Drug Discovery

Drug Discovery From Nature Book PDF
✏Book Title : Drug Discovery from Nature
✏Author : S. Grabley
✏Publisher : Springer Science & Business Media
✏Release Date : 1998-11-26
✏Pages : 347
✏ISBN : 3540648445
✏Available Language : English, Spanish, And French

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✏Drug Discovery from Nature Book Summary : This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

The Science And Business Of Drug Discovery Book PDF
✏Book Title : The Science and Business of Drug Discovery
✏Author : Edward D. Zanders
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-07-08
✏Pages : 397
✏ISBN : 1441999027
✏Available Language : English, Spanish, And French

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✏The Science and Business of Drug Discovery Book Summary : The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the nineteen chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators.

📒Drug Discovery ✍ Tamas Bartfai

Drug Discovery Book PDF
✏Book Title : Drug Discovery
✏Author : Tamas Bartfai
✏Publisher : Academic Press
✏Release Date : 2010-07-26
✏Pages : 328
✏ISBN : 9780080919232
✏Available Language : English, Spanish, And French

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✏Drug Discovery Book Summary : Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs ‘work’ medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable? This book opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process. * Co-written by Graham Lees and Tamas Bartfai who has been involved in the development of drugs taken by more that 20 million people every day * Opens the windows and doors of the most regulated industry in the world, the pharmaceutical industry * Tells the story of drug development by using real examples based on current research and events * Provides an objective, lucid account of the successes and failures, shortcomings and constraints of the pharmaceutical and biotech industries * Gives insights into the development of new drugs to combat multiple conditions including cancer and pain * Balanced, unbiased account of how better to translate basic science into drug discovery

Basic Principles Of Drug Discovery And Development Book PDF
✏Book Title : Basic Principles of Drug Discovery and Development
✏Author : Benjamin Blass
✏Publisher : Elsevier
✏Release Date : 2015-04-24
✏Pages : 580
✏ISBN : 9780124115255
✏Available Language : English, Spanish, And French

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✏Basic Principles of Drug Discovery and Development Book Summary : Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." Provides a clear explanation of how the pharmaceutical industry works Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry Explains the transition process from academia or other industries

📒Target Discovery And Validation ✍ Alleyn T. Plowright

Target Discovery And Validation Book PDF
✏Book Title : Target Discovery and Validation
✏Author : Alleyn T. Plowright
✏Publisher : John Wiley & Sons
✏Release Date : 2019-12-31
✏Pages : 400
✏ISBN : 9783527345298
✏Available Language : English, Spanish, And French

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✏Target Discovery and Validation Book Summary : The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.

Macrocycles In Drug Discovery Book PDF
✏Book Title : Macrocycles in Drug Discovery
✏Author : Jeremy I Levin
✏Publisher : Royal Society of Chemistry
✏Release Date : 2014-10-16
✏Pages : 499
✏ISBN : 9781849737012
✏Available Language : English, Spanish, And French

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✏Macrocycles in Drug Discovery Book Summary : This book reviews macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. The medicinal chemistry of macrocyclic natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, are now informing the design of fully synthetic macrocyclic drug candidates against a variety of targets including kinases, ATPases, proteases, GPCRs and others. Furthermore, as more non-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are generating increasing interest as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules. A variety of macrocycles have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds, their pharmacology and synthesis, in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.

📒Chronicles Of Drug Discovery ✍ Jasjit S. Bindra

Chronicles Of Drug Discovery Book PDF
✏Book Title : Chronicles of Drug Discovery
✏Author : Jasjit S. Bindra
✏Publisher : American Chemical Society
✏Release Date : 1993
✏Pages : 350
✏ISBN : 0841225230
✏Available Language : English, Spanish, And French

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✏Chronicles of Drug Discovery Book Summary : Offers a unique insight into the drug discovery process through informal histories presented by the drugs' inventor. A compilation of accounts describing the events leading from the initial discovery to successful introduction on the market of fourteen important new drugs, including RU 486 (mifepristone) and taxol. Many chapters outline in detail the chemical/biological rationale which led to the discovery. Includes drugs with a wide selection of therapeutic indications. Presents a broad range of development strategies.

📒Drug Discovery ✍ Hany El-Shemy

Drug Discovery Book PDF
✏Book Title : Drug Discovery
✏Author : Hany El-Shemy
✏Publisher : BoD – Books on Demand
✏Release Date : 2013-01-23
✏Pages : 526
✏ISBN : 9789535109068
✏Available Language : English, Spanish, And French

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✏Drug Discovery Book Summary : Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive. Books on drug discovery will play vital role in the new era of disease treatment using natural products.

Applied Biophysics For Drug Discovery Book PDF
✏Book Title : Applied Biophysics for Drug Discovery
✏Author : Donald Huddler
✏Publisher : John Wiley & Sons
✏Release Date : 2017-10-02
✏Pages : 312
✏ISBN : 9781119099482
✏Available Language : English, Spanish, And French

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✏Applied Biophysics for Drug Discovery Book Summary : 13.2.1 Protein Dynamics of SA WT and S1 Mutant DHFR in Apo and Bound States

📒Modern Methods Of Drug Discovery ✍ Alexander Hillisch

Modern Methods Of Drug Discovery Book PDF
✏Book Title : Modern Methods of Drug Discovery
✏Author : Alexander Hillisch
✏Publisher : Birkhäuser
✏Release Date : 2012-11-28
✏Pages : 292
✏ISBN : 9783034879972
✏Available Language : English, Spanish, And French

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✏Modern Methods of Drug Discovery Book Summary : Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Natural Product Chemistry For Drug Discovery Book PDF
✏Book Title : Natural Product Chemistry for Drug Discovery
✏Author : Antony D. Buss
✏Publisher : Royal Society of Chemistry
✏Release Date : 2010
✏Pages : 440
✏ISBN : 9780854041930
✏Available Language : English, Spanish, And French

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✏Natural Product Chemistry for Drug Discovery Book Summary : This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.

📒Drug Discovery And Development ✍ Omboon Vallisuta

Drug Discovery And Development Book PDF
✏Book Title : Drug Discovery and Development
✏Author : Omboon Vallisuta
✏Publisher : BoD – Books on Demand
✏Release Date : 2015-06-03
✏Pages : 330
✏ISBN : 9789535121282
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Development Book Summary : It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Drug Discovery And Development Book PDF
✏Book Title : Drug Discovery and Development
✏Author : H. P. Rang
✏Publisher : Churchill Livingstone
✏Release Date : 2006
✏Pages : 346
✏ISBN : UOM:39015063653672
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Development Book Summary : 'Drug Discovery and Development' describes the huge complexities involved in bringing a drug to market and how new molecular understanding and techniques can make the process more targeted and successful.

📒Drug Discovery ✍ Jie Jack Li

Drug Discovery Book PDF
✏Book Title : Drug Discovery
✏Author : Jie Jack Li
✏Publisher : John Wiley & Sons
✏Release Date : 2013-04-03
✏Pages : 570
✏ISBN : 9781118354469
✏Available Language : English, Spanish, And French

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✏Drug Discovery Book Summary : Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.

Drug Discovery And Clinical Research Book PDF
✏Book Title : Drug Discovery and Clinical Research
✏Author : SK Gupta
✏Publisher : JP Medical Ltd
✏Release Date : 2011-06-01
✏Pages : 668
✏ISBN : 9789350252727
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Clinical Research Book Summary : The Drug Discovery and Clinical Research bandwagon has been joined by scientists and researchers from all fields including basic sciences, medical sciences, biophysicists, biotechnologists, statisticians, regulatory officials and many more. The joint effort and contribution from all is translating into the fast development of this multi-faceted field. At the same time, it has become challenging for all stakeholders to keep abreast with the explosion in information. The race for the finish-line leaves very little time for the researchers to update themselves and keep tabs on the latest developments in the industry. To meet these challenges, this book entitled Drug Discovery and Clinical Research has been compiled. All chapters have been written by stalwarts of the field who have their finger on the pulse of the industry. The aim of the book is to provide succinctly within one cover, an update on all aspects of this wide area. Although each of the chapter dealt here starting from drug discovery and development, clinical development, bioethics, medical devices, pharmacovigilance, data management, safety monitoring, patient recruitment, etc. are topics for full-fledged book in themselves, an effort has been made via this book to provide a bird’s eye view to readers and help them to keep abreast with the latest development despite constraints of time. It is hoped that the book will contribute to the growth of readers, which should translate into drug discovery and clinical research industry’s growth.

Drug Discovery And Evaluation Methods In Clinical Pharmacology Book PDF
✏Book Title : Drug Discovery and Evaluation Methods in Clinical Pharmacology
✏Author : H.Gerhard Vogel
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-12-15
✏Pages : 564
✏ISBN : 9783540898900
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Evaluation Methods in Clinical Pharmacology Book Summary : Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

Computational Medicinal Chemistry For Drug Discovery Book PDF
✏Book Title : Computational Medicinal Chemistry for Drug Discovery
✏Author : Patrick Bultinck
✏Publisher : CRC Press
✏Release Date : 2003-12-17
✏Pages : 1169
✏ISBN : 0203913396
✏Available Language : English, Spanish, And French

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✏Computational Medicinal Chemistry for Drug Discovery Book Summary : Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure computa

📒Natural Products ✍ Lixin Zhang

Natural Products Book PDF
✏Book Title : Natural Products
✏Author : Lixin Zhang
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-11-17
✏Pages : 386
✏ISBN : 9781592599769
✏Available Language : English, Spanish, And French

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✏Natural Products Book Summary : A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Analogue Based Drug Discovery Book PDF
✏Book Title : Analogue based Drug Discovery
✏Author : IUPAC
✏Publisher : John Wiley & Sons
✏Release Date : 2006-12-13
✏Pages : 606
✏ISBN : 9783527607495
✏Available Language : English, Spanish, And French

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✏Analogue based Drug Discovery Book Summary : The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds. Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them. The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability.

Chemogenomics In Drug Discovery Book PDF
✏Book Title : Chemogenomics in Drug Discovery
✏Author : Hugo Kubinyi
✏Publisher : John Wiley & Sons
✏Release Date : 2006-03-06
✏Pages : 487
✏ISBN : 9783527604029
✏Available Language : English, Spanish, And French

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✏Chemogenomics in Drug Discovery Book Summary : Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.

📒Translational Medicine ✍ Robert A. Meyers

Translational Medicine Book PDF
✏Book Title : Translational Medicine
✏Author : Robert A. Meyers
✏Publisher : John Wiley & Sons
✏Release Date : 2018-07-16
✏Pages : 1064
✏ISBN : 9783527336593
✏Available Language : English, Spanish, And French

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✏Translational Medicine Book Summary : This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Comprehensive Analysis Of Parasite Biology Book PDF
✏Book Title : Comprehensive Analysis of Parasite Biology
✏Author : Sylke M?ller
✏Publisher : John Wiley & Sons
✏Release Date : 2016-10-17
✏Pages : 576
✏ISBN : 9783527339044
✏Available Language : English, Spanish, And French

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✏Comprehensive Analysis of Parasite Biology Book Summary : Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

Drug Discovery And Evaluation Book PDF
✏Book Title : Drug Discovery and Evaluation
✏Author : Hans G. Vogel
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-04-17
✏Pages : 759
✏ISBN : 9783662033333
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Evaluation Book Summary : This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

📒Drug Discovery In Japan ✍ Sadao Nagaoka

Drug Discovery In Japan Book PDF
✏Book Title : Drug Discovery in Japan
✏Author : Sadao Nagaoka
✏Publisher : Springer Nature
✏Release Date : 2019-10-24
✏Pages : 333
✏ISBN : 9789811389061
✏Available Language : English, Spanish, And French

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✏Drug Discovery in Japan Book Summary : This book analyzes the drug-discovery process in Japan, based on detailed case studies of 12 groups of 15 innovative drugs. It covers the first statin in the world up to the recent major breakthrough in cancer therapy, the recent immune checkpoint inhibitor, the scientific discovery for which a 2018 Nobel Prize in Physiology or Medicine was awarded to Prof. Tasuku Honjo, Kyoto University. The book shows the pervasive high uncertainty in drug discovery: frequent occurrences of unexpected difficulties, discontinuations, serendipities, and good luck, significantly because drug discovery starts when the underlying science is incomplete. Thus, there exist dynamic interactions between scientific progress and drug discovery. High uncertainty also makes the value of an entrepreneurial scientist high. Such scientists fill the knowledge gaps by absorbing external scientific progress and by relentless pursuit of possibilities through their own research, often including unauthorized research, to overcome crises. Further, high uncertainty and its resolution significantly characterize the evolution of competition in the drug industry. The patent system promotes innovation under high uncertainty not only by enhancing appropriability of R&D investment but also by facilitating the combination of knowledge and capabilities among different firms through disclosure. Understanding such a process significantly benefits the creation of innovation management and policy practices.

📒Drug Discovery And Evaluation ✍ H. Gerhard Vogel

Drug Discovery And Evaluation Book PDF
✏Book Title : Drug Discovery and Evaluation
✏Author : H. Gerhard Vogel
✏Publisher : Springer Science & Business Media
✏Release Date : 2006-01-01
✏Pages : 889
✏ISBN : 3540256385
✏Available Language : English, Spanish, And French

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✏Drug Discovery and Evaluation Book Summary : This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.

Toxins In Drug Discovery And Pharmacology Book PDF
✏Book Title : Toxins in Drug Discovery and Pharmacology
✏Author : Steve Peigneur
✏Publisher : MDPI
✏Release Date : 2018-05-04
✏Pages : 316
✏ISBN : 9783038428619
✏Available Language : English, Spanish, And French

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✏Toxins in Drug Discovery and Pharmacology Book Summary : This book is a printed edition of the Special Issue "Toxins in Drug Discovery and Pharmacology" that was published in Toxins

📒Kinase Drug Discovery ✍ Richard A. Ward

Kinase Drug Discovery Book PDF
✏Book Title : Kinase Drug Discovery
✏Author : Richard A. Ward
✏Publisher : Royal Society of Chemistry
✏Release Date : 2011-12
✏Pages : 318
✏ISBN : 9781849731744
✏Available Language : English, Spanish, And French

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✏Kinase Drug Discovery Book Summary : This is the first book to examine the future opportunities and challenges in the development of drugs which target kinases

Innovative Approaches In Drug Discovery Book PDF
✏Book Title : Innovative Approaches in Drug Discovery
✏Author : Bhushan Patwardhan
✏Publisher : Academic Press
✏Release Date : 2016-10-03
✏Pages : 480
✏ISBN : 9780128018224
✏Available Language : English, Spanish, And French

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✏Innovative Approaches in Drug Discovery Book Summary : Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

Protein Crystallography In Drug Discovery Book PDF
✏Book Title : Protein Crystallography in Drug Discovery
✏Author : Robert E. Babine
✏Publisher : John Wiley & Sons
✏Release Date : 2008-07-15
✏Pages : 278
✏ISBN : 9783527606351
✏Available Language : English, Spanish, And French

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✏Protein Crystallography in Drug Discovery Book Summary : The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

📒Anti Fibrotic Drug Discovery ✍ Jehrod Brenneman

Anti Fibrotic Drug Discovery Book PDF
✏Book Title : Anti fibrotic Drug Discovery
✏Author : Jehrod Brenneman
✏Publisher : Royal Society of Chemistry
✏Release Date : 2020-02-17
✏Pages : 340
✏ISBN : 9781839160516
✏Available Language : English, Spanish, And French

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✏Anti fibrotic Drug Discovery Book Summary : Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.