Epigenetics of Aging and Longevity

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  • Author : Alexey Moskalev
  • Publisher : Academic Press
  • Pages : 544 pages
  • ISBN : 9780128110607
  • Rating : /5 from reviews
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Download or Read online Epigenetics of Aging and Longevity full in PDF, ePub and kindle. this book written by Alexey Moskalev and published by Academic Press which was released on 13 November 2017 with total page 544 pages. We cannot guarantee that Epigenetics of Aging and Longevity book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses--including cancer and cardiovascular, metabolic, and neurodegenerative diseases--are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity
  • Author : Alexey Moskalev,Alexander M. Vaiserman
  • Publisher : Academic Press
  • Release : 13 November 2017
GET THIS BOOK Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in

Epigenetics of Aging

Epigenetics of Aging
  • Author : Trygve O. Tollefsbol
  • Publisher : Springer Science & Business Media
  • Release : 11 November 2009
GET THIS BOOK Epigenetics of Aging

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major

Nutrition Exercise and Epigenetics Ageing Interventions

Nutrition  Exercise and Epigenetics  Ageing Interventions
  • Author : Byung Pal Yu
  • Publisher : Springer
  • Release : 11 February 2015
GET THIS BOOK Nutrition Exercise and Epigenetics Ageing Interventions

This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing

Longevity Genes

Longevity Genes
  • Author : Gil Atzmon, PhD
  • Publisher : Springer
  • Release : 27 April 2015
GET THIS BOOK Longevity Genes

The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular

Biomarkers of Human Aging

Biomarkers of Human Aging
  • Author : Alexey Moskalev
  • Publisher : Springer Nature
  • Release : 13 September 2019
GET THIS BOOK Biomarkers of Human Aging

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity
  • Author : Alexey Moskalev,Alexander M. Vaiserman
  • Publisher : Academic Press
  • Release : 17 November 2017
GET THIS BOOK Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in

Early Life Origins of Ageing and Longevity

Early Life Origins of Ageing and Longevity
  • Author : Alexander Vaiserman
  • Publisher : Springer
  • Release : 29 July 2019
GET THIS BOOK Early Life Origins of Ageing and Longevity

This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of

Centenarians

Centenarians
  • Author : Calogero Caruso
  • Publisher : Springer
  • Release : 03 September 2019
GET THIS BOOK Centenarians

This state-of-the-art review on longevity focuses on centenarians, studied as a model of positive biology. The extraordinary rise in the elderly population in developed countries underscores the importance of studies on ageing and longevity in order to decrease the medical, economic and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies. Centenarians have reached the extreme limits of human life span. Those in relatively good health, who are able to perform their routine daily tasks,

Life Extension

Life Extension
  • Author : Alexander M. Vaiserman,Alexey A. Moskalev,Elena G. Pasyukova
  • Publisher : Springer
  • Release : 09 June 2015
GET THIS BOOK Life Extension

​This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases,

The Abolition of Aging

The Abolition of Aging
  • Author : David W Wood
  • Publisher : Delta Wisdom
  • Release : 06 June 2016
GET THIS BOOK The Abolition of Aging

Within our collective grasp dwells the remarkable possibility of the abolition of biological aging. It's a big "if," but if we decide as a species to make this project a priority, there's around a 50% chance that practical rejuvenation therapies resulting in the comprehensive reversal of aging will be widely available as early as 2040. People everywhere, on the application of these treatments, will, if they wish, stop becoming biologically older. Instead, again if they wish, they'll start to become biologically younger,

Epigenetic and PTEN Regulation of Longevity Pathways Related to Idiopathic Pulmonary Fibrosis and Organismal Aging

Epigenetic and PTEN Regulation of Longevity Pathways Related to Idiopathic Pulmonary Fibrosis and Organismal Aging
  • Author : Tierra A. Ware
  • Publisher : Unknown
  • Release : 26 October 2021
GET THIS BOOK Epigenetic and PTEN Regulation of Longevity Pathways Related to Idiopathic Pulmonary Fibrosis and Organismal Aging

Understanding the cellular and molecular mechanisms that impact aging is important to improve accelerated aging diseases and promote healthy living in the aging population. Recent genetic studies provide clues on the mechanisms important in aging, specifically stem cell exhaustion, cellular senescence, telomere attrition and protein quality control mechanisms such as autophagy. Aging and some-age related diseases, such as pulmonary fibrosis are linked to these impaired mechanisms. The PTEN/PI3K/Akt/mTOR pathway is evolutionarily implicated and conserved in organismal

Transgenerational Epigenetics

Transgenerational Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 18 May 2019
GET THIS BOOK Transgenerational Epigenetics

Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the

Circadian Rhythms and Their Impact on Aging

Circadian Rhythms and Their Impact on Aging
  • Author : S. Michal Jazwinski,Victoria P Belancio,Steven M Hill
  • Publisher : Springer
  • Release : 24 October 2017
GET THIS BOOK Circadian Rhythms and Their Impact on Aging

Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how