Intracellular Consequences of Amyloid in Alzheimer s Disease

• Author : Michael R. D'Andrea
• Publisher : Academic Press
• Release : 21 February 2016

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid

• Author : Anonim
• Publisher : Unknown
• Release : 23 March 1999

• Author : Eliya Nenkova
• Publisher : diplom.de
• Release : 22 August 2016

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment, loss of neuronal cells and synaptic connections. The main pathological feature of the disease is the β amyloid peptide, generated by the cleavage of the Amyloid Precursor Protein by the β-secretase enzyme (Beta-site APP-cleaving enzyme 1 (BACE1)). There have been many factors involved in the increase in BACE1 gene expression and activity, including energy inhibition, hypoxia and increased cholesterol. The biological function of BACE1 makes it a perfect target

• Author : Michael S. Wolfe
• Publisher : Academic Press
• Release : 27 May 2016

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the

• Author : Adeboye Adejare
• Publisher : Academic Press
• Release : 20 September 2016

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies,

• Author : Michael Paul Murphy
• Publisher : Unknown
• Release : 23 March 1998

• Author : George A. Kyriazis
• Publisher : Unknown
• Release : 23 March 2023

Increased production of amyloid [beta] (A[beta]) peptide, via altered proteolytic cleavage of amyloid protein precursor (APP), and abnormalities in neuronal calcium homeostasis play central roles in the pathogenesis of Alzheimer's disease (AD). Notch1, a membrane receptor that controls cell fate decisions during development of the nervous system, has been linked to AD because it is a substrate for the [gamma]-secretase enzyme activity that involves the presenilin-1 protein in which mutations cause early-onset inherited AD. Numb is an evolutionarily

• Author : Sol M. Reyna
• Publisher : Unknown
• Release : 23 March 2023

Alzheimer's Disease (AD) is a devastating neurodegenerative disease that currently affects more than 26 million people worldwide and is projected to triple in prevalence by 2015. As such it represents an enormous economic, medical, scientific, and emotional burden on society. Despite extensive efforts, there is no cure and current treatments are only effective at ameloriating symptoms without delaying the progression of disease. Part of the challenge may stem from the use of model systems that incompletely recapitulate human disease. The recently discovered

• Author : Renee D. Wegrzyn,Alan S. Rudolph
• Publisher : CRC Press
• Release : 26 April 2012

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from

• Author : Anonim
• Publisher : Unknown
• Release : 23 March 2023

• Author : Raz Jelinek
• Publisher : John Wiley & Sons
• Release : 27 April 2011

Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studes, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation. Required reading for any researcher interested in amyloid formation and

• Author : Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev
• Publisher : Elsevier
• Release : 18 October 2019

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many

• Author : Norbert Wrobel
• Publisher : BoD – Books on Demand
• Release : 30 January 2023

With regard to the sporadic form of Alzheimer's disease, a reduction to molecular-biological or genetic processes does not sufficiently contribute to the understanding of its development. Its pathogenesis only becomes clearer from an emergent perspective, a critical examination of the existing hypotheses on the development of the disease and the inclusion of fundamental scientific findings. Against an extremely complex background, the energetic factor stands out. The efficiency of some processes in cellular energy use and production points to principles of

• Author : Suzanne De La Monte
• Publisher : BoD – Books on Demand
• Release : 12 September 2011

Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of

• Author : J. Robin Harris,Falk Fahrenholz
• Publisher : Springer Science & Business Media
• Release : 22 November 2006

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a