Epigenetic Mechanisms in Cancer

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  • Author : Sabita Saldanha
  • Publisher : Academic Press
  • Pages : 392 pages
  • ISBN : 0128134607
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Epigenetic Mechanisms in Cancer

Download or Read online Epigenetic Mechanisms in Cancer full in PDF, ePub and kindle. this book written by Sabita Saldanha and published by Academic Press which was released on 16 November 2017 with total page 392 pages. We cannot guarantee that Epigenetic Mechanisms in Cancer book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes. Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc. Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis Features contributions by leading experts in the field Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs

Epigenetic Mechanisms in Cancer

Epigenetic Mechanisms in Cancer
  • Author : Sabita Saldanha
  • Publisher : Academic Press
  • Release : 16 November 2017
GET THIS BOOK Epigenetic Mechanisms in Cancer

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of

Epigenetic Advancements in Cancer

Epigenetic Advancements in Cancer
  • Author : Manoj K. Mishra,Kumar S. Bishnupuri
  • Publisher : Springer
  • Release : 04 May 2016
GET THIS BOOK Epigenetic Advancements in Cancer

This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent

Discovery of Novel Epigenetic Mechanisms of Carcinogenesis by Genome wide Profiling of Non coding Regulatory Elements

Discovery of Novel Epigenetic Mechanisms of Carcinogenesis by Genome wide Profiling of Non coding Regulatory Elements
  • Author : Batool Akhtar-Zaidi
  • Publisher : Unknown
  • Release : 19 January 2022
GET THIS BOOK Discovery of Novel Epigenetic Mechanisms of Carcinogenesis by Genome wide Profiling of Non coding Regulatory Elements

Epigenetic mechanisms are of paramount importance in cancer. Historically, epigenetic studies of cancer have focused on aberrant DNA methylation events. Far less is known about the role of histone modifications in epigenetic mechanisms of human cancers, and of disease in general. There are a number of reasons why histone modifications are especially important to investigate in the context of tumor formation. While DNA methylation contributes to stable gene silencing and formation of heterochromatin, histone modifications are associated with much more

Epigenetic Mechanisms in Human Cancer

Epigenetic Mechanisms in Human Cancer
  • Author : Luis G. Acevedo
  • Publisher : LAP Lambert Academic Publishing
  • Release : 01 March 2012
GET THIS BOOK Epigenetic Mechanisms in Human Cancer

Epigenetics is the field that studies the changes that regulate gene expression without affecting the coding sequence of DNA, such as changes in DNA methylation and postranslational modifications at the histone tails. Using chromatin immunoprecipitation (ChIP) scientists are able to study which proteins (histones or transcription factors) bind to DNA at a specific locus. ChIP becomes a powerful tool when it is coupled to sequencing or DNA microarrays, a technique known as ChIP-chip, enabling the study of all possible binding

Molecular mechanisms and physiology of disease

Molecular mechanisms and physiology of disease
  • Author : Nilanjana Maulik,Tom Karagiannis
  • Publisher : Springer
  • Release : 31 May 2014
GET THIS BOOK Molecular mechanisms and physiology of disease

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field.

DNA Methylation Epigenetics and Metastasis

DNA Methylation  Epigenetics and Metastasis
  • Author : Manel Esteller
  • Publisher : Springer Science & Business Media
  • Release : 30 March 2006
GET THIS BOOK DNA Methylation Epigenetics and Metastasis

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally,

Patho Epigenetics of Disease

Patho Epigenetics of Disease
  • Author : Janos Minarovits,Hans Helmut Niller
  • Publisher : Springer Science & Business Media
  • Release : 14 June 2012
GET THIS BOOK Patho Epigenetics of Disease

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance

Epigenetic Effects of Benzopyrene Exposures in Breast Cancer

Epigenetic Effects of Benzopyrene Exposures in Breast Cancer
  • Author : Bekim Sadikovic
  • Publisher : Unknown
  • Release : 19 January 2022
GET THIS BOOK Epigenetic Effects of Benzopyrene Exposures in Breast Cancer

Epigenetic mechanisms including DNA methylation and histone modifications are essential in many cellular processes including gene expression, chromatin compaction, genetic imprinting, cell differentiation, and X-chromosome and retrotransposon inactivation. Disruption of epigenetic mechanisms through genetic or environmental factors results in development of many diseases, including cancer. Benzo(a)pyrene (BaP) is an environmental pollutant found in air, diet, or unhealthy lifestyle choices such as smoking, and has been linked to carcinogenesis. BaP exposure-associated DNA damage and disruption of gene expression have

Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention
  • Author : Anupam Bishayee,Deepak Bhatia
  • Publisher : Academic Press
  • Release : 27 November 2018
GET THIS BOOK Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and

Epigenetics and Cancer

Epigenetics and Cancer
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 22 November 2010
GET THIS BOOK Epigenetics and Cancer

Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects

Epigenetics

Epigenetics
  • Author : Balázs Pintér,Zsolt Mészáros
  • Publisher : Nova Science Pub Incorporated
  • Release : 19 January 2022
GET THIS BOOK Epigenetics

"Epigenetics refers to DNA and chromatin modifications that persist from one cell division to the next despite a lack of change in the underlying DNA sequence. It is an emergent field since its implication in physiological and disease processes is now widely accepted. The effects of epigenetics play an important role in development but can also arise stochastically with aging. Since their discovery in 1983, cancer-associated epigenetic changes have become accepted as playing a pivotal role in carcinogenesis, in conjunction with

Cancer Epigenetics

Cancer Epigenetics
  • Author : Mukesh Verma
  • Publisher : Humana Press
  • Release : 23 August 2016
GET THIS BOOK Cancer Epigenetics

This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on

Gynecological Cancers

Gynecological Cancers
  • Author : Antonio Giordano,Marcella Macaluso
  • Publisher : Springer
  • Release : 12 July 2016
GET THIS BOOK Gynecological Cancers

Facilitating the collaboration between the basic, translational, and clinical sciences, this book provides an overview of the genetic and epigenetic mechanisms underlying the formation and progression of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development gathers all of the molecular and cellular aspects of gynecological cancer together within one volume, providing detailed and up-to-date information on the etiology, diagnosis, and treatment of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development ​also discusses the racial

Epigenetics in Retinoblastoma

Epigenetics in Retinoblastoma
  • Author : Sophia Stahl
  • Publisher : GRIN Verlag
  • Release : 08 January 2013
GET THIS BOOK Epigenetics in Retinoblastoma

Essay from the year 2012 in the subject Medicine - Ophthalmology, grade: 1,3, University of Heidelberg, language: English, abstract: Today's DNA sequencing technologies are becoming more and more impressive. That it is not only important to focus on mutations in the sequence of DNA, however, but also on differences that occur on the level above the genes, the epigenetic modifications of the DNA, has been found out by the researchers of Michael Dyer's group. The quickly developing childhood cancer retinoblastoma is directly