Hypoxia

✏Book Title : Surviving Hypoxia
✏Author : Peter W. Hochachka
✏Publisher : CRC Press
✏Release Date : 1993-03-24
✏Pages : 592
✏ISBN : 0849342260
✏Available Language : English, Spanish, And French

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✏Surviving Hypoxia Book Summary : Surviving Hypoxia: Mechanisms of Control and Adaptation is a synthesis of findings and thoughts concerning hypoxia. The thermodynamics of hypoxia are discussed in detail, including acid-base balance and self-pollution resulting from the accumulation of anaerobic end-products. The book focuses on descriptions and discussions of common facets, contrasting solutions in a variety of physiological hypoxia defense strategies, including those shown by plants, invertebrates, and vertebrates. Special treatment is given to the distinctive problems that hypoxia presents to vulnerable organs such as the kidney, liver, and brain. It also addresses pathological events in addition to protective mechanisms. Clinical implications of basic research are examined in the book, which provides new insights into underlying pathological processes occuring in hypoxic-induced organ failure and indicates new paths for successful clinical intervention. Surviving Hypoxia: Mechanisms of Control and Adaptation is an excellent reference for all researchers interested in the physiological effects of hypoxia, underlying pathological events, and protective mechanisms.

✏Book Title : New Trends in Brain Hypoxia Ischemia Research
✏Author : Eetu Hämäläinen
✏Publisher : Nova Publishers
✏Release Date : 2008
✏Pages : 315
✏ISBN : 1604561408
✏Available Language : English, Spanish, And French

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✏New Trends in Brain Hypoxia Ischemia Research Book Summary : This book presents recent and significant research from around the world dedicated to brain hypoxia-ischemia which is a disorder characterised by a reduction in oxygen supply (hypoxia) combined with reduced blood flow (ischemia) to the brain. This condition may result from a localised obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain edema; coma; and other conditions.

✏Book Title : Hypoxia and the Circulation
✏Author : Robert Roach
✏Publisher : Springer Science & Business Media
✏Release Date : 2008-01-08
✏Pages : 348
✏ISBN : 0387754342
✏Available Language : English, Spanish, And French

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✏Hypoxia and the Circulation Book Summary : Just one of a series of volumes on differing aspects of hypoxia, this authoritative text focuses on cutting-edge research at the interface of hypoxia and biomedicine. Hypoxia – or lack of oxygen – is a constant threat to the human body and its vital organs, one that can take its toll in a number of situations. There are many situations in which the threat is heightened in health and disease, but mechanisms have evolved to lessen its detrimental effects. The International Hypoxia Symposia was founded to enable scientists, clinicians, physiologists, immunologists, mountaineers and other interested individuals to share their experiences of the situations associated with the lack of oxygen and the adaptations that allow us to survive.

✏Book Title : Fetal Hypoxia
✏Author : Ph. Arbeille
✏Publisher : CRC Press
✏Release Date : 1999-06-15
✏Pages : 146
✏ISBN : 1850700125
✏Available Language : English, Spanish, And French

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✏Fetal Hypoxia Book Summary : This is a high-level clinical reference text on sonographic findings in a range of cases of fetal hypoxia. It contains eleven chapters on hypoxic-ischemic events during fetal life, fetal hemodynamics and brain damage, fetal chronic hypoxia from cocaine exposure, fetal hypoxia from malaria, cerebral and umbilical Doppler ultrasonography, fetal placental embolization, cerebral asphyxial encephalopathy, brain damage, integrity of the fetal nervous system, and fetal heart rate, movement, and blood flow velocity waveform patterns. It also contains a case study of fetal hemodynamics and brain damage related to hypoxia. Unique in its field, the book contains original new material by the world's leading experts on fetal medicine and ultrasound, fully illustrated. Includes bibliographic references and index.

✏Book Title : Brain Hypoxia and Ischemia
✏Author : Gabriel G. Haddad
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-01-06
✏Pages : 268
✏ISBN : 1603275797
✏Available Language : English, Spanish, And French

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✏Brain Hypoxia and Ischemia Book Summary : Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.

✏Book Title : Oxygen Biology and Hypoxia
✏Author :
✏Publisher : Academic Press
✏Release Date : 2007-11-08
✏Pages : 592
✏ISBN : 0080554865
✏Available Language : English, Spanish, And French

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✏Oxygen Biology and Hypoxia Book Summary : For over fifty years the Methods in Enzymology series has been the critically acclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume features articles on the topic of oxygen biology and hypoxia.

✏Book Title : Hypoxia
✏Author : Robert C. Roach
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-04-17
✏Pages : 445
✏ISBN : 9781475734010
✏Available Language : English, Spanish, And French

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✏Hypoxia Book Summary : Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.

✏Book Title : Hypoxia and Exercise
✏Author : Robert Roach
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-04-03
✏Pages : 353
✏ISBN : 9780387348179
✏Available Language : English, Spanish, And French

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✏Hypoxia and Exercise Book Summary : The 14th volume in the series will focus on cutting edge research at the interface of hypoxia and exercise. The work will cover the range from molecular mechanisms of muscle fatigue and muscle wasting to whole body exercise on the world’s highest mountains. State of the art papers on training at high altitude for low altitude athletic performance will also be featured.

✏Book Title : Imaging of Hypoxia
✏Author : H.J. Machulla
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-03-09
✏Pages : 180
✏ISBN : 9789401718288
✏Available Language : English, Spanish, And French

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✏Imaging of Hypoxia Book Summary : Hypoxia, i.e. insufficient availability of oxygen within the tissue, is a more serious problem than realized in clinical routine work, although a large variety of theoretical and experimental data give clearly proven indications. During incidences and progress of many types of diseases hypoxia may enhance development and progress of the disease and, furthermore, decrease chances of efficient treatment of, e.g., tumors. Hypoxic tumor cells are up to three times more resistant towards radiation therapy than normoxic cells. With a diagnostic tool such as provided by hypoxia tracers suitable for PET and SPECT imaging, the particular tissue situation becomes detectable and, thus, treatable. Although the clinical importance of hypoxia imaging is obviously great, to date neither the clinical nor the scientific community at an international level has focused many research activities on the hypoxia problem. As the result of a workshop held by the Section for Radiopharmacy in Tübingen, this book collects observations and findings in order to stimulate the on-going research resulting in important clinical applications. Hypoxia imaging is needed in areas of cardiology, neurology and oncology. Additional applications are to be expected in the field of diabetes, infections and organ transplantation. Therefore, the book addresses those who are basically involved in research in radiochemistry and radiopharmacy as well as those dealing with all biological aspects and facing direct clinical applications.

✏Book Title : Brain Hypoxia Ischemia Research Progress
✏Author : Océane M. Roux
✏Publisher : Nova Publishers
✏Release Date : 2008
✏Pages : 291
✏ISBN : 1604561394
✏Available Language : English, Spanish, And French

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✏Brain Hypoxia Ischemia Research Progress Book Summary : Brain hypoxia-ischemia is a disorder characterised by a reduction in oxygen supply (hypoxia) combined with reduced blood flow (ischemia) to the brain. This condition may result from a localised obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain oedema; coma; and other conditions. This book presents the latest research in this field from around the world.

✏Book Title : Fish Physiology Hypoxia
✏Author : Jeffrey G. Richards
✏Publisher : Academic Press
✏Release Date : 2009-03-10
✏Pages : 517
✏ISBN : 0080877990
✏Available Language : English, Spanish, And French

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✏Fish Physiology Hypoxia Book Summary : Periods of environmental hypoxia (Low Oxygen Availability) are extremely common in aquatic systems due to both natural causes such as diurnal oscillations in algal respiration, seasonal flooding, stratification, under ice cover in lakes, and isolation of densely vegetated water bodies, as well as more recent anthropogenic causes (e.g. eutrophication). In view of this, it is perhaps not surprising that among all vertebrates, fish boast the largest number of hypoxia tolerant species; hypoxia has clearly played an important role in shaping the evolution of many unique adaptive strategies. These unique adaptive strategies either allow fish to maintain function at low oxygen levels, thus extending hypoxia tolerance limits, or permit them to defend against the metabolic consequences of oxygen levels that fall below a threshold where metabolic functions cannot be maintained. The aim of this volume is two-fold. First, this book will review and synthesize the adaptive behavioural, morphological, physiological, biochemical, and molecular strategies used by fish to survive hypoxia exposure and place them within an environmental and ecological context. Second, through the development of a synthesis chapter this book will serve as the cornerstone for directing future research into the effects of hypoxia exposures on fish physiology and biochemistry. The only single volume available to provide an in-depth discussion of the adaptations and responses of fish to environmental hypoxia Reviews and synthesizes the adaptive behavioural, morphological, physiological, biochemical, and molecular strategies used by fish to survive hypoxia exposure Includes discussion of the evolutionary and ecological consequences of hypoxia exposure in fish

✏Book Title : Diverse Effects of Hypoxia on Tumor Progression
✏Author : M. Celeste Simon
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-09-28
✏Pages : 146
✏ISBN : 3642133290
✏Available Language : English, Spanish, And French

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✏Diverse Effects of Hypoxia on Tumor Progression Book Summary : Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

✏Book Title : Intermittent Hypoxia and Human Diseases
✏Author : Lei Xi
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-06-05
✏Pages : 316
✏ISBN : 9781447129066
✏Available Language : English, Spanish, And French

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✏Intermittent Hypoxia and Human Diseases Book Summary : Intermittent hypoxia can cause significant structural and functional impact on the systemic, organic, cellular and molecular processes of human physiology and pathophysiology. This book focuses on the most updated scientific understanding of the adaptive (beneficial) and maladaptive (detrimental) responses to intermittent hypoxia and their potential pathogenetic or prophylactic roles in the development and progression of major human diseases. This is a comprehensive monograph for clinicians, research scientists, academic faculty, postgraduate and medical students, and allied health professionals who are interested in enhancing their up-to-date knowledge of intermittent hypoxia research and its translational applications in preventing and treating major human diseases.

✏Book Title : Hypoxia
✏Author : John R. Sutton
✏Publisher : Brown & Benchmark Pub
✏Release Date : 1988
✏Pages : 373
✏ISBN : UOM:39015014489135
✏Available Language : English, Spanish, And French

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✏Hypoxia Book Summary : Fifth International Hypoxia Symposium explored the tolerable limits of hypoxia in animals and man. The human neonate tolerates hypoxia better than the adult yet it is vulnerable and easily damaged by it. Presented results of Operation Everst II in which eight normal subjects were gradually decompressed to the equivalent of the summit of Mount Everst. The adaptations in each link of the oxygen transport chain were seen as important to the adaptative process. The conference explored the mechanisms of thisfrom the cardiorespiratory system to the level of the mitochondria.

✏Book Title : Hypoxia in the Northern Gulf of Mexico
✏Author : Virginia H. Dale
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-04-12
✏Pages : 284
✏ISBN : 0387896864
✏Available Language : English, Spanish, And French

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✏Hypoxia in the Northern Gulf of Mexico Book Summary : Since 1985, scientists have been documenting a hypoxic zone in the Gulf of Mexico each year. The hypoxic zone, an area of low dissolved oxygen that cannot s- port marine life, generally manifests itself in the spring. Since marine species either die or ee the hypoxic zone, the spread of hypoxia reduces the available habitat for marine species, which are important for the ecosystem as well as commercial and recreational shing in the Gulf. Since 2001, the hypoxic zone has averaged 2 1 16,500 km during its peak summer months , an area slightly larger than the state 2 2 of Connecticut, and ranged from a low of 8,500 km to a high of 22,000 km . To address the hypoxia problem, the Mississippi River/Gulf of Mexico Watershed Nutrient Task Force (or Task Force) was formed to bring together represen- tives from federal agencies, states, and tribes to consider options for responding to hypoxia. The Task Force asked the White House Of ce of Science and Technology Policy to conduct a scienti c assessment of the causes and consequences of Gulf hypoxia through its Committee on Environment and Natural Resources (CENR).

✏Book Title : Hypoxia and Cancer
✏Author : Giovanni Melillo
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-11-09
✏Pages : 363
✏ISBN : 9781461491675
✏Available Language : English, Spanish, And French

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✏Hypoxia and Cancer Book Summary : ​​​The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes. This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry.

✏Book Title : A Science Strategy to Support Management Decisions Related to Hypoxia in the Northern Gulf of Mexico and Excess Nutrients in the Mississippi River Basin
✏Author : Mississippi River/Gulf of Mexico Watershed Nutrient Task Force. Monitoring, Modeling, and Research Workgroup
✏Publisher : U S Geological Survey
✏Release Date : 2004
✏Pages : 50
✏ISBN : MINN:31951D02398437T
✏Available Language : English, Spanish, And French

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✏A Science Strategy to Support Management Decisions Related to Hypoxia in the Northern Gulf of Mexico and Excess Nutrients in the Mississippi River Basin Book Summary :

✏Book Title : Animal Models and Hypoxia
✏Author : V. Stefanovich
✏Publisher : Elsevier
✏Release Date : 2013-10-22
✏Pages : 134
✏ISBN : 9781483189680
✏Available Language : English, Spanish, And French

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✏Animal Models and Hypoxia Book Summary : Animal Models and Hypoxia consists of proceedings from an international symposium. The text discusses the developments made on the study of brain metabolism. An article about the regional utilization of glucose in the brain of mammals is presented. There is also a section that reviews the energy metabolism in the nervous system of insects. The topics covered includes the role of sympathetic innervation in the regulation of cerebral blood flow during hypercapnia, the comparative aspects of energy metabolism in non-mammalian brains under normoxic and hypoxic conditions, and an anoxic rat model. A method developed to gauge the rates of glucose utilization in the central nervous system is evaluated. This method is effective in mapping the functional neural pathways base on stimulated metabolic responses. Factors that contribute to the development of gerontopsychiatric disorders in men are reviewed. The book will provide useful information to doctors, veterinarians, neurologists, students, and researchers in the field of neurology.

✏Book Title : Physiological Responses to Intermittent Hypoxia in Humans
✏Author : Jon C. Kolb
✏Publisher : Universal-Publishers
✏Release Date : 2004
✏Pages : 196
✏ISBN : 1581122411
✏Available Language : English, Spanish, And French

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✏Physiological Responses to Intermittent Hypoxia in Humans Book Summary : Recently, endurance athletes and high altitude climbers have gained access to commercially available, portable normobaric hypoxic chambers. Intermittent exposures to hypoxia in these chambers may elicit adaptations similar to those observed during acclimatization to altitude. Manufactures of these systems purport that intermittent exposures may elicit adaptations similar to those observed in response to the hypoxia of high altitude, however there have been no reports in the scientific literature that ventilatory acclimatization or alterations in cerebrovascular dynamics occur following repeated episodes in the portable chambers. The main conclusions are that an intermittent normobaric hypoxic intervention, consisting of five consecutive overnight exposures to a simulated altitude of 4300m, elicits perturbations in the acute cerebrovascular and ventilatory responses to both hypoxia and hypercapnia, which are similar to changes following chronic altitude exposure. Individual variability to intermittent hypoxia may have an impact on the rate at which the process of acclimatization proceeds. The extent of physiological and symptomatic responses to intermittent hypoxia are likely to be associated with the severity of hypoxia as well as the length and number of recurrent episodes of hypoxia.

✏Book Title : Hypoxia
✏Author : Dirk Vordermark
✏Publisher : Nova Biomedical
✏Release Date : 2013-01-01
✏Pages : 339
✏ISBN : 1620817691
✏Available Language : English, Spanish, And French

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✏Hypoxia Book Summary : Low oxygenation levels are a hallmark of numerous pathologic conditions. Hypoxia occurs in chronic diseases of brain, kidneys and liver. Malignant tumours grow rapidly with insufficient vasculature, thereby producing areas of chronic hypoxia. This book contains contributions from an international group of authors covering a wide range of situations in benign as well as malignant diseases, in which understanding the role of hypoxia may lead to novel diagnostic and therapeutic strategies. These include modulation of tissue oxygenation as well as treatment concepts directed specifically at hypoxic cells.

✏Book Title : Hypoxia Mechanisms and Effects
✏Author : Ronin Wahlberg
✏Publisher :
✏Release Date : 2020-09-08
✏Pages : 184
✏ISBN : 1632418827
✏Available Language : English, Spanish, And French

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✏Hypoxia Mechanisms and Effects Book Summary : Hypoxia is the condition in which there is a deprivation in the supply of oxygen in the body or a region of the body. It occurs when there is a reduction in oxygen pressure below the normal range. However, it can be a part of the normal physiology, and may occur with strenuous physical exercise or during hypoventilation training. It may be generalized or local. Generalized hypoxia can be a high-altitude disease or one in which a mixture of gases with low oxygen content has been inhaled. Fatigue, nausea, numbness and cerebral anoxia are some common symptoms. Hypoxia can result in cyanosis when severe and tissues may become gangrenous. Such tissue hypoxia may be due to low cardiac output, low hemoglobin concentration and low hemoglobin saturation. This book provides comprehensive insights into the mechanisms and effects of hypoxia. It will also provide interesting topics for research, which interested readers can take up. With state-of-the-art inputs by acclaimed experts in pulmonology, this book targets students and professionals.

✏Book Title : Effects of Hypoxia with and Without Hyperventilation on the Control of Ventilation
✏Author : Michael T. Sharratt
✏Publisher :
✏Release Date : 1974
✏Pages : 562
✏ISBN : WISC:89010813814
✏Available Language : English, Spanish, And French

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✏Effects of Hypoxia with and Without Hyperventilation on the Control of Ventilation Book Summary :

✏Book Title : Effects of Hypoxia and Some Anesthetics on the Isolated Extralobar Pulmonary of Guinea pig
✏Author : Shtaywy Saleh Abdalla
✏Publisher :
✏Release Date : 1984
✏Pages : 412
✏ISBN : WISC:89010703437
✏Available Language : English, Spanish, And French

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✏Effects of Hypoxia and Some Anesthetics on the Isolated Extralobar Pulmonary of Guinea pig Book Summary :

✏Book Title : The Interaction of Ouabain and Hypoxia on the Transmembrane Potential of the Canine Purkinje Fiber
✏Author : Robert allen Chilson
✏Publisher :
✏Release Date : 1975
✏Pages : 224
✏ISBN : WISC:89011026259
✏Available Language : English, Spanish, And French

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✏The Interaction of Ouabain and Hypoxia on the Transmembrane Potential of the Canine Purkinje Fiber Book Summary :

✏Book Title : Acclimatization to Hypoxia and Its Physiological Mechanisms
✏Author : Zoiı̐aı̐Ł Ivanovna Barbashova
✏Publisher :
✏Release Date : 1968
✏Pages : 237
✏ISBN : UCLA:31158004975420
✏Available Language : English, Spanish, And French

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✏Acclimatization to Hypoxia and Its Physiological Mechanisms Book Summary :

✏Book Title : Hypoxia
✏Author : Kasey Stevenson
✏Publisher :
✏Release Date : 2019
✏Pages : 87
✏ISBN : OCLC:1155924274
✏Available Language : English, Spanish, And French

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✏Hypoxia Book Summary : Hypoxic hypoxia is a physiological condition which can manifest as a result of reduced barometric pressure, resulting in an insufficient amount of oxygen for use by the tissues in the body. Hypoxic hypoxia is of concern to pilots due to dangerous impairment the condition can cause in-flight, such as short term memory loss, incoordination, or incapacitation. Several aircraft incidents and accidents have been attributed to hypoxia in the past ten years. To train for hypoxia recognition, high altitude chambers are used to induce hypoxia in participants, through a reduction of pressure inside a reinforced chamber. The training allows participants to experience their personal physiological symptoms of hypoxia in a controlled environment, in order to be trained in recognition and intervention techniques. This study surveyed 110 participants of high altitude chamber training to analyze perceptions, experience, and attitudes of respondents toward the training. Significant results were found; to include 99% of participants stating they would recommend the training to others, and 96.8% stating they felt they were a safer pilot, crewmember, or other support personnel due to attending high altitude chamber training. Two questions related to formal regulatory oversight revealed non-significant results. The purpose and results of this study are intended to support the improvement of aviation physiological training practices, in an effort to reduce hypoxia-related aircraft incidents an accidents in the future.

✏Book Title : The Influence of Hypoxia and Reduced Extracellular PH on the Membrane Potential of Canine Cardiac Purkinje Fibers
✏Author : Carl E. Gulbrandsen
✏Publisher :
✏Release Date : 1978
✏Pages : 324
✏ISBN : WISC:89010966018
✏Available Language : English, Spanish, And French

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✏The Influence of Hypoxia and Reduced Extracellular PH on the Membrane Potential of Canine Cardiac Purkinje Fibers Book Summary :

✏Book Title : Report for the Integrated Assessment on Hypoxia in the Gulf of Mexico
✏Author :
✏Publisher :
✏Release Date : 1999
✏Pages :
✏ISBN : OSU:32435063125512
✏Available Language : English, Spanish, And French

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✏Report for the Integrated Assessment on Hypoxia in the Gulf of Mexico Book Summary :

✏Book Title : Exposure to Plasma from Helium Breathing Volunteers Reduces Hypoxia Induced Cell Damage in Human Endothelial Cells
✏Author : Kirsten Smit
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1163832440
✏Available Language : English, Spanish, And French

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✏Exposure to Plasma from Helium Breathing Volunteers Reduces Hypoxia Induced Cell Damage in Human Endothelial Cells Book Summary : Background:Remote ischemic preconditioning, induced by short repetitive ischemic stimuli in one organ, can protect another organ from prolonged ischemia/reperfusion. Plasma taken from volunteers subjected to 4x5 minutes of forearm ischemia protects endothelial cells in vitro against hypoxia-induced damage. In vivo, preconditioning with helium protected healthy volunteers against post-ischemic endothelial dysfunction. The mechanism behind helium preconditioning is not yet clear. Here we investigate whether plasma from helium treated volunteers in vivo can protect human umbilical vein endothelial cells (HUVEC) remotely against hypoxia.Methods:After ethical approval, 20 healthy male volunteers inhaled heliox (79% helium, 21% oxygen) or air for 30 minutes, in a crossover design with two weeks between experiments. Plasma was collected at baseline (T0), directly after inhalation (T1), 6h (T3) and 24h (T4) after start of the experiment. HUVEC were incubated with either 5% or 10% of the plasma for 1-2 hours and were subsequently subjected to enzymatically induced hypoxia for 24 hours. Cell damage was measured by LDH content of supernatant and cellular fractions. Caveolin-1 (Cav-1), hypoxic inducible factor (HIF)1uf061, extracellular signal-regulated kinase (ERK) 1/2, signal transducer and activator of transcription (STAT) 3 and endothelial nitric oxide synthase (eNOS) were determined by Western blot analysis and enzyme-linked immuno sorbent assay (ELISA). Additional experiments were performed using siRNA cav-1 transfected HUVEC (n=10). Results: Prolonged pre-hypoxic exposure to 10% plasma obtained 6 hours after helium inhalation significantly decreased hypoxia induced cell damage in HUVEC compared to baseline. Mean 95%CI 0,86 (0,77;0.95). T0=1. Plasma obtained directly after (T1) and 24 h after (T3) helium inhalation caused a significant increase in cytosolic Cav-1 levels T0=0.95 [0.86, 1.03], T1=1.1 [0.99, 1.16] and T3=1.0 [0.98-1.15] respectively, p

✏Book Title : The Harmful Algal Blooms and Hypoxia Research and Control Amendments Act of 2009
✏Author : United States. Congress. Senate. Committee on Commerce, Science, and Transportation
✏Publisher :
✏Release Date : 2010
✏Pages : 26
✏ISBN : UOM:39015084690778
✏Available Language : English, Spanish, And French

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✏The Harmful Algal Blooms and Hypoxia Research and Control Amendments Act of 2009 Book Summary :