GPCRs From Deorphanization to Lead Structure Identification

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  • Author : H. Bourne
  • Publisher : Springer Science & Business Media
  • Pages : 269 pages
  • ISBN : 3540489827
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>GPCRs From Deorphanization to Lead Structure Identification

Download or Read online GPCRs From Deorphanization to Lead Structure Identification full in PDF, ePub and kindle. this book written by H. Bourne and published by Springer Science & Business Media which was released on 23 May 2007 with total page 269 pages. We cannot guarantee that GPCRs From Deorphanization to Lead Structure Identification book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006.

GPCRs From Deorphanization to Lead Structure Identification

GPCRs  From Deorphanization to Lead Structure Identification
  • Author : H. Bourne,Richard Horuk,J. Kuhnke,H. Michel
  • Publisher : Springer Science & Business Media
  • Release : 23 May 2007
GET THIS BOOK GPCRs From Deorphanization to Lead Structure Identification

This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006.

Modelling of GPCRs

Modelling of GPCRs
  • Author : Andrea Strasser,Hans-Joachim Wittmann
  • Publisher : Springer Science & Business Media
  • Release : 13 August 2012
GET THIS BOOK Modelling of GPCRs

G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is – in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book “Modelling of GPCRs – a practical handbook” is focussed onto a practical introduction into molecular modelling

Neuropeptide GPCRs in neuroendocrinology

Neuropeptide GPCRs in neuroendocrinology
  • Author : Jae Young Seong,Hubert Vaudry
  • Publisher : Frontiers E-books
  • Release : 07 November 2014
GET THIS BOOK Neuropeptide GPCRs in neuroendocrinology

The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of

Structure and Function of GPCRs

Structure and Function of GPCRs
  • Author : Guillaume Lebon
  • Publisher : Springer
  • Release : 01 August 2019
GET THIS BOOK Structure and Function of GPCRs

This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to

Monitoring endogenous GPCRs lessons for drug design

Monitoring endogenous GPCRs  lessons for drug design
  • Author : Dominique Massotte
  • Publisher : Unknown
  • Release : 07 October 2015
GET THIS BOOK Monitoring endogenous GPCRs lessons for drug design

G protein-coupled receptors (GPCRs) are integral membrane proteins forming the fourth largest superfamily in the human genome. Many of these receptors play key physiological roles and several pathologies have been associated with receptor functional abnormalities. GPCRs therefore represent important goals for drug design in pharmaceutical companies since they constitute the target of about one third of the drugs currently on the market. However, endogenous GPCRs are most often difficult to study because of a lack of tools to target them

Adhesion GPCRs

Adhesion   GPCRs
  • Author : Simon Yona,Martin Stacey
  • Publisher : Springer Science & Business Media
  • Release : 26 June 2011
GET THIS BOOK Adhesion GPCRs

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders.

Metabotropic GPCRs TGR5 and P2Y Receptors in Health and Diseases

Metabotropic GPCRs  TGR5 and P2Y Receptors in Health and Diseases
  • Author : Senthilkumar Rajagopal,Murugavel Ponnusamy
  • Publisher : Springer
  • Release : 19 November 2018
GET THIS BOOK Metabotropic GPCRs TGR5 and P2Y Receptors in Health and Diseases

This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors.

Trafficking of GPCRs

Trafficking of GPCRs
  • Author : Guangyu Wu
  • Publisher : Academic Press
  • Release : 05 June 2015
GET THIS BOOK Trafficking of GPCRs

G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms. Written by future leaders in the

The Physiology and Pharmacology of Leucine rich Repeat GPCRs

The Physiology and Pharmacology of Leucine rich Repeat GPCRs
  • Author : Brian J. Arey,James A. Dias
  • Publisher : Frontiers Media SA
  • Release : 05 August 2016
GET THIS BOOK The Physiology and Pharmacology of Leucine rich Repeat GPCRs

G protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therapeutically, GPCRs represent a fertile source for the development of therapies as they are a significant percentage of our current pharmacopeia. Among the three subclasses of GPCRs, the Class A (rhodopsin-like) receptors are by far the most prevalent and extensively

Ligand Design for G Protein coupled Receptors Volume 30

Ligand Design for G Protein coupled Receptors  Volume 30
  • Author : Didier Rognan,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release : 10 March 2006
GET THIS BOOK Ligand Design for G Protein coupled Receptors Volume 30

1. G protein-coupled receptors in the human genome -- 2. Why G protein-coupled receptors databases are needed -- 3. A novel drug screening assay for G protein-coupled receptors -- 4. Importance of GPCR dimerization for function : the case of the class C GPCRs -- 5. Molecular mechanisms of GPCR activation -- 6. Allosteric properties and regulation of G protein-coupled receptors -- 7. Chemogenomics approaches to ligand design -- 8. Strategies for the design of pGPCR-targeted libraries -- 9. Ligand-based rational design : virtual screening -- 10. 3-D structure of G protein-coupled

G Protein Coupled Receptors

G Protein Coupled Receptors
  • Author : Gabriel Berstein
  • Publisher : CRC Press
  • Release : 24 April 2019
GET THIS BOOK G Protein Coupled Receptors

Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the r

G Protein Coupled Receptors

G Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 17 January 2013
GET THIS BOOK G Protein Coupled Receptors

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on

G Protein Coupled Receptors

G Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 05 January 2019
GET THIS BOOK G Protein Coupled Receptors

G-Protein-Coupled Receptors, Part B, 2nd Edition, Volume 149, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers Optical Approaches for Visualization of Arrestin Binding to Muscarinic Receptors, Luciferase Reporter Assay for Unlocking Ligand-mediated Signaling of GPCRs, Assays to Measure GPCR Dependent Cellular Migration, Characterization of the Frizzled GPCRs, Binding Assays for Bradykinin and Angiotensin Receptors, Detection of Misfolded Rhodopsin Aggregates in

Structure Function Analysis of G Protein Coupled Receptors

Structure Function Analysis of G Protein Coupled Receptors
  • Author : Jürgen Wess,Wess
  • Publisher : Wiley-Liss
  • Release : 15 June 1999
GET THIS BOOK Structure Function Analysis of G Protein Coupled Receptors

Structure-Function Analysis of G Protein-Coupled Receptors edited by Jürgen Wess. G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity. This volume