Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

• Author : Anonim
• Publisher : Academic Press
• Release : 27 November 2019

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated

• Author : Anonim
• Publisher : Academic Press
• Release : 07 November 2019

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated

• Author : Chi Hin Cho,Tao Hu
• Publisher : Academic Press
• Release : 24 May 2020

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with

• Author : Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
• Publisher : Springer
• Release : 21 March 2017

This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased

• Author : Ripudaman Singh
• Publisher : Unknown
• Release : 18 June 2021

The PI3kinase pathway and ABC transporters play a crucial role in normal growth, survival and death of a cell. However in cancer cells, disturbances in these pathways lead to uncontrolled growth even under treatment of various anticancer drugs. Two major efflux pumps i.e. p-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP1) are found to be involved in conferring resistance to vast variety of compounds. Similarly, activated PI3kinse pathway controls many other downstream signal transduction elements that in the

• Author : Sir Norman Lockyer
• Publisher : Unknown
• Release : 18 June 2021

• Author : Amrit Rattan K. Baidwan-macfarland
• Publisher : Authorhouse UK
• Release : 30 March 2019

The ground-breaking scientific study of Amrit Rattan K Baidwan Macfarland (Amrit K Macfarland) asks why and how malignant cancers can be cured. This scientific status is visualised through novel ALL cells lines in vitro, in vivo, and in developing natural human foetal tissues. The resistance status of malignancy to treatment is determined by an inextricable connection between P-gp expression in malignant cell membranes exposed to drugs, blood-brain barrier developmental cells in human foetal cells, and ALL blood cells undergoing chemotherapy.

• Author : Kara Michelle Pearson
• Publisher : Unknown
• Release : 18 June 2021

• Author : Kerry Ann O'Brien
• Publisher : Unknown
• Release : 18 June 2021

Examination and comparison of the activation of MAP kinase pathways revealed that ERK and p38 were preferentially activated by the mitochondrial toxicants and anticancer drugs in the ST486 cell line. Vincristine and rotenone also activated the JNK/c-jun pathway in all three cell lines, which was correlated with apoptosis induction in the EW36 cells. Pharmacological inhibition of the ERK and p38 pathways augmented apoptosis induction in the ST486 cells. These studies demonstrate the multifactorial nature of drug resistance and susceptibility

• Author : Martin Clynes
• Publisher : Springer Science & Business Media
• Release : 17 April 2013

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation

• Author : Anonim
• Publisher : Unknown
• Release : 18 June 2021

• Author : National Academy of Sciences (U.S.)
• Publisher : Unknown
• Release : 18 June 2021

• Author : Anonim
• Publisher : Unknown
• Release : 18 June 2021

• Author : Klaus-Michael Debatin,Simone Fulda
• Publisher : Wiley-Blackwell
• Release : 17 March 2006

Since most cancer therapies primarily act by inducing apoptosis in tumor cells, insights into the molecular mechanisms regulating apoptosis are crucial to developing novel, more effective treatment strategies. Here, a highly distinguished team of authors from top institutes around the world leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria,

• Author : Anonim
• Publisher : Unknown
• Release : 18 June 1998