Drug Biomembrane Interaction Studies

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  • Author : Rosario Pignatello
  • Publisher : Elsevier
  • Pages : 440 pages
  • ISBN : 1908818344
  • Rating : /5 from reviews
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Download or Read online Drug Biomembrane Interaction Studies full in PDF, ePub and kindle. this book written by Rosario Pignatello and published by Elsevier which was released on 31 October 2013 with total page 440 pages. We cannot guarantee that Drug Biomembrane Interaction Studies book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material. Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions. Summarizes and updates the recent development in a unique handbook format Consists of a combination of scientific updates within the field Contains chapters written by some of the highest-level experts in the field of DSC

Drug Biomembrane Interaction Studies

Drug Biomembrane Interaction Studies
  • Author : Rosario Pignatello
  • Publisher : Elsevier
  • Release : 31 October 2013
GET THIS BOOK Drug Biomembrane Interaction Studies

The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
  • Author : C. Carbone,R. Pignatello
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOK Drug biomembrane interaction studies

Interest in using DSC to study the interaction between different compounds and biomembrane models has increased in the last 20years. This is confirmed by the number of published research studies concerning the feasibility of investigating the behavior of different molecules, such as local anesthetics, anticancer drugs, anti-inflammatory drugs, antioxidants, antibiotics, peptides, proteins, polymers, surfactants, genetic materials, macromolecules, and also drug delivery systems (DDSs). This chapter provides a general consideration of the current applications of DSC in evaluating the interaction of

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
  • Author : M. Grazia Sarpietro,F. Castelli
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOK Drug biomembrane interaction studies

This chapter describes a method for evaluating the release of a drug by different delivery systems to biomembrane models made of multilamellar and unilamellar vesicles, using DSC techniques. First, different delivery systems as well as biomembrane models are described followed by a detailed description of the experimental protocols that are the basis of the technique. A drug-loaded delivery system is incubated with the biomembrane model and drug release is evaluated by considering the effect of the drug on the biomembrane’

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
  • Author : R. Pignatello
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOK Drug biomembrane interaction studies

DSC studies of the interaction between drugs or other biologically active compounds with biomembrane models has often been associated or integrated with other analytical methodologies. The information gained from various techniques can depict the different and complex elements that compose such interactions. This chapter will summarize some recent examples of successfully combining DSC with other physico-chemical methods, such as spectroscopy, chromatography, calorimetry, the Langmuir–Blodgett film technique and microscopy.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
  • Author : T. Musumeci,G. Puglisi
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOK Drug biomembrane interaction studies

Antimicrobial agents are from different classes of molecules that suppress multiplication and growth of or kill microorganisms such as bacteria, fungi, or viruses. The precise mechanism of action of some antimicrobial agents is unknown but they must interact with or cross the cell membrane to have an effect. Identification of the damage induced by these compounds is difficult due to the complexity of cell membranes. Studying interactions using membrane models is a first step in obtaining elementary information about the

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
  • Author : M.H. Chiu,N.S. Berezowski,E.J. Prenner
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOK Drug biomembrane interaction studies

DSC is a straightforward, non-perturbing thermodynamic technique first developed in the early 1960s. The large number of parameters and the high sensitivity has made DSC one of the key calorimetric tools used for investigating thermodynamic properties of biopolymers, proteins, peptides and nucleic acids. There are numerous reviews covering the different macromolecular applications of DSC: this chapter will primarily focus on proteins and nucleic acids.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
  • Author : S. Giatrellis,G. Nounesis
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOK Drug biomembrane interaction studies

DSC is a non-invasive experimental technique, which, besides other numerous applications, has been extensively applied in investigating the thermodynamic properties of synthetic and biological membranes. The calorimetric profiles of phase transitions of self-organized lipid membranes can provide valuable information about membrane interactions with biomolecules, pharmaceutical agents, other membranes, etc. The scope of this chapter is to review specific applications of DSC in studying membrane– nucleic acid interactions, which have attracted scientific attention for their biological relevance, as well as for

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
  • Author : A. Wiśniewska-Becker,W.I. Gruszecki
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOK Drug biomembrane interaction studies

Biological membranes consisting of two main components, lipids and proteins, have many important functions in cells. Membrane structure, physical and chemical properties of lipids and proteins, and interactions between them determine membrane functions such as the barrier separating a cell from its environment, selective transport, cell recognition, signalling and compartmentalization of cellular processes. To investigate membrane structure and dynamics, and the interactions between membrane components on a molecular level, simplified artificial models of biological membranes have been developed. Various biophysical

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
  • Author : A. Raudino,M.G. Sarpietro,M. Pannuzzo
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOK Drug biomembrane interaction studies

In this chapter we briefly introduce the main physical principles of DSC as well as related techniques. After a quick survey of the more common experimental techniques, we describe the thermodynamics and kinetics of events accompanying a heating/cooling process. We focus on lipid membranes of one or more components. Both the thermotropic and the barotropic behaviours are investigated, as well as the water/lipid ratio. The effect of foreign impurities (hydrophobic molecules, proteins) dissolved in the lipid matrix on

Drug Membrane Interactions

Drug Membrane Interactions
  • Author : Joachim K. Seydel,Michael Wiese
  • Publisher : Wiley-VCH
  • Release : 10 July 2009
GET THIS BOOK Drug Membrane Interactions

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided

Biomimetic Lipid Membranes Fundamentals Applications and Commercialization

Biomimetic Lipid Membranes  Fundamentals  Applications  and Commercialization
  • Author : Fatma N. Kök,Ahu Arslan Yildiz,Fatih Inci
  • Publisher : Springer
  • Release : 16 April 2019
GET THIS BOOK Biomimetic Lipid Membranes Fundamentals Applications and Commercialization

This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research

Drug Membrane Interactions

Drug Membrane Interactions
  • Author : Joachim K. Seydel,Michael Wiese
  • Publisher : John Wiley & Sons
  • Release : 10 July 2009
GET THIS BOOK Drug Membrane Interactions

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided

Soft Matter Systems for Biomedical Applications

Soft Matter Systems for Biomedical Applications
  • Author : Leonid Bulavin,Nikolai Lebovka
  • Publisher : Springer Nature
  • Release : 27 September 2021
GET THIS BOOK Soft Matter Systems for Biomedical Applications

This book addresses new challenges in soft matter and colloids. It presents timely reports on colloidal self-assembly, soft matters from liquid crystals, nanoparticles in liquid crystals, hydrocolloids, hybrid nanosystems, nanosuspensions, and dispersion of nanoparticles in different media, soft matter processing and modern experiments related with soft matters.

Ideas in Chemistry and Molecular Sciences

Ideas in Chemistry and Molecular Sciences
  • Author : Bruno Pignataro
  • Publisher : John Wiley & Sons
  • Release : 16 April 2010
GET THIS BOOK Ideas in Chemistry and Molecular Sciences

Ideas in Chemistry and Molecular Sciences gives an account of the most recent results of research in life sciences in Europe based on a selection of leading young scientists participating in the 2008 European Young Chemists Award competition. In addition to this, the authors provide the state of the art of their field of research and the perspective or preview of future directions.

Advances in Biomembranes and Lipid Self Assembly

Advances in Biomembranes and Lipid Self Assembly
  • Author : Ales Iglic,Michael Rappolt,Patricia Losada Perez
  • Publisher : Academic Press
  • Release : 15 June 2022
GET THIS BOOK Advances in Biomembranes and Lipid Self Assembly

Advances in Biomembranes and Lipid Self-Assembly, Volume 35, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for the study of cell membranes, lipid model membranes and lipid self-assemblies, from the micro- to the nanoscale. As planar lipid bilayers are widely studied due to their ubiquity in nature, this book presents research on their application in the formulation of biomimetic model membranes, and in the design of artificial dispersion of liposomes. Chapters cover Physical properties of SOPC