Epigenetics In Precision Medicine

Cancer Epigenetics For Precision Medicine Book PDF
✏Book Title : Cancer Epigenetics for Precision Medicine
✏Author : Ramona G. Dumitrescu
✏Publisher : Humana
✏Release Date : 2019-09-17
✏Pages : 298
✏ISBN : 1493993836
✏Available Language : English, Spanish, And French

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✏Cancer Epigenetics for Precision Medicine Book Summary : This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.

Progress And Challenges In Precision Medicine Book PDF
✏Book Title : Progress and Challenges in Precision Medicine
✏Author : Mukesh Verma
✏Publisher : Academic Press
✏Release Date : 2016-12-22
✏Pages : 344
✏ISBN : 9780128095027
✏Available Language : English, Spanish, And French

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✏Progress and Challenges in Precision Medicine Book Summary : Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development

📒Clinical Precision Medicine ✍ Judy S. Crabtree

Clinical Precision Medicine Book PDF
✏Book Title : Clinical Precision Medicine
✏Author : Judy S. Crabtree
✏Publisher : Academic Press
✏Release Date : 2019-11-15
✏Pages : 112
✏ISBN : 9780128204023
✏Available Language : English, Spanish, And French

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✏Clinical Precision Medicine Book Summary : Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Pharmacoepigenetics Book PDF
✏Book Title : Pharmacoepigenetics
✏Author :
✏Publisher : Academic Press
✏Release Date : 2019-06-04
✏Pages : 983
✏ISBN : 9780128139400
✏Available Language : English, Spanish, And French

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✏Pharmacoepigenetics Book Summary : Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Epigenetics In Allergy And Autoimmunity Book PDF
✏Book Title : Epigenetics in Allergy and Autoimmunity
✏Author : Christopher Chang
✏Publisher : Springer Nature
✏Release Date : 2020-05-22
✏Pages : 403
✏ISBN : 9789811534492
✏Available Language : English, Spanish, And French

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✏Epigenetics in Allergy and Autoimmunity Book Summary : This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Genomics In Precision Medicine Book PDF
✏Book Title : Genomics in Precision Medicine
✏Author : Shiv Sanjeevi
✏Publisher : Delve Publishing
✏Release Date : 2019-11
✏Pages : 290
✏ISBN : 1774073447
✏Available Language : English, Spanish, And French

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✏Genomics in Precision Medicine Book Summary : Genomics in Precision Medicine makes the people aware about the field of genomics and that of precision medicine, by taking the readers through all the details related to genomics and precision medicine. It also updates the readers about the various innovations that have taken place in the field of precision medicine and discusses the path that is to be followed further. Also discussed in the book is a review on the relation between the precision medicine and the mutations that drive it, delving on the various computational methods and conformational principles for the detection of the factors that drive cancer. It also discusses the various genetic mutations and epigenetic modifications and goes on to explore the various benefits and harms in the research on precision medicine.

Handbook Of Biomarkers And Precision Medicine Book PDF
✏Book Title : Handbook of Biomarkers and Precision Medicine
✏Author : Claudio Carini
✏Publisher : CRC Press
✏Release Date : 2019-04-16
✏Pages : 631
✏ISBN : 9780429576737
✏Available Language : English, Spanish, And French

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✏Handbook of Biomarkers and Precision Medicine Book Summary : "The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Precision Medicine In Cancers And Non Communicable Diseases Book PDF
✏Book Title : Precision Medicine in Cancers and Non Communicable Diseases
✏Author : Debmalya Barh
✏Publisher : CRC Press
✏Release Date : 2018-09-03
✏Pages : 326
✏ISBN : 9781498775625
✏Available Language : English, Spanish, And French

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✏Precision Medicine in Cancers and Non Communicable Diseases Book Summary : The availability of human genome, large amount of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the era of clinical practice of "Precision Medicine". This book aims to provide a readily available resource on all the important developments achieved so far in the field of oncology. All recent developments have been explained along with epidemiology, technologies and approaches to manage the included diseases. Therefore, readers will get the up to date information on the next-generation approach in tackling all kinds of cancer. Key Features • Presents the latest trend of cancer management based on precision/predictive medicine approach • Reviews the latest and up to date literature in the field of Precision Medicine • Highlights the next generation approach in tackling malignant diseases • Discusses how a life-threatening disease like cancer can be managed with the help of Precision Medicine • Encapsulates a global prospective

Implementing Precision Medicine In Best Practices Of Chronic Airway Diseases Book PDF
✏Book Title : Implementing Precision Medicine in Best Practices of Chronic Airway Diseases
✏Author : Ioana Agache
✏Publisher : Academic Press
✏Release Date : 2018-09-19
✏Pages : 228
✏ISBN : 9780128134726
✏Available Language : English, Spanish, And French

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✏Implementing Precision Medicine in Best Practices of Chronic Airway Diseases Book Summary : Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, the book highlights the need for implementation of the principles of precision medicine into the bedside management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient. Written for basic researchers, medical doctors and other healthcare practitioners this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice. Bridges the gap between precision medicine research and the implementation of the principles into daily clinical practice Includes contributions from key opinion leaders in the field of airway disease giving a worldwide perspective Discusses precision medicine in terms of personalized and stratified medicine, biomarkers, prediction of success, participation of the patient and prevention of disease

Clinical And Statistical Considerations In Personalized Medicine Book PDF
✏Book Title : Clinical and Statistical Considerations in Personalized Medicine
✏Author : Claudio Carini
✏Publisher : CRC Press
✏Release Date : 2014-03-27
✏Pages : 376
✏ISBN : 9781466593879
✏Available Language : English, Spanish, And French

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✏Clinical and Statistical Considerations in Personalized Medicine Book Summary : The Future of Clinical Research and Health Care: From Empirical to Precision Medicine Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

📒Genomic And Precision Medicine ✍ Geoffrey S. Ginsburg

Genomic And Precision Medicine Book PDF
✏Book Title : Genomic and Precision Medicine
✏Author : Geoffrey S. Ginsburg
✏Publisher : Academic Press
✏Release Date : 2016-11-22
✏Pages : 398
✏ISBN : 9780128006566
✏Available Language : English, Spanish, And French

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✏Genomic and Precision Medicine Book Summary : Genomic and Precision Medicine: Translation and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care. Provides a comprehensive volume on the translation and implementation of biology into health care provision Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation Includes an up-to-date overview on major ‘translational events’ in genomic and personalized medicine, along with lessons learned

Oncology In The Precision Medicine Era Book PDF
✏Book Title : Oncology in the Precision Medicine Era
✏Author : Ravi Salgia
✏Publisher : Springer Nature
✏Release Date : 2019-12-17
✏Pages : 351
✏ISBN : 9783030314712
✏Available Language : English, Spanish, And French

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✏Oncology in the Precision Medicine Era Book Summary : This volume comprehensively reviews oncology in the precision medicine era of personalized care, latest developments in the field, and indications and clinical trials for the treatment of cancer with targeted therapies, immunotherapy, and epigenetic modulators. It thoroughly addresses concerns of various types of cancers including cancers of the head and neck, lung, colon, esophagus, bladder, pancreas, and breast; melanoma; multiple myeloma; hepatocellular carcinoma; renal cell carcinoma; and sarcomas. It is organized and written in a format that is easy to follow for both clinicians and non-clinical scientists interested in personalized medicine. Chapters cover the identification of the clinical problem and summary of recent findings, tumor biology and heterogeneity, genomics, examples of simple and complex cases, biological pathways, future clinical trials, and financial considerations. Oncology in the Precision Medicine Era: Value-Based Medicine will serve as a useful resource for medical oncologists and healthcare providers tailoring medicine to the needs of the individual patient, from prevention and diagnosis to treatment and follow up.

📒Integrative Preventive Medicine ✍ Richard H. Carmona

Integrative Preventive Medicine Book PDF
✏Book Title : Integrative Preventive Medicine
✏Author : Richard H. Carmona
✏Publisher : Oxford University Press
✏Release Date : 2017-12
✏Pages : 584
✏ISBN : 9780190241254
✏Available Language : English, Spanish, And French

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✏Integrative Preventive Medicine Book Summary : As the preventable disease and economic burden continues to mount for the United States and the world, it is becoming apparent that embracing prevention strategies is essential. Simply continuing on the same course and infrastructure will not suffice. The future we will leave our children is unsustainable without change. Amidst all the partisan political chaos, Integrative Preventive Medicine (IPM) practices are strongly entering the public consciousness since many are dissatisfied with their traditional health (sick) care delivery systems and the scientific validity of IPM is increasing rapidly. This IPM textbook, the first of its kind, authored by nationally recognized thought leaders and edited by the 17th Surgeon General of the United States and the Canyon Ranch Medical Director will serve to bring together the science of IPM so that health practitioners have a ready reference containing practices that can prevent disease, decrease cost of care and improve the quality of life. Our IPM textbook is divided into three sections, Public Health and Evolving Science in IPM, Multidisciplinary Nature of IPM and The IPM Approach of Selected Clinical Problems, providing a continuum of IPM from basic science to clinical science to practical application. This depth and breadth of scientific information and comprehensive approach is a first for a single textbook in IPM. A must read for all health providers and students in order to incorporate these essential concepts into practice.

Prognostic Epigenetics Book PDF
✏Book Title : Prognostic Epigenetics
✏Author :
✏Publisher : Academic Press
✏Release Date : 2019-11-01
✏Pages : 442
✏ISBN : 9780128142608
✏Available Language : English, Spanish, And French

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✏Prognostic Epigenetics Book Summary : This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook. Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime Features chapter contributions from leading international researchers

Gene Environment Interactions Book PDF
✏Book Title : Gene Environment Interactions
✏Author : Moyra Smith
✏Publisher : Academic Press
✏Release Date : 2020-01-24
✏Pages : 438
✏ISBN : 9780128196137
✏Available Language : English, Spanish, And French

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✏Gene Environment Interactions Book Summary : Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies Illuminates environmental factors affecting disease-gene etiology and treatment Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine

Bioscience Lost In Translation  Book PDF
✏Book Title : Bioscience Lost in Translation
✏Author : Richard Barker
✏Publisher : Oxford University Press
✏Release Date : 2016-09-01
✏Pages : 240
✏ISBN : 9780198737780
✏Available Language : English, Spanish, And French

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✏Bioscience Lost in Translation Book Summary : Medical innovation as it stands today is fundamentally unsustainable. There is a widening gap between what biomedical research promises and the impact that it is currently achieving, in terms of patient benefit and health system improvement. This book highlights the global problem of the ineffective translation of bioscience innovation into health system improvements and its consequences, analyses the underlying causative factors and provides powerful prescriptions for change to close the gap. It contrasts the progress in biomedicine with other areas of scientific and technological endeavour, such as information technology, in which there are faster and more reliable returns for society from scientific advance. It asks searching questions about whether society is right to expect so much from biomedicine and why we have become accustomed to such poor returns. Throughout the book, techniques such as stratified medicine, open innovation, adaptive development and personalised adherence are discussed and described in terms accessible to the non-specialist, and their impact on the innovation gap explored. By using examples in which bottlenecks have prevented progress, such as dementia and antibiotic-resistant infections, and in which these barriers have been overcome, such as HIV treatment, Bioscience - Lost in Translation? lays out a strategy for advancing the innovation process, presenting suggestions for how health systems can move from being passive recipients of innovation to being active participants in development.

Application Of Next Generation Sequencing In The Era Of Precision Medicine Book PDF
✏Book Title : Application of Next Generation Sequencing in the Era of Precision Medicine
✏Author : Michele Araújo Pereira
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1154245573
✏Available Language : English, Spanish, And French

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✏Application of Next Generation Sequencing in the Era of Precision Medicine Book Summary : Next-generation sequencing (NGS) technologies represented the next step in the evolution of DNA sequencing, through the generation of thousands to millions of DNA sequences in a short time. The relatively fast emergence and success of NGS in research revolutionized the field of genomics and medical diagnosis. The traditional medicine model of diagnosis has changed to one precision medicine model, leading to a more accurate diagnosis of human diseases and allowing the selection of molecular target drugs for individual treatment. This chapter attempts to review the main features of NGS technique (concepts, data analysis, applications, advances and challenges), starting with a brief history of DNA sequencing followed by a comprehensive description of most used NGS platforms. Further topics will highlight the application of NGS towards routine practice, including variant detection, whole-exome sequencing (WES), whole-genome sequencing (WGS), custom panels (multi-gene), RNA-seq and epigenetic. The potential use of NGS in precision medicine is vast and a better knowledge of this technique is necessary for an efficacious implementation in the clinical workplace. A centralized chapter describing the main NGS aspects in the clinic could help beginners, scientists, researchers and health care professionals, as they will be responsible for translating genomic data into genomic medicine.

Targeted Therapy In Translational Cancer Research Book PDF
✏Book Title : Targeted Therapy in Translational Cancer Research
✏Author : Apostolia-Maria Tsimberidou
✏Publisher : John Wiley & Sons
✏Release Date : 2015-12-21
✏Pages : 400
✏ISBN : 9781118468579
✏Available Language : English, Spanish, And French

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✏Targeted Therapy in Translational Cancer Research Book Summary : Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Translational Oncology: Targeted Therapy in Translational Cancer Research provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains the clinical ramifications and utility of these on targeted cancer therapies. Beginning with a chapter introducing the “Bench to Bedside and Back” paradigm, an overview is presented of the exponential growth in the field of translational medicine, including historical perspectives and recent progress. Following the introduction, subsequent chapters review the progress of targeted therapy within three major categories: hematological malignancies, solid tumors, and hereditary cancers. Each of these categories comprises a single a chapter with subsections that discuss specific cancer types. Following this is a chapter on targeted and functional imaging that reviews progress in the different modalities of anatomical and molecular imaging used to complement targeted therapy. The next chapter discusses the need to combine individual agents with existing therapies or in novel combinations in order to overcome drug resistance. Following this is a chapter presenting the challenges in drug development and the selection of targets for cancer therapeutics. The final chapter offers perspectives on personalized medicine and presents future challenges in the investigation of optimal combinations and the identification of biomarkers that can provide both predictive and prognostic information for tailoring targeted therapies to individual patients.

📒Unzip Your Genes ✍ Jennifer Stagg

Unzip Your Genes Book PDF
✏Book Title : Unzip Your Genes
✏Author : Jennifer Stagg
✏Publisher : Simon and Schuster
✏Release Date : 2016-11-15
✏Pages : 256
✏ISBN : 9781682610343
✏Available Language : English, Spanish, And French

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✏Unzip Your Genes Book Summary : Your genes don't have to be your destiny. Now you can take charge of your genes and your health. Unzip Your Genes will show you how take your own health into your own hands. You will no longer sit on the sidelines—instead you can play an active and empowered role in the state of your own health. In this book you will: • Understand how the environment and your genes interact. • Learn how to use your own genetic information to your advantage. • Create an actionable plan based on your genomics to radically transform your health and improve your vitality. • Discover how to improve your health span and lead a productive, happy and healthy life. Dr. Jennifer Stagg is an experienced physician and expert in Precision Medicine—an emerging approach for disease prevention that takes into account an individual’s genes, environment, and lifestyle. In Unzip Your Genes Dr. Stagg provides insight on how you can take practical steps that can radically transform the state of your health and well-being.

Precision Medicine A Guide To Genomics In Clinical Practice Book PDF
✏Book Title : Precision Medicine A Guide to Genomics in Clinical Practice
✏Author : Jeanette J. McCarthy
✏Publisher : McGraw Hill Professional
✏Release Date : 2017-01-05
✏Pages : 304
✏ISBN : 9781259644146
✏Available Language : English, Spanish, And French

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✏Precision Medicine A Guide to Genomics in Clinical Practice Book Summary : Incorporate genomics into every applicable area of your clinical practice with this complete how-to guide Precision Medicine: A Guide to Genomics in Clinical Practice is a comprehensive, yet succinct overview of the practice of genomic medicine. It is written for general healthcare practitioners, specialists, and trainees with the goal of providing detailed guidance on how to incorporate genomic medicine into daily practice. Features that make this book valuable to every practice: •Intentionally avoids excessive technical content and consistently emphasizes real-life patient care and decision support •Follows the course of a human life, beginning before conception through pregnancy, childhood, and adulthood, discussing the current and future applications of genomics and precision medicine at each stage •Organization allows healthcare providers to quickly and easily find the information relevant to their practice. •The authors highlight common pitfalls – technical and ethical – that might complicate the delivery of quality genomic healthcare •Enhanced by eleven valuable appendices that cover important topics ranging from the basics of genetics to ethical issues to regulation and reimbursement If you are searching for a clinically relevant, non-technical resource that will teach you how genomic medicine can and should be practiced in your specific field of interest, Precision Medicine: A Guide to Genomics in Clinical Practicebelongs on your desk.

📒Abeloff S Clinical Oncology E Book ✍ John E. Niederhuber

Abeloff S Clinical Oncology E Book Book PDF
✏Book Title : Abeloff s Clinical Oncology E Book
✏Author : John E. Niederhuber
✏Publisher : Elsevier Health Sciences
✏Release Date : 2013-09-12
✏Pages : 2224
✏ISBN : 9781455728817
✏Available Language : English, Spanish, And French

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✏Abeloff s Clinical Oncology E Book Book Summary : Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

The Odyssey Of Humanity S Diseases Volume 3 Book PDF
✏Book Title : The Odyssey of Humanity s Diseases Volume 3
✏Author : Alain L Fymat
✏Publisher :
✏Release Date : 2020-01-28
✏Pages : 388
✏ISBN : 0228823900
✏Available Language : English, Spanish, And French

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✏The Odyssey of Humanity s Diseases Volume 3 Book Summary : The history of human medicine traces the approaches followed by different societies regarding diseases from ancient times to the present. By contrast, perhaps for the first time, this book traces the odyssey of humanity's diseases viewed differently through the lenses of epigenetic and ecogenetic modulations across ancestry, inheritance, ethnicity, environment, culture, and behavior. Many of the diseases considered result from gene-environment interactions and, in some instances, even gene-gene-environment interactions. Not being driven and predetermined by our inherited genetic code, we have a tremendous amount of control over how our genetic traits are expressed and, therefore, on our health and lifespan. Our genes do not control our lives and we are not victims of our heredity! How much control do we have over our lives and health has puzzled many since the beginning of time. The emerging science of epigenetics/ecogenetics offers us some answers that put a large degree of control within our reach. Owing to its scope, this book has been divided into three volumes that should interest the educated lay reader interested in this different perspective on humanity's diseases, but also to students and healthcare professionals. From such a perspective, a more illuminating and engaging view of medicine and the health sciences could be obtained. This Volume 3, the final in the trilogy, brings us to the modern era where exciting new developments are happening in nanomedicine, personalized/precision medicine, cancer, cardiovascular diseases, infectious diseases including HIV/AIDs, human gene therapy, stem cell therapy, and others. It behooves us to keep abreast of these new medical and biotechnological developments.

Toward Precision Assessment And Psychotherapy Understanding Individual Differences Through Neurobiology Genetics And Epigenetics Book PDF
✏Book Title : Toward Precision Assessment and Psychotherapy Understanding Individual Differences Through Neurobiology Genetics and Epigenetics
✏Author : Thomas G. Arizmendi, Ph.d.
✏Publisher :
✏Release Date : 2020-02-12
✏Pages :
✏ISBN : 1536165360
✏Available Language : English, Spanish, And French

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✏Toward Precision Assessment and Psychotherapy Understanding Individual Differences Through Neurobiology Genetics and Epigenetics Book Summary : This book provides a transformative approach to the understanding of mental health in the 21st century. It does so by encouraging the replacement of traditional subjective techniques with more precise and objective measures that are designed to discover individual differences in our patients. Just as in personalised medicine, where diagnostic and treatment techniques are becoming more targeted toward the specific conditions of a particular patient, so to in the mental health field we need to develop targeted and focused methods through the use of clinical science concepts and through the adoption of an agnostic, unassuming posture where the presentation of each patient is viewed as unique. For example, treatments may draw from an integrative approach that incorporates genomic and epigenomic analyses of the patient to inform a more targeted medication regimen or psychotherapy approach (some psychiatrists are beginning to use genomic analysis to aid in the choice of a specific antidepressant, for example, that would most likely be effective for a certain patient). Diagnostically, paper and pencil questionnaires leading to current diagnostic labels, long the standard, must be replaced, for the most part, by objective measures of stress that prioritise "reports from the body". Additionally, research methods of extremely complex psychological disorders can be enhanced by breaking them down into smaller subtypes (or endophenotypes) versus large phenomenologically-based symptom clusters (ie: DSM diagnoses). Individual differences, a consistent focus throughout the book, may be the product of genetic variants and/or epigenetic mechanisms. The latter mediate gene X environment interaction that is now the primary paradigmatic lens through which we investigate and seek to explain resultant behavioural profiles. A major focus of the book is on the effects of early adversity, particularly trauma, and how they contribute to a "re-programming" of the brain through epigenetic alterations of gene expression. This results in increased vulnerability to possible psychological disorders, such as various anxiety conditions, depression, and character disorders which may manifest later in life. By identifying the epigenetic effects caused by early stressors, that is, how gene expression is altered, we can eventually make significant advances in primary prevention. This book represents an attempt to move us into a transitional domain and beyond, where causes and the treatment of psychological disorders are re-conceptualized through our developing insights from neurobiology, genetics, and epigenetics.

Personhood In The Age Of Biolegality Book PDF
✏Book Title : Personhood in the Age of Biolegality
✏Author : Marc de Leeuw
✏Publisher : Springer Nature
✏Release Date : 2019-11-18
✏Pages : 261
✏ISBN : 9783030278489
✏Available Language : English, Spanish, And French

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✏Personhood in the Age of Biolegality Book Summary : This volume showcases emerging interdisciplinary scholarship that captures the complex ways in which biological knowledge is testing the nature and structure of legal personhood. Key questions include: What do the new biosciences do to our social, cultural, and legal conceptions of personhood? How does our legal apparatus incorporate new legitimations from the emerging biosciences into its knowledge system? And what kind of ethical, socio-political, and scientific consequences are attached to the establishment of such new legalities? The book examines these problems by looking at materialities, the posthuman, and the relational in the (un)making of legalities. Themes and topics include postgenomic research, gene editing, neuroscience, epigenetics, precision medicine, regenerative medicine, reproductive technologies, border technologies, and theoretical debates in legal theory on the relationship between persons, property, and rights.

Genome Analysis And Human Health Book PDF
✏Book Title : Genome Analysis and Human Health
✏Author : Leena Rawal
✏Publisher : Springer
✏Release Date : 2017-06-08
✏Pages : 168
✏ISBN : 9789811042980
✏Available Language : English, Spanish, And French

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✏Genome Analysis and Human Health Book Summary : This book highlights selected current data and its relevance in the human health care system, offering a fundamental primer on genetics and human health. With the advent of new high-throughput technologies (for the whole genome including exome sequencing), the conventional focus on genetics and individual genes is now shifting toward the analysis of complex genes, gene-gene interactions and the association between genes and environment, including epigenetics. The rapidly changing scientific research landscape, with the ever-growing influx of data on one hand and emergence of newer and more complicated diseases on the other, has created a dilemma for researchers and caregivers, who are still hopeful that advances in genetics and genomics will provide avenues for the understanding, prevention and possible cure of human diseases. The book focuses on the interactions between genes and proteins at both the transcriptome and proteome levels, which in turn affect the human genome and health. Additionally, it covers the domain that must be explored in order to understand the gene-gene and protein-protein interactions that contribute to human health. The book offers a valuable guide for all students and researchers working in the area of molecular genetics and genomics.

Translational Informatics In Smart Healthcare Book PDF
✏Book Title : Translational Informatics in Smart Healthcare
✏Author : Bairong Shen
✏Publisher : Springer
✏Release Date : 2017-09-15
✏Pages : 220
✏ISBN : 9789811057175
✏Available Language : English, Spanish, And French

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✏Translational Informatics in Smart Healthcare Book Summary : This book is about the transformation of the biomedical information to smart healthcare, the chapters are designed to discuss the health associated factors such as genetics, lifestyle, nutrition and environmental factors. The interactions of these factors and the informatics for the analyses of their effects on health are also covered. The era of aging is approaching and the P4 (predictive, preventive, personalized and participatory) medicine paradigm is becoming practical and reality. According to the Kondratiev's long wave theory, IT (information technology) and health will be the next technological revolution for the new economic cycle. This book is written for biomedical informatics scientists, clinicians, health practitioners and researchers, etc.

📒Pharmacogenomics ✍ Paul F. Kisak

Pharmacogenomics Book PDF
✏Book Title : Pharmacogenomics
✏Author : Paul F. Kisak
✏Publisher : Createspace Independent Publishing Platform
✏Release Date : 2017-07
✏Pages : 208
✏ISBN : 1548521574
✏Available Language : English, Spanish, And French

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✏Pharmacogenomics Book Summary : Pharmacogenomics may be one of the most important current discoveries in medicine and is the study of the role of the genome in drug response. The name reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects their response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with pharmacokinetics (drug absorption, distribution, metabolism, and elimination) and pharmacodynamics (effects mediated through a drug's biological targets). The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response. Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that pharmaceutical drug treatments can deviate from what is dubbed as the "one-dose-fits-all" approach. Pharmacogenomics also attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient's genes, the functionality of these genes, and how this may affect the efficacy of the patient's current or future treatments. Such approaches promise the advent of precision medicine and even personalized medicine, in which drugs and drug combinations are optimized for narrow subsets of patients or even for each individual's unique genetic makeup. This book is designed to be a state of the art, superb academic reference work and provide an overview of the topic and give the reader a structured knowledge to familiarize yourself with the topic at the most affordable price possible. The accuracy and knowledge is of an international viewpoint as the edited articles represent the inputs of many knowledgeable individuals and some of the most current knowledge on the topic, based on the date of publication.

Precision Molecular Pathology Of Prostate Cancer Book PDF
✏Book Title : Precision Molecular Pathology of Prostate Cancer
✏Author : Brian D. Robinson
✏Publisher : Springer
✏Release Date : 2018-02-13
✏Pages : 570
✏ISBN : 9783319640969
✏Available Language : English, Spanish, And French

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✏Precision Molecular Pathology of Prostate Cancer Book Summary : This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.

📒Next Generation Biomarkers ✍ Wim Van Criekinge

Next Generation Biomarkers Book PDF
✏Book Title : Next Generation Biomarkers
✏Author : Wim Van Criekinge
✏Publisher : Academic Press
✏Release Date : 2019-09-15
✏Pages : 400
✏ISBN : 0128143150
✏Available Language : English, Spanish, And French

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✏Next Generation Biomarkers Book Summary : Next Generation Biomarkers: From Omics to Precision Medicine offers a clear methodology for successfully discovering and validating biomarkers using next generation sequencing, along with a comprehensive overview of next generation biomarkers currently used in the clinic. With recent advances in genomics and -omics approaches, elaborative molecular profiling is increasingly employed to gain fundamental insights into disease etiology and progression. Through a case-study based approach, the book examines a variety of NGS genomic and omics approaches to biomarker discovery and validation, along with lessons learned from recent studies and clinical trials. Chapters explore common challenges, regulations and strategies for more accurate and efficient development of next generation biomarkers, and NGS approaches, ranging from whole exome sequencing, to whole genome sequencing, epigenomic profiling, transcriptomics, peptidomics, proteomics, liquid biopsy, ethical considerations, and patient empowerment in biomarker development. Establishes a clear methodology for successfully discovering and validating biomarkers using next generation sequencing Provides a comprehensive overview of next generation biomarkers currently used Examines a variety of NGS approaches to biomarker identification, lessons learned from recent studies, common challenges, regulations, and strategies for more accurate and efficient identification of next generation biomarkers for use in precision medicine Covers NGS approaches, ranging from whole exome sequencing, to whole genome sequencing, epigenomic profiling, transcriptomics, peptidomics, proteomics, and liquid biopsy, as well as ethical considerations and patient empowerment in biomarker development Features contributions from leading international researchers working at the forefront of NGS biomarker discovery and validation

Andreoli And Carpenter S Cecil Essentials Of Medicine E Book Book PDF
✏Book Title : Andreoli and Carpenter s Cecil Essentials of Medicine E Book
✏Author : Ivor Benjamin
✏Publisher : Elsevier Health Sciences
✏Release Date : 2010-04-06
✏Pages : 1312
✏ISBN : 9781437726732
✏Available Language : English, Spanish, And French

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✏Andreoli and Carpenter s Cecil Essentials of Medicine E Book Book Summary : Students, residents, and instructors swear by Andreoli and Carpenter’s Cecil Essentials of Medicine because it presents just the right amount of information, just the right way. Edited by the late Thomas E. Andreoli, MD as well as Ivor Benjamin, MD, Robert C. Griggs, MD, and Edward J. Wing, MD, it focuses on core principles and how they apply to patient care, covering everything you need to know to succeed on a medical rotation or residency. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible. New chapters on "Pre- and Post-Operative Care" and "Palliative Care," plus the integration of molecular biology and other new horizons in medicine, familiarize you with the most current clinical concepts. An expanded International Editorial Board provides increased input from respected practitioners worldwide. Excellent images and clinical photographs vividly illustrate the appearance and clinical features of disease. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible.