Epigenetic Regulation in the Nervous System

• Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
• Publisher : Academic Press
• Release : 31 December 2012

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter

• Author : Daniel Ortuño-Sahagún,Reinhard Schliebs,Merce Pallàs
• Publisher : Frontiers Media SA
• Release : 20 September 2019

Neural plasticity is a unique and adaptive feature of nervous system, which allows neurons to reorganize their interactions in response to a stimulation (intrinsic or extrinsic) to maintain their function. For these reasons, epigenetics emerges as a potential field for developing strategies to modulate changes in pathological situation because extrinsic factors and pharmacological tools can modify neural functioning in organisms during their life. Diet, exercise, environmental aspects, stressors or drugs are available to alter those mechanisms. Epigenetic involves certain molecular

• Author : Andrew J. Kennedy,Gabriella N. L. Chua
• Publisher : Academic Press
• Release : 01 June 2020

Epigenetic mechanisms are the biological processes that determine how our genome is used and the same principle can be applied to our neuron genes. In recent findings in the field of neuroepigenetics, it has been determined that our genes encode our memories, transmit information about stressful events, and play apart in our addictions. This book helps to unlock these abstract processes, leading to improved individualized treatments.

• Author : Jie Lu
• Publisher : Unknown
• Release : 17 September 2021

Genetic and Epigenetic Mechanisms in Down Syndrome Brain.

• Author : Paolo Sassone Corsi,Yves Christen
• Publisher : Springer Science & Business Media
• Release : 19 October 2012

Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The

• Author : Andrew J. Kennedy,Gabriella N.L. Chua
• Publisher : Academic Press
• Release : 01 December 2022

Epigenetic Mechanisms in the Brain provides recent findings in the field of neuroepigenetics, covering how our genes encode our memories, transmit information about stressful events, and play a part in our addictions. This book helps to unlock these abstract processes, with a forward goal of improving individualized treatments. Discusses how the epigenome affects long-term memory, stress and addiction Reviews the concept of transgenerational memory Describes treatment options for the epigenome

• Author : Jeremy J. Day,J. David Sweatt
• Publisher : Elsevier Inc. Chapters
• Release : 31 December 2012

• Author : Lawrence R. Edelstein,John Raymond Smythies,Denis Noble
• Publisher : Unknown
• Release : 17 September 2021

• Author : Arturas Petronis,Jonathan Mill
• Publisher : Springer Science & Business Media
• Release : 19 May 2011

Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of

• Author : Rebecca Kaye Simmons
• Publisher : Unknown
• Release : 17 September 2021

Epigenetic mechanisms provide a critical and plausible mechanism by which genes and the environment can interact and have been implicated in a number of diseases and disorders. In order to better understand how epigenetic mechanisms go awry in a diseased brain we must first understand how epigenetic mechanisms unfold during normal development. The present body of work begins to examine the role of DNA methylation in normal development and how it may contribute to a rodent model of emotion dysfunction.

• Author : Timothy W. Bredy
• Publisher : Academic Press
• Release : 05 January 2017

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate

• Author : Tania L Roth,David M Diamond,Karestan C Koenen
• Publisher : Frontiers Media SA
• Release : 14 April 2015

This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in

• Author : Hannah Duffy
• Publisher : Unknown
• Release : 17 September 2021

Aversive caregiving causes epigenetic alterations that may lead to neurological and behavioral problems later in life. These issues presumably originate in the brain, and, as such, epigenetic changes within the brain would appear to be the most relevant to better understand the origin of and possible alleviation of these issues. However, it is difficult to study epigenetics in the brain in living humans, so many researchers rely on epigenetic alterations in peripheral tissues to be an indication of aberrant epigenetic

• Author : Negar Montakhab Ghahramani
• Publisher : Unknown
• Release : 17 September 2021

The major drivers underlying sexually dimorphic brain development are gonadal hormones, namely testosterone (T). During the perinatal sensitive period, a time when the embryonic brain is maximally sensitive to changes in the levels of gonadal hormones, exposure to T has permanent organizing effects on the brain, the molecular basis of which is not known. One potential mechanism for the long term permanence may be DNA methylation. To examine the contribution of epigenetic mechanisms to both the establishment and maintenance of

• Author : George Fink
• Publisher : Academic Press
• Release : 24 October 2020

This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases. The Handbook of Stress