Structure and Function of GPCRs

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  • Author : Guillaume Lebon
  • Publisher : Springer
  • Pages : 289 pages
  • ISBN : 3030245918
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Structure and Function of GPCRs

Download or Read online Structure and Function of GPCRs full in PDF, ePub and kindle. this book written by Guillaume Lebon and published by Springer which was released on 01 August 2019 with total page 289 pages. We cannot guarantee that Structure and Function of GPCRs book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field.

Structure and Function of GPCRs

Structure and Function of GPCRs
  • Author : Guillaume Lebon
  • Publisher : Springer
  • Release : 01 August 2019
GET THIS BOOK Structure and Function of GPCRs

This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to

Metabotropic GPCRs TGR5 and P2Y Receptors in Health and Diseases

Metabotropic GPCRs  TGR5 and P2Y Receptors in Health and Diseases
  • Author : Senthilkumar Rajagopal,Murugavel Ponnusamy
  • Publisher : Springer
  • Release : 19 November 2018
GET THIS BOOK Metabotropic GPCRs TGR5 and P2Y Receptors in Health and Diseases

This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors.

Modelling of GPCRs

Modelling of GPCRs
  • Author : Andrea Strasser,Hans-Joachim Wittmann
  • Publisher : Springer Science & Business Media
  • Release : 13 August 2012
GET THIS BOOK Modelling of GPCRs

G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is – in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book “Modelling of GPCRs – a practical handbook” is focussed onto a practical introduction into molecular modelling

G Protein Coupled Receptors in Drug Discovery

G Protein Coupled Receptors in Drug Discovery
  • Author : Wayne R. Leifert
  • Publisher : Humana Press
  • Release : 23 August 2016
GET THIS BOOK G Protein Coupled Receptors in Drug Discovery

The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a multitude of physiological processes. The GPCRs represent one of the largest superfamilies in the human genome and are a significant target for bioactive and drug discovery programs. It is estimated that greater than 50% of all drugs, including those in development, currently target GPCRs. Many of the characterized GPCRs have known ligands; however, approximately 20% of GPCRs are described as orphan GPCRs, apparent GPCRs that share the generic high-level structure

The G Protein Coupled Receptors Handbook

The G Protein Coupled Receptors Handbook
  • Author : Lakshmi A. Devi
  • Publisher : Springer Science & Business Media
  • Release : 01 March 2008
GET THIS BOOK The G Protein Coupled Receptors Handbook

A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as

Adhesion GPCRs

Adhesion   GPCRs
  • Author : Simon Yona,Martin Stacey
  • Publisher : Springer
  • Release : 11 January 2011
GET THIS BOOK Adhesion GPCRs

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders.

GPCRs From Deorphanization to Lead Structure Identification

GPCRs  From Deorphanization to Lead Structure Identification
  • Author : H. Bourne,Richard Horuk,J. Kuhnke,H. Michel
  • Publisher : Springer Science & Business Media
  • Release : 23 May 2007
GET THIS BOOK GPCRs From Deorphanization to Lead Structure Identification

This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006.

Adhesion GPCRs

Adhesion   GPCRs
  • Author : Simon Yona,Martin Stacey
  • Publisher : Springer Science & Business Media
  • Release : 26 June 2011
GET THIS BOOK Adhesion GPCRs

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders.

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S.-H. Park
  • Publisher : Academic Press
  • Release : 11 September 2019
GET THIS BOOK GPCRs

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible

Identification and Expression of G Protein Coupled Receptors

Identification and Expression of G Protein Coupled Receptors
  • Author : Kevin R. Lynch
  • Publisher : John Wiley & Sons
  • Release : 10 May 1999
GET THIS BOOK Identification and Expression of G Protein Coupled Receptors

The past decade has seen tremendous advances in the study of G protein-coupled receptors (GPCRs), including the molecular cloning and identification of more than 100 hundred GPCR genes. But while GPCRs serve as targets for more than 300 medicines in the modern pharmacopoeia, the shrinking pool of known ligands and the continuing discovery of orphan GPCR genes have underscored the need for new approaches to ligand identification. Identification and Expression of G Protein-Coupled Receptors addresses this new direction in GPCR biochemistry-offering a

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 02 December 2012
GET THIS BOOK Oligomerization and Allosteric Modulation in G Protein Coupled Receptors

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments

Monitoring endogenous GPCRs lessons for drug design

Monitoring endogenous GPCRs  lessons for drug design
  • Author : Dominique Massotte
  • Publisher : Unknown
  • Release : 07 October 2015
GET THIS BOOK Monitoring endogenous GPCRs lessons for drug design

G protein-coupled receptors (GPCRs) are integral membrane proteins forming the fourth largest superfamily in the human genome. Many of these receptors play key physiological roles and several pathologies have been associated with receptor functional abnormalities. GPCRs therefore represent important goals for drug design in pharmaceutical companies since they constitute the target of about one third of the drugs currently on the market. However, endogenous GPCRs are most often difficult to study because of a lack of tools to target them

G Protein coupled Receptors

G Protein coupled Receptors
  • Author : Georges Vauquelin,Bengt von Mentzer
  • Publisher : John Wiley & Sons
  • Release : 11 March 2008
GET THIS BOOK G Protein coupled Receptors

G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly. G Protein-coupled Receptors: Molecular Pharmacology provides a