Genome Stability

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  • Author : Igor Kovalchuk
  • Publisher : Academic Press
  • Pages : 760 pages
  • ISBN : 0323856802
  • Rating : /5 from reviews
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Download or Read online Genome Stability full in PDF, ePub and kindle. this book written by Igor Kovalchuk and published by Academic Press which was released on 17 July 2021 with total page 760 pages. We cannot guarantee that Genome Stability book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Academic Press
  • Release : 17 July 2021
GET THIS BOOK Genome Stability

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Science
  • Release : 16 December 2013
GET THIS BOOK Genome Stability

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An

Genome Stability and Human Diseases

Genome Stability and Human Diseases
  • Author : Heinz-Peter Nasheuer
  • Publisher : Springer Science & Business Media
  • Release : 11 December 2009
GET THIS BOOK Genome Stability and Human Diseases

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Pub
  • Release : 26 January 2022
GET THIS BOOK Genome Stability

"Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and

Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer

Mobile Genetic Elements in Cellular Differentiation  Genome Stability  and Cancer
  • Author : Tammy A. Morrish,Jose Luis García Pérez
  • Publisher : Frontiers Media SA
  • Release : 16 January 2018
GET THIS BOOK Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer

The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (

The Genome Stability is Preserved by a Stress Response Protein CCDC6

The Genome Stability is Preserved by a Stress Response Protein  CCDC6
  • Author : Chiara Luise,Angela Celetti
  • Publisher : LAP Lambert Academic Publishing
  • Release : 01 July 2012
GET THIS BOOK The Genome Stability is Preserved by a Stress Response Protein CCDC6

The maintenance of genomic stability is beneficial for the survival of an individual cell and crucial for cancer avoidance. Cells invest huge resources to maintain genomic stability, and cancer cells undergo an array of genetic changes to escape these barriers. The initiation of carcinogenesis represents a mutational event, which in most instances occurs despite functional DNA damage response (DDR) mechanisms. This dissertation aims to study the mechanisms of chromosomal instability in tumor development. We intend to investigate the role of

Genome Instability

Genome Instability
  • Author : Marco Muzi-Falconi,Grant W Brown
  • Publisher : Humana Press
  • Release : 20 October 2017
GET THIS BOOK Genome Instability

This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and

Functional Roles of Nucleases in DNA Metabolism and Genome Stability

Functional Roles of Nucleases in DNA Metabolism and Genome Stability
  • Author : Justin Lee Sparks
  • Publisher : Unknown
  • Release : 26 January 2022
GET THIS BOOK Functional Roles of Nucleases in DNA Metabolism and Genome Stability

The work outlined in this dissertation focuses on two distinct areas that are important for genome stability. Both areas focus on DNA repair pathways that require the action of nucleases, specifically Exonuclease 5 and Ribonuclease H2. First, I describe the biochemical and molecular characterization of the novel Exonuclease 5 family of enzymes from S. cerevisiae, S. pombe, and humans. The Exo5 family consists of bi-directional single-strand DNA specific exonucleases that all contain an iron-sulfur cluster as a structural motif and all have

Maintaining Genome Stability The Role of Helicases and Deaminases

Maintaining Genome Stability  The Role of Helicases and Deaminases
  • Author : Anonim
  • Publisher : Unknown
  • Release : 26 January 2022
GET THIS BOOK Maintaining Genome Stability The Role of Helicases and Deaminases

Both helicases and deaminases are enzymes that play an important role in maintaining genomic stability and immune responses. Errors in duplicating DNA can result in genomic instability, leading to various human diseases, such as cancer, immune system disorder, muscle dystrophy, and neurodegenerations. Thus, maintaining genomic integrity is vital to the normal growth of cells and to human health. Maintenance of genome integrity during S phase depends in part on the activity and regulation of the replication enzymes, including replicative helicase

Genome Instability and Transgenerational Effects

Genome Instability and Transgenerational Effects
  • Author : Igor Kovalchuk,Olga Kovalchuk (MD.)
  • Publisher : Nova Science Pub Incorporated
  • Release : 26 January 2022
GET THIS BOOK Genome Instability and Transgenerational Effects

Genome stability of every species depends on complex interaction of predefined and environmentally induced genetic and epigenetic states. Predefined states consist of chromatin structure and cell metabolic processes such as DNA repair, radical scavenging and cell signalling, whereas induced states depend on interactions with the environment. Organisms are able to respond to a changing environment by various alterations in their somatic cells as well as in their germline and progeny. In this book, we will describe various phenomena associated with

Exploring Pathways that Maintain Genome Stability by Preventing the Formation of Gross Chromosomal Rearrangements

Exploring Pathways that Maintain Genome Stability by Preventing the Formation of Gross Chromosomal Rearrangements
  • Author : Pamela Kanellis
  • Publisher : Unknown
  • Release : 26 January 2022
GET THIS BOOK Exploring Pathways that Maintain Genome Stability by Preventing the Formation of Gross Chromosomal Rearrangements

Genetic instability is a hallmark of cancer. A commonly observed class of genetic alterations in tumor cells is termed gross chromosomal rearrangements (GCRs) that encompass translocations, large-scale interstitial deletions and chromosome arm deletions. To identify novel GCR regulators, the budding yeast, Saccharomyces cerevisiae, was used as a model system. Using unbiased large-scale and candidate approaches, I have identified at least ten novel regulators of chromosome stability. Firstly, from a small screen of putative genome regulators, I identified the GCR suppressor,

The Effect of Pathogens on Plant Genome Stability

The Effect of Pathogens on Plant Genome Stability
  • Author : Jody Filkowski
  • Publisher : Unknown
  • Release : 26 January 2022
GET THIS BOOK The Effect of Pathogens on Plant Genome Stability

Resistance (R) genes, a key factor in determining the resistance of plants, have been shown often to be highly allelic entities existing in duplicated regions of the genome. This characteristic suggests that R-gene acquisition may have arisen through frequent genetic rearrangements as a result of transient, reduced genome stability. Tabacco plants transgenic for a recombination construct exhibited reduced genome stability upon infection with a virulent pathogen (tobacco mosaic virus). The reduced genome stability manifested as an increase in recombination events