Genome Stability

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  • Author : Igor Kovalchuk
  • Publisher : Academic Press
  • Pages : 712 pages
  • ISBN : 0128033452
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Genome Stability

Download or Read online Genome Stability full in PDF, ePub and kindle. this book written by Igor Kovalchuk and published by Academic Press which was released on 03 September 2016 with total page 712 pages. We cannot guarantee that Genome Stability book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability and its effect on human diseases Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Academic Press
  • Release : 03 September 2016
GET THIS BOOK Genome Stability

Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments.

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Pub
  • Release : 14 June 2021
GET THIS BOOK Genome Stability

"Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk
  • Publisher : Academic Press
  • Release : 30 September 2016
GET THIS BOOK Genome Stability

"Genome Stability: From Virus to Human Application" covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging. Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time,

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Science
  • Release : 16 December 2013
GET THIS BOOK Genome Stability

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An

Genome Stability and Human Diseases

Genome Stability and Human Diseases
  • Author : Heinz-Peter Nasheuer
  • Publisher : Springer Science & Business Media
  • Release : 11 December 2009
GET THIS BOOK Genome Stability and Human Diseases

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our

Human Papillomavirus Oncoproteins Alter Genomic Stability and Regulate the Viral Life Cycle

Human Papillomavirus Oncoproteins Alter Genomic Stability and Regulate the Viral Life Cycle
  • Author : Jennifer Teresa Thomas
  • Publisher : Unknown
  • Release : 14 June 1999
GET THIS BOOK Human Papillomavirus Oncoproteins Alter Genomic Stability and Regulate the Viral Life Cycle

Understanding how human papillomaviruses (HPVs) induce the proliferative lesions associated with genital warts and cervical cancers relies on our appreciation of the functions of the E6 and E7 viral proteins. These "oncoproteins" of the high risk HPV types interfere with the activities of cellular tumor suppressor proteins; E7 proteins act by associating with members of the retinoblastoma family, while E6 increases the turnover of p53. This work describes studies which (1) demonstrate that E6 and E7 alter cell cycle control and

Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer

Mobile Genetic Elements in Cellular Differentiation  Genome Stability  and Cancer
  • Author : Tammy A. Morrish,Jose Luis García Pérez
  • Publisher : Frontiers Media SA
  • Release : 16 January 2018
GET THIS BOOK Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer

The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (

Maintaining Genome Stability The Role of Helicases and Deaminases

Maintaining Genome Stability  The Role of Helicases and Deaminases
  • Author : Anonim
  • Publisher : Unknown
  • Release : 14 June 2021
GET THIS BOOK Maintaining Genome Stability The Role of Helicases and Deaminases

Both helicases and deaminases are enzymes that play an important role in maintaining genomic stability and immune responses. Errors in duplicating DNA can result in genomic instability, leading to various human diseases, such as cancer, immune system disorder, muscle dystrophy, and neurodegenerations. Thus, maintaining genomic integrity is vital to the normal growth of cells and to human health. Maintenance of genome integrity during S phase depends in part on the activity and regulation of the replication enzymes, including replicative helicase

The Genome Stability is Preserved by a Stress Response Protein CCDC6

The Genome Stability is Preserved by a Stress Response Protein  CCDC6
  • Author : Chiara Luise,Angela Celetti
  • Publisher : LAP Lambert Academic Publishing
  • Release : 01 July 2012
GET THIS BOOK The Genome Stability is Preserved by a Stress Response Protein CCDC6

The maintenance of genomic stability is beneficial for the survival of an individual cell and crucial for cancer avoidance. Cells invest huge resources to maintain genomic stability, and cancer cells undergo an array of genetic changes to escape these barriers. The initiation of carcinogenesis represents a mutational event, which in most instances occurs despite functional DNA damage response (DDR) mechanisms. This dissertation aims to study the mechanisms of chromosomal instability in tumor development. We intend to investigate the role of

Promoting Genome Stability Via Multiple Dna Repair Pathways

Promoting Genome Stability Via Multiple Dna Repair Pathways
  • Author : Scott Cukras
  • Publisher : Unknown
  • Release : 14 June 2021
GET THIS BOOK Promoting Genome Stability Via Multiple Dna Repair Pathways

ABSTRACT Maintaining genome integrity is indispensible for cells to prevent and limit accruement of deleterious mutations and to promote viable cell growth and proliferation. Cells possess a myriad of mechanisms to detect, prevent and repair incurred cellular damage. Here we discuss various proteins and their accompanying cellular pathways that promote genome stability. We first investigate the NEDD8 protein and its role in promoting homologous recombination repair via multiple Cullin E3 ubiquitin ligases. We provide specific mechanisms through which, UBE2M,

Functional Roles of Nucleases in DNA Metabolism and Genome Stability

Functional Roles of Nucleases in DNA Metabolism and Genome Stability
  • Author : Justin Lee Sparks
  • Publisher : Unknown
  • Release : 14 June 2021
GET THIS BOOK Functional Roles of Nucleases in DNA Metabolism and Genome Stability

The work outlined in this dissertation focuses on two distinct areas that are important for genome stability. Both areas focus on DNA repair pathways that require the action of nucleases, specifically Exonuclease 5 and Ribonuclease H2. First, I describe the biochemical and molecular characterization of the novel Exonuclease 5 family of enzymes from S. cerevisiae, S. pombe, and humans. The Exo5 family consists of bi-directional single-strand DNA specific exonucleases that all contain an iron-sulfur cluster as a structural motif and all have

Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination

Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination
  • Author : Juan Argueso Almeida
  • Publisher : Unknown
  • Release : 14 June 2021
GET THIS BOOK Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination

Mismatch repair (MMR) systems correct mismatches formed during DNA replication and genetic recombination and as the result of DNA damage. MMR is initiated by a conserved family of MutS (MSH) and MutL (MLH) homolog proteins. MLH1 is unique among these proteins because it is also required for high levels of crossing over which are necessary for the proper disjunction of homologous chromosomes during the first meiotic division.

Genome Instability and Transgenerational Effects

Genome Instability and Transgenerational Effects
  • Author : Igor Kovalchuk,Olga Kovalchuk (MD.)
  • Publisher : Nova Science Pub Incorporated
  • Release : 14 June 2021
GET THIS BOOK Genome Instability and Transgenerational Effects

Genome stability of every species depends on complex interaction of predefined and environmentally induced genetic and epigenetic states. Predefined states consist of chromatin structure and cell metabolic processes such as DNA repair, radical scavenging and cell signalling, whereas induced states depend on interactions with the environment. Organisms are able to respond to a changing environment by various alterations in their somatic cells as well as in their germline and progeny. In this book, we will describe various phenomena associated with