Hyaluronan in Cancer Biology

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  • Author : Robert Stern
  • Publisher : Academic Press
  • Pages : 468 pages
  • ISBN : 9780080921082
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Hyaluronan in Cancer Biology

Download or Read online Hyaluronan in Cancer Biology full in PDF, ePub and kindle. this book written by Robert Stern and published by Academic Press which was released on 07 March 2009 with total page 468 pages. We cannot guarantee that Hyaluronan in Cancer Biology book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. * Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer * Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination * Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

Hyaluronan in Cancer Biology

Hyaluronan in Cancer Biology
  • Author : Robert Stern
  • Publisher : Academic Press
  • Release : 07 March 2009
GET THIS BOOK Hyaluronan in Cancer Biology

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example

Hyaluronan Signaling and Turnover

Hyaluronan Signaling and Turnover
  • Author : Melanie Simpson,Paraskevi Heldin
  • Publisher : Academic Press
  • Release : 26 July 2014
GET THIS BOOK Hyaluronan Signaling and Turnover

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers hyaluronan signaling and turnover. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students

Chemistry and Biology of Hyaluronan

Chemistry and Biology of Hyaluronan
  • Author : Hari G. Garg,Charles A. Hales
  • Publisher : Elsevier
  • Release : 14 July 2004
GET THIS BOOK Chemistry and Biology of Hyaluronan

It was probably the French chemist Portes, who first reported in 1880 that the mucin in the vitreous body, which he named hyalomucine, behaved differently from other mucoids in cornea and cartilage. Fifty four years later Karl Meyer isolated a new polysaccharide from the vitreous, which he named hyaluronic acid. Today its official name is hyaluronan, and modern-day research on this polysaccharide continues to grow. Expertly written by leading scientists in the field, this book provides readers with a broad, yet

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  • Author : Alexander Birbrair
  • Publisher : Springer Nature
  • Release : 07 April 2020
GET THIS BOOK Tumor Microenvironment

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of

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  • Author : Rolf A. Brekken,Dwayne Stupack
  • Publisher : Springer
  • Release : 04 August 2017
GET THIS BOOK Extracellular Matrix in Tumor Biology

This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how

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  • Author : Thomas Dittmar,Kurt S. Zänker
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOK Role of Cancer Stem Cells in Cancer Biology and Therapy

This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence

Hyaluronan CD44 Interactions Decrease the Metastatic Potential of Breast Cancer Cells

Hyaluronan CD44 Interactions Decrease the Metastatic Potential of Breast Cancer Cells
  • Author : Anonim
  • Publisher : Unknown
  • Release : 03 July 2022
GET THIS BOOK Hyaluronan CD44 Interactions Decrease the Metastatic Potential of Breast Cancer Cells

The adhesion receptor CD44 is known to decrease the metastatic potential of breast cancer cells in vivo. This study focuses on understanding the mechanisms by which CD44 inhibits breast cancer cell invasion. We have found that the interaction between CD44 and Hyaluronan leads to decreased phosphorylation of FAK. Additionally, this interaction also leads to decreased transcription of the metalloprotease MMP9. Together, these mechanisms provide significant insight into how CD44 inhibits the movement of breast cancer cells away from their primary

Interaction between Hyaluronic Acid and Its Receptors CD44 RHAMM Regulates the Activity of Inflammation and Cancer

Interaction between Hyaluronic Acid and Its Receptors  CD44  RHAMM  Regulates the Activity of Inflammation and Cancer
  • Author : David Naor
  • Publisher : Frontiers Media SA
  • Release : 18 July 2016
GET THIS BOOK Interaction between Hyaluronic Acid and Its Receptors CD44 RHAMM Regulates the Activity of Inflammation and Cancer

The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast

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  • Publisher : Academic Press
  • Release : 07 August 2015
GET THIS BOOK Encyclopedia of Cell Biology

The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced

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  • Publisher : Unknown
  • Release : 03 July 2022
GET THIS BOOK Receptor mediated Targeting to Enhance Therapeutic Efficacy of Chemotherapeutic Agents

Dr. Paul Ehlrich introduced the concept of targeted drug delivery in 1904. With the advancement in technology, and molecular biology techniques, several new targeting moieties have been developed in the past two decades. These targeting molecules improve the therapeutic efficacy of the drug, and alleviate systemic toxicity. Drug delivery devices, including, nanoparticles and polymer-drug pendant chains have been thoroughly investigated for targeting applications. Cancer has been the focus for development of efficient targeted drug delivery devices and new therapies because of

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  • Author : Cato T. Laurencin,Lakshmi S. Nair
  • Publisher : CRC Press
  • Release : 28 October 2014
GET THIS BOOK Nanotechnology and Regenerative Engineering

Nanotechnology and regenerative engineering have emerged to the forefront as the most versatile and innovative technologies to foster novel therapeutic techniques and strategies of the twenty-first century. The first edition of Nanotechnology and Tissue Engineering: The Scaffold was the first comprehensive source to explain the developments in nanostructured biomaterials for tissue engineering, the relevance of nanostructured materials in tissue regeneration, and the current applications of nanostructured scaffolds for engineering various tissues. This fully revised second edition, renamed Nanotechnology and Regenerative

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  • Publisher : Academic Press
  • Release : 20 August 2015
GET THIS BOOK Handbook of the Biology of Aging

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to

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  • Publisher : BoD – Books on Demand
  • Release : 14 December 2011
GET THIS BOOK Breast Cancer

Cancer is the leading cause of death in most countries and its consequences result in huge economic, social and psychological burden. Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death among females. In this book, we discussed characteristics of breast cancer cell, role of microenvironment, stem cells and metastasis for this deadly cancer. We hope that this book will contribute to the development of novel diagnostic as well as therapeutic approaches.

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  • Publisher : CRC Press
  • Release : 18 July 2012
GET THIS BOOK Natural Polymers Biopolymers Biomaterials and Their Composites Blends and IPNs

Natural Polymers, Biopolymers, Biomaterials, and Their Composites, Blends, and IPNs focuses on the recent advances in natural polymers, biopolymers, biomaterials, and their composites, blends, and IPNs. Biobased polymer blends and composites occupy a unique position in the dynamic world of new biomaterials. The growing need for lubricious coatings and surfaces in medical devices—an outcome of the move from invasive to noninvasive medicines/procedures—is playing a major role in the advancement of biomaterials technology. Natural polymers have attained their