Hands On Approach For The Conduct Of Nonclinical Studies

✏Book Title : Targeted Therapy in Translational Cancer Research
✏Author : Apostolia-Maria Tsimberidou
✏Publisher : John Wiley & Sons
✏Release Date : 2015-10-08
✏Pages : 320
✏ISBN : 9781118468685
✏Available Language : English, Spanish, And French

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✏Targeted Therapy in Translational Cancer Research Book Summary : Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

✏Book Title : Global Approach in Safety Testing
✏Author : Jan Willem van der Laan
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-02-11
✏Pages : 315
✏ISBN : 9781461459507
✏Available Language : English, Spanish, And French

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✏Global Approach in Safety Testing Book Summary : This volume will consider one of ICH’s major categories, Safety i.e. topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but even after ICH6 no explanations have been given during a formal Congress about the background of the ICH Guidance documents. Even more important than what has been written, might have been those thoughts of the experts that are not included in the Guidance documents. Why has the guideline been written as it is written, and why have some aspects been deleted. These and other related questions are the contents of this book, written by experts who were involved in the ICH process. Furthermore, the chapters will contain discussions on the “lessons learnt” and “future developments”.

✏Book Title : Conducting
✏Author : Anthony Joseph Maiello
✏Publisher : Alfred Music Publishing
✏Release Date : 1996
✏Pages : 232
✏ISBN : 1576234533
✏Available Language : English, Spanish, And French

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✏Conducting Book Summary : This comprehensive text by Anthony Maiello on the art of conducting is designed to be hands on, user friendly, playable by any instrumentation, a step-by-step approach to baton technique, great for use with a wind, string or voice conducting class, and excellent as a refresher course for all conductors at all levels of ability. The 232-page book covers a variety of conducting issues and the included CD contains all the musical exercises in the book (there are more than 100).

✏Book Title : Nonhuman Primates in Biomedical Research
✏Author : Christian R. Abee
✏Publisher : Academic Press
✏Release Date : 2012-05-09
✏Pages : 536
✏ISBN : 9780123978370
✏Available Language : English, Spanish, And French

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✏Nonhuman Primates in Biomedical Research Book Summary : The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Now in four color throughout, making the book more visually stimulating to enhance learning and ease of use Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in biomedical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information

✏Book Title : The Role of the Study Director in Nonclinical Studies
✏Author : William J. Brock
✏Publisher : John Wiley & Sons
✏Release Date : 2014-05-02
✏Pages : 560
✏ISBN : 9781118874080
✏Available Language : English, Spanish, And French

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✏The Role of the Study Director in Nonclinical Studies Book Summary : A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry

✏Book Title : Psychological Abstracts
✏Author : American psychological association
✏Publisher :
✏Release Date : 2003
✏Pages :
✏ISBN : 00332887
✏Available Language : English, Spanish, And French

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✏Psychological Abstracts Book Summary :

✏Book Title : Advances in Clinical Child Psychology
✏Author : Benjamin Lahey
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-12-06
✏Pages : 326
✏ISBN : 9781461398202
✏Available Language : English, Spanish, And French

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✏Advances in Clinical Child Psychology Book Summary : A decade ago, Advances in Clinical Child Psychology was conceived to provide approximately annual updates on the forward edge of research and practice in this rapidly growing field. A look back at the 56 chapters published in previous volumes provides a broad overview of the direc tion of advancement in clinical child psychology, at least as viewed by one collection of editors, consulting editors, and authors. The trends are clear: There have been decreasing numbers of advances in modes and methods of therapy, an increasing emphasis on the family, a renewed interest in experimental psychopathology (studies of classification, etiol ogy, and prognosis), a growing rapprochement between biological and psychological perspectives, and continued strong interest in cognition and social relationships. The current volume clearly shows these directions in the growth of the field. One chapter discusses etiology, four are concerned with the psychopathology of specific diagnostic categories, one takes an ex panded cognitive approach to social competence, and two look at the family system by examining the effects of male parents and children on other members of the family. A final chapter opens discussion on the important topic of the nature of excellence in the training of clinical child psychologists. It is hoped that this chapter will initiate a national di alogue on this multifaceted and often neglected topic.

✏Book Title : Oncology Clinical Trials
✏Author : Susan Halabi, PhD
✏Publisher : Demos Medical Publishing
✏Release Date : 2009-12-22
✏Pages : 168
✏ISBN : 1935281763
✏Available Language : English, Spanish, And French

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✏Oncology Clinical Trials Book Summary : Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well conceived, carefully designed and efficiently conducted clinical trial can produce results that change clinical practice overnight, deliver new oncology drugs and diagnostics to the marketplace, and expand the horizon of contemporary thinking about cancer biology. A poorly done trial does little to advance the field or guide clinical practice, consumes precious clinical and financial resources and challenges the validity of the ethical contract between investigators and the volunteers who willingly give their time and effort to benefit future patients. With chapters written by oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives, Oncology Clinical Trials, provides a comprehensive guide for both early-career and senior oncology investigators into the successful design, conduct and analysis of an oncology clinical trial. Oncology Clinical Trials covers how to formulate a study question, selecting a study population, study design of Phase I, II, and III trials, toxicity monitoring, data analysis and reporting, use of genomics, cost-effectiveness analysis, systemic review and meta-analysis, and many other issues. Many examples of real-life flaws in clinical trials that have been reported in the literature are included throughout. The book discusses clinical trials from start to finish focusing on real-life examples in the development, design and analysis of clinical trials. Oncology Clinical Trials features: A systematic guide to all aspects of the design, conduct, analysis, and reporting of clinical trials in oncology Contributions from oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives Hot topics in oncology trials including multi-arm trials, meta-analysis and adaptive design, use of genomics, and cost-effectiveness analysis Real-life examples from reported clinical trials included throughout

✏Book Title : Cancer Gene Therapy
✏Author : David T. Curiel
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-11-03
✏Pages : 490
✏ISBN : 9781592597857
✏Available Language : English, Spanish, And French

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✏Cancer Gene Therapy Book Summary : A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

✏Book Title : Developmental and Reproductive Toxicology
✏Author : Ronald D Hood
✏Publisher : CRC Press
✏Release Date : 2011-12-14
✏Pages : 856
✏ISBN : 1841847771
✏Available Language : English, Spanish, And French

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✏Developmental and Reproductive Toxicology Book Summary : The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment. In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. It contains new chapters that reflect emerging topics of interest, including testing of biologics (including vaccines), nonhuman primates as nonclinical models, developmental immunotoxicity testing, in vitro assays (such as use of zebrafish and stem cells, as well as high throughput screening), in silico systems modelling, evaluating mechanisms of reproductive toxicity, in-depth coverage of neurobehavioral testing, and testing under the EU’s REACH regulations, as well as updated chapters on nonclinical juvenile toxicity testing, endocrine disruptor screening, and on functional and computational genomics. The study of hazard and risk associated with exposure to toxicants during prenatal development has been expanded in recent years to include effects on development until the time of puberty. Concern over the adverse effects of chemical or physical agents on the reproductive processes of both sexes has increased, and progress has been made in identifying the causes and mechanisms eliciting congenital defects and determining the genetic, epigenetic, and environmental factors involved. This book provides up-to-date guidance on the use and interpretation of the newest research techniques in developmental and reproductive toxicology, as well as the more traditional approaches. Developmental and Reproductive Toxicology, Third Edition: Contains valuable insights gained from hands-on experience, together with a critical evaluation of current testing strategies. Includes guidance for the design, conduct, and interpretation of tests in all areas of developmental and reproductive toxicity. Contains reprinted guidelines from major regulatory agencies, as well as terminology for description of developmental abnormalities in laboratory animals, for easy reference. Provides guidance for planning and conducting preclinical toxicity studies and follow-up studies, and interpreting their results in a regulatory environment. This book continues to be the ideal practical reference for developmental and reproductive toxicologists who perform research in industry, government, and academia and for anyone who intends to enter these research areas.

✏Book Title : Biotechnology Recombinant Proteins Monoclonal Antibodies and Therapeutic Genes
✏Author : A. Mountain
✏Publisher : Wiley-Blackwell
✏Release Date : 1999-03-19
✏Pages : 580
✏ISBN : 3527283153
✏Available Language : English, Spanish, And French

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✏Biotechnology Recombinant Proteins Monoclonal Antibodies and Therapeutic Genes Book Summary : In the field of medicinal biotechnology three major developments have caused a revolution in research that has a lot of innovative effects on clinical medicine and future applications on humans. With the availability of tailored recombinant proteins and the opportunity to produce high amounts of monoclonal antibodies new diagnostic applications have emerged and many therapeutic perspectives, e.g. in the treatment of multiple sclerosis and of cancer, are being discussed today. The aim of somatic gene therapy is to re-establish normal cell function by supplying the cells with the respective intact gene. This is a very difficult task and different diseases, e.g. AIDS and several metabolic disorders, are under investigation now. So far first promising approaches exist in cancer therapy. Moreover the book informs about regulatory and economic aspects of these new methods and their applications.

✏Book Title : The Handbook of Narcissism and Narcissistic Personality Disorder
✏Author : W. Keith Campbell
✏Publisher : John Wiley & Sons
✏Release Date : 2011-07-07
✏Pages : 528
✏ISBN : 1118029267
✏Available Language : English, Spanish, And French

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✏The Handbook of Narcissism and Narcissistic Personality Disorder Book Summary : The Handbook of Narcissism and Narcissistic Personality Disorder is the definitive resource for empirically sound information on narcissism for researchers, students, and clinicians at a time when this personality disorder has become a particularly relevant area of interest. This unique work deepens understanding of how narcissistic behavior influences behavior and impedes progress in the worlds of work, relationships, and politics.!--EndFragment--

✏Book Title : Current Index to Journals in Education
✏Author :
✏Publisher :
✏Release Date : 1996-10
✏Pages :
✏ISBN : MINN:31951P00746688K
✏Available Language : English, Spanish, And French

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✏Current Index to Journals in Education Book Summary :

✏Book Title : Abeloff s Clinical Oncology E Book
✏Author : John E. Niederhuber
✏Publisher : Elsevier Health Sciences
✏Release Date : 2013-09-12
✏Pages : 2224
✏ISBN : 9781455728817
✏Available Language : English, Spanish, And French

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✏Abeloff s Clinical Oncology E Book Book Summary : Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

✏Book Title : Comprehensive toxicology
✏Author : I. Glenn Sipes
✏Publisher :
✏Release Date : 1997
✏Pages :
✏ISBN : CORNELL:31924073492807
✏Available Language : English, Spanish, And French

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✏Comprehensive toxicology Book Summary :

✏Book Title : Agronomy Abstracts
✏Author :
✏Publisher :
✏Release Date : 1987
✏Pages :
✏ISBN : UCSC:32106020761430
✏Available Language : English, Spanish, And French

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✏Agronomy Abstracts Book Summary : Includes abstracts of the annual meetings of the American Society of Agronomy; Soil Science Society of America; Crop Science Society of America ( - of its Agronomic Education Division).

✏Book Title : New Scientist
✏Author :
✏Publisher :
✏Release Date : 2000-08
✏Pages :
✏ISBN : CHI:54508659
✏Available Language : English, Spanish, And French

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✏New Scientist Book Summary :

✏Book Title : Veterinary and Human Toxicology
✏Author :
✏Publisher :
✏Release Date : 1992
✏Pages :
✏ISBN : CORNELL:31924062903202
✏Available Language : English, Spanish, And French

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✏Veterinary and Human Toxicology Book Summary :

✏Book Title : Handbook of Organizational Design Adapting organizations to their environments
✏Author : Professor of Business Administration Paul C Nystrom
✏Publisher : Oxford ; New York : Oxford University Press
✏Release Date : 1981
✏Pages : 582
✏ISBN : STANFORD:36105004682535
✏Available Language : English, Spanish, And French

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✏Handbook of Organizational Design Adapting organizations to their environments Book Summary : The two volumes summarize and reinterpret research and suggest applications to the design of organizations.Volume I analyses the effects of environments on organizations, and discusses the adaptive capabilities of organizations such as planning, forecasting, and innovation. Contributors examine the effects of change, particularly changes in technologies and in legal and political systems.

✏Book Title : Cancer Risk Assessment
✏Author : Ching-Hung Hsu
✏Publisher : John Wiley & Sons
✏Release Date : 2010-12-08
✏Pages : 856
✏ISBN : 1118035127
✏Available Language : English, Spanish, And French

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✏Cancer Risk Assessment Book Summary : With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.

✏Book Title : Oncology of Infancy and Childhood E Book
✏Author : Stuart H. Orkin
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-06-09
✏Pages : 1392
✏ISBN : 9781437721386
✏Available Language : English, Spanish, And French

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✏Oncology of Infancy and Childhood E Book Book Summary : To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.

✏Book Title : Preclinical Safety of Biotechnology Products Intended for Human Use
✏Author : George J. Brewer
✏Publisher :
✏Release Date : 1987
✏Pages : 213
✏ISBN : 0845150855
✏Available Language : English, Spanish, And French

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✏Preclinical Safety of Biotechnology Products Intended for Human Use Book Summary :

✏Book Title : Pharmacokinetics
✏Author : Peter G. Welling
✏Publisher : Amer Chemical Society
✏Release Date : 1997
✏Pages : 393
✏ISBN : STANFORD:36105110341216
✏Available Language : English, Spanish, And French

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✏Pharmacokinetics Book Summary : Pharmacokinetics is the study of the absorption, distribution, metabolism, and excretion of drugs in humans. This book, written by an internationally known researcher, teaches the basic principles, including drug transport, parenteral and enteral routes of drug administration, and factors affecting drug absorption, distribution, and metabolism. Extensively revised, this edition presents the mathematics of pharmacokinetics with various single- and multi-compartment models including detailed descriptions of metabolite and nonlinear pharmacokinetics. It also describes renal and hepatic drug clearance, and the influence of kidney and liver impairment on these functions. Taking a tutorial approach throughout, the author provides both a clear introduction to pharmacokinetics and a critical look at how this science affects drug discovery and development.

✏Book Title : Population Studies
✏Author :
✏Publisher :
✏Release Date : 1948
✏Pages :
✏ISBN : WISC:89059834739
✏Available Language : English, Spanish, And French

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✏Population Studies Book Summary :

✏Book Title : Cancer Research
✏Author :
✏Publisher :
✏Release Date : 2001-11
✏Pages :
✏ISBN : CORNELL:31924090571203
✏Available Language : English, Spanish, And French

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✏Cancer Research Book Summary :

✏Book Title : Psychology
✏Author : Addison-Wesley Longman, Incorporated
✏Publisher :
✏Release Date : 1997
✏Pages :
✏ISBN : 0673998967
✏Available Language : English, Spanish, And French

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✏Psychology Book Summary :

✏Book Title : American Sociological Review
✏Author :
✏Publisher :
✏Release Date : 1936
✏Pages :
✏ISBN : UOM:39076000327861
✏Available Language : English, Spanish, And French

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✏American Sociological Review Book Summary : Includes sections "Book reviews" and "Periodical literature."

✏Book Title : Companion to Psychiatric Studies
✏Author : Robert Evan Kendell
✏Publisher :
✏Release Date : 1983
✏Pages : 719
✏ISBN : UOM:39015003195719
✏Available Language : English, Spanish, And French

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✏Companion to Psychiatric Studies Book Summary :

✏Book Title : Studies to Enhance the Evaluation of Family Planning Programmes
✏Author : United Nations. Department of International Economic and Social Affairs. Population Division
✏Publisher :
✏Release Date : 1985
✏Pages : 246
✏ISBN : UOM:39015020702612
✏Available Language : English, Spanish, And French

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✏Studies to Enhance the Evaluation of Family Planning Programmes Book Summary :

✏Book Title : Impact of Toxicology on Food Processing
✏Author : International Union of Food Science and Technology
✏Publisher :
✏Release Date : 1981
✏Pages : 320
✏ISBN : UCSC:32106005283699
✏Available Language : English, Spanish, And French

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✏Impact of Toxicology on Food Processing Book Summary :