Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies

• Author : Chi Hin Cho,Tao Hu
• Publisher : Academic Press
• Release : 10 June 2020

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with

• Author : Dhananjay Shukla,Naveen Kumar Vishvakarma,Ganji Purnachandra Nagaraju
• Publisher : Springer Nature
• Release : 14 February 2022

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the

• Author : Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma
• Publisher : Springer Nature
• Release : 26 January 2023

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the

• Author : Naveen Kumar Vishvakarma,Ganji Purnachandra Nagaraju,Dhananjay Shukla
• Publisher : Springer Nature
• Release : 04 June 2021

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the

• Author : Chi Hin Cho,Tao Hu
• Publisher : Academic Press
• Release : 24 May 2020

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with

• Author : Fatma M. Abdel Bar,Mai H. El-Naggar
• Publisher : LAP Lambert Academic Publishing
• Release : 24 March 2015

Emerging New Therapy Against Colorectal Cancer and Human Drug Resistant Breast Cancer are among our continuous efforts and need for developing novel drug-like lead natural compounds. This book presents a remarkable anticancer activity of natural-derived compound as gingerol and its derivatives compared to the standard universal therapeutic regimen. This book describes new and modern applications of gingerols for treatment of both colorectal and breast cancer. Interestingly this book presents biological and in-silico (virtual) evaluation of potential activity of gingerols-derivatives and

• Author : Ajaikumar B. Kunnumakkara,Devivasha Bordoloi,Javadi Monisha
• Publisher : World Scientific
• Release : 26 January 2023

Introduction and basic concepts of cancer / Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Nafiseh Mantegh, Ganesan Padmavathi, Ajaikumar B. Kunnumakkara -- Cancer cell chemoresistance : a prime obstacle in cancer therapy -- Javadi Monisha [and 6 others] -- Bladder cancer : chemoresistance and chemosensitization / Nand Kishor Roy, Anand Sharma, Anuj Kumar Singh, Devivasha Bordoloi, Ajaikumar B. Kunnumakkara -- Mechanism of chemoresistance in bone cancer and different chemosensitization approaches / Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik, Anuj Kumar Singh, Ajaikumar B. Kunnumakkara -- Chemoresistance in brain cancer

• Author : Benjamin Bonavida
• Publisher : Springer Science & Business Media
• Release : 04 July 2013

​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order

• Author : W. Y. Tan,Leonid G. Hanin
• Publisher : World Scientific
• Release : 26 January 2023

Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications.Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple

• Author : DKV Prasad,Pinninti Santosh Sushma
• Publisher : Springer Nature
• Release : 09 July 2022

This book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells.

• Author : Cristina Maccalli,Matilde Todaro,Soldano Ferrone
• Publisher : Springer
• Release : 04 June 2019

This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that

• Author : Ganji Seeta Rama Raju,L.V.K.S. Bhaskar
• Publisher : Springer Nature
• Release : 04 March 2020

This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to

• Author : Jindong Chen
• Publisher : BoD – Books on Demand
• Release : 16 May 2018

With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will

• Author : Adeeb Shehzad
• Publisher : Springer Nature
• Release : 27 May 2022

This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the

• Author : Kajsa Viktorsson
• Publisher : Nova Biomedical
• Release : 26 January 2023

This book presents current research in the biology, diagnosis and treatment of cancer. Topics discussed include breast cancer knowledge, risk factors and screenings; uterine neoplasms; dendritic cell immunotherapy for the treatment of malignant melanoma; role of effectors on hypoxia due to nitric oxide production in human alveolar epithelial cells; complementary and alternative medicine approaches in the treatment of cancer; intrinsic and extrinsic mechanisms of drug resistance and adjuvant chemotherapy for resected colorectal cancer.