Drug Discovery in Cancer Epigenetics

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  • Author : Gerda Egger
  • Publisher : Academic Press
  • Pages : 475 pages
  • ISBN : 9780128022085
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Drug Discovery in Cancer Epigenetics

Download or Read online Drug Discovery in Cancer Epigenetics full in PDF, ePub and kindle. this book written by Gerda Egger and published by Academic Press which was released on 16 December 2015 with total page 475 pages. We cannot guarantee that Drug Discovery in Cancer Epigenetics book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics
  • Author : Gerda Egger,Paola Arimondo
  • Publisher : Academic Press
  • Release : 16 December 2015
GET THIS BOOK Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin

Epigenetic Drug Discovery

Epigenetic Drug Discovery
  • Author : Wolfgang Sippl,Manfred Jung
  • Publisher : John Wiley & Sons
  • Release : 25 March 2019
GET THIS BOOK Epigenetic Drug Discovery

This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics
  • Author : Gerda Egger,Paola Arimondo
  • Publisher : Academic Press
  • Release : 19 November 2015
GET THIS BOOK Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin

Histone Mutations and Cancer

Histone Mutations and Cancer
  • Author : Dong Fang,Junhong Han
  • Publisher : Springer Nature
  • Release : 06 November 2020
GET THIS BOOK Histone Mutations and Cancer

This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of

DNA and Histone Methylation as Cancer Targets

DNA and Histone Methylation as Cancer Targets
  • Author : Atsushi Kaneda,Yu-ichi Tsukada
  • Publisher : Humana Press
  • Release : 12 September 2017
GET THIS BOOK DNA and Histone Methylation as Cancer Targets

This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Cancer Epigenetics

Cancer Epigenetics
  • Author : Antonio Giordano,Marcella Macaluso
  • Publisher : John Wiley & Sons
  • Release : 07 October 2011
GET THIS BOOK Cancer Epigenetics

Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.

Epigenetics in Organ Specific Disorders

Epigenetics in Organ Specific Disorders
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 09 December 2022
GET THIS BOOK Epigenetics in Organ Specific Disorders

Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration,

Chemical Epigenetics

Chemical Epigenetics
  • Author : Antonello Mai
  • Publisher : Springer Nature
  • Release : 31 March 2020
GET THIS BOOK Chemical Epigenetics

This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want

Prognostic Epigenetics

Prognostic Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 01 November 2019
GET THIS BOOK Prognostic Epigenetics

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can

Epigenetics in Precision Medicine

Epigenetics in Precision Medicine
  • Author : Jose Luis Garcia-Gimenez
  • Publisher : Elsevier
  • Release : 16 November 2021
GET THIS BOOK Epigenetics in Precision Medicine

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic

Successful Drug Discovery Volume 2

Successful Drug Discovery  Volume 2
  • Author : J¿nos Fischer,Wayne E. Childers
  • Publisher : John Wiley & Sons
  • Release : 06 June 2017
GET THIS BOOK Successful Drug Discovery Volume 2

Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. 11 selected case studies describe recently introduced drugs that have not been previously covered in textbooks or general references. These range across six different therapeutic fields and provide a representative cross-section

Transgenerational Epigenetics

Transgenerational Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 18 May 2019
GET THIS BOOK Transgenerational Epigenetics

Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the

Epigenetics Territory and Cancer

Epigenetics Territory and Cancer
  • Author : Parvin Mehdipour
  • Publisher : Springer
  • Release : 31 March 2015
GET THIS BOOK Epigenetics Territory and Cancer

This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to