Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics

Produk Detail:
  • Author : Simons Michael
  • Publisher : World Scientific
  • Pages : 284 pages
  • ISBN : 981314338X
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics

Download or Read online Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics full in PDF, ePub and kindle. this book written by Simons Michael and published by World Scientific which was released on 27 December 2016 with total page 284 pages. We cannot guarantee that Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states. Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches. With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments — endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer. It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.

Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics

Fibroblast Growth Factors  Biology And Clinical Application   Fgf Biology And Therapeutics
  • Author : Simons Michael
  • Publisher : World Scientific
  • Release : 27 December 2016
GET THIS BOOK Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a

Fibroblast Growth Factors

Fibroblast Growth Factors
  • Author : Xiaokun Li
  • Publisher : Academic Press
  • Release : 20 June 2018
GET THIS BOOK Fibroblast Growth Factors

Fibroblast Growth Factors presents research and results from the leading global research group on FGF, providing up-to-date and comprehensive coverage of the field. The book describes the history, basic research and growth engineering technology involved with FGFs, while also introducing detailed research methods. It comprises eight chapters that detail successes and problems in relation to wound healing of engineered growth factors and considers injury repair and regeneration, non-mitogenic mutants, structure modification, pathology, physiology, pharmacology, development, FGF/FGFR inhibitors, bioengineering, and

Fibroblast Growth Factor 23

Fibroblast Growth Factor 23
  • Author : Christian Faul,Kenneth White,Orlando Gutierrez
  • Publisher : Elsevier
  • Release : 06 April 2021
GET THIS BOOK Fibroblast Growth Factor 23

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology