Mesenchymal Stem Cells in Human Health and Diseases

• Author : Ahmed El-Hashash
• Publisher : Academic Press
• Release : 06 January 2020

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural

• Author : Khalid Shah
• Publisher : Elsevier
• Release : 18 December 2013

With the thorough understanding of stem cell biology and the advent of targeted therapeutics for cancer, stem cell-based therapeutic strategies are being increasingly explored for the treatment of various cancer types. Mesenchymal Stem Cells in Cancer Therapy sheds light on current stem cell based targeted therapies for cancer, by focusing on the application of mesenchymal stem cells (MSC) in various cancers with emphasis on a number of aspects that are critical to the success of future stem cell based therapies

• Author : M.A. Hayat
• Publisher : Springer Science & Business Media
• Release : 07 February 2012

Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on this type of stem cells in this volume. The role

• Author : Phuc Van Pham,Ahmed El-Hashash
• Publisher : Springer
• Release : 07 November 2018

This invaluable resource discusses insights ranging from basic biological mechanisms of various types of stem cells through the potential applications in the treatment of human diseases, including cancer and genetic disorders. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding different types of stem cell biology and their potential applications in tissue repair and regeneration and in the treatment different types of human cancer and genetic diseases or

• Author : Thomas Dittmar,Kurt S. Zänker
• Publisher : CRC Press
• Release : 01 March 2013

This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence

• Author : Anonim
• Publisher : Unknown
• Release : 01 December 2004

• Author : Ramon Lopez Perez,Franziska Münz,Denise Vidoni,Alexander Rühle,Thuy Trinh,Sonevisay Sisombath,Bingwen Zou,Patrick Wuchter,Jürgen Debus,Anca-Ligia Grosu,Rainer Saffrich,Peter E. Huber,Nils Nicolay
• Publisher : Unknown
• Release : 10 April 2021

Abstract: Background Mesenchymal stem cells (MSCs) participate in the regeneration of tissue lesions induced by antimetabolite chemotherapy; however, the influence of this class of anti-cancer compounds on the stem cells remains largely unknown. Methods The survival of MSCs after exposure to 5-fluorouracil (5-FU) and gemcitabine was measured by viability and clonogenic assays. MSC morphology, surface marker expression, adhesion potential, cellular velocity and differentiation potential were determined after antimetabolite treatment. Cell cycle distribution and apoptosis were assessed using flow cytometry, and

• Author : President's Council on Bioethics (U.S.)
• Publisher : Diane Publishing Company
• Release : 10 April 2021

This report summarizes some of the more interesting and significant recent developments, both in the basic science and medical applications of stem cell research and in the related ethical, legal, and policy discussions. It does not attempt to be a definitive or comprehensive study of the whole topic. It contains no proposed guidelines and regulations, nor indeed any specific recommendations for policy change. Rather, it seeks to shed light on where we are now: ethically, legally, scientifically, and medically, in

• Author : Rebecca N. Campbell
• Publisher : Nova Publishers
• Release : 10 April 2021

Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment

• Author : Anonim
• Publisher : ScholarlyEditions
• Release : 09 January 2012

Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition

• Author : Yoshimasa Saito
• Publisher : Frontiers E-books
• Release : 10 November 2014

Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine 9 (H3K9) and tri-methylation of H3K27. MiRNAs are small non-coding RNAs that regulate expression of various target genes. Specific miRNAs are aberrantly expressed and play roles as tumor suppressors

• Author : Birgit Weyand,Massimo Dominici,Ralf Hass,Roland Jacobs,Cornelia Kasper
• Publisher : Springer
• Release : 08 July 2014

Prospective Isolation and Characterization of Human Bone Marrow-Derived MSCs, by A. Harichandan, K. Sivasubramaniyan, H.-J. Bühring Urine as a Source of Stem Cells, by Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Johannes Grillari, Hung-Fat Tse, Regina Grillari-Voglauer, Duanqing Pei, Miguel A. Esteban Expansion of Mesenchymal Stem/Stromal Cells under Xenogenic-Free Culture Conditions, by Sven Kinzebach, Karen Bieback Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications, by Danielle Minteer, Kacey G Marra, J Peter Rubin Potential for Osteogenic

• Author : M.A. Hayat
• Publisher : Springer Science & Business Media
• Release : 22 November 2011

It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent

• Author : M.A. Hayat
• Publisher : Springer Science & Business Media
• Release : 27 February 2012

The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell

• Author : Anonim
• Publisher : Unknown
• Release : 01 April 2009