Genetics of Bone Biology and Skeletal Disease

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  • Author : Rajesh V. Thakker
  • Publisher : Academic Press
  • Pages : 878 pages
  • ISBN : 0128041986
  • Rating : /5 from reviews
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Download or Read online Genetics of Bone Biology and Skeletal Disease full in PDF, ePub and kindle. this book written by Rajesh V. Thakker and published by Academic Press which was released on 31 October 2017 with total page 878 pages. We cannot guarantee that Genetics of Bone Biology and Skeletal Disease book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease
  • Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
  • Publisher : Academic Press
  • Release : 31 October 2017
GET THIS BOOK Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint,

Principles of Bone Biology

Principles of Bone Biology
  • Author : John P. Bilezikian,T. John Martin,Thomas L. Clemens,Clifford Rosen
  • Publisher : Academic Press
  • Release : 22 August 2019
GET THIS BOOK Principles of Bone Biology

Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science... we assembled experts from all over the world and asked them to focus on the

The Genetics of Osteoporosis and Metabolic Bone Disease

The Genetics of Osteoporosis and Metabolic Bone Disease
  • Author : Michael J. Econs
  • Publisher : Springer Science & Business Media
  • Release : 12 May 2000
GET THIS BOOK The Genetics of Osteoporosis and Metabolic Bone Disease

The explosive growth in the field of molecular biology over the last two decades has started to make a great impact on clinical medicine. Genes have been cloned for diseases that were poorly understood only a decade ago. Additionally, investigators are increasingly aware that there are strong genetic components to complex disorders, such as osteoporosis, that are not classically thought of as genetic disorders. New insights into the pathogenesis of metabolic bone diseases have been obtained from investigations into the

Skeletal Biology and Medicine II

Skeletal Biology and Medicine II
  • Author : Mone Zaidi
  • Publisher : Wiley-Blackwell
  • Release : 24 January 2012
GET THIS BOOK Skeletal Biology and Medicine II

The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, infection, and cancer on musculoskeletal health. Recent findings are shaping therapeutic directions that focus on both anti-resorptive and anabolic therapies.

Current Topics in Bone Biology

Current Topics in Bone Biology
  • Author : Hong-wen Deng,Yao-zhong Liu,Chun-Yuan Guo
  • Publisher : World Scientific
  • Release : 30 June 2022
GET THIS BOOK Current Topics in Bone Biology

This book covers a wide spectrum of areas related to basic bone research. While bone remodeling, bone development, and osteoclast biology constitute the main contents, topics important to the understanding of bone metabolism and treatment of bone-related diseases are also intensively reviewed. Three chapters are dedicated to the classic topic of bone mechanics, which include a brief overview of the mechanostat hypothesis, a more detailed review on mechanotransduction and bone adaptation, and a chapter illustrating the basic principles of bone

The Skeletal System

The Skeletal System
  • Author : Olivier Pourquié
  • Publisher : Unknown
  • Release : 30 June 2022
GET THIS BOOK The Skeletal System

Geared toward scientists and clinicians, this book summarizes the current understanding of the development, biology, and evolution of the vertebrate skeleton. It covers such topics as the differentiation of chondrocytes, the origins and evolution of bone, and the genetics of human skeletal disease.

Skeletal Biology and Medicine

Skeletal Biology and Medicine
  • Author : Anonim
  • Publisher : Unknown
  • Release : 30 June 2022
GET THIS BOOK Skeletal Biology and Medicine

"This second of two volumes from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27-30, 2011, features papers focussed on bone and cartilage homeostasis and bone disease. The two volumes in this series, 1240 and 1237, present current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular

The Genetics of the Skeleton

The Genetics of the Skeleton
  • Author : David Roderick Johnson
  • Publisher : Oxford University Press, USA
  • Release : 30 June 1986
GET THIS BOOK The Genetics of the Skeleton

The effects of genetic mutations on the mammalian skeleton are a useful aid in understanding how the skeleton develops. This book describes these effects, using the mouse as a primary source for considering the precartilaginous, cartilaginous, and bony skeletons, regional anatomy, and the interactions between genes and teratogens. The author summarizes the normal development of each part before discussing its mutations and completes his study by synthesizing the contributions mutants make to our understanding of the development of each part

Advances in Pathobiology and Management of Paget s Disease of Bone

Advances in Pathobiology and Management of Paget   s Disease of Bone
  • Author : Sakamuri V. Reddy
  • Publisher : Academic Press
  • Release : 28 April 2016
GET THIS BOOK Advances in Pathobiology and Management of Paget s Disease of Bone

Advances in Pathobiology and Management of Paget’s Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Paget’s disease. It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology, molecular abnormalities, complications such as osteosarcoma, and current and future treatment for Paget’s disease. This book serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology,

Skeletal Biology and Medicine II

Skeletal Biology and Medicine II
  • Author : Anonim
  • Publisher : Unknown
  • Release : 30 June 2022
GET THIS BOOK Skeletal Biology and Medicine II

"This second of two volumes from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27-30, 2011, features papers focussed on bone and cartilage homeostasis and bone disease. The two volumes in this series, 1240 and 1237, present current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular

Vertebrate Skeletal Development

Vertebrate Skeletal Development
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 20 March 2019
GET THIS BOOK Vertebrate Skeletal Development

Vertebrate Skeletal Development, Volume 133, the latest release in the Current Topics in Developmental Biology series, presents interesting chapters on a variety of topics, with this edition focusing on Craniofacial skeletal development, Regulatory mechanism of jawbone and tooth development, Development of the axial skeleton and intervertebral discs, Stem and progenitor cells in skeletal development, Origin, functioning and morphogenetic activity of limb synovial joint, ECM signaling in cartilage development and endochondral ossification, Sox genes in skeletal development, Wnt-Signaling in Skeletal Development, Gα

Osteoimmunology

Osteoimmunology
  • Author : Joseph Lorenzo,Mark Horowitz,Yongwon Choi,Georg Schett,Hiroshi Takayanagi
  • Publisher : Academic Press
  • Release : 01 July 2015
GET THIS BOOK Osteoimmunology

Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and

Skeletal Biology and Medicine I

Skeletal Biology and Medicine I
  • Author : Mone Zaidi
  • Publisher : Wiley-Blackwell
  • Release : 12 December 2011
GET THIS BOOK Skeletal Biology and Medicine I

The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, infection, and cancer on musculoskeletal health. Recent findings are shaping therapeutic directions that focus on both anti-resorptive and anabolic therapies.

The Parathyroids

The Parathyroids
  • Author : John P. Bilezikian,Robert Marcus,Michael A. Levine,Claudio Marcocci,Shonni J Silverberg,John T. Potts Jr.
  • Publisher : Academic Press
  • Release : 09 September 2014
GET THIS BOOK The Parathyroids

The third edition of The Parathyroids, led by a new stellar editorial team, has been thoroughly updated to reflect the considerable advances in just about every aspect of PTH biology over the past decade. It continues to be the authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium. This translational resource is invaluable to graduate students, fellows, researchers, and research clinicians in the fields of endocrinology, bone biology, osteology,

Cartilage and Bone Development and Its Disorders

Cartilage and Bone Development and Its Disorders
  • Author : C. Camacho-Hübner,O. Nilsson,L. Sävendahl
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 23 August 2011
GET THIS BOOK Cartilage and Bone Development and Its Disorders

In systemic childhood diseases, including cancer, gastrointestinal, pulmonary and cardiac disorders, childhood growth is severely impaired. In addition, almost 400 known genetic diseases inhibit the ability of the growth plate to form new bone, leaving affected children with growth failure and bony deformities which can severely impact their quality of life and may lead to morbidity and early mortality.This book provides a comprehensive review of bone and cartilage development, growth and disease. Focusing on novel treatment strategies, regulatory signals and