Epigenetics In Cardiovascular Disease

Epigenetics In Cardiovascular Disease Book PDF
✏Book Title : Epigenetics in Cardiovascular Disease
✏Author : Yvan Devaux
✏Publisher : Academic Press
✏Release Date : 2021-03-15
✏Pages : 416
✏ISBN : 0128222581
✏Available Language : English, Spanish, And French

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✏Epigenetics in Cardiovascular Disease Book Summary : Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare Features chapter contributions from a wide range of international researchers in the field

📒Epigenetics In Human Disease ✍ Trygve Tollefsbol

Epigenetics In Human Disease Book PDF
✏Book Title : Epigenetics in Human Disease
✏Author : Trygve Tollefsbol
✏Publisher : Academic Press
✏Release Date : 2012-07-26
✏Pages : 592
✏ISBN : 9780123884169
✏Available Language : English, Spanish, And French

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✏Epigenetics in Human Disease Book Summary : Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Epigenetic Programming Of Cardiovascular Disease By Perinatal Hypoxia And Fetal Growth Restriction Book PDF
✏Book Title : Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction
✏Author : Paola Casanello
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1154283590
✏Available Language : English, Spanish, And French

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✏Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction Book Summary : Most of the worldwide deaths in patients with non-communicable diseases are due to cardiovascular and metabolic diseases, which are determined by a mix of environmental, genetic and epigenetic factors, and by their interactions. The aetiology of most cardiovascular diseases has been partially linked with in utero adverse conditions that may increase the risk of developing diseases later in life, known as Developmental Origins of Health and Disease (DOHaD). Perinatal hypoxia can program the fetal and postnatal developmental patterns, resulting in permanent modifications of cells, organs and systems function. In spite of the vast evidence obtained from human and animal studies linking development under adverse intrauterine conditions with increased cardiovascular risk, still few is known about the specific effects of intrauterine oxygen deficiency and the related pathogenic mechanisms. Currently, the most accepted processes that program cellular function are epigenetic mechanisms which determine gene expression in a cell-specific fashion. In this chapter we will review the current literature regarding the perinatal exposure to chronic hypoxia and Fetal Growth Restriction (FGR) in humans and animals and how this impinges the cardiovascular physiology through epigenetic, biochemical, morphologic and pathophysiologic modifications that translate into diseases blasting at postnatal life.

Epigenetics In Biology And Medicine Book PDF
✏Book Title : Epigenetics in Biology and Medicine
✏Author : Manel Esteller
✏Publisher : CRC Press
✏Release Date : 2008-09-17
✏Pages : 312
✏ISBN : 1420007076
✏Available Language : English, Spanish, And French

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✏Epigenetics in Biology and Medicine Book Summary : Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

📒Environmental Epigenetics ✍ L. Joseph Su

Environmental Epigenetics Book PDF
✏Book Title : Environmental Epigenetics
✏Author : L. Joseph Su
✏Publisher : Springer
✏Release Date : 2015-05-18
✏Pages : 321
✏ISBN : 9781447166788
✏Available Language : English, Spanish, And French

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✏Environmental Epigenetics Book Summary : This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

📒Medical Epigenetics ✍ Trygve Tollefsbol

Medical Epigenetics Book PDF
✏Book Title : Medical Epigenetics
✏Author : Trygve Tollefsbol
✏Publisher : Academic Press
✏Release Date : 2016-06-21
✏Pages : 924
✏ISBN : 9780128032404
✏Available Language : English, Spanish, And French

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✏Medical Epigenetics Book Summary : Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Nutrition Epigenetics And Health Book PDF
✏Book Title : Nutrition Epigenetics and Health
✏Author : Burdge Graham
✏Publisher : World Scientific
✏Release Date : 2016-10-07
✏Pages : 236
✏ISBN : 9789813143326
✏Available Language : English, Spanish, And French

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✏Nutrition Epigenetics and Health Book Summary : Epigenetics is emerging as an important factor in risk of diseases of global importance including obesity, cardiovascular disease and cancer. Unlike gene polymorphisms which have been the focus of understanding the role of inherited disease susceptibility for some time, epigenetic can be modified by environmental factors, in particular nutrition. Thus research into the role of epigenetics in disease has substantial potential for explaining the impact of the environmental factors such as diet on disease risk. Since epigenetic processes can be modified by nutrition, it may be possible to modify inappropriate epigenetic marks by nutritional interventions to reduce disease risk. This book will explore current understanding of the interaction between nutrition, epigenetics and disease risk, will place this knowledge in the context of global health and discuss the ethical implications of this research.

Epigenetics In Cardiac Disease Book PDF
✏Book Title : Epigenetics in Cardiac Disease
✏Author : Johannes Backs
✏Publisher : Springer
✏Release Date : 2016-12-02
✏Pages : 316
✏ISBN : 3319414550
✏Available Language : English, Spanish, And French

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✏Epigenetics in Cardiac Disease Book Summary : This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.

📒Personalized Epigenetics ✍ Trygve Tollefsbol

Personalized Epigenetics Book PDF
✏Book Title : Personalized Epigenetics
✏Author : Trygve Tollefsbol
✏Publisher : Academic Press
✏Release Date : 2015-04-28
✏Pages : 610
✏ISBN : 9780128004364
✏Available Language : English, Spanish, And French

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✏Personalized Epigenetics Book Summary : Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

📒Cardiovascular Diseases ✍ Nilanjana Maulik, Ph.D.

Cardiovascular Diseases Book PDF
✏Book Title : Cardiovascular Diseases
✏Author : Nilanjana Maulik, Ph.D.
✏Publisher : CRC Press
✏Release Date : 2013-04-09
✏Pages : 614
✏ISBN : 9781439882016
✏Available Language : English, Spanish, And French

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✏Cardiovascular Diseases Book Summary : With cardiovascular disease remaining one of the primary causes of morbidity and mortality worldwide, there is a great need to further understand the molecular basis of this disease class and develop new therapeutic or preventative measures. Cardiovascular Diseases: Nutritional and Therapeutic Interventions presents up-to-date information on the pathobiology of cardiovascular diseases, emphasizing emerging therapeutics and nutritional interventions. The book is divided into four parts: epidemiology, epigenetics, pathobiology, and therapies for cardiovascular diseases. Part I details epidemiological studies, highlighting the extent of the clinical problem. Part II describes the genetic and, primarily, epigenetic modifications associated with cardiovascular disease, including the importance of DNA methylation status and the possibility of early intervention using simple dietary modifications. The text also discusses histone modifications associated with disease and potential therapeutic synthetic and dietary compounds such as resveratrol and garlic. Covering the etiology and pathobiology, part III discusses lipid regulation, micro-RNAs, emerging cell-based therapies, and new receptor targets for therapeutics as well as targeted imaging. It also describes the link between cancer therapies and cardiomyopathy and the potential of vitamin C to ameliorate this effect. Part IV focuses on therapeutic and nutritional interventions, namely, stem cell therapies, emerging nanomedicines, and a wide range of dietary interventions. These include general healthy diets, fruits and vegetables, botanicals, effects of specific compounds such as antioxidants, and discussions on garlic, curcumin, and resveratrol. The text also covers lifestyle factors, emphasizing the importance of stress in the occurrence of and meditation and yoga in the management of cardiovascular disease. This book provides a comprehensive reference for clinicians and scientists, combining epidemiology, prevention, and modern treatment strategies.

Computational Epigenetics And Diseases Book PDF
✏Book Title : Computational Epigenetics and Diseases
✏Author :
✏Publisher : Academic Press
✏Release Date : 2019-02-06
✏Pages : 450
✏ISBN : 9780128145142
✏Available Language : English, Spanish, And French

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✏Computational Epigenetics and Diseases Book Summary : Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Cardiovascular Genetics And Genomics In Clinical Practice Book PDF
✏Book Title : Cardiovascular Genetics and Genomics in Clinical Practice
✏Author : Donna K. Arnett, PhD
✏Publisher : Demos Medical Publishing
✏Release Date : 2014-11-10
✏Pages : 246
✏ISBN : 9781617051784
✏Available Language : English, Spanish, And French

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✏Cardiovascular Genetics and Genomics in Clinical Practice Book Summary : Weighted Numerical Score: 100 - 5 Stars! This is a systematic guide to cardiovascular genetics and genomics from basic concepts to clinical application. It organizes a large volume of information from an active area of research, which holds promise for future discovery. --Doody's Reviews Cardiovascular Genetics and Genomics in Clinical Practice presents clinical cases to illuminate basic concepts of cardiovascular genetics and genomics as practitioners encounter them in day-to-day practice. The unique use of real-world case discussions facilitates the memorization and understanding of basic principles, which can be more readily applied to actual cases. Cardiovascular Genetics and Genomics in Clinical Practice features a step-by-step learning process that begins with an easy-to-understand "primer" of basic scientific concepts regarding cardiovascular genetics and genomics followed by state-of-the-art research and applications for treatment of cardiovascular disorders. Expert clinicians and researchers describe illustrative cases for each topic along with detailed discussions of current scientific understanding and its application in current disease management and treatment. Summaries, key teaching points, and illustrations are highlighted to facilitate quick recall and review. The book will be useful for cardiovascular clinicians in training, board preparation, or as a review for those already in clinical practice. Cardiovascular Genetics and Genomics in Clinical Practice features: Clinical case scenarios to illuminate the basic concepts of cardiovascular genetics and genomics as they are used in daily practice Explanation of fundamental concepts as a foundation for more in-depth understanding Detailed discussions of current scientific knowledge and clinical management The expertise of renowned clinician-scientists in the field Real practical insight for practice

Sex Specific Analysis Of Cardiovascular Function Book PDF
✏Book Title : Sex Specific Analysis of Cardiovascular Function
✏Author : Peter L. M. Kerkhof
✏Publisher : Springer
✏Release Date : 2018-07-26
✏Pages : 725
✏ISBN : 9783319779324
✏Available Language : English, Spanish, And French

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✏Sex Specific Analysis of Cardiovascular Function Book Summary : This book gathers together contributions from internationally renowned authors in the field of cardiovascular systems and provides crucial insight into the importance of sex- and gender-concepts during the analysis of patient data. This innovative title is the first to offer the elements necessary to consider sex-related properties in both clinical and basic studies regarding the heart and circulation on multiscale levels (i.e. molecular, cellular, electrophysiologically, neuroendocrine, immunoregulatory, organ, allometric, and modeling). Observed differences at (ultra)cellular and organ level are quantified, with focus on clinical relevance and implications for diagnosis and patient management. Since the cardiovascular system is of vital importance for all tissues, Sex-Specific Analysis of Cardiovascular Function is an essential source of information for clinicians, biologists, and biomedical investigators. The wide spectrum of differences described in this book will also act as an eye-opener and serve as a handbook for students, teachers, scientists and practitioners.

📒Toxicology And Epigenetics ✍ Saura C. Sahu

Toxicology And Epigenetics Book PDF
✏Book Title : Toxicology and Epigenetics
✏Author : Saura C. Sahu
✏Publisher : John Wiley & Sons
✏Release Date : 2012-08-23
✏Pages : 688
✏ISBN : 9781118349069
✏Available Language : English, Spanish, And French

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✏Toxicology and Epigenetics Book Summary : Epigenetics is the study of both heritable and non-heritablechanges in the regulation of gene activity and expression thatoccur without an alteration in the DNA sequence. Thisdynamic and rapidly developing discipline is making its impactacross the biomedical sciences, in particular in toxicology whereepigenetic differences can mean that different individuals responddifferently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensionalcharacter of this emerging area of toxicology, describingcutting-edge molecular technologies to unravel epigenetic changes,the use of in vivo and in vitro models, as well asthe potential use of toxicological epigenetics in regulatoryenvironments. An international team of experts consider theinterplay between epigenetics and toxicology in a number of areas,including environmental, nutritional, pharmacological, andcomputational toxicology, nanomaterials, proteomics andmetabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact indevelopment and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight intothe current trends and future directions of research in thisrapidly expanding field for investigators, toxicologists, riskassessors and regulators in academia, industry and government.

Nutrition Exercise And Epigenetics Ageing Interventions Book PDF
✏Book Title : Nutrition Exercise and Epigenetics Ageing Interventions
✏Author : Byung Pal Yu
✏Publisher : Springer
✏Release Date : 2015-02-11
✏Pages : 278
✏ISBN : 9783319148304
✏Available Language : English, Spanish, And French

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✏Nutrition Exercise and Epigenetics Ageing Interventions Book Summary : This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.

📒Epigenetics And Human Health ✍ Alexander Haslberger

Epigenetics And Human Health Book PDF
✏Book Title : Epigenetics and Human Health
✏Author : Alexander Haslberger
✏Publisher : John Wiley & Sons
✏Release Date : 2011-08-24
✏Pages : 316
✏ISBN : 9783527644759
✏Available Language : English, Spanish, And French

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✏Epigenetics and Human Health Book Summary : After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

📒Epigenetics ✍ Rosaria Meccariello

Epigenetics Book PDF
✏Book Title : Epigenetics
✏Author : Rosaria Meccariello
✏Publisher : BoD – Books on Demand
✏Release Date : 2019-09-11
✏Pages : 96
✏ISBN : 9781789840872
✏Available Language : English, Spanish, And French

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✏Epigenetics Book Summary : Epigenetic changes are heritable and reversible modifications that significantly affect gene expression without any change in DNA sequence. The epigenetic signature is remodelled during the lifespan as a direct consequence of both environment and lifestyle. Therefore, health or disease status strongly depends on epigenetic marks. This book summarizes the current knowledge in the field and includes chapters on epigenetics in plants and epigenetics in health and disease. It is written for a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding of epigenetics.

📒Transgenerational Epigenetics ✍ Trygve Tollefsbol

Transgenerational Epigenetics Book PDF
✏Book Title : Transgenerational Epigenetics
✏Author : Trygve Tollefsbol
✏Publisher : Elsevier
✏Release Date : 2014-05-02
✏Pages : 412
✏ISBN : 9780124059221
✏Available Language : English, Spanish, And French

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✏Transgenerational Epigenetics Book Summary : Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversies

📒Nutrients And Epigenetics ✍ Sang-Woon Choi

Nutrients And Epigenetics Book PDF
✏Book Title : Nutrients and Epigenetics
✏Author : Sang-Woon Choi
✏Publisher : CRC Press
✏Release Date : 2009-05-07
✏Pages : 258
✏ISBN : 9781420063561
✏Available Language : English, Spanish, And French

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✏Nutrients and Epigenetics Book Summary : Explores the Newly Discovered Link Between Nutrition and EpigeneticsCurrent research suggests that nutrients are more than just food components and that certain nutrients can impact the expression of genes that lead to the development of chronic diseases. With contributions from experts in both fields, Nutrients and Epigenetics examines the epigene

Issues In Cardiovascular Medicine 2013 Edition Book PDF
✏Book Title : Issues in Cardiovascular Medicine 2013 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2013-05-01
✏Pages : 1187
✏ISBN : 9781490106274
✏Available Language : English, Spanish, And French

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✏Issues in Cardiovascular Medicine 2013 Edition Book Summary : Issues in Cardiovascular Medicine / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Cardiovascular Toxicology. The editors have built Issues in Cardiovascular Medicine: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiovascular Toxicology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Cardiovascular Medicine: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

📒The Complexity Paradox ✍ Kenneth Mossman

The Complexity Paradox Book PDF
✏Book Title : The Complexity Paradox
✏Author : Kenneth Mossman
✏Publisher : Oxford University Press
✏Release Date : 2014-08-26
✏Pages : 240
✏ISBN : 9780199330362
✏Available Language : English, Spanish, And French

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✏The Complexity Paradox Book Summary : Living systems exhibit a fundamental contradiction: they are highly stable and reliable, yet they have the capacity to adapt to changing environmental conditions. This paradoxical behavior arises from the complexity of life--a high degree of order and cooperation that emerges from relatively simple interactions among cellular components. The Complexity Paradox proposes inventive, interdisciplinary approaches to maintaining health and managing and preventing disease by considering the totality of human biology, from the cellular level on up to entire populations of individuals. From the perspective of complexity, which acknowledges that there are limits to what we can know, Kenneth L. Mossman opens the door to understanding essential life processes in new and extraordinary ways. By tying together evolution, functional dynamics, and investigations into how the body processes energy and uses genetic information, Mossman's analysis expresses a unified theory of biology that fills a critical niche for future research in biology, medicine, and public health.

Epigenetics In Health And Disease Book PDF
✏Book Title : Epigenetics in Health and Disease
✏Author : Igor Kovalchuk
✏Publisher : FT Press
✏Release Date : 2012
✏Pages : 598
✏ISBN : 9780132597081
✏Available Language : English, Spanish, And French

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✏Epigenetics in Health and Disease Book Summary : "After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Cover, p. [4].

📒Heart Failure ✍ José Marín-García

Heart Failure Book PDF
✏Book Title : Heart Failure
✏Author : José Marín-García
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-06-23
✏Pages : 470
✏ISBN : 9781607611479
✏Available Language : English, Spanish, And French

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✏Heart Failure Book Summary : Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.

Epigenetic Aspects Of Chronic Diseases Book PDF
✏Book Title : Epigenetic Aspects of Chronic Diseases
✏Author : Helmtrud I. Roach
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-04-01
✏Pages : 236
✏ISBN : 1848826443
✏Available Language : English, Spanish, And French

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✏Epigenetic Aspects of Chronic Diseases Book Summary : Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.

Stress In Health And Disease An Issue Of Psychiatric Clinics Of North America  Book PDF
✏Book Title : Stress in Health and Disease An Issue of Psychiatric Clinics of North America
✏Author : Daniel L. Kirsch
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-12-27
✏Pages : 281
✏ISBN : 9780323326773
✏Available Language : English, Spanish, And French

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✏Stress in Health and Disease An Issue of Psychiatric Clinics of North America Book Summary : Stress in the DSM is referred to only in the sense of post traumatic stress disorder (PTSD). However, some research studies estimate up to two thirds of illnesses seen by general practitioners are ‘stress related’–GI problems, sleep disturbance, mental concentration, headaches, fatigue, shortness of breath, high blood pressure, dermatitis, illnesses from lowered immune system, and vague aches and pains – all can be symptoms and outcomes of the elusive stress factor. This issue of Psychiatric Clinics of North America discusses the scientific medical facets of stress, written by mental health and medical practitioners. It looks at the brain-body connection of stress – what the body does to result in stress and varying results stress has on the body. This fascinating cross-discipline look at stress is intended for psychiatrists, general practitioners, cardiologists, GI specialists, neurologists, sleep medicine specialists, respiratory specialists, and others who diagnose and treat patients with stress suspected as part of the illness equation or with self-reported stress. Topics include: Measurement of stress; Anxiety and stress-how they work together; Relationship between genetics and stress; Role of glia in stress; Sleep and stress; Diet and stress; Supplements and stress; Effect of severe stress on early brain development, attachment, and emotions; Role of stress and fear on the development of psychopathology; Expressions of stress in psychiatric illness; Dermatologic manifestations of stress in normal and psychiatric populations; Humor and the psychological buffers of stress; Stress expression in children and adolescents; Stress in service members; Stress in the geriatric population.

Molecular Mechanisms And Physiology Of Disease Book PDF
✏Book Title : Molecular mechanisms and physiology of disease
✏Author : Nilanjana Maulik
✏Publisher : Springer
✏Release Date : 2014-05-31
✏Pages : 505
✏ISBN : 9781493907069
✏Available Language : English, Spanish, And French

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✏Molecular mechanisms and physiology of disease Book Summary : In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

📒Nutrition In Epigenetics ✍ Mihai D. Niculescu

Nutrition In Epigenetics Book PDF
✏Book Title : Nutrition in Epigenetics
✏Author : Mihai D. Niculescu
✏Publisher : John Wiley & Sons
✏Release Date : 2011-03-25
✏Pages : 332
✏ISBN : 0470959800
✏Available Language : English, Spanish, And French

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✏Nutrition in Epigenetics Book Summary : The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.

Camkii In Cardiac Health And Disease Book PDF
✏Book Title : CaMKII in Cardiac Health and Disease
✏Author : Eleonora Grandi
✏Publisher : Frontiers E-books
✏Release Date : 2014-10-22
✏Pages :
✏ISBN : 9782889192991
✏Available Language : English, Spanish, And French

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✏CaMKII in Cardiac Health and Disease Book Summary : The calcium-calmodulin dependent protein kinases (CaMKs) are a broadly expressed family of calcium-sensitive intracellular kinases, which are responsible for transducing cytosolic calcium signals into phosphorylation-based regulation of proteins and physiological functions. As the multifunctional member of the family, CaMKII has become the most prominent for its roles in the central nervous system and heart, where it controls a diverse range of calcium-dependent processes; from learning and memory at the neuronal synapse, to cellular growth and death in the myocardium. In the heart, CaMKII directly regulates many of the most important ion channels and calcium handling proteins, and controls the expression of an ever-increasing number of transcripts and their downstream products. Functionally, these actions are thought to orchestrate many of the electrophysiologic and contractile adaptations to common cardiac stressors, such as rapid pacing, chronic adrenergic stimulation, and oxidative challenge. In the context of disease, CaMKII has been shown to contribute to a remarkably wide variety of cardiac pathologies, of which heart failure (HF) is the most conspicuous. Hyperactivity of CaMKII is an established contributor to pathological cardiac remodeling, and is widely thought to directly promote arrhythmia and contractile dysfunction during HF. Moreover, several non-failing arrhythmia-susceptible phenotypes, which result from specific genetic channelopathies, functionally mimic constitutive channel phosphorylation by CaMKII. Because CaMKII contributes to both the acute and chronic manifestations of major cardiac diseases, but may be only minimally required for homeostasis in the absence of chronic stress, it has come to be one of the most promising therapeutic drug targets in cardiac biology. Thus, development of more specific and deliverable small molecule antagonists remains a key priority for the field. Here we provide a selection of articles to summarize the state of our knowledge regarding CaMKII in cardiac health and disease, with a particular view to highlighting recent developments in CaMKII activation, and new targets in CaMKII-mediated control of myocyte physiology.

Effect Of Bioactive Nutriments In Health And Disease The Role Of Epigenetic Modifications Book PDF
✏Book Title : Effect of Bioactive Nutriments in Health and Disease The Role of Epigenetic Modifications
✏Author : Pablo Bautista-García
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1154227423
✏Available Language : English, Spanish, And French

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✏Effect of Bioactive Nutriments in Health and Disease The Role of Epigenetic Modifications Book Summary : Recently, a list of clinical, physiopathological, and epidemiological studies has underlined the detrimental or beneficial role of nutritional factors in some chronic diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer. It has been described that lifestyle, environmental conditions, and nutritional compounds influence gene expression. In the last instance, it has been demonstrated that bioactive nutrimental components are important signal molecules that carry information from the external environment and could affect in biological terms, processes related to gene expression. Bioactive nutriments can work in different ways: regulating the chromatin structure or factors that directly regulate the activity of nuclear receptors. The relevance of the changes in the chromatin structure has been demonstrated by the fact that many chronic diseases and metabolic disorders are related with changes in DNA methylation patterns. For this reason, recently, the bioactive food nutriments have been investigated to characterize the molecular mechanism involved in changes of the chromatin structure, such as acetylation and methylation, and their potential benefit on chronic diseases. The dietary compounds intake involved in the regulation of epigenetic modifications can provide significant health effects and may prevent various pathological processes involved in the development of cancer and other serious diseases.

Heart Failure A Companion To Braunwald S Heart Disease E Book Book PDF
✏Book Title : Heart Failure A Companion to Braunwald s Heart Disease E book
✏Author : Douglas L. Mann
✏Publisher : Elsevier Health Sciences
✏Release Date : 2010-11-11
✏Pages : 928
✏ISBN : 9781437703634
✏Available Language : English, Spanish, And French

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✏Heart Failure A Companion to Braunwald s Heart Disease E book Book Summary : Dr. Douglas L. Mann, one of the foremost experts in the field, presents the 2nd Edition of Heart Failure: A Companion to Braunwald’s Heart Disease. This completely reworked edition covers the scientific and clinical guidance you need to effectively manage your patients and captures the dramatic advances made in the field over the last five years. Now in full color, this edition features eleven new chapters, including advanced cardiac imaging techniques, use of biomarkers, cell-based therapies and tissue engineering, device therapies, and much more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Use this Braunwald’s companion as the definitive source to prepare for the ABIM’s new Heart Failure board exam. Access the fully searchable contents of the book online at Expert Consult. This edition includes 67 new authors, who are experts in the field of heart failure Stay on the cutting edge with new chapters on: The latest practice guidelines for medical and device therapy Hemodynamic assessment of heart failure Contemporary medical therapy for heart failure patients with reduced and preserved ejection fraction Biomarkers in heart failure Pulmonary hypertension Management of co-morbidities in heart failure Mechanical cardiac support devices Get up to speed with the latest clinical trials, as well as how they have influenced current practice guidelines Explore what’s changing in key areas such as basic mechanisms of heart failure, genetic screening, cell and gene therapies, pulmonary hypertension, heart failure prevention, co-morbid conditions, telemedicine/remote monitoring, and palliative care