Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

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  • Author : Anonim
  • Publisher : Academic Press
  • Pages : 394 pages
  • ISBN : 0128164344
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

Download or Read online Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy full in PDF, ePub and kindle. this book written by Anonim and published by Academic Press which was released on 27 November 2019 with total page 394 pages. We cannot guarantee that Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance. Offers comprehensive and detailed descriptions of the basic aspects of efflux pumps in a very schematic and didactic manner Describes the involvement of efflux pumps in cancer resistance in different cancer types Encompasses an updated overview on state-of-the-art approaches that capitalize on their inhibition to improve chemotherapy and overcome resistance

Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

Drug Efflux Pumps in Cancer Resistance Pathways  From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 27 November 2019
GET THIS BOOK Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated

Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

Drug Efflux Pumps in Cancer Resistance Pathways  From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 07 November 2019
GET THIS BOOK Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated

Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer  Molecular Mechanisms and Therapeutic Strategies
  • Author : Chi Hin Cho,Tao Hu
  • Publisher : Academic Press
  • Release : 24 May 2020
GET THIS BOOK Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with

Drug Resistance in Bacteria Fungi Malaria and Cancer

Drug Resistance in Bacteria  Fungi  Malaria  and Cancer
  • Author : Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
  • Publisher : Springer
  • Release : 21 March 2017
GET THIS BOOK Drug Resistance in Bacteria Fungi Malaria and Cancer

This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased

The PI3kinase Pathway and the Susceptibility of Its Inhibitors to ABC Transporters

The PI3kinase Pathway and the Susceptibility of Its Inhibitors to ABC Transporters
  • Author : Ripudaman Singh
  • Publisher : Unknown
  • Release : 18 June 2021
GET THIS BOOK The PI3kinase Pathway and the Susceptibility of Its Inhibitors to ABC Transporters

The PI3kinase pathway and ABC transporters play a crucial role in normal growth, survival and death of a cell. However in cancer cells, disturbances in these pathways lead to uncontrolled growth even under treatment of various anticancer drugs. Two major efflux pumps i.e. p-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP1) are found to be involved in conferring resistance to vast variety of compounds. Similarly, activated PI3kinse pathway controls many other downstream signal transduction elements that in the

Signal and Response Signal Transduction

Signal and Response   Signal Transduction
  • Author : Amrit Rattan K. Baidwan-macfarland
  • Publisher : Authorhouse UK
  • Release : 30 March 2019
GET THIS BOOK Signal and Response Signal Transduction

The ground-breaking scientific study of Amrit Rattan K Baidwan Macfarland (Amrit K Macfarland) asks why and how malignant cancers can be cured. This scientific status is visualised through novel ALL cells lines in vitro, in vivo, and in developing natural human foetal tissues. The resistance status of malignancy to treatment is determined by an inextricable connection between P-gp expression in malignant cell membranes exposed to drugs, blood-brain barrier developmental cells in human foetal cells, and ALL blood cells undergoing chemotherapy.

Role of Mitochondrial Sensitivity and Preferential Activation of MAP Kinase Pathways in Regulating Drug Sensitivity and Resistance of Selected B lymphoma Cell Lines

Role of Mitochondrial Sensitivity and Preferential Activation of MAP Kinase Pathways in Regulating Drug Sensitivity and Resistance of Selected B lymphoma Cell Lines
  • Author : Kerry Ann O'Brien
  • Publisher : Unknown
  • Release : 18 June 2021
GET THIS BOOK Role of Mitochondrial Sensitivity and Preferential Activation of MAP Kinase Pathways in Regulating Drug Sensitivity and Resistance of Selected B lymphoma Cell Lines

Examination and comparison of the activation of MAP kinase pathways revealed that ERK and p38 were preferentially activated by the mitochondrial toxicants and anticancer drugs in the ST486 cell line. Vincristine and rotenone also activated the JNK/c-jun pathway in all three cell lines, which was correlated with apoptosis induction in the EW36 cells. Pharmacological inhibition of the ERK and p38 pathways augmented apoptosis induction in the ST486 cells. These studies demonstrate the multifactorial nature of drug resistance and susceptibility

Multiple Drug Resistance in Cancer 2

Multiple Drug Resistance in Cancer 2
  • Author : Martin Clynes
  • Publisher : Springer Science & Business Media
  • Release : 17 April 2013
GET THIS BOOK Multiple Drug Resistance in Cancer 2

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation

Apoptosis and Cancer Therapy

Apoptosis and Cancer Therapy
  • Author : Klaus-Michael Debatin,Simone Fulda
  • Publisher : Wiley-Blackwell
  • Release : 17 March 2006
GET THIS BOOK Apoptosis and Cancer Therapy

Since most cancer therapies primarily act by inducing apoptosis in tumor cells, insights into the molecular mechanisms regulating apoptosis are crucial to developing novel, more effective treatment strategies. Here, a highly distinguished team of authors from top institutes around the world leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria,