In Vitro Toxicology

• Author : Alok Dhawan,Seok (Soga) Kwon
• Publisher : Academic Press
• Release : 13 November 2017

In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance

• Author : Sheila O’Hare,Christopher K. Atterwill
• Publisher : Humana Press
• Release : 23 August 2013

In vitro toxicology is one of the most rapidly expanding areas of biological research today. It is generally conceded that this is a result of pressure from the public for safer products and environmental conditions and, in these recessionary times, pressure from company accountants, who often perceive in vitro experimentation as a cheaper option than lawsuits, fines, and expensive remediation. Toxicologists themselves form one group whose vigor and influence on the evolution of in vitro toxicology is often underestimated. Many

• Author : Shayne C. Gad
• Publisher : CRC Press
• Release : 02 November 2000

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists

• Author : I.P. Sword,S.D. Thomson
• Publisher : Springer
• Release : 09 October 2011

When Volume 1 (Toxicolpgy) in this series of Standard Operating Procedures was pub lished in early 1979, the FDA's Good Laboratory Practice Regulations did not have the force of United States Law, but nevertheless had a substantial impact on the conduct of toxicology in laboratories throughout the world. These Regulations are now in force, and Volume 2 (Pathology) was published later the same year. Our critics have implied that we have attempted to reduce toxicology to the level of the cookery book, or

• Author : Anna Bal-Price,Paul Jennings
• Publisher : Humana Press
• Release : 03 September 2016

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism,

• Author : G. Stacey,Alan Doyle,Margherita Ferro
• Publisher : Springer Science & Business Media
• Release : 29 June 2013

Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation these are key issues

• Author : Alan M. Goldberg,Marilyn L. Principe
• Publisher : Mary Ann Liebert
• Release : 24 July 1991

• Author : Anonim
• Publisher : Unknown
• Release : 24 July 2021

• Author : Daniel Acosta
• Publisher : CRC Press
• Release : 28 July 2017

This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin,

• Author : Alan M. Goldberg
• Publisher : Mary Ann Liebert
• Release : 24 July 1985

• Author : Industrial In Vitro Toxicology Group
• Publisher : Unknown
• Release : 24 July 1989

• Author : Frank A Barile
• Publisher : CRC Press
• Release : 02 April 2013

Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development.

• Author : J. P. W. Gilman
• Publisher : Division de la toxicologie des médicaments, Bureau de recherche sur les médicaments, Santé et bien-être social Canada
• Release : 24 July 1991

The primary purposes of toxicological testing are the protection of human health and the safeguarding of the environment from excessive manmade contamination. Responsibility for setting safety standards and monitoring their implementation lies mainly with the federal departments of health, agriculture, and the environment. This report discusses in some detail the state-of-the-art of in vitro toxicology and other trends in alternative toxicological testing that may lead to a reduction in the use of animals for these purposes. It covers both the

• Author : John M. Frazier
• Publisher : CRC Press
• Release : 31 January 1992

This volume focuses on the potential application of in vitro procedures to identify and quantify the toxicological risk to target organs associated with the use of commerical products and therapeutic drugs.;Revealing how the results of in vitro toxicity testing can be used in safety assessment, In Vitro Toxicity Testing: explores whether existing test methods can accomplish the necessary goals and, if not, what research is needed to make these techniques a practical reality; presents the current status of toxicity

• Author : C. K. Atterwill,C. E. Steele
• Publisher : Cambridge University Press
• Release : 22 October 1987

The volume brings together the once disparate knowledge of cultural techniques and thus provides an important reference work for industrial and academic toxicologists.