Discovery Toxicology

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers