Innovative Approaches in Drug Discovery

• Author : Bhushan Patwardhan,Rathnam Chaguturu
• Publisher : Academic Press
• Release : 03 October 2016

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches.

• Author : A. F. Harms
• Publisher : Elsevier Publishing Company
• Release : 04 July 1986

• Author : Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch
• Publisher : Springer
• Release : 30 March 2016

This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new

• Author : A. F. Harms
• Publisher : Unknown
• Release : 04 July 1986

• Author : Maria Rosalia Pasca,Yossef Av-Gay,Giorgia Mori
• Publisher : Frontiers Media SA
• Release : 09 June 2021

• Author : Alexander Hillisch,Rolf Hilgenfeld
• Publisher : Birkhäuser
• Release : 28 November 2012

Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of

• Author : Bhushan Patwardhan
• Publisher : New India Publishing
• Release : 04 July 2022

While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have

• Author : Edward J. Glamkowski
• Publisher : Unknown
• Release : 04 July 1981

• Author : Alan Talevi,Luisa Rocha
• Publisher : Methods in Pharmacology and To
• Release : 08 October 2018

• Author : FERNANDES,PRABHAVATHI
• Publisher : Springer Science & Business Media
• Release : 09 November 2013

• Author : Paul Workman
• Publisher : Springer Science & Business Media
• Release : 06 December 2012

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment

• Author : Dusanka Janezic
• Publisher : Unknown
• Release : 04 July 2022

We have developed new computational tools at the molecular scale for protein-ligand binding in drug discovery, ProBiS Tools (algorithm, database, and web servers) for predicting and modeling of medically interesting proteins based on graph theoretical approaches, combined with molecular simulations based on our earlier developed fast maximum clique algorithm, for finding a maximum clique in an undirected graph that is up to 100 times faster than the best comparable algorithm. ProBiS Tools opens a whole new range of possibilities in drug

• Author : Bijo Mathew,Della Grace Thomas Parambi
• Publisher : Springer Nature
• Release : 21 September 2020

This book provides medical professionals and researchers with a comprehensive overview of fundamental concepts and recent advances in neurochemistry, and offers new perspectives for all those involved with research in related disciplines. As drug discovery for neurodegenerative diseases is one of the largest subspecialties in the field of medicine, the book addresses topics that transcend the borders between disciplines, and presents a wealth of investigations into and discussions on critical questions relevant to the entire field of CNS drug research.

• Author : Hans Vogel
• Publisher : Springer Science & Business Media
• Release : 30 October 2007

The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

• Author : Izet Kapetanović
• Publisher : IntechOpen
• Release : 16 December 2011

Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant