Lipid Signaling And Metabolism

✏Book Title : Lipid Signaling and Metabolism
✏Author : James M. Ntambi
✏Publisher : Academic Press
✏Release Date : 2020-08-09
✏Pages : 566
✏ISBN : 9780128194058
✏Available Language : English, Spanish, And French

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✏Lipid Signaling and Metabolism Book Summary : Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

✏Book Title : Druggable Lipid Signaling Pathways
✏Author : Yasuyuki Kihara
✏Publisher : Springer Nature
✏Release Date :
✏Pages :
✏ISBN : 9783030506216
✏Available Language : English, Spanish, And French

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✏Druggable Lipid Signaling Pathways Book Summary :

✏Book Title : Lipid Signaling Protocols
✏Author : Mark Waugh
✏Publisher : Humana Press
✏Release Date : 2016-08-23
✏Pages : 257
✏ISBN : 149395007X
✏Available Language : English, Spanish, And French

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✏Lipid Signaling Protocols Book Summary : In this second edition methods are described to measure the synthesis of lipids such as the phosphoinositides, ceramides and sphingomyelin, as well as techniques to molecularly characterize the various kinases and phosphatases that regulate the intracellular metabolism of these lipids. Lipid Signaling Protocols, Second Edition guides readers through detailed experimental protocols, which are complimented by review chapters that highlight the technical considerations, challenges and potential pitfalls associated with using these laboratory-based approaches. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Lipid Signaling Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

✏Book Title : Lipid Signaling in Human Diseases
✏Author : Julian Gomez-Cambronero
✏Publisher : Springer Nature
✏Release Date : 2020-04-24
✏Pages : 336
✏ISBN : 9783030336684
✏Available Language : English, Spanish, And French

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✏Lipid Signaling in Human Diseases Book Summary : Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important.

✏Book Title : Membrane Lipid Signaling in Aging and Age Related Disease
✏Author : M.P. Mattson
✏Publisher : Elsevier
✏Release Date : 2003-05-06
✏Pages : 236
✏ISBN : 0080522505
✏Available Language : English, Spanish, And French

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✏Membrane Lipid Signaling in Aging and Age Related Disease Book Summary : The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases. This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

✏Book Title : Lipid Signaling in T Cell Development and Function
✏Author : Karsten Sauer
✏Publisher : Frontiers Media SA
✏Release Date : 2015-11-12
✏Pages : 140
✏ISBN : 9782889196975
✏Available Language : English, Spanish, And French

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✏Lipid Signaling in T Cell Development and Function Book Summary : Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.

✏Book Title : Polyamine Metabolism and Activation of Lipid Signalling Pathways in Arabidopsis Thaliana
✏Author : J. Zarza Cubero
✏Publisher :
✏Release Date : 2017
✏Pages : 175
✏ISBN : OCLC:1107987839
✏Available Language : English, Spanish, And French

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✏Polyamine Metabolism and Activation of Lipid Signalling Pathways in Arabidopsis Thaliana Book Summary : Polyamine metabolism has emerged during the last 40 years as an important stress-related pathway and its accumulation is often a metabolic hallmark of enhanced plant stress tolerance. These small and versatile polycationic molecules are not only involved in stress responses, but also in many aspects of cellular biology and -physiology, affecting processes such as ion transport, protein- and lipid-kinase activity, transcription, protein synthesis, or stabilization of membrane- and nuclear components. Nonetheless, the molecular mechanism by which polyamines exert such a wide range of effects is still not well understood. To extend these studies, in this thesis we investigate the polyamine back-conversion pathway during salt stress in Arabidopsis thaliana using loss-of-function mutants of the AtPAO5 gene, the most-induced PAO member in salt conditions. In a different approach, we investigate the effect of polyamines on plasma membrane-associated phospholipid signalling, using an optimized 32Pi-labelling procedure that analyses phospholipid synthesis and turnover in vivo. In those studies, we demonstrate that polyamines trigger an increase of the lipid-signalling molecules phosphatidylinositol 4,5-bisphosphate and phosphatidic acid, in root cells of Arabidopsis seedlings. The detailed characterization of the phospholipid responses carried out in this thesis, provides novel and interesting tools to further unravel the role of polyamines in eukaryotic cell biology in general and in plant biology in particular.

✏Book Title : Lipid Signaling in Plants
✏Author : Teun Munnik
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-12-03
✏Pages : 330
✏ISBN : 3642038735
✏Available Language : English, Spanish, And French

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✏Lipid Signaling in Plants Book Summary : This comprehensive update on plant lipid signaling covers the measurement, regulation and function of phospholipases, lipid kinases, lipid phosphatases, inositolpolphosphates, polyphosphoinositides, phosphatic acid, and other lipid signals such as oxylipins.

✏Book Title : Lipid signaling in plants
✏Author :
✏Publisher : Frontiers E-books
✏Release Date :
✏Pages :
✏ISBN : 9782889191482
✏Available Language : English, Spanish, And French

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✏Lipid signaling in plants Book Summary :

✏Book Title : The Multifaceted Role of Hypoxia Inducible Factor 1 HIF1 in Lipid Metabolism
✏Author : Guomin Shen
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1154176530
✏Available Language : English, Spanish, And French

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✏The Multifaceted Role of Hypoxia Inducible Factor 1 HIF1 in Lipid Metabolism Book Summary : Hypoxia-inducible factor 1 (HIF1) is a master transcription factor and regulates expression of a large number of genes involving many aspects of biology. In addition to HIF1's roles in glucose metabolism and angiogenesis, numerous studies have revealed an emerging role of HIF1 in controlling lipid homeostasis. In this chapter, we discuss that lipid accumulation is related to HIF1's activity in several diseases and the growing evidence demonstrating the functional importance of HIF1 in controlling lipid metabolism. The functions include lipid uptake and trafficking, fatty acid metabolism, sterol metabolism, triacylglycerol synthesis, phospholipid metabolism, lipid droplet biogenesis, and lipid signaling. Defining the role of HIF1 in lipid metabolism is crucial to understand the pathophysiology of lipid in disease and may help us to identify additional target sites for drug development. This review would shed light on our understanding of the critical role of HIF1 in lipid metabolism.

✏Book Title : Lipidomics and Bioactive Lipids Lipids and Cell Signaling
✏Author :
✏Publisher : Elsevier
✏Release Date : 2007-11-12
✏Pages : 392
✏ISBN : 0080554091
✏Available Language : English, Spanish, And French

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✏Lipidomics and Bioactive Lipids Lipids and Cell Signaling Book Summary : This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Phospholipase A1 assays using a radio-labeled substrate and mass spectrometry; Real-time Cell Assays of Phospholipases A2 Using Fluorogenic Phospholipids; Analysis and Pharmacological Targeting of Phospholipase C â interactions with G proteins; Biochemical Analysis of Phospholipase D.; Measurement of Autotaxin/Lysophospholipase D Activity; Platelet-Activating Factor; Quantitative measurement of PtdIns(3,4,5)P3; Measuring Phosphorylated Akt And Other Phosphoinositide 3-Kinase-Regulated Phosphoproteins In Primary Lymphocytes; Regulation of Phosphatidylinositol 4-Phosphate 5-Kinase activity by partner proteins; Biochemical Analysis of Inositol Phosphate Kinases; Analysis of the phosphoinositides and their aqueous metabolites; Combination of C17-sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism; Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo; A rapid and sensitive method to measure secretion of sphingosine-1-phosphate; Ceramide Kinase and Ceramide-1-Phosphate; Measurement of Mammalian Diacylglycerol Kinase Activity in vitro and in Cells; Lipid Phosphate Phosphatases from Saccharomyces cerevisiae.

✏Book Title : Lipid Metabolism in Signaling Systems
✏Author : John N. Fain
✏Publisher : Academic Press
✏Release Date : 2013-10-22
✏Pages : 357
✏ISBN : 9781483288321
✏Available Language : English, Spanish, And French

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✏Lipid Metabolism in Signaling Systems Book Summary : Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Techniques for examining the role of phosphoinositides in signal transduction Techniques related to protein kinase C Analysis of inositol phosphates Techniques to analyze phospholipid turnover in the brain

✏Book Title : The Regulation of Membrane Lipid Metabolism Second Edition
✏Author : Guy A. Thompson, Jr.
✏Publisher : CRC Press
✏Release Date : 1992-03-10
✏Pages : 240
✏ISBN : 0849345618
✏Available Language : English, Spanish, And French

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✏The Regulation of Membrane Lipid Metabolism Second Edition Book Summary : This book provides a concise description of the metabolic pathways by which lipids of animal and plant membranes are formed. The book emphasizes modulation of these pathways by hormones, diet, environmental stress, and other factors. This new edition is extensively revised, containing new material on topics such as lipid-mediated signal transduction and lipid-induced protein translocation. The new edition also features an entirely new chapter on lipids covalently bound to proteins. The book is excellent for all researchers and students interested in membrane lipid metabolism.

✏Book Title : Membrane Microdomain Signaling
✏Author : Mark P. Mattson
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-10-27
✏Pages : 214
✏ISBN : 9781592598038
✏Available Language : English, Spanish, And French

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✏Membrane Microdomain Signaling Book Summary : Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

✏Book Title : Lipid Signaling Protocols
✏Author : Banafshé Larijani
✏Publisher : Humana Press
✏Release Date : 2008-11-11
✏Pages : 429
✏ISBN : 1588297276
✏Available Language : English, Spanish, And French

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✏Lipid Signaling Protocols Book Summary : Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular BiologyTM series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls. Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology.

✏Book Title : Lipidomics and Bioactive Lipids Mass Spectrometry Based Lipid Analysis
✏Author :
✏Publisher : Elsevier
✏Release Date : 2007-11-26
✏Pages : 432
✏ISBN : 0080554881
✏Available Language : English, Spanish, And French

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✏Lipidomics and Bioactive Lipids Mass Spectrometry Based Lipid Analysis Book Summary : This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Qualitative Analysis and Quantitative Assessment of Changes in Neutral Glycerol Lipid Molecular Species within Cells; Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry; Detection and Quantitation of Eicosanoids via High Performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry; Structure-specific, quantitative methods for "lipidomic" analysis of sphingolipids by tandem mass spectrometry; Analysis of Ubiquinones, Dolichols and Dolichol Diphosphate-Oligosaccharides by Liquid Chromatography Electrospray Ionization Mass Spectrometry; Extraction and Analysis of Sterols in Biological Matrices by High-Performance Liquid Chromatography Electrospray Ionization Mass Spectrometry; The Lipid Maps Initiative in Lipidomics; Basic analytical systems for lipidomics by mass spectrometry in Japan; The European Lipidomics Initiative Enabling technologies; Lipidomic analysis of Signaling Pathways; Bioinformatics for Lipidomics; Mediator Lipidomics: Search Algorithms for Eicosanoids, Resolvins and Protectins; A guide to biochemical systems modeling of sphingolipids for the biochemist; and Quantitation and Standardization of Lipid Internal Standards for Mass Spectroscopy.

✏Book Title : Phospholipid Metabolism in Cellular Signaling
✏Author : Jose M. Mato
✏Publisher : CRC Press
✏Release Date : 1990-11-12
✏Pages : 160
✏ISBN : 0849359783
✏Available Language : English, Spanish, And French

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✏Phospholipid Metabolism in Cellular Signaling Book Summary : Phospholipids are no longer considered exclusively as the building blocks of biomembranes, but are now regarded to be exceptionally important to cellular signalling. Another conclusion resulting from studies over the past several years is that no single general scheme for the role of phospholipids during cell activation can be drawn as representative of all cells. Phospholipid Metabolism in Cellular Signaling presents a comprehensive view of the recent advances made in certain major research areas within the field of phospholipid metabolism in cellular signalling. Topics discussed within this volume include lipid composition of cellular membranes and their organization in biological systems, the dynamic aspects of phospholipid metabolism and its regulation by extracellular stimuli, and the role of newly discovered glycosyl-phosphatidylinositols in insulin action . The book also discusses two biologically active phospholipids: the sphingolipids, and ether-linked glycerophospholipids (the platelet activating factor). Phospholipid Metabolism in Cellular Signaling is an important research reference that should be considered required reading by all scientists and graduate students working on cell activation (e.g., growth factors, hormones, and oncogenes).

✏Book Title : Lipidomics and Bioactive Lipids Specialized Analytical Methods and Lipids in Disease
✏Author :
✏Publisher : Elsevier
✏Release Date : 2007-11-09
✏Pages : 296
✏ISBN : 0080560652
✏Available Language : English, Spanish, And French

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✏Lipidomics and Bioactive Lipids Specialized Analytical Methods and Lipids in Disease Book Summary : This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis; Measurement of eicosanoids in cancer tissues; Noninvasive Assessment of the Role of Cyclooxygenases in Cardiovascular Health A Detailed HPLC/MS/MS Method; Lipidomics in Diabetes and the Metabolic Syndrome; LC-MS-MS Analysis of Neutral Eicosanoids; Quantification Of F2-Isoprostanes In Biological Fluids And Tissues As A Measure Of Oxidant Stress; Measurement of Products of Docosahexaenoic Acid Peroxidation, Neuroprostanes, and Neurofurans; Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography; Targeted Chiral Lipidomics Analysis by Liquid Chromatography Electron Capture Atmospheric Pressure Chemical Ionization Mass Spectrometry (LC-ECAPCI/MS); Shotgun Lipidomics by Tandem Mass Spectrometry under Data-Dependent Acquisition Control; Identification of Intact Lipid Peroxides by Ag+ Coordination Ionspray Mass Spectrometry (CIS-MS); Quantification of Cardiolipin by Liquid Chromatography Electrospray Ionization Mass Spectrometry.

✏Book Title : Lipid Mediators and Their Metabolism in the Brain
✏Author : Akhlaq A. Farooqui
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-08-12
✏Pages : 327
✏ISBN : 144199940X
✏Available Language : English, Spanish, And French

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✏Lipid Mediators and Their Metabolism in the Brain Book Summary : Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.

✏Book Title : Signaling in the Heart
✏Author : José Marín-García
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-06-21
✏Pages : 507
✏ISBN : 1441994610
✏Available Language : English, Spanish, And French

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✏Signaling in the Heart Book Summary : Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.

✏Book Title : Lipid Metabolism
✏Author : Rodrigo Valenzuela Baez
✏Publisher : BoD – Books on Demand
✏Release Date : 2013-01-23
✏Pages : 474
✏ISBN : 9789535109440
✏Available Language : English, Spanish, And French

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✏Lipid Metabolism Book Summary : Lipids (fats and oils) are a wide range of organic molecules that serve several functions in organisms. Lipids are essential components of our diet, highlighting their important contribution in energy, representing 9 kcal/g (or 37.7 kJ/g), and by some components relevant to the metabolism, such as essential fatty acids, fat soluble vitamins and sterols (cholesterol and phytosterols). Besides this, lipids have key roles in human growth and development, along with promoting, preventing and/or participating in the origin or eventually in the treatment of various diseases. This book presents a systematic and comprehensive review about the structure and metabolism of lipids, particularly highlighting the importance of these molecules in the body and considering the interest of some lipids in health and disease.

✏Book Title : Cellular Lipid Metabolism
✏Author : Christian Ehnholm
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-07-07
✏Pages : 376
✏ISBN : 3642003001
✏Available Language : English, Spanish, And French

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✏Cellular Lipid Metabolism Book Summary : For years lipids have fascinated cell biologists and biochemists due to their profound effects on cell function. "Cellular Lipid Metabolism" highlights new concepts and recent findings, but also reviews important discoveries made in the past. Outstanding international experts contribute 13 chapters on the genetics, molecular and cell biology of lipids. Presenting analyses at the molecular level they reveal the principles by which cellular lipid metabolism functions. Further, numerous intriguing observations that cannot yet be explained are identified, stimulating the readers to future studies. This book provides an invaluable source of information for biomedical researchers in energy metabolism, vascular biology, endocrinology and lipidology.

✏Book Title : Lipid Mediated Signaling
✏Author : Eric J. Murphy
✏Publisher : CRC Press
✏Release Date : 2010-03-05
✏Pages : 452
✏ISBN : 0849381428
✏Available Language : English, Spanish, And French

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✏Lipid Mediated Signaling Book Summary : As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade’s worth of advances in research techniques that are pertinent in understanding how lipid-mediated signal transduction ties to pathologic disorders. Part I describes methods used to identify activities of and assay the expression of different enzymes involved in lipid-mediated signaling. Part II highlights the use of mass spectrometry to ascertain the lipid content in various systems. Part III contains two chapters devoted to techniques used to determine the role of lipids in the activation of gene transcription. Part IV rounds out the book’s solid coverage by focusing on methods used to assess fatty acid uptake and metabolism. Lipid-Mediating Signaling is an unrivaled reference for this rapidly expanding, yet resource-limited field, and it is a valuable resource for for cell biologists, biochemists, and pharmacologists, as well as for researchers studying signaling transduction.

✏Book Title : Lipids
✏Author :
✏Publisher : Academic Press
✏Release Date : 2012-03-28
✏Pages : 528
✏ISBN : 9780123864888
✏Available Language : English, Spanish, And French

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✏Lipids Book Summary : Lipids are a broad group of naturally occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules. This volume of Methods in Cell Biology covers such areas as Membrane structure and dynamics, Imaging, and Lipid Protein Interactions. It will be an essential tool for researchers and students alike. Covers such areas as membrane structure and dynamics, imaging, and lipid protein interactions An essential tool for researchers and students alike International authors Renowned editors

✏Book Title : Processing and Nutrition of Fats and Oils
✏Author :
✏Publisher : John Wiley & Sons
✏Release Date : 2013-07-25
✏Pages : 276
✏ISBN : 9781118528785
✏Available Language : English, Spanish, And French

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✏Processing and Nutrition of Fats and Oils Book Summary : Processing and Nutrition of Fats and Oils reviews current and new practices of fats and oils production. The book examines the different aspects of fats and oils processing, how the nutritional properties are affected, and how fats interact with other components and nutrients in food products. Coverage includes current trends in the consumption of edible fats and oils; properties of fats, oils and bioactive lipids; techniques to process and modify edible oils; nutritional aspects of lipids; and regulatory aspects, labeling and certifications of fats and oils in foods.

✏Book Title : Stearoyl CoA Desaturase Genes in Lipid Metabolism
✏Author : James M. Ntambi, Ph.D.
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-08-15
✏Pages : 239
✏ISBN : 9781461479697
✏Available Language : English, Spanish, And French

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✏Stearoyl CoA Desaturase Genes in Lipid Metabolism Book Summary : Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans. At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor’s studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse tissues have all established that the expression of SCD1 gene isoform represents a key step in partitioning of lipids between storage and oxidation. High SCD expression favors fat storage leading to obesity while reduced SCD expression favors fat burning and leanness. Although these studies clearly illustrated that SCD1 expression is involved in the development of obesity and insulin resistance, questions remain in the elucidation of the mechanisms involved and role of SCD1. This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver metabolism, Colitis, and more. ​

✏Book Title : Functional Lipidomics
✏Author : Li Feng
✏Publisher : CRC Press
✏Release Date : 2005-09-14
✏Pages : 352
✏ISBN : 9781420027655
✏Available Language : English, Spanish, And French

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✏Functional Lipidomics Book Summary : Lipids play an essential role in cell signaling and subcellular structure. Systematic analysis of the total lipid structure of a cell or organism, the lipodome, can reveal novel avenues of therapeutic intervention and diagnosis. This analysis is best modeled after the lessons learned from proteomics. With contributions from pioneering researchers from the US, Europe, Canada, Japan, and China, Functional Lipidomics introduces lipidomics, explores the current state of the field, and provides a comprehensive background for future groundbreaking work in this burgeoning field. The first book dedicated to the topic, Functional Lipidomics first defines and introduces the field before delving deeply into the methods, processes, analyses, and research aspects. The book uncovers the biosynthesis, metabolism, and function of fatty acids, acylglyerols, glycerophospholipids, sphingolipids, terpenes, and lipids that complex with proteins. Taking both academic and industrial perspectives, the contributors elaborate upon cutting-edge approaches to lipid analysis, diagnostic approaches using lipid and lipid-binding protein patterns, and the therapeutic significance of targeting proteins involved with the lipid signaling pathway. Functional Lipidomics elucidates state-of-the-art strategies and techniques that enable us to understand biochemical patterns related to disease states, develop new targets for drug design, and identify important markers of a developmental stage, pathological condition, or disease treatment.

✏Book Title : Endocrinology E Book
✏Author : J. Larry Jameson
✏Publisher : Elsevier Health Sciences
✏Release Date : 2010-05-18
✏Pages : 3064
✏ISBN : 9781455711260
✏Available Language : English, Spanish, And French

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✏Endocrinology E Book Book Summary : ENDOCRINOLOGY, edited by J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD, has been considered the definitive source in its field for decades. Now this landmark reference has been exhaustively updated to bring you the latest clinical guidance on all aspects of diagnosis and treatment for the full range of endocrine and metabolism disorders, including new information on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors. Entirely new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis keep you well informed on today’s hot topics. You’ll benefit from unique, global perspectives on adult and pediatric endocrinology prepared by an international team of renowned authorities. This reference is optimally designed to help you succeed in your demanding practice and ensure the best possible outcomes for every patient. Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field. Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors ... brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis ... expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration ... and the newest discoveries in genetics and how they affect patient care. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information more quickly, while still getting the complete coverage you expect.

✏Book Title : Endocrinology Adult and Pediatric Diabetes Mellitus and Obesity E Book
✏Author : Gordon C Weir
✏Publisher : Elsevier Health Sciences
✏Release Date : 2013-06-18
✏Pages : 496
✏ISBN : 9780323221542
✏Available Language : English, Spanish, And French

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✏Endocrinology Adult and Pediatric Diabetes Mellitus and Obesity E Book Book Summary : Meet the growing challenges of diabetes and obesity management with Endocrinology: Adult and Pediatric: Diabetes Mellitus and Obesity - a new diabetes and obesity eBook from the same expert endocrinologists responsible for the highly acclaimed two-volume Endocrinology clinical reference. With all of the latest advances loaded on your favorite eReader, you’ll be able to put today’s best practices to work for your patients. Stay abreast of the newest knowledge and advances in diabetes mellitus and obesity, including today’s increased focus on controlling autoimmunity and preserving or replenishing beta-cell mass in the management of type 1 diabetes; complications of diabetes and their pathogenesis, morbidity, and treatment; new findings and treatments for obesity; and much more. Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and DeGroot, the go-to clinical reference for endocrinologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.

✏Book Title : Phospholipid Metabolism in Apoptosis
✏Author : Peter J. Quinn
✏Publisher : Springer Science & Business Media
✏Release Date : 2002-05-31
✏Pages : 340
✏ISBN : 9780306467820
✏Available Language : English, Spanish, And French

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✏Phospholipid Metabolism in Apoptosis Book Summary : The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. It is now well recognised that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The molecular mechanisms of apoptosis are presently unknown and the subject of focused research effort. It is clear that cell membrane structure and properties play an early part in the induction process. There is increasing evidence that the arrangement of polar lipids in the membrane lipid matrix is an important factor coupled with the homeostatic mechanisms responsible for preserving membrane lipid composition and asymmetry. Changes in membrane permeability are also likely to be involved, possibly as a direct consequence of disturbances in the lipid bilayer matrix. The purpose of this volume is to examine the involvement of membrane lipids in early events of apoptosis. In particular, the role of phospholipids in mitochondrial permeability, membrane lipid asymmetry, and sphingolipid and phospholipid signalling processes in early apoptotic events are reviewed by current researchers in these fields.