Dynemicin A Uncialamycin and Analogues

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  • Author : Daniel Best
  • Publisher : Elsevier
  • Pages : 144 pages
  • ISBN : 0081010869
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Dynemicin A Uncialamycin and Analogues

Download or Read online Dynemicin A Uncialamycin and Analogues full in PDF, ePub and kindle. this book written by Daniel Best and published by Elsevier which was released on 14 June 2016 with total page 144 pages. We cannot guarantee that Dynemicin A Uncialamycin and Analogues book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds

Dynemicin A Uncialamycin and Analogues

Dynemicin A  Uncialamycin and Analogues
  • Author : Daniel Best,Mickael Jean,Pierre Van De Weghe
  • Publisher : Elsevier
  • Release : 14 June 2016
GET THIS BOOK Dynemicin A Uncialamycin and Analogues

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details

Anticancer Agents from Natural Products Second Edition

Anticancer Agents from Natural Products  Second Edition
  • Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
  • Publisher : CRC Press
  • Release : 10 October 2011
GET THIS BOOK Anticancer Agents from Natural Products Second Edition

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a

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  • Author : Atta-ur-Rahman
  • Publisher : Elsevier
  • Release : 08 August 2018
GET THIS BOOK Studies in Natural Products Chemistry

Studies in Natural Products Chemistry, Volume 58, covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in

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Chemical Biology of Natural Products
  • Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
  • Publisher : CRC Press
  • Release : 22 September 2017
GET THIS BOOK Chemical Biology of Natural Products

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing