Intrinsically Disordered Proteins

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  • Author : Vladimir N. Uversky
  • Publisher : Springer
  • Pages : 61 pages
  • ISBN : 3319089218
  • Rating : /5 from reviews
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Download or Read online Intrinsically Disordered Proteins full in PDF, ePub and kindle. this book written by Vladimir N. Uversky and published by Springer which was released on 05 August 2014 with total page 61 pages. We cannot guarantee that Intrinsically Disordered Proteins book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 21 November 2018
GET THIS BOOK Intrinsically Disordered Proteins

Intrinsically Disordered Proteins, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics of interest, including the Characterization of Structure-Function relationships in the intrinsically disordered protein complexin, Distances, distance distributions, and ensembles of IDPs from single-molecule FRET, Biophysical characterization of disordered protein liquid phases, The Use of Mass Spectrometry to Examine IDPs – Unique Insights and Caveats, Fluorescence Depolarization Kinetics to Study Conformational Preference, Structural Plasticity

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Vladimir N. Uversky
  • Publisher : Springer
  • Release : 05 August 2014
GET THIS BOOK Intrinsically Disordered Proteins

In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers

Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Intrinsically Disordered Proteins Studied by NMR Spectroscopy
  • Author : Isabella C. Felli,Roberta Pierattelli
  • Publisher : Springer
  • Release : 19 September 2015
GET THIS BOOK Intrinsically Disordered Proteins Studied by NMR Spectroscopy

This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrinsic protein disorder is now recognized as one of the key features for a large variety of cellular functions, where structural flexibility presents a functional advantage

Structure and Function of Intrinsically Disordered Proteins

Structure and Function of Intrinsically Disordered Proteins
  • Author : Peter Tompa,Alan Fersht
  • Publisher : CRC Press
  • Release : 18 November 2009
GET THIS BOOK Structure and Function of Intrinsically Disordered Proteins

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered Proteins thoroughly covers the history up to the latest developments in this field. After examining the principles of protein structure, the classical paradigm, and the history of structural disorder, the

Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology

Dancing Protein Clouds  Intrinsically Disordered Proteins in the Norm and Pathology
  • Author : Vladimir Uversky
  • Publisher : Academic Press
  • Release : 15 September 2019
GET THIS BOOK Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the

Intrinsically Disordered Protein Analysis

Intrinsically Disordered Protein Analysis
  • Author : Vladimir N. Uversky,A. Keith Dunker
  • Publisher : Humana Press
  • Release : 23 August 2016
GET THIS BOOK Intrinsically Disordered Protein Analysis

Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis :Methods and Experimental Tools, expert researchers explore the high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 1 includes sections on

Dancing Protein Clouds Intrinsically Disordered Proteins in Health and Disease Part B

Dancing Protein Clouds  Intrinsically Disordered Proteins in Health and Disease  Part B
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 01 September 2020
GET THIS BOOK Dancing Protein Clouds Intrinsically Disordered Proteins in Health and Disease Part B

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of

Intrinsically Disordered Protein Analysis

Intrinsically Disordered Protein Analysis
  • Author : Vladimir N. Uversky,A. Keith Dunker
  • Publisher : Springer
  • Release : 23 August 2016
GET THIS BOOK Intrinsically Disordered Protein Analysis

Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis: Methods and Experimental Tools, expert researchers explore the high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 2 includes sections on

Intrinsically Disordered Proteins in Molecular Recognition and Structural Proteomics

Intrinsically Disordered Proteins in Molecular Recognition and Structural Proteomics
  • Author : Christopher John Oldfield
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Intrinsically Disordered Proteins in Molecular Recognition and Structural Proteomics

Intrinsically disordered proteins (IDPs) are abundant in nature, being more prevalent in the proteomes of eukaryotes than those of bacteria or archaea. As introduced in Chapter I, these proteins, or portions of these proteins, lack stable equilibrium structures and instead have dynamic conformations that vary over time and population. Despite the lack of preformed structure, IDPs carry out many and varied molecular functions and participate in vital biological pathways. In particular, IDPs play important roles in cellular signaling that is,

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Nicola Salvi
  • Publisher : Academic Press
  • Release : 14 June 2019
GET THIS BOOK Intrinsically Disordered Proteins

Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Birthe B Kragelund,Karen Skriver
  • Publisher : Humana
  • Release : 05 July 2020
GET THIS BOOK Intrinsically Disordered Proteins

The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Intrinsically Disordered Proteins: Methods and Protocols aims

Fuzziness

Fuzziness
  • Author : Monika Fuxreiter,Peter Tompa
  • Publisher : Springer Science & Business Media
  • Release : 07 March 2012
GET THIS BOOK Fuzziness

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral

Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology Part C

Dancing Protein Clouds  Intrinsically Disordered Proteins in the Norm and Pathology  Part C
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 15 November 2021
GET THIS BOOK Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology Part C

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussion of the evolution of disorder; consideration of the peculiarities of phase separation of the prion protein; general discussion of the relationships between intrinsic disorder and protein functions; structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins,

Instrumental Analysis of Intrinsically Disordered Proteins

Instrumental Analysis of Intrinsically Disordered Proteins
  • Author : Vladimir Uversky,Sonia Longhi
  • Publisher : John Wiley & Sons
  • Release : 31 January 2011
GET THIS BOOK Instrumental Analysis of Intrinsically Disordered Proteins

Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters

Dancing Protein Clouds

Dancing Protein Clouds
  • Author : Vladimir N. Uversky
  • Publisher : Unknown
  • Release : 15 June 2021
GET THIS BOOK Dancing Protein Clouds

""Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the