Epigenetic Cancer Therapy

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  • Author : Steven Gray
  • Publisher : Academic Press
  • Pages : 748 pages
  • ISBN : 0128002247
  • Rating : /5 from reviews
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Download or Read online Epigenetic Cancer Therapy full in PDF, ePub and kindle. this book written by Steven Gray and published by Academic Press which was released on 01 July 2015 with total page 748 pages. We cannot guarantee that Epigenetic Cancer Therapy book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy
  • Author : Steven Gray
  • Publisher : Academic Press
  • Release : 01 July 2015
GET THIS BOOK Epigenetic Cancer Therapy

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).

Epigenetic Therapy of Cancer

Epigenetic Therapy of Cancer
  • Author : Michael Lübbert,Peter A. Jones
  • Publisher : Springer Science & Business Media
  • Release : 12 December 2013
GET THIS BOOK Epigenetic Therapy of Cancer

The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the

Cancer Epigenetics

Cancer Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : CRC Press
  • Release : 30 August 2019
GET THIS BOOK Cancer Epigenetics

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are

The Histone Code and Beyond

The Histone Code and Beyond
  • Author : Shelley L. Berger,O. Nakanishi,Bernhard Haendler
  • Publisher : Springer Science & Business Media
  • Release : 19 January 2007
GET THIS BOOK The Histone Code and Beyond

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and

Epigenetics and Cancer

Epigenetics and Cancer
  • Author : Fazlul H. Sarkar
  • Publisher : Springer Science & Business Media
  • Release : 29 May 2013
GET THIS BOOK Epigenetics and Cancer

Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic

Epigenetics in Cancer

Epigenetics in Cancer
  • Author : Junjiang Fu,Saber Imani
  • Publisher : Alpha Science International, Limited
  • Release : 30 April 2019
GET THIS BOOK Epigenetics in Cancer

As the second leading cause of death, cancer has cast an overwhelming shadow on millions of lives worldwide. Everyone is affected in some way, if not by having the disease themselves, then by witnessing it in friends or loved ones. Epigenetics is a rapidly-growing field and a fascinating area of cancer research. The book addresses the importance of fighting cancers with an epigenetics approach. Specifically, the following topics are reviewed: - (1) DNA methylation and cancer. - (2) Non-coding RNAs in cancer.

Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention
  • Author : Anupam Bishayee,Deepak Bhatia
  • Publisher : Academic Press
  • Release : 27 November 2018
GET THIS BOOK Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and

DNA Methylation and Cancer Therapy

DNA Methylation and Cancer Therapy
  • Author : Moshe Szyf
  • Publisher : Springer Science & Business Media
  • Release : 03 April 2007
GET THIS BOOK DNA Methylation and Cancer Therapy

NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Edular biologists. An obvious question was whether DNA methylation was a

The Histone Code and Beyond

The Histone Code and Beyond
  • Author : Shelley L. Berger,O. Nakanishi,Bernhard Haendler
  • Publisher : Springer
  • Release : 02 September 2009
GET THIS BOOK The Histone Code and Beyond

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and

Cancer Epigenetics

Cancer Epigenetics
  • Author : Antonio Giordano,Marcella Macaluso
  • Publisher : John Wiley & Sons
  • Release : 07 October 2011
GET THIS BOOK Cancer Epigenetics

Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.

Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell

Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell
  • Author : Yoshimasa Saito
  • Publisher : Frontiers E-books
  • Release : 10 November 2014
GET THIS BOOK Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell

Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine 9 (H3K9) and tri-methylation of H3K27. MiRNAs are small non-coding RNAs that regulate expression of various target genes. Specific miRNAs are aberrantly expressed and play roles as tumor suppressors

Epigenetic Mechanisms in Cancer

Epigenetic Mechanisms in Cancer
  • Author : Sabita Saldanha
  • Publisher : Academic Press
  • Release : 16 November 2017
GET THIS BOOK Epigenetic Mechanisms in Cancer

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of