Drug Like Properties

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  • Author : Li Di
  • Publisher : Academic Press
  • Pages : 580 pages
  • ISBN : 0128013222
  • Rating : /5 from reviews
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Download or Read online Drug Like Properties full in PDF, ePub and kindle. this book written by Li Di and published by Academic Press which was released on 17 December 2015 with total page 580 pages. We cannot guarantee that Drug Like Properties book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

Drug Like Properties

Drug Like Properties
  • Author : Li Di,Edward H Kerns
  • Publisher : Academic Press
  • Release : 17 December 2015
GET THIS BOOK Drug Like Properties

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This

Drug like Properties

Drug like Properties
  • Author : Li Di,Edward H. Kerns
  • Publisher : Academic Press
  • Release : 12 January 2016
GET THIS BOOK Drug like Properties

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This

Optimizing the Drug Like Properties of Leads in Drug Discovery

Optimizing the  Drug Like  Properties of Leads in Drug Discovery
  • Author : Ronald Borchardt,Edward Kerns,Michael Hageman,Dhrien Thakker,James Stevens
  • Publisher : Springer Science & Business Media
  • Release : 31 December 2007
GET THIS BOOK Optimizing the Drug Like Properties of Leads in Drug Discovery

This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.

Discovering and Developing Molecules with Optimal Drug Like Properties

Discovering and Developing Molecules with Optimal Drug Like Properties
  • Author : Allen C Templeton,Stephen R. Byrn,Roy J Haskell,Thomas E. Prisinzano
  • Publisher : Springer
  • Release : 31 October 2014
GET THIS BOOK Discovering and Developing Molecules with Optimal Drug Like Properties

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery

ADMET for Medicinal Chemists

ADMET for Medicinal Chemists
  • Author : Katya Tsaioun,Steven A. Kates
  • Publisher : John Wiley & Sons
  • Release : 15 February 2011
GET THIS BOOK ADMET for Medicinal Chemists

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and

Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide
  • Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
  • Publisher : Springer
  • Release : 19 April 2011
GET THIS BOOK Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key

Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide
  • Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
  • Publisher : Springer Science & Business Media
  • Release : 07 April 2011
GET THIS BOOK Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key

Structure based Design of Drugs and Other Bioactive Molecules

Structure based Design of Drugs and Other Bioactive Molecules
  • Author : Arun K. Ghosh,Sandra Gemma
  • Publisher : John Wiley & Sons
  • Release : 16 July 2014
GET THIS BOOK Structure based Design of Drugs and Other Bioactive Molecules

Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use

Drug like Properties Concepts Structure Design and Methods

Drug like Properties  Concepts  Structure Design and Methods
  • Author : Li Di,Edward H Kerns
  • Publisher : Elsevier
  • Release : 26 July 2010
GET THIS BOOK Drug like Properties Concepts Structure Design and Methods

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be

Optimization in Drug Discovery

Optimization in Drug Discovery
  • Author : Zhengyin Yan,Gary W. Caldwell
  • Publisher : Humana Press
  • Release : 28 October 2010
GET THIS BOOK Optimization in Drug Discovery

Recent analyses of drug attrition rates reveal that a significant number of drug candidates fail in the later stage of clinical development owing to absorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. At present, parallel synthesis combining with high-throughput screening has made it

Absorption and Drug Development

Absorption and Drug Development
  • Author : Alex Avdeef
  • Publisher : John Wiley & Sons
  • Release : 19 September 2003
GET THIS BOOK Absorption and Drug Development

Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules: Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of

Molecular Drug Properties

Molecular Drug Properties
  • Author : Raimund Mannhold
  • Publisher : John Wiley & Sons
  • Release : 25 June 2008
GET THIS BOOK Molecular Drug Properties

This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity,solubility, electronic properties and conformation.

Textbook of Drug Design and Discovery Fifth Edition

Textbook of Drug Design and Discovery  Fifth Edition
  • Author : Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen
  • Publisher : CRC Press
  • Release : 19 August 2016
GET THIS BOOK Textbook of Drug Design and Discovery Fifth Edition

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover

Current Methods In Medicinal Chemistry And Biological Physics

Current Methods In Medicinal Chemistry And Biological Physics
  • Author : Carlton A. Taft
  • Publisher : Unknown
  • Release : 01 January 2008
GET THIS BOOK Current Methods In Medicinal Chemistry And Biological Physics

This book is aimed at, from students to advanced researchers, for anyone that is interested or works with current experimental and theoretical methods in medicinal chemistry and biological physics, with particular interest in chemoinformatics, bioinformatics, molecular modeling, QSAR, spectrometry, molecular biology and combinatorial chemistry for many therapeutic purposes. This book attempts to convey something of the fascination of working in these multidisciplinar areas, which overlap knowledge of chemistry, physics, biochemistry, biology and pharmacology. This second volume, in particular, contains 11 chapters,

Synthetic Methods in Drug Discovery

Synthetic Methods in Drug Discovery
  • Author : David C. Blakemore,Paul M. Doyle,Yvette M. Fobian
  • Publisher : Royal Society of Chemistry
  • Release : 30 May 2016
GET THIS BOOK Synthetic Methods in Drug Discovery

The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact