Drug Biomembrane Interaction Studies

• Author : Rosario Pignatello
• Publisher : Elsevier
• Release : 31 October 2013

The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC

• Author : M.H. Chiu,N.S. Berezowski,E.J. Prenner
• Publisher : Elsevier Inc. Chapters
• Release : 31 October 2013

DSC is a straightforward, non-perturbing thermodynamic technique first developed in the early 1960s. The large number of parameters and the high sensitivity has made DSC one of the key calorimetric tools used for investigating thermodynamic properties of biopolymers, proteins, peptides and nucleic acids. There are numerous reviews covering the different macromolecular applications of DSC: this chapter will primarily focus on proteins and nucleic acids.

• Author : C. Carbone,R. Pignatello
• Publisher : Elsevier Inc. Chapters
• Release : 31 October 2013

Interest in using DSC to study the interaction between different compounds and biomembrane models has increased in the last 20years. This is confirmed by the number of published research studies concerning the feasibility of investigating the behavior of different molecules, such as local anesthetics, anticancer drugs, anti-inflammatory drugs, antioxidants, antibiotics, peptides, proteins, polymers, surfactants, genetic materials, macromolecules, and also drug delivery systems (DDSs). This chapter provides a general consideration of the current applications of DSC in evaluating the interaction of

• Author : R. Pignatello
• Publisher : Elsevier Inc. Chapters
• Release : 31 October 2013

DSC studies of the interaction between drugs or other biologically active compounds with biomembrane models has often been associated or integrated with other analytical methodologies. The information gained from various techniques can depict the different and complex elements that compose such interactions. This chapter will summarize some recent examples of successfully combining DSC with other physico-chemical methods, such as spectroscopy, chromatography, calorimetry, the Langmuir–Blodgett film technique and microscopy.

• Author : M. Grazia Sarpietro,F. Castelli
• Publisher : Elsevier Inc. Chapters
• Release : 31 October 2013

This chapter describes a method for evaluating the release of a drug by different delivery systems to biomembrane models made of multilamellar and unilamellar vesicles, using DSC techniques. First, different delivery systems as well as biomembrane models are described followed by a detailed description of the experimental protocols that are the basis of the technique. A drug-loaded delivery system is incubated with the biomembrane model and drug release is evaluated by considering the effect of the drug on the biomembrane’

• Author : Anonim
• Publisher : Unknown
• Release : 12 May 1994

• Author : Alex Dopico
• Publisher : Springer Science & Business Media
• Release : 30 August 2007

This book presents a compendium of methodologies for the study of membrane lipids, varying from traditional lab bench experimentation to computer simulation and theoretical models. The volume provides a comprehensive set of techniques for studying membrane lipids with a strong biophysical emphasis. It compares the various available techniques including the pros and cons as seen by the experts.

• Author : Indra K. Varma,A. C. Momin
• Publisher : Unknown
• Release : 12 May 1989

• Author : S.P. Gupta
• Publisher : Springer Verlag
• Release : 22 June 2006

• Author : Anonim
• Publisher : Unknown
• Release : 12 May 1982

• Author : Charles William Sharp,Leo G. Abood
• Publisher : Unknown
• Release : 12 May 1979

• Author : Anonim
• Publisher : Unknown
• Release : 12 May 1974

• Author : Anonim
• Publisher : Unknown
• Release : 12 May 1987

• Author : Henry H. Mantsch,Dennis Chapman
• Publisher : Wiley-Liss
• Release : 01 March 1996

Infrared Spectroscopy of Biomolecules Edited by Henry H. Mantsch and Dennis Chapman Dramatic new advances in the application of infrared spectroscopy to biomolecules and instrumentation are revolutionizing this branch of molecular spectroscopy. Infrared Spectroscopy of Biomolecules provides an up-to-date, detailed look at the different spectroscopic techniques now available and offers a framework for progression in the field, including the evolution of Fourier transform methods, the development of time-resolved techniques and difference spectroscopy, as well as new modulation methods. The book

• Author : James M. Anderson,Sung Wan Kim
• Publisher : Elsevier Science Limited
• Release : 12 May 1987