Host Response to Biomaterials

• Author : Stephen F Badylak
• Publisher : Academic Press
• Release : 08 May 2015

Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the

• Author : Nihal Engin Vrana
• Publisher : CRC Press
• Release : 20 July 2018

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted

• Author : Jaap Jan Boelens
• Publisher : Unknown
• Release : 03 June 1999

• Author : Bruna Corradetti
• Publisher : Springer
• Release : 30 November 2016

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development

• Author : Stephen F. Badylak,Jennifer Elisseeff
• Publisher : Woodhead Publishing
• Release : 30 July 2021

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative

• Author : John W. Boretos,Murray Eden
• Publisher : William Andrew
• Release : 03 June 1984

This book distinguishes between biomaterials for clinical use, and medical devices or components of devices. Biomaterials are defined as substances which can be placed in intimate contact with living structures without harmful effects. They become devices (internal or external to the body) when processed or shaped to serve a specific function. Implants are a subclass of devices which need to be located inside the body to achieve their purpose.

• Author : Ralph S. Greco
• Publisher : CRC Press
• Release : 24 March 1994

This new book is the first of its kind to characterize the host implant interface at both the basic science and clinical level. The book defines the interactions of various cell types with a variety of biomaterials by discussing the basic science of these interactions. This study is important because in today's world of bionics, implantable devices represent a major component of medical practice. They are associated with significant cost and substantial benefit to many patients and morbid complications for

• Author : Jonathan Black
• Publisher : CRC Press
• Release : 20 December 2005

Bioengineers need a thorough grounding in biocompatibility - the biological performance of materials. Until now, there were no publications suitable for a neophyte in the field; prior publications were either not comprehensive or focused on rather narrow interests. Drawing on the author's 35 years of experience as a teacher, researcher, and consultant in biomaterials science and engineering (BSE), Biological Performance of Materials: Fundamentals of Biocompatibility, Fourth Edition focuses primarily on principles of biological performance at a relatively fundamental level, analyzing interactions

• Author : Xingdong Zhang,David Williams
• Publisher : Elsevier
• Release : 20 June 2019

Definitions of Biomaterials for the Twenty-First Century is a review of key, critical biomaterial terms and definitions endorsed by the International Union of Societies for Biomaterials Science and Engineering. The topics and definitions discussed include those in general biomaterials and applications, biocompatibility, implantable and interventional devices, drug delivery systems, regenerative medicine and emerging biomaterials. The book reviews the discussion of these terms by leaders in the global biomaterials community and summarizes the agreed upon definitions. Provides readers with the official

• Author : Florian Billing
• Publisher : Unknown
• Release : 03 June 2023

Medical implants are widely used nowadays. Following tissue contact, proteins adhere to the device's surface and surrounding cells become activated, causing an initial inflammatory host response. If this host response develops into a chronic inflammatory state, significant adverse effects such as implant rejection and loss might occur. The physico-chemical qualities of the biomaterials employed have a substantial influence on the degree of the immune response. Therefore, modulating surface properties such as topography or wettability may be a viable strategy for

• Author : Jonathan Black
• Publisher : CRC Press
• Release : 21 July 1999

A balanced approach to understanding the response of living tissues and systems to manufactured biomaterials and the effect of life processes on the properties and behaviour of successful and unsuccessful biomaterials. This third edition contains a glossary of specialized terms; discussion of the emerging area of tissue engineering; more sources; and more tables to additional generic biomaterials properties.

• Author : Masoud Mozafari
• Publisher : Woodhead Publishing
• Release : 17 June 2020

Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and

• Author : Thuy Tram Dang (Ph. D.),Massachusetts Institute of Technology. Department of Chemical Engineering
• Publisher : Unknown
• Release : 03 June 2023

Host response to implanted biomaterials and medical devices poses tremendous challenges to their clinical applications. Today, the quest to mitigate this immunological attack for improved longevity of these devices remains daunting. This thesis aims to explore the use of anti-inflammatory drugs in minimizing the host response and improve the efficacy of implantable and transplantable therapeutics. Firstly, we developed a new non-invasive in vivo imaging technique to study the activity of early immune cells in the host response to implanted biomaterials.

• Author : Kevin L. Ong,Scott Lovald,Jonathan Black
• Publisher : CRC Press
• Release : 21 February 2014

Revised, expanded, and updated, Orthopaedic Biomaterials in Research and Practice, Second Edition introduces materials science and applies it to medical research and treatment. This book incorporates math and engineering, which makes it accessible to trainees and others working in the industry who are lacking primary mathematical and engineering training. What’s New in the Second Edition: In the second edition, the new material includes regeneration, hybrid and replant materials, tissue engineering, electrical stimulation for tissue growth and repair, modeling of

• Author : Abigail Corrin Parks
• Publisher : Unknown
• Release : 03 June 2023

Soft tissue loss can be the result of many clinical issues. An engineered injectable material to stimulate soft tissue regeneration would be an improvement for many clinical applications within tissue augmentation including dermal augmentation, periurethral bulking, and gingival augmentation. Implanted biomaterials are usually held to a standard of biocompatibility meaning that the overall goal for a biomaterial is to have it as inert as possible and to act stealthily when it comes in contact with the body. This is to