Fragment based Drug Discovery

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  • Author : Daniel A. Erlanson
  • Publisher : John Wiley & Sons
  • Pages : 528 pages
  • ISBN : 352733775X
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Fragment based Drug Discovery

Download or Read online Fragment based Drug Discovery full in PDF, ePub and kindle. this book written by Daniel A. Erlanson and published by John Wiley & Sons which was released on 23 February 2016 with total page 528 pages. We cannot guarantee that Fragment based Drug Discovery book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

Successful Drug Discovery

Successful Drug Discovery
  • Author : János Fischer,Christian Klein,Wayne E. Childers
  • Publisher : John Wiley & Sons
  • Release : 07 October 2019
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Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that

Drug Discovery and Development

Drug Discovery and Development
  • Author : Raymond G. Hill,H. P. Rang
  • Publisher : Churchill Livingstone
  • Release : 03 December 2021
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The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries' trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories

Drug Discovery and Clinical Research

Drug Discovery and Clinical Research
  • Author : SK Gupta
  • Publisher : JP Medical Ltd
  • Release : 01 June 2011
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The Drug Discovery and Clinical Research bandwagon has been joined by scientists and researchers from all fields including basic sciences, medical sciences, biophysicists, biotechnologists, statisticians, regulatory officials and many more. The joint effort and contribution from all is translating into the fast development of this multi-faceted field. At the same time, it has become challenging for all stakeholders to keep abreast with the explosion in information. The race for the finish-line leaves very little time for the researchers to update

Fragment based Drug Discovery

Fragment based Drug Discovery
  • Author : Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release : 23 February 2016
GET THIS BOOK Fragment based Drug Discovery

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and

Pharmaceutical Profiling in Drug Discovery for Lead Selection

Pharmaceutical Profiling in Drug Discovery for Lead Selection
  • Author : Ronald Borchardt,Edward Kerns,Christopher Lipinski,Dhrien Thakker,Binghe Wang
  • Publisher : Springer Science & Business Media
  • Release : 05 December 2005
GET THIS BOOK Pharmaceutical Profiling in Drug Discovery for Lead Selection

This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.

Antiepileptic Drug Discovery

Antiepileptic Drug Discovery
  • Author : Alan Talevi,Luisa Rocha
  • Publisher : Humana Press
  • Release : 24 September 2016
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This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind

Epigenetic Drug Discovery

Epigenetic Drug Discovery
  • Author : Wolfgang Sippl,Manfred Jung
  • Publisher : John Wiley & Sons
  • Release : 25 March 2019
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This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and

Neurobiology of Huntington s Disease

Neurobiology of Huntington   s Disease
  • Author : Donald C. Lo,Robert E. Hughes
  • Publisher : CRC Press
  • Release : 02 July 2010
GET THIS BOOK Neurobiology of Huntington s Disease

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding

Drug Discovery

Drug Discovery
  • Author : Jie Jack Li,E. J. Corey
  • Publisher : John Wiley & Sons
  • Release : 12 April 2013
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Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection,

Molecular Cancer Therapeutics

Molecular Cancer Therapeutics
  • Author : George C. Prendergast
  • Publisher : John Wiley & Sons
  • Release : 02 April 2004
GET THIS BOOK Molecular Cancer Therapeutics

Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry

Modern Methods of Drug Discovery

Modern Methods of Drug Discovery
  • Author : Alexander Hillisch,Rolf Hilgenfeld
  • Publisher : Springer Science & Business Media
  • Release : 11 December 2002
GET THIS BOOK Modern Methods of Drug Discovery

Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of

Pharmacology for Chemists

Pharmacology for Chemists
  • Author : Raymond Hill,Terry Kenakin,Tom Blackburn
  • Publisher : Royal Society of Chemistry
  • Release : 25 October 2017
GET THIS BOOK Pharmacology for Chemists

Assuming little previous knowledge of biology, this book aids graduate chemists to close the gap in their knowledge of pharmacology and make the link between medicinal chemistry and the way in which drugs act on the body. The availability of receptor structures has revolutionized drug discovery and development necessitating an up-to-date source of information for chemists entering this new pharmacological world. Chapters, written by experts with an appreciation of most graduate chemists’ knowledge, explain the history of pharmacology, the relationship

Achieving Proof of Concept in Drug Discovery and Development

Achieving Proof of Concept in Drug Discovery and Development
  • Author : Helen Yu
  • Publisher : Edward Elgar Publishing
  • Release : 25 November 2016
GET THIS BOOK Achieving Proof of Concept in Drug Discovery and Development

One of the major shortcomings of the current drug discovery and development process is the inability to bridge the gap between early stage discoveries and pre-clinical research in order to advance innovations beyond the discovery phase. This book examines a drug discovery and development model, where the respective expertise of academia and industry are brought together to take promising discoveries through to proof of concept, providing a means to de-risk the drug discovery and development process.

Deep Learning for the Life Sciences

Deep Learning for the Life Sciences
  • Author : Bharath Ramsundar,Peter Eastman,Vijay Pande,Patrick Walters
  • Publisher : O'Reilly Media
  • Release : 30 April 2019
GET THIS BOOK Deep Learning for the Life Sciences

With much success already attributed to deep learning, this discipline has started making waves throughout science broadly and the life sciences in particular. With this practical book, developers and scientists will learn how deep learning is used for genomics, chemistry, biophysics, microscopy, medical analysis, drug discovery, and other fields. As a running case study, the authors focus on the problem of designing new therapeutics, one of science's greatest challenges because this practice ties together physics, chemistry, biology and medicine. Using