Microfluidic Cell Culture Systems

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  • Author : Jeffrey T Borenstein
  • Publisher : Elsevier
  • Pages : 396 pages
  • ISBN : 0128136723
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Microfluidic Cell Culture Systems

Download or Read online Microfluidic Cell Culture Systems full in PDF, ePub and kindle. this book written by Jeffrey T Borenstein and published by Elsevier which was released on 12 September 2018 with total page 396 pages. We cannot guarantee that Microfluidic Cell Culture Systems book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems
  • Author : Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest
  • Publisher : Elsevier
  • Release : 12 September 2018
GET THIS BOOK Microfluidic Cell Culture Systems

Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This

Multiplexed Microfabricated Cell Culture Device for Stem Cell Process Development

Multiplexed Microfabricated Cell Culture Device for Stem Cell Process Development
  • Author : M. Reichen
  • Publisher : Unknown
  • Release : 29 July 2021
GET THIS BOOK Multiplexed Microfabricated Cell Culture Device for Stem Cell Process Development

In this thesis, a multiplexed micro-fabricated cell culture device is presented to probe the soluble micro-environment of stem cells. A large number of biological, physical and chemical variables determine the micro-environment of stem cells and affect therefore their fate. The soluble micro-environment is believed to play a pivotal role in controlling stem cell fate and its optimisation may therefore allow exploitation of applications such as regenerative medicine or drug discovery. However, novel tools are required to probe and optimise the

Cardiac Cell Culture Technologies

Cardiac Cell Culture Technologies
  • Author : Zbigniew Brzozka,Elzbieta Jastrzebska
  • Publisher : Springer
  • Release : 21 November 2017
GET THIS BOOK Cardiac Cell Culture Technologies

This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems
  • Author : Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao
  • Publisher : William Andrew
  • Release : 31 December 2012
GET THIS BOOK Microfluidic Cell Culture Systems

The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles

Cardiac Cell Culture Technologies

Cardiac Cell Culture Technologies
  • Author : Zbigniew Brzozka,Elzbieta Jastrzebska
  • Publisher : Springer
  • Release : 04 September 2018
GET THIS BOOK Cardiac Cell Culture Technologies

This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and

Medical and Industrial Applications of Microfluidic based Cell Tissue Culture and Organs on a Chip Advances in Organs on a Chip and Organoids Technologies

Medical and Industrial Applications of Microfluidic based Cell Tissue Culture and Organs on a Chip  Advances in Organs on a Chip and Organoids Technologies
  • Author : Qasem Ramadan,Massimo Alberti,Martin Dufva,Yi-Chung Tung
  • Publisher : Frontiers Media SA
  • Release : 16 October 2019
GET THIS BOOK Medical and Industrial Applications of Microfluidic based Cell Tissue Culture and Organs on a Chip Advances in Organs on a Chip and Organoids Technologies

Recent developments in microfluidics have demonstrated enormous potential of microscale cell culture for biology studies and recognized as instrumental in performing rapid and efficient experiments on small-sample volumes. Microfluidic-based cell culture is an area of research that keeps growing and gaining importance as a prominent technology, able to link scientific disciplines with industrial and clinical applications. In particular, organotypic cell culture and its integration in microfluidic devices would enable the realization of “in vivo-like” cell microenvironment within systems that are

Studying Intercellular Signaling Underlying Human Diseases Using Open Microfluidic Coculture

Studying Intercellular Signaling Underlying Human Diseases Using Open Microfluidic Coculture
  • Author : Tianzi Zhang
  • Publisher : Unknown
  • Release : 29 July 2021
GET THIS BOOK Studying Intercellular Signaling Underlying Human Diseases Using Open Microfluidic Coculture

This dissertation focuses on the development of innovative open microfluidic cell culture platforms and their application in studying intercellular signaling underlying human diseases in controlled ex vivo microenvironments. Chapter 1 introduces the background of open microfluidic capillary systems, including the design considerations and current fabrication techniques, and addresses the advantages of using open microfluidic cell culture systems to study intercellular signaling. Chapter 2 presents a new open microfluidic capillary platform, which patterns biocompatible hydrogel walls along a rail insert set inside established

Organs on chips for the pharmaceutical development process

Organs on chips for the pharmaceutical development process
  • Author : Jonas Christoffersson
  • Publisher : Linköping University Electronic Press
  • Release : 22 January 2019
GET THIS BOOK Organs on chips for the pharmaceutical development process

Organs-on-chips are dynamic cell culture devices created with the intention to mimic organ function in vitro. Their purpose is to assess the toxicity and efficacy of drugs and, as early as possible in the pharmaceutical development process, predict the outcome of clinical trials. The aim of this thesis is to explain and discuss these cell culture devices from a design perspective and to experimentally exemplify some of the specific functions that characterize organs-on-chips. The cells in our body reside in

Cell Analysis on Microfluidics

Cell Analysis on Microfluidics
  • Author : Jin-Ming Lin
  • Publisher : Springer
  • Release : 25 October 2017
GET THIS BOOK Cell Analysis on Microfluidics

This book presents a detailed overview of the design, formatting, application, and development of microfluidic chips in the context of cell biology research, enumerating each element involved in microfluidics-based cell analysis, discussing its history, status quo, and future prospects, It also offers an extensive review of the research completed in the past decade, including numerous color figures. The individual chapters are based on the respective authors' studies and experiences, providing tips from the frontline to help researchers overcome bottlenecks in

Small Volume Cell Cultures

Small Volume Cell Cultures
  • Author : Pantea Gheibi
  • Publisher : Unknown
  • Release : 29 July 2021
GET THIS BOOK Small Volume Cell Cultures

In vitro cell cultures are used widely in cell biology, drug discovery and toxicology. In the past two decades, there has been a steady shift in focus from simplistic 2D monolayer cultures to more sophisticated cultures introducing heterotypic cellular interactions, mechanical cues or a third dimension. In general, the trend is to recapitulate aspects of in vivo microenvironment into in vitro culture systems. The emphasis of my research has been on creating cell culture conditions for accumulation and retention of