Drug Design and Discovery in Alzheimer s Disease

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  • Author : Atta-Ur-Rahman
  • Publisher : Bentham Science Publishers
  • Pages : 784 pages
  • ISBN : 9780128039595
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Drug Design and Discovery in Alzheimer s Disease

Download or Read online Drug Design and Discovery in Alzheimer s Disease full in PDF, ePub and kindle. this book written by Atta-Ur-Rahman and published by Bentham Science Publishers which was released on 02 June 2015 with total page 784 pages. We cannot guarantee that Drug Design and Discovery in Alzheimer s Disease book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer's disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Drug Design and Discovery in Alzheimer s Disease

Drug Design and Discovery in Alzheimer s Disease
  • Author : Atta-Ur-Rahman,Muhammad Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release : 02 June 2015
GET THIS BOOK Drug Design and Discovery in Alzheimer s Disease

Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning

Drug Design and Discovery in Alzheimer s Disease

Drug Design and Discovery in Alzheimer   s Disease
  • Author : Atta-ur-Rahman,Muhammad Iqbal Choudhary
  • Publisher : Elsevier
  • Release : 27 June 2015
GET THIS BOOK Drug Design and Discovery in Alzheimer s Disease

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery.

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
  • Author : Adeboye Adejare
  • Publisher : Academic Press
  • Release : 20 September 2016
GET THIS BOOK Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies,

Frontiers in CNS Drug Discovery

Frontiers in CNS Drug Discovery
  • Author : Atta-ur- Rahman,M. Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release : 19 December 2017
GET THIS BOOK Frontiers in CNS Drug Discovery

Frontiers in CNS Drug Discovery is a book series devoted to publishing reviews which highlight the latest advances in drug design and discovery for disorders of the central nervous system (CNS). Eminent scientists write contributions on all areas of CNS drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series is essential reading for all pharmaceutical scientists involved in CNS drug design and discovery

BACE

BACE
  • Author : Varghese John
  • Publisher : John Wiley & Sons
  • Release : 15 March 2010
GET THIS BOOK BACE

BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book

Imaging in CNS Drug Discovery and Development

Imaging in CNS Drug Discovery and Development
  • Author : David Borsook,Lino R. Beccera,Edward Bullmore,Richard J. Hargreaves
  • Publisher : Springer Science & Business Media
  • Release : 10 March 2010
GET THIS BOOK Imaging in CNS Drug Discovery and Development

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and

Structure Based Drug Design for Diagnosis and Treatment of Neurological Diseases

Structure Based Drug Design for Diagnosis and Treatment of Neurological Diseases
  • Author : Rona R. Ramsay,Giuseppe Di Giovanni
  • Publisher : Frontiers Media SA
  • Release : 24 March 2017
GET THIS BOOK Structure Based Drug Design for Diagnosis and Treatment of Neurological Diseases

European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought

Frontiers in CNS Drug Discovery

Frontiers in CNS Drug Discovery
  • Author : Atta-ur Rahman,M. Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release : 12 August 2011
GET THIS BOOK Frontiers in CNS Drug Discovery

"Frontiers in CNS Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design an

Design of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development
  • Author : Michael Decker
  • Publisher : Elsevier
  • Release : 05 April 2017
GET THIS BOOK Design of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of

Computational Approaches for Identifying Drugs Against Alzheimer s Disease

Computational Approaches for Identifying Drugs Against Alzheimer s Disease
  • Author : Radha Mahendran,Suganya Jeyabaskar,Astral Gabriella Francis
  • Publisher : Anchor Academic Publishing
  • Release : 01 May 2017
GET THIS BOOK Computational Approaches for Identifying Drugs Against Alzheimer s Disease

Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling

Molecular Insight of Drug Design

Molecular Insight of Drug Design
  • Author : Arli Aditya Parikesit
  • Publisher : BoD – Books on Demand
  • Release : 29 August 2018
GET THIS BOOK Molecular Insight of Drug Design

The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism,

Drug Design Principles and Applications

Drug Design  Principles and Applications
  • Author : Abhinav Grover
  • Publisher : Springer
  • Release : 09 August 2017
GET THIS BOOK Drug Design Principles and Applications

This book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary application of drug-designing methodologies to inspire others to further expand the utility of this field in other diseases.It is intended for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in bioinformatics, computational biology, medicine, pharmaceutics and other related fields.

Frontiers in Anti Infective Drug Discovery

Frontiers in Anti Infective Drug Discovery
  • Author : Atta -ur- Rahman,M. Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release : 11 August 2017
GET THIS BOOK Frontiers in Anti Infective Drug Discovery

This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships.

Blood Brain Barrier in Drug Discovery

Blood Brain Barrier in Drug Discovery
  • Author : Li Di,Edward H. Kerns
  • Publisher : John Wiley & Sons
  • Release : 02 February 2015
GET THIS BOOK Blood Brain Barrier in Drug Discovery

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design