Ketamine For Treatment Resistant Depression

Ketamine For Treatment Resistant Depression Book PDF
✏Book Title : Ketamine for Treatment Resistant Depression
✏Author : Sanjay J. Mathew
✏Publisher : Springer
✏Release Date : 2016-11-25
✏Pages : 155
✏ISBN : 9783319429250
✏Available Language : English, Spanish, And French

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✏Ketamine for Treatment Resistant Depression Book Summary : This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.

Ketamine For Treatment Resistant Depression Book PDF
✏Book Title : Ketamine for Treatment Resistant Depression
✏Author : Gustavo H. Vazquez
✏Publisher : Academic Press
✏Release Date : 2020-10-01
✏Pages : 168
✏ISBN : 9780128210345
✏Available Language : English, Spanish, And French

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✏Ketamine for Treatment Resistant Depression Book Summary : Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. Provides efficacy research on ketamine as a treatment for depression Identifies best practices for clinical use, both long-term and acute Discusses the molecular mechanisms and neurobiology of action

📒Ketamine For Depression ✍ Dr. Stephen J. Hyde

Ketamine For Depression Book PDF
✏Book Title : Ketamine for Depression
✏Author : Dr. Stephen J. Hyde
✏Publisher : Xlibris Corporation
✏Release Date : 2015-09-04
✏Pages : 222
✏ISBN : 9781503509535
✏Available Language : English, Spanish, And French

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✏Ketamine for Depression Book Summary : Given the unacceptably high rates of suffering, disability and premature death experienced by people with treatment-resistant depression and the surprisingly low rates of problems arising from the use of ketamine to treat the disorder, this is a therapy that all patients and their doctors should be discussing. This book summarises the research that has been carried out into ketamine for the treatment of depression over the past 15 years and, most importantly, describes different ways of using ketamine that are both practical and cost–effective. Currently most ketamine therapy is given intravenously in specialised clinics at considerable expense, but the author has successfully treated patients with low-dose sublingual ketamine and his patients have been able to safely take this at home. Profits from the sales of this book will assist further research into the use of ketamine for the treatment of depression.

Repeated Intranasal Ketamine For Treatment Resistant Depression The Way To Go Results From A Pilot Randomised Controlled Trial Book PDF
✏Book Title : Repeated Intranasal Ketamine for Treatment resistant Depression the Way to Go Results from a Pilot Randomised Controlled Trial
✏Author :
✏Publisher :
✏Release Date :
✏Pages :
✏ISBN : OCLC:1051947420
✏Available Language : English, Spanish, And French

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✏Repeated Intranasal Ketamine for Treatment resistant Depression the Way to Go Results from a Pilot Randomised Controlled Trial Book Summary : Background: Ketamine research in depression has mostly used intravenous, weight-based approaches, which are difficult to translate clinically. Intranasal (IN) ketamine is a promising alternative but no controlled data has been published on the feasibility, safety and potential efficacy of repeated IN ketamine treatments. Methods: This randomised, double-blind, placebo-controlled pilot study compared a 4-week course of eight treatments of 100 mg ketamine or 4.5 mg midazolam. Each treatment was given as 10 separate IN sprays, self-administered 5 min apart. The study was stopped early due to poor tolerability after five treatment-resistant depressed participants were included. Feasibility, safety (acute and cumulative), cognitive and efficacy outcomes were assessed. Plasma ketamine and norketamine concentrations were assayed after the first treatment. Results: Significant acute cardiovascular, psychotomimetic and neurological side effects occurred at doses 100 mg ketamine. No participants were able to self-administer all 10 ketamine sprays due to incoordination; treatment time occasionally had to be extended (45 min) due to acute side effects. No hepatic, cognitive or urinary changes were observed after the treatment course in either group. There was an approximately two-fold variation in ketamine and norketamine plasma concentrations between ketamine participants. At course end, one participant had remitted in each of the ketamine and midazolam groups. Conclusions: IN ketamine, with the drug formulation and delivery device used, was not a useful treatment approach in this study. Absorption was variable between individuals and acute tolerability was poor, requiring prolonged treatment administration time in some individuals. The drug formulation, the delivery device, the insufflation technique and individual patient factors play an important role in tolerability and efficacy when using IN ketamine for TRD.

11 The Use Of Subcutaneous Ketamine For Treatment Resistant Depression Book PDF
✏Book Title : 11 THE USE OF SUBCUTANEOUS KETAMINE FOR TREATMENT RESISTANT DEPRESSION
✏Author : Mariane Quieroti Rodrigues
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1163811374
✏Available Language : English, Spanish, And French

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✏11 THE USE OF SUBCUTANEOUS KETAMINE FOR TREATMENT RESISTANT DEPRESSION Book Summary : Introduction: Major depressive disorder is highly common with up to 50% to 60% of the patients not achieving adequate response following antidepressant treatment. In this scenario, ketamine emerges as an important alternative to conventional treatments, with its action of being an antagonist of N-methyl- D-aspartate (NMDA) receptor, once its has a quick and effective action. Ketamine is most frequently administered intravenous. However, oral, sublingual, transmucosal, intranasal, subcutaneous (SC), and intramuscular routes of administration have also been examined.Aim: This study aims to investigate whether SC ketamine is effective in the treatment of unipolar major depression and if it has more effective and sustainable response than electroconvulsivetherapy (ECT).Methods: Participants will be comprised of patients with unipolar depression resistant to conventional treatment, men and women, aged u2265 18 across a range of ethnicities, recruited from General Hospital Servidor of State of Su00e3o Paulo, Brazil. Participants will be separeted in two groups. The first one will recieve a SC administration of ketamine in the dose of 0,5mg/kg weekly, for 6 weeks. The second will be submitted to ECT treatment, two sessions a week, for at least 8 sessions. The response of each treatment will be evaluated and compared by MADRS questionnaire.Results: We expect that SC ketamine has a good response in the treatment of major depression and that it has a similar response compared to ECT.Conclusion: SC ketamine, once it is a secure, quick and simple procedure, is a promising alternative to the available treatments.

Intravenous Ketamine For Adults With Treatment Resistant Depression Or Post Traumatic Stress Disorder A Review Of Clinical Effectiveness Cost Effectiveness And Guidelines Book PDF
✏Book Title : Intravenous Ketamine for Adults with Treatment Resistant Depression Or Post Traumatic Stress Disorder A Review of Clinical Effectiveness Cost Effectiveness and Guidelines
✏Author :
✏Publisher :
✏Release Date : 2019
✏Pages :
✏ISBN : OCLC:1151537743
✏Available Language : English, Spanish, And French

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✏Intravenous Ketamine for Adults with Treatment Resistant Depression Or Post Traumatic Stress Disorder A Review of Clinical Effectiveness Cost Effectiveness and Guidelines Book Summary :

05 Ketamine Antidepressant Actions In Electroconvulsive Therapy Of Treatment Resistant Depression Book PDF
✏Book Title : 05 KETAMINE ANTIDEPRESSANT ACTIONS IN ELECTROCONVULSIVE THERAPY OF TREATMENT RESISTANT DEPRESSION
✏Author : Bruno Josu00e9 Prates
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1163811932
✏Available Language : English, Spanish, And French

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✏05 KETAMINE ANTIDEPRESSANT ACTIONS IN ELECTROCONVULSIVE THERAPY OF TREATMENT RESISTANT DEPRESSION Book Summary : Background and aims: Major depressive disorder affects approximately 5% of the population with nearly 1-third of patients failing to achieve remission, despite adequate pharmacological treatment [1]. Although electroconvulsive therapy (ECT) is the gold standard approach for treatment resistant depression (TRD), a considerable fraction of patients also show a delayed improvement or appear to be resistant to ECT. One of the most promising rapid-acting antidepressants is ketamine, a noncompetitive N-methyl-D-Aspartate receptor antagonist that can be used as an anesthetic during ECT to augment antidepressant efficacy [2].Data on ECTs using ketamine are both scarce and conflicting which lead the American Psychiatric Association to call for further studies [3]. We aim to clarify the potential synergism of ketamine and ECT for the treatment of TRD.Materials and methods: An experimental, non-randomized clinical trial with consecutive sampling of TRD patients with a HAM-D and PDAS scores u2265 23 was conducted. Patients that were initially assigned to 6 ECT sessions using thiopental anesthesia (ECT Std) but showed a very limited symptomatic relief were included in the study. Patients in Group 1 were then treated with further 6 ECT sessions using ketamine anesthesia (ECT Ket) whereas Group 2 maintained treatment with ECT Std (Fig. 1).Results: Clinical assessment showed no significant reduction in the mean HAM-D and PDAS scores for Group 1 but a significant reduction of the HAMD score of 38,8u00b12,4 to 13.4u00b110.55 (p

📒The Ect Handbook ✍ I. Nicol Ferrier

The Ect Handbook Book PDF
✏Book Title : The ECT Handbook
✏Author : I. Nicol Ferrier
✏Publisher : Cambridge University Press
✏Release Date : 2019-07-04
✏Pages : 241
✏ISBN : 9781911623168
✏Available Language : English, Spanish, And French

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✏The ECT Handbook Book Summary : A thorough update to the 'must-have' guide to ECT for clinical psychiatrists, providing practical advice on safe and efficacious treatment.

📒Ketamine ✍ Kenji Hashimoto

Ketamine Book PDF
✏Book Title : Ketamine
✏Author : Kenji Hashimoto
✏Publisher : Springer Nature
✏Release Date : 2020-03-05
✏Pages : 189
✏ISBN : 9789811529023
✏Available Language : English, Spanish, And French

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✏Ketamine Book Summary : This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants.

Rapid Acting Antidepressants Book PDF
✏Book Title : Rapid Acting Antidepressants
✏Author :
✏Publisher : Academic Press
✏Release Date : 2020-06-29
✏Pages : 402
✏ISBN : 9780128201909
✏Available Language : English, Spanish, And French

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✏Rapid Acting Antidepressants Book Summary : The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

📒Neuroprotective Natural Products ✍ Goutam Brahmachari

Neuroprotective Natural Products Book PDF
✏Book Title : Neuroprotective Natural Products
✏Author : Goutam Brahmachari
✏Publisher : John Wiley & Sons
✏Release Date : 2017-04-24
✏Pages : 376
✏ISBN : 9783527341863
✏Available Language : English, Spanish, And French

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✏Neuroprotective Natural Products Book Summary : Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.

Ketamine S Dose Related Effects On Anxiety Symptoms In Patients With Treatment Refractory Anxiety Disorders Book PDF
✏Book Title : Ketamine s Dose related Effects on Anxiety Symptoms in Patients with Treatment Refractory Anxiety Disorders
✏Author :
✏Publisher :
✏Release Date :
✏Pages :
✏ISBN : OCLC:1051945863
✏Available Language : English, Spanish, And French

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✏Ketamine s Dose related Effects on Anxiety Symptoms in Patients with Treatment Refractory Anxiety Disorders Book Summary : The N-methyl-D-aspartate receptor antagonist ketamine has rapid onset activity in treatment-resistant depression, post-traumatic stress disorder and obsessive compulsive disorder. Due to similarities in brain network activity in depression and anxiety disorders, we hypothesized that ketamine might also be active in other refractory anxiety disorders. We evaluated the efficacy and safety of ketamine in 12 patients with refractory generalized anxiety disorder and/or social anxiety disorder who were not currently depressed, using an ascending single dose study design (0.25, 0.5, 1 mg/kg administered subcutaneously) at weekly intervals. Within 1 h of dosing, patients reported reduced anxiety, which persisted for up to seven days. A dose-response profile was noted for anxiolytic effects, dissociative side effects, and changes in blood pressure and heart rate, with minor changes at 0.25 mg/kg, and progressively greater and more durable changes at the higher doses. Ten of 12 patients were treatment responders at 0.5–1 mg/kg. Ketamine was safe and well tolerated in this population. Ketamine may be a potential therapeutic alternative for patients with refractory generalized anxiety disorder/social anxiety disorder. Along with its demonstrated effectiveness in patients with treatment-resistant depression, obsessive compulsive disorder and post-traumatic stress disorder, these data raise the intriguing possibility that ketamine may have broad efficacy in disorders characterized by negative emotional states, and that these disorders may share a common precipitating neurobiology.

Intravenous Ketamine For Treatment Of Major Depressive Disorder In A Patient With A History Of Repetitive Traumatic Brain Injuries Book PDF
✏Book Title : Intravenous Ketamine for Treatment of Major Depressive Disorder in a Patient with a History of Repetitive Traumatic Brain Injuries
✏Author : John William III
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1163806793
✏Available Language : English, Spanish, And French

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✏Intravenous Ketamine for Treatment of Major Depressive Disorder in a Patient with a History of Repetitive Traumatic Brain Injuries Book Summary : INTRODUCTION: Depression is the most common psychiatric disorder that occurs following a Traumatic Brain Injury. To date, there are limited studies demonstrating the effectiveness of current treatments for this disorder and even less for those with repetitive injuries or rTBIs. Ketamine has been demonstrated to be effective in successfully treating depression and helping with damaged connectivity within the brain. It can be hypothesized that Ketamine may help with both of these areas that many TBI patients face after injury. This particular case report describes the successful treatment of a patient with a history of rTBIs who struggled with depression for the past several years. CASE PRESENTATION: Mr. M is as 51 year old single caucasian male who presented to the Actify Neurotherapies Treatment Center for treatment of his Major Depressive Disorder. He had been depressed for five years but refused oral medication treatment due to fears over side effects. He presented with anergia, amotivation, feelings of sadness, anhedonia, impaired concentration and guilt/worthlessness with a QIDS score of 20 (Severe Depression) and GAD-7 of 18 (Severe Anxiety). Previous neuropsychological records revealed some cognitive impairment likely attributed to his multiple head injuries which included being hit over the head in an alley leading to amnesia for one month along with permanent anosmia. After completing a course of five Ketamine treatments, his symptoms either completely resolved or vastly improved as measured by the Levine Treatment Resistant Depression Scale (LRDTS). CONCLUSION: This case appears to be the first published report of a patient with multiple TBIs/rTBIs and Major depressive disorder successfully treated with intravenous ketamine. Overall, this illustrates the potential role that Ketamine may play in the treatment of psychiatric sequelae in individuals with a history of rTBIs. Ketamine has been demonstrated to increase BDNF and increase synaptogenesis which should encourage further research for brain injured individuals. Ketamine is also believed to potentially have neuroprotective effects as well which need to be further studied. Those with a history of one TBI are also at increased risk of having further rTBIs and therefore further increasing the chances of a depressive disorder. If one might be able to treat the individual before the repetitive event occurs, it may lead to quicker resolution of symptoms and may even decrease the chances of a subsequent event from occurring. Further studies are necessary to validate and replicate the symptom resolution of the above case but indicates that this treatment may be a potential viable rapid treatment option for those struggling without relief in sight.

📒Ketafusion Llc ✍ Doris Tarrillion

Ketafusion Llc Book PDF
✏Book Title : Ketafusion LLC
✏Author : Doris Tarrillion
✏Publisher :
✏Release Date : 2019
✏Pages : 59
✏ISBN : 1088322255
✏Available Language : English, Spanish, And French

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✏Ketafusion LLC Book Summary : Abstract: Depression is a debilitating and devastating mood disorder that can affect all ages and people of all races across all socioeconomic statuses. Conventional antidepressant medications only give one-third of relief from symptoms of depression, leaving the remainder to suffer from treatment-resistant depression (TRD). For the past two decades, researchers have looked into ketamine for the treatment of depression with promising results. All studies have validated that the intravenous (IV) use of ketamine is now the breakthrough treatment for TRD. This creates demand and a dire need to those are suffering from treatment-resistant depression. Ketafusion, LLC will specialize in delivery of safe and affordable intravenous ketamine infusion in the heart of Los Angeles County. It will provide personalized concierge care throughout every step of the treatment and recovery process to improve the quality of life of individuals battling TRD.

Clinical Handbook For The Management Of Mood Disorders Book PDF
✏Book Title : Clinical Handbook for the Management of Mood Disorders
✏Author : J. John Mann
✏Publisher : Cambridge University Press
✏Release Date : 2013-05-09
✏Pages : 426
✏ISBN : 9781107024632
✏Available Language : English, Spanish, And French

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✏Clinical Handbook for the Management of Mood Disorders Book Summary : Provides a one-stop evidence-based guide to the management of all types of mood disorders.

📒Psychiatry ✍ Allan Tasman

Psychiatry Book PDF
✏Book Title : Psychiatry
✏Author : Allan Tasman
✏Publisher : John Wiley & Sons
✏Release Date : 2015-02-05
✏Pages : 2768
✏ISBN : 9781118753361
✏Available Language : English, Spanish, And French

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✏Psychiatry Book Summary : Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at www.tasmanpsychiatry.com featuring PDFs of each chapter and downloadable images

Ketamine S Mechanism Of Action A Path To Rapid Acting Antidepressants  Book PDF
✏Book Title : KETAMINE S MECHANISM OF ACTION A PATH TO RAPID ACTING ANTIDEPRESSANTS
✏Author :
✏Publisher :
✏Release Date : 2016
✏Pages :
✏ISBN : OCLC:1051359204
✏Available Language : English, Spanish, And French

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✏KETAMINE S MECHANISM OF ACTION A PATH TO RAPID ACTING ANTIDEPRESSANTS Book Summary : Abstract : Major depressive disorder (MDD) is a common and debilitating psychiatric disorder. Traditional antidepressants are of limited efficacy and take weeks to months to yield full therapeutic effects. Thus, there is a clear need for effective rapid‐acting antidepressant medications. The N ‐methyl‐d ‐aspartate receptor (NMDA‐R) antagonist, ketamine, has received a great deal of attention over the last 20 years due to the discovery that a single subanesthetic dose leads to a rapid antidepressant effect in individuals with treatment‐resistant depression. Animal and human research suggest that ketamine's antidepressant effects are mediated by a glutamate surge that leads to a cascade of events that result in synaptogenesis and reversal of the negative effects of chronic stress and depression, particularly within the prefrontal cortex (PFC). Preclinical and clinical data have provided compelling insights into the mechanisms underlying the rapid‐acting antidepressant effects of ketamine. This review discusses stress‐related neurobiology of depression and the safety, tolerability, and efficacy of ketamine for MDD, along with a review of ketamine's mechanism of action and prospective predictors of treatment response. Research limitations and future clinical prospects are also discussed.

Development And Validation Of An Animal Model Of Treatment Resistant Depression Book PDF
✏Book Title : Development and Validation of an Animal Model of Treatment Resistant Depression
✏Author : Sarel Jacobus Brand
✏Publisher :
✏Release Date : 2017
✏Pages : 373
✏ISBN : OCLC:990337623
✏Available Language : English, Spanish, And French

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✏Development and Validation of an Animal Model of Treatment Resistant Depression Book Summary : Biomarkers -- Depression -- FSL -- Gene-environment -- Imipramine -- Ketamine -- Noradrenalin -- PTSD -- Serotonin -- Treatment resistance -- Venlafaxine -- Behandelingsweerstandigheid -- Biomerkers -- Depressie -- Geen-omgewing -- Imipramien -- Ketamien -- PTSV -- Venlafaksien.

I Fell In Love With My Ketamine Nurse Book PDF
✏Book Title : I Fell in Love with My Ketamine Nurse
✏Author : Siobhan Bledsoe
✏Publisher : Createspace Independent Publishing Platform
✏Release Date : 2017-11-20
✏Pages : 42
✏ISBN : 1979736170
✏Available Language : English, Spanish, And French

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✏I Fell in Love with My Ketamine Nurse Book Summary : This book tells the journey of a woman's trial with the experimental, and nascent, Ketamine Infusion treatment which combats medicine resistant depression. She completed the intensive treatment in the summer of 2017, catalyzed by heartbreak but also chemical depression, and continues to do maintenance appointments monthly. Although heavy subject matter, the author strives to make severe depression less stigmatized and taboo, and does this through a flirty and cheeky prism of writing this "about" her nurse, who affectionately (metaphorically and literally) held her hand through this process. The graphics, done by Saba Moeel, move from black and white to color as the trip progresses. In the end, she finds alleviation from her depression by way of the solace Ketamine provided her.

📒The Noonday Demon ✍ Andrew Solomon

The Noonday Demon Book PDF
✏Book Title : The Noonday Demon
✏Author : Andrew Solomon
✏Publisher : Simon and Schuster
✏Release Date : 2011-11-16
✏Pages : 576
✏ISBN : 9781451676884
✏Available Language : English, Spanish, And French

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✏The Noonday Demon Book Summary : With uncommon humanity, candor, wit, and erudition, award-winning author Andrew Solomon takes the reader on a journey of incomparable range and resonance into the most pervasive of family secrets. His contribution to our understanding not only of mental illness but also of the human condition is truly stunning. The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policymakers and politicians, drug designers and philosophers, Solomon reveals the subtle complexities and sheer agony of the disease. He confronts the challenge of defining the illness and describes the vast range of available medications, the efficacy of alternative treatments, and the impact the malady has had on various demographic populations around the world and throughout history. He also explores the thorny patch of moral and ethical questions posed by emerging biological explanations for mental illness. The depth of human experience Solomon chronicles, the range of his intelligence, and his boundless curiosity and compassion will change the reader's view of the world.

Depression An Issue Of Psychiatric Clinics E Book Book PDF
✏Book Title : Depression An Issue of Psychiatric Clinics E Book
✏Author : David Mintz
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-03-26
✏Pages : 296
✏ISBN : 9781455743100
✏Available Language : English, Spanish, And French

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✏Depression An Issue of Psychiatric Clinics E Book Book Summary : This issue discusses the diagnosis and treatment of major depressive disorder (MDD) and other depressive disorders, with an emphasis on the psychosocial aspects of depression: how it affects societies, how it is affected by culture, and what the true meaning of recovery is for those suffering from MDD. The issue is divided into three section: Etiology, Diagnosis and Treatment. Authors address the evidence where biology and subjectivity meet. They discuss what is adaptive and what is pathologic and discuss population-based solutions that take into account the specificity of the individual. Authors also take into account combination treatments of psychotherapy and pharmacotherapy and weigh the treatment choices against specific patient subtypes.

Ferri S Clinical Advisor 2015 E Book Book PDF
✏Book Title : Ferri s Clinical Advisor 2015 E Book
✏Author : Fred F. Ferri
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-07-26
✏Pages : 3237
✏ISBN : 9780323084307
✏Available Language : English, Spanish, And French

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✏Ferri s Clinical Advisor 2015 E Book Book Summary : Ferri’s Clinical Advisor 2015 is the fastest, most effective way to access current diagnostic and therapeutic information on more than 700 common medical conditions. Dr. Ferri’s popular "5 books in 1" format provides quick guidance on short QT syndrome, microscopic polyangiitis, fungal meningitis, and much more. This medical reference makes the answers you need even easier to find - anytime, anywhere. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Review normal values and interpret results for more than 200 lab tests. Improve your family healthcare practice’s efficiency with cost-effective referral and consultation guidelines. Identify and treat a broader range of disorders, including diabetic foot infections, hypergonadism, and acute liver failure, with 22 new topics in the Diseases & Disorders section. Improve your interpretation of presenting symptoms with 38 new topics and 40 new images in the Differential Diagnosis section, and optimize patient care with more than 250 new figures and tables. Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets, tables, boxes, and algorithms to expedite your search. Expedite insurance reimbursements with current ICD-9 and future ICD-10 insurance billing codes. Access full-color images and more than 90 online-only topics at Expert Consult, as well as EBMs, Suggested Reading, Patient Teaching Guides, and additional algorithms.

07 Kynurenine Pathway As A Target And Biomarker Of The Antidepressant Effect Of Ketamine Book PDF
✏Book Title : 07 KYNURENINE PATHWAY AS A TARGET AND BIOMARKER OF THE ANTIDEPRESSANT EFFECT OF KETAMINE
✏Author : Fabien Vinckier
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1163822257
✏Available Language : English, Spanish, And French

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✏07 KYNURENINE PATHWAY AS A TARGET AND BIOMARKER OF THE ANTIDEPRESSANT EFFECT OF KETAMINE Book Summary : IntroductionIn recent decades, comprehensive evidence has accumulated that inflammation might be implied in the etiology of major depressive disorder besides monoamine imbalance classically described. In inflammatory conditions, the degradation of tryptophan is prioritized towards the production of kynurenine, leading to the production by microglial cells of quinolinic acid (QUIN), an excitotoxic NMDA receptor agonist. Ketamine is then a very promising antidepressant, and its NMDA antagonism might counteract QUIN accumulation. ObjectivesIn this study, the immune-modulating capacities of ketamine was investigated in depressed patients by examining the effect of ketamine treatment on tryptophan metabolites plasma levels. Methods15 treatment-resistant depressed in-patients received a cure of ketamine infusions (0.5 mg/kg intravenously), one or two times per week. Before and after each infusion, depression severity was assessed with the MADRS and plasma levels of tryptophan, kynurenine, kynurenic acid (KYNA), and QUIN were measured by HPLC and mass spectrometry. ResultsWe observed that pre-treatment KYNA/QUIN is a predictor of MADRS score after a ketamine infusion and after a whole cure of ketamine independently to depression severity (beta=0.28u00b10.07, p=0.0002 and beta=1.05u00b10.35, p=0.016 respectively). The variation of QUIN after a ketamine infusion is also a predictor of the percentage of variation in MADRS score after a ketamine infusion (beta=0.35u00b10.14, p=0.015). ConclusionsKetamine acts not only by counteracting QUIN on NMDA receptors but by reducing its production. As the tryptophan metabolism pathway is mainly supported by microglia in the brain, these findings underpin the immune-modulatory capacity of ketamine, suggesting microglia as a key therapeutic target and QUIN as a biomarker of ketamine response.

Improvised Medicine Providing Care In Extreme Environments 2nd Edition Book PDF
✏Book Title : Improvised Medicine Providing Care in Extreme Environments 2nd edition
✏Author : Kenneth V. Iserson
✏Publisher : McGraw Hill Professional
✏Release Date : 2016-01-07
✏Pages : 688
✏ISBN : 9780071847636
✏Available Language : English, Spanish, And French

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✏Improvised Medicine Providing Care in Extreme Environments 2nd edition Book Summary : Deliver quality healthcare in the most challenging field conditions Comprehensive yet compact, practical, and enduring, Improvised Medicine: Providing Care in Extreme Environments, Second Edition, is the one book to toss into your bag when going to practice medicine in global, disaster, or other resource-poor settings, including theaters of war, regions of civil unrest, and economically deprived areas. Full of practical clinical pearls and field-tested strategies, this indispensable guide provides detailed instructions on how to work successfully outside of your comfort zone. It demonstrates how to devise effective treatment solutions when the traditional tools (medications, equipment, and staff) are unavailable or when providing care outside your primary area of expertise. In any crisis, from power failures and computer crashes to floods, tsunamis, and earthquakes, knowing how to deal with the unique challenges encountered saves lives and communities. This reference gives you that knowledge and inspires innovative crisis resolution. FROM REVIEWS OF THE FIRST EDITION: "Dr Iserson has given us a most remarkable book. Many readers may be familiar with David Werner's lay healthworker book, Where There Is No Doctor; this new volume could be titled Where There Is a Doctor–But No Stuff. Drawing from his experience providing care in international, wilderness, and disaster settings, he has compiled an impressive collection of bare-bones equipment and work-around strategies to provide the best possible care in resource-poor settings. While presenting many creative examples, the purpose of the book is not to offer an exhaustive list of solutions to missing resource challenges but to inspire creativity in readers who may find themselves needing to improvise." -- Family Medicine “There is a lot of material here and, if nothing else, it may motivate more people to practice low-tech medicine and be willing to go where health care is dependent more on caring than on cost. I recommend this book to anyone who must practice in austere environments, and it will be in my rucksack when I respond to the next disaster.” – The Journal of Emergency Medicine FEATURES: ·Simple-to-follow directions, diagrams, and illustrations describing practical techniques and improvised equipment necessary to provide quality care during crises ·Contains improvisations in anesthesia and airway management, dentistry, gynecology/obstetrics, infectious disease/laboratory diagnosis, internal medicine, otolaryngology, pediatrics and malnutrition, orthopedics, psychiatry, and surgery·Covers situational analysis and basic needs in a crisis; specific triage, diagnosis, and stabilization efforts; medical interventions for surgical and non-surgical problems; and debunks some commonly reported improvised techniques ·Features public health measures, basic disaster communication techniques, post-disaster forensics, a model hospital disaster plan, and innovative patient-transport methods·New to the second edition: More concisely written, more extensively illustrated, and updated improvisations and references LEARN HOW TO:·Make an endotracheal tube in seconds ·Perform digital-oral and blind-nasotracheal intubations ·Make plaster bandages for splints/casts ·Give open-drop ether, ketamine drips, and halothane ·Use subcutaneous/intraperitoneal rehydration/transfusion ·Make ORS and standard nutrition formulas ·Clean, disinfect, and sterilize equipment for reuse ·Warm blood units in seconds inexpensively ·Take/view stereoscopic x-rays with standard equipment ·Quickly and easily stop postpartum hemorrhage ·Fashion surgical equipment from common items ·Build an evaporative refrigerator·Make esophageal and precordial stethoscopes ·Quickly improvise a saline lock ·Make ECG electrode/defibrillator pads and ultrasound gel·Evacuate patients easily from high-rise hospitals

📒Stress And Your Health ✍ Hymie Anisman

Stress And Your Health Book PDF
✏Book Title : Stress and Your Health
✏Author : Hymie Anisman
✏Publisher : John Wiley & Sons
✏Release Date : 2015-02-12
✏Pages : 296
✏ISBN : 9781118850336
✏Available Language : English, Spanish, And French

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✏Stress and Your Health Book Summary : Stress and Your Health: From Vulnerability to Resilience presents an evidence-based evaluation of the various effects of stress, along with methods to alleviate distress and stress-related illnesses. Examines myriad stressor effects and proven ways to alleviate stress in our lives Covers a wide range of stressor-related topics including therapeutic strategies to deal with stress and factors that hinder treatment of stress Makes difficult biochemical and immunological concepts accessible to a non-specialist audience Addresses many of the factors that cause individuals to be more vulnerable to the impact of stressors and at increased risk for pathology

Emerging Perspectives On Substance Misuse Book PDF
✏Book Title : Emerging Perspectives on Substance Misuse
✏Author : Willm Mistral
✏Publisher : John Wiley & Sons
✏Release Date : 2013-06-27
✏Pages : 232
✏ISBN : 9781118306628
✏Available Language : English, Spanish, And French

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✏Emerging Perspectives on Substance Misuse Book Summary : Copy – Web Catalog: Emerging Perspectives on Substance Misuse addresses theoretical, practice and policy issues with regard to the problematic use of alcohol and illegal drugs. Comprises chapters from some of the most internationally well-known academics and practitioners representing a range of different specializations and perspectives in the field Presents a wide range of emerging evidence-based perspectives Includes content relevant for researchers, practitioners, and policy makers who work with individuals or policy related to drug and alcohol misuse Areas covered include - gender and substance use, working with children and families of substance misusers and the emerging recovery movement

Basic And Clinical Pharmacology 15e Book PDF
✏Book Title : Basic and Clinical Pharmacology 15e
✏Author : Bertram G. Katzung
✏Publisher : McGraw Hill Professional
✏Release Date : 2020-11-22
✏Pages : 1328
✏ISBN : 9781260452327
✏Available Language : English, Spanish, And French

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✏Basic and Clinical Pharmacology 15e Book Summary : Master key pharmacological concepts and practices with the most comprehensive, authoritative guide available Presented in full-color and packed with hundreds of illustrations, Basic and Clinical Pharmacology is the wide-ranging, engaging guide students have counted on for decades. Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, the guide covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters

Molecular Neuropharmacology A Foundation For Clinical Neuroscience Fourth Edition Book PDF
✏Book Title : Molecular Neuropharmacology A Foundation for Clinical Neuroscience Fourth Edition
✏Author : Eric J. Nestler
✏Publisher : McGraw Hill Professional
✏Release Date : 2020-09-05
✏Pages : 592
✏ISBN : 9781260456912
✏Available Language : English, Spanish, And French

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✏Molecular Neuropharmacology A Foundation for Clinical Neuroscience Fourth Edition Book Summary : Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The definitive guide to treating neurologic and psychiatric disorders with drugs and other approaches Fully updated with the latest research and drugs, Nestler, Hyman, & Malenka’s Molecular Neuropharmacology, Fourth Edition, is the leading guide to molecular neuroscience. Providing an in-depth look at the neuropharmacological fundamentals of the nervous system, it delivers the knowledge and insight you need to master the pathophysiology of neurologic and psychiatric disorders. Complete with tables, diagrams, and figures clearly illustrating the intricacies of neurochemistry and molecular neuroscience, this peerless guide reviews the effects of drug action (organized by drug category) to enhance your understanding of major disease mechanisms, and it explains the pathophysiology and neuropharmacology of all major neurologic and psychiatric disorders. Concise overviews of the effects of drugs and other treatment approaches are presented in a way that boosts your understanding and retention of critical concepts. Nestler, Hyman, & Malenka’s Molecular Neuropharmacology provides a deep dive into: General principles of neurophar¬macology Nervous system function Drugs that act on neuronal and glial function Major neurotrans¬mitter systems in the brain and spinal cord Atypical neurotransmitters, including peptides, growth factors, and cytokines Major brain and spinal cord systems at the molecular, cellular, and circuit levels in health and disease

Expanding The Nurse Practitioner Role In Treatment Resistant Major Depression Book PDF
✏Book Title : Expanding the Nurse Practitioner Role in Treatment Resistant Major Depression
✏Author : Travis K Svensson
✏Publisher :
✏Release Date : 2015
✏Pages :
✏ISBN : OCLC:924342194
✏Available Language : English, Spanish, And French

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✏Expanding the Nurse Practitioner Role in Treatment Resistant Major Depression Book Summary : Treatment resistant major depression (TRMD) is a common problem with significant consequences in terms of bio-psycho-social disability and economic impact for the individual, family and community. A 2014 survey of San Francisco bay area community resources confirms that nurse practitioners (NPs) are under represented in the advanced management of TRMD using electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS) and ketamine infusion therapy (KIT). An expansion in the role of the NP in the management of TRMD is indicated. The purpose of this project was to develop and implement an education course that prepares a cohort of NPs to demonstrate mastery of advanced clinical techniques through direct provision of safe, tolerable and efficacious care to TRMD populations using ECT, TMS and KIT. Five NPs participated in a continuing education program that included four hours of didactic and twelve hours of bedside clinical continuing education in the advanced management of TRMD. Implementation of this quality improvement project resulted in a high level of satisfaction among NP participants and patient. Upon completion of the training, a considerable increase was evident in self-efficacy in the management of TRMD (95%), ketamine infusion therapy (90%), electroconvulsive therapy (85%), and transcranial magnetic stimulation (80%), relative to pre-training levels. In the 60-day follow-up period, all five NP participants directly managed an average of 8.6 patients with TRMD using advanced techniques. Safety, efficacy and tolerability were comparable to published data for psychiatrist provided services.

Treatment Of Neurodevelopmental Disorders Book PDF
✏Book Title : Treatment of Neurodevelopmental Disorders
✏Author : Randi Hagerman
✏Publisher : Oxford University Press
✏Release Date : 2014-04-25
✏Pages : 352
✏ISBN : 9780199378883
✏Available Language : English, Spanish, And French

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✏Treatment of Neurodevelopmental Disorders Book Summary : This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have led to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.