Drug Discovery in Cancer Epigenetics

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  • Author : Gerda Egger
  • Publisher : Academic Press
  • Pages : 498 pages
  • ISBN : 0128024925
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Drug Discovery in Cancer Epigenetics

Download or Read online Drug Discovery in Cancer Epigenetics full in PDF, ePub and kindle. this book written by Gerda Egger and published by Academic Press which was released on 19 November 2015 with total page 498 pages. We cannot guarantee that Drug Discovery in Cancer Epigenetics book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics
  • Author : Gerda Egger,Paola Arimondo
  • Publisher : Academic Press
  • Release : 19 November 2015
GET THIS BOOK Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin

Epigenetic Approaches in Drug Discovery Development and Treatment

Epigenetic Approaches in Drug Discovery  Development and Treatment
  • Author : Shibashish Giri,Chandravanu Dash
  • Publisher : Frontiers Media SA
  • Release : 07 August 2020
GET THIS BOOK Epigenetic Approaches in Drug Discovery Development and Treatment

Establishment of a normal phenotype involves dynamic epigenetic regulation of gene expression that when affected contributes to human diseases. On a molecular level, epigenetic regulation is marked by specific covalent modifications (acetylation, methylation, phosphorylation, sumoylation, PARylation and ubiquitylation) of DNA and its associated histones. Studies also suggest the influence of such epigenetic modifications on non-coding RNA expression implicated in normal and diseased phenotypes. Epigenetic control of genetic expression is a reversible process essential for normal development and function of an

Epigenetic Drug Discovery

Epigenetic Drug Discovery
  • Author : Wolfgang Sippl,Manfred Jung
  • Publisher : John Wiley & Sons
  • Release : 25 March 2019
GET THIS BOOK Epigenetic Drug Discovery

This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and

DNA and Histone Methylation as Cancer Targets

DNA and Histone Methylation as Cancer Targets
  • Author : Atsushi Kaneda,Yu-ichi Tsukada
  • Publisher : Springer
  • Release : 04 September 2017
GET THIS BOOK DNA and Histone Methylation as Cancer Targets

This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Epigenetic Pharmacology and Therapeutics

Epigenetic Pharmacology and Therapeutics
  • Author : Zacharoula Konsoula
  • Publisher : Academic Press
  • Release : 01 October 2014
GET THIS BOOK Epigenetic Pharmacology and Therapeutics

Epigenetic Pharmacology and Therapeutics highlights the interface between epigenetics and pharmacology by examining the role of epigenetics in the regulation of ADME genes and metabolism and delineating the importance of epigenetic enzymes in nuclear receptors signaling. This book discusses in detail the current trends in epigenetic therapy in cancer, epigenetic modifications and neurological disorders and epigenetic mechanisms in inflammation. A valuable guide for researchers and students interested in epigenetic pharmacology, this book provides new insight into the emerging role of

Cancer Epigenetics

Cancer Epigenetics
  • Author : Antonio Giordano,Marcella Macaluso
  • Publisher : John Wiley & Sons
  • Release : 07 October 2011
GET THIS BOOK Cancer Epigenetics

Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.

Cancer Epigenetics

Cancer Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : CRC Press
  • Release : 19 September 2008
GET THIS BOOK Cancer Epigenetics

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are

Pharmacoepigenetics

Pharmacoepigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 04 June 2019
GET THIS BOOK Pharmacoepigenetics

Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the

Epigenetic Therapy of Cancer

Epigenetic Therapy of Cancer
  • Author : Michael Lübbert,Peter A. Jones
  • Publisher : Springer Science & Business Media
  • Release : 12 December 2013
GET THIS BOOK Epigenetic Therapy of Cancer

The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the

Frontiers in Anti Cancer Drug Discovery Volume 10

Frontiers in Anti Cancer Drug Discovery Volume 10
  • Author : Atta-ur-Rahman ,M. Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release : 31 May 2019
GET THIS BOOK Frontiers in Anti Cancer Drug Discovery Volume 10

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry,in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The

Epigenetics and Disease

Epigenetics and Disease
  • Author : Susan M. Gasser,En Li
  • Publisher : Springer Science & Business Media
  • Release : 17 October 2010
GET THIS BOOK Epigenetics and Disease

Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and

Gynecological Cancers

Gynecological Cancers
  • Author : Antonio Giordano,Marcella Macaluso
  • Publisher : Springer
  • Release : 12 July 2016
GET THIS BOOK Gynecological Cancers

Facilitating the collaboration between the basic, translational, and clinical sciences, this book provides an overview of the genetic and epigenetic mechanisms underlying the formation and progression of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development gathers all of the molecular and cellular aspects of gynecological cancer together within one volume, providing detailed and up-to-date information on the etiology, diagnosis, and treatment of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development ​also discusses the racial

Epigenetic Targets in Drug Discovery

Epigenetic Targets in Drug Discovery
  • Author : Wolfgang Sippl,Manfred Jung
  • Publisher : Wiley-VCH
  • Release : 03 August 2009
GET THIS BOOK Epigenetic Targets in Drug Discovery

Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.

Cell Press Reviews Cancer Therapeutics

Cell Press Reviews  Cancer Therapeutics
  • Author : Cell Press
  • Publisher : Elsevier
  • Release : 10 December 2013
GET THIS BOOK Cell Press Reviews Cancer Therapeutics

Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including: Genetic approaches for personal oncology Targeting epigenetic dysregulation and protein interaction networks Vaccines and antibodies in cancer immunotherapy Tumor heterogeneity and chemotherapy resistance Tumor associated macrophages in anticancer treatment Contributions