In Vitro Toxicology Second Edition

• Author : Shayne C. Gad
• Publisher : CRC Press
• Release : 02 November 2000

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists

• Author : G. Stacey,Alan Doyle,Margherita Ferro
• Publisher : Springer Science & Business Media
• Release : 29 June 2013

Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation these are key issues

• Author : Frank A Barile
• Publisher : CRC Press
• Release : 02 April 2013

Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development.

• Author : Sebastian Hoffmann
• Publisher : Unknown
• Release : 01 February 2023

• Author : Alan M. Goldberg
• Publisher : Mary Ann Liebert
• Release : 01 February 1985

• Author : Anna Bal-Price,Paul Jennings
• Publisher : Humana Press
• Release : 03 September 2016

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism,

• Author : Alan M. Goldberg,Marilyn L. Principe
• Publisher : Mary Ann Liebert
• Release : 01 February 1991

• Author : Sheila O’Hare,Christopher K. Atterwill
• Publisher : Humana Press
• Release : 23 August 2013

In vitro toxicology is one of the most rapidly expanding areas of biological research today. It is generally conceded that this is a result of pressure from the public for safer products and environmental conditions and, in these recessionary times, pressure from company accountants, who often perceive in vitro experimentation as a cheaper option than lawsuits, fines, and expensive remediation. Toxicologists themselves form one group whose vigor and influence on the evolution of in vitro toxicology is often underestimated. Many

• Author : I.P. Sword,S.D. Thomson
• Publisher : Springer
• Release : 09 October 2011

When Volume 1 (Toxicolpgy) in this series of Standard Operating Procedures was pub lished in early 1979, the FDA's Good Laboratory Practice Regulations did not have the force of United States Law, but nevertheless had a substantial impact on the conduct of toxicology in laboratories throughout the world. These Regulations are now in force, and Volume 2 (Pathology) was published later the same year. Our critics have implied that we have attempted to reduce toxicology to the level of the cookery book, or

• Author : Sheila O’Hare,C. K. Atterwill
• Publisher : Humana Press
• Release : 04 May 1995

In Vitro Toxicity Testing Protocols is a collection of proven, state-of-the-art methods that toxicologists can use in carrying out laboratory studies. The book's expert contributors offer a variety of efficient in vitro toxicology techniques that can be applied regularly in your lab, or can serve as the fundamental basis for the establishment of novel techniques in working laboratories. All the procedures are highly reliable. Also included are ex vivo techniques, whose development embraces the twin aims of reduction and refinement

• Author : Shayne C. Gad,Christopher P. Chengelis
• Publisher : Academic Press
• Release : 27 October 1997

Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health. Key Features * Over 100 tables summarizing

• Author : C. K. Atterwill,C. E. Steele
• Publisher : Cambridge University Press
• Release : 22 October 1987

The volume brings together the once disparate knowledge of cultural techniques and thus provides an important reference work for industrial and academic toxicologists.

• Author : Daniel Acosta
• Publisher : CRC Press
• Release : 28 July 2017

This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin,

• Author : John M. Frazier
• Publisher : CRC Press
• Release : 31 January 1992

This volume focuses on the potential application of in vitro procedures to identify and quantify the toxicological risk to target organs associated with the use of commerical products and therapeutic drugs.;Revealing how the results of in vitro toxicity testing can be used in safety assessment, In Vitro Toxicity Testing: explores whether existing test methods can accomplish the necessary goals and, if not, what research is needed to make these techniques a practical reality; presents the current status of toxicity

• Author : NATO Advanced Research Institute on in Vitro Toxicity Testing of Envi,North Atlantic Treaty Organization. Scientific Affairs Division,North Atlantic Treaty Organization
• Publisher : Springer
• Release : 01 February 1983

These two volumes contain the papers presented at a North Atlantic Treaty Organization (NATO) Advanced Study Institute held on September 22-28, 1979 in Monte Carlo, Monaco. The conference was entitled "In Vitro Toxicity Testing of Environmental Agents: Current and Future Possibilities." This international conference presented an opportunity for the participants to exchange informa tion and ideas on the current approaches (both scientific and po litical) for toxic assessment of environmental agents. The poten tial health effects of these compounds as well