Drug like Properties Concepts Structure Design and Methods

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  • Author : Li Di
  • Publisher : Elsevier
  • Pages : 552 pages
  • ISBN : 0080557619
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Drug like Properties Concepts Structure Design and Methods

Download or Read online Drug like Properties Concepts Structure Design and Methods full in PDF, ePub and kindle. this book written by Li Di and published by Elsevier which was released on 26 July 2010 with total page 552 pages. We cannot guarantee that Drug like Properties Concepts Structure Design and Methods book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Drug like Properties Concepts Structure Design and Methods

Drug like Properties  Concepts  Structure Design and Methods
  • Author : Li Di,Edward H Kerns
  • Publisher : Elsevier
  • Release : 26 July 2010
GET THIS BOOK Drug like Properties Concepts Structure Design and Methods

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be

Drug Like Properties

Drug Like Properties
  • Author : Li Di,Edward H Kerns
  • Publisher : Academic Press
  • Release : 17 December 2015
GET THIS BOOK Drug Like Properties

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This

Optimizing the Drug Like Properties of Leads in Drug Discovery

Optimizing the  Drug Like  Properties of Leads in Drug Discovery
  • Author : Ronald Borchardt,Edward Kerns,Michael Hageman,Dhrien Thakker,James Stevens
  • Publisher : Springer Science & Business Media
  • Release : 31 December 2007
GET THIS BOOK Optimizing the Drug Like Properties of Leads in Drug Discovery

This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.

Discovering and Developing Molecules with Optimal Drug Like Properties

Discovering and Developing Molecules with Optimal Drug Like Properties
  • Author : Allen C Templeton,Stephen R. Byrn,Roy J Haskell,Thomas E. Prisinzano
  • Publisher : Springer
  • Release : 31 October 2014
GET THIS BOOK Discovering and Developing Molecules with Optimal Drug Like Properties

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery

ADMET for Medicinal Chemists

ADMET for Medicinal Chemists
  • Author : Katya Tsaioun,Steven A. Kates
  • Publisher : John Wiley & Sons
  • Release : 15 February 2011
GET THIS BOOK ADMET for Medicinal Chemists

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and

Molecular Drug Properties

Molecular Drug Properties
  • Author : Raimund Mannhold
  • Publisher : John Wiley & Sons
  • Release : 25 June 2008
GET THIS BOOK Molecular Drug Properties

This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity,solubility, electronic properties and conformation.

Drug Design Strategies

Drug Design Strategies
  • Author : David J. Livingstone,Andrew M. Davis
  • Publisher : Royal Society of Chemistry
  • Release : 01 November 2011
GET THIS BOOK Drug Design Strategies

Shows how different parts of the drug discovery process have developed, with particular emphasis on quantitative aspects and possible future progress.

BioNMR in Drug Research

BioNMR in Drug Research
  • Author : Oliver Zerbe,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : Wiley-VCH
  • Release : 10 January 2003
GET THIS BOOK BioNMR in Drug Research

Thanks to the vast progress made in the investigation of biomolecules using NMR during the later 1990s, NMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use also benefits the development of drugs in particular.

Adaptive Systems in Drug Design

Adaptive Systems in Drug Design
  • Author : Gisbert Schneider,Sung-Sau So
  • Publisher : Eurekah.Com Incorporated
  • Release : 16 May 2021
GET THIS BOOK Adaptive Systems in Drug Design

Major concepts in the field of drug design are described in this book, with a strong focus on complex adaptive systems. Special emphasis is placed on neural network applications and evolutionary algorithms. The book is meant to complement a text on computational chemistry and bioinformatices and to present some new challenging ideas. A conceptual framework is presented for the use of adaptive systems and evolutionary algorithms, then the concept of chemical space is discussed and numerous examples of algorithms for

Textbook of Drug Design and Discovery Fifth Edition

Textbook of Drug Design and Discovery  Fifth Edition
  • Author : Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen
  • Publisher : CRC Press
  • Release : 19 August 2016
GET THIS BOOK Textbook of Drug Design and Discovery Fifth Edition

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover

Synthetic Methods in Drug Discovery

Synthetic Methods in Drug Discovery
  • Author : David C. Blakemore,Paul M. Doyle,Yvette M. Fobian
  • Publisher : Royal Society of Chemistry
  • Release : 30 May 2016
GET THIS BOOK Synthetic Methods in Drug Discovery

The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact

Blood Brain Barrier in Drug Discovery

Blood Brain Barrier in Drug Discovery
  • Author : Li Di,Edward H. Kerns
  • Publisher : John Wiley & Sons
  • Release : 02 February 2015
GET THIS BOOK Blood Brain Barrier in Drug Discovery

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design

Virtual Screening for Bioactive Molecules Volume 10

Virtual Screening for Bioactive Molecules  Volume 10
  • Author : Hans-Joachim Böhm,Gisbert Schneider,Hugo Kubinyi,Raimund Mannhold,Hendrik Timmerman
  • Publisher : Wiley-VCH
  • Release : 17 November 2000
GET THIS BOOK Virtual Screening for Bioactive Molecules Volume 10

Recent progress in high-throughput screening, combinatorial chemistry and molecular biology has radically changed the approach to drug discovery in the pharmaceutical industry. New challenges in synthesis result in new analytical methods. At present, typically 100,000 to one million molecules have to be tested within a short period and, therefore, highly effective screening methods are necessary for today's researchers - preparing and characterizing one compound after another belongs to the past. Intelligent, computer-based search agents are needed and "virtual screening" provides solutions