Domino Reactions in Drug Discovery

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  • Author : Shanta Bhar
  • Publisher : Elsevier
  • Pages : 315 pages
  • ISBN : 9780128193747
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Domino Reactions in Drug Discovery

Download or Read online Domino Reactions in Drug Discovery full in PDF, ePub and kindle. this book written by Shanta Bhar and published by Elsevier which was released on 01 October 2020 with total page 315 pages. We cannot guarantee that Domino Reactions in Drug Discovery book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors. Features illustrated schemes with mechanisms, procedures and results Includes a compendium of Domino Name Reactions for drugs Provides a concise, comprehensive coverage of domino reactions in drug discovery, with a focus on sustainable practices

Domino Reactions in Drug Discovery

Domino Reactions in Drug Discovery
  • Author : Shanta Bhar
  • Publisher : Elsevier
  • Release : 01 October 2020
GET THIS BOOK Domino Reactions in Drug Discovery

Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at

Multicomponent Reactions

Multicomponent Reactions
  • Author : Jieping Zhu,Hugues Bienaymé
  • Publisher : John Wiley & Sons
  • Release : 06 March 2006
GET THIS BOOK Multicomponent Reactions

In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic

Domino Reactions

Domino Reactions
  • Author : Lutz F. Tietze
  • Publisher : John Wiley & Sons
  • Release : 23 December 2013
GET THIS BOOK Domino Reactions

The follow-up to the successful "Domino Reaction in Organic Synthesis", this ready reference brings up to date on the original concept. The chapters have been arranged according to the name of well-known transformations of the first step and in combination with the formed products. Each chapter is written by an internationally renowned expert, and the book is edited by L. F. Tietze, who established the concept of domino reactions. The one-stop source for all synthetic chemists to improve the synthetic

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
  • Author : Carmen Avendano,J. Carlos Menendez
  • Publisher : Elsevier
  • Release : 11 June 2015
GET THIS BOOK Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a

Catalytic Cascade Reactions

Catalytic Cascade Reactions
  • Author : Peng-Fei Xu,Wei Wang
  • Publisher : John Wiley & Sons
  • Release : 02 October 2013
GET THIS BOOK Catalytic Cascade Reactions

Demonstrates the advantages of catalytic cascade reactionsfor synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactionshave become one of the most active research areas in organicsynthesis. During a cascade reaction, just one reaction solvent,one workup procedure, and one purification step are needed, thussignificantly increasing synthetic efficiency. Featuring contributions from an international team of pioneersin the field, Catalytic Cascade Reactions demonstrates theversatility and application of these reactions for synthesizingvaluable compounds. The book examines both organocatalysis

Synthesis of Heterocycles via Multicomponent Reactions II

Synthesis of Heterocycles via Multicomponent Reactions II
  • Author : Romano V. A. Orru,Eelco Ruijter
  • Publisher : Springer
  • Release : 26 July 2010
GET THIS BOOK Synthesis of Heterocycles via Multicomponent Reactions II

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis
  • Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
  • Publisher : John Wiley & Sons
  • Release : 13 December 2006
GET THIS BOOK Domino Reactions in Organic Synthesis

Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release : 07 March 2018
GET THIS BOOK Privileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—

Asymmetric Domino Reactions

Asymmetric Domino Reactions
  • Author : Helene Pellissier
  • Publisher : Royal Society of Chemistry
  • Release : 13 March 2013
GET THIS BOOK Asymmetric Domino Reactions

This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of

Small Molecule Drug Discovery

Small Molecule Drug Discovery
  • Author : Andrea Trabocchi,Elena Lenci
  • Publisher : Elsevier
  • Release : 23 November 2019
GET THIS BOOK Small Molecule Drug Discovery

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The

Diversity Oriented Synthesis

Diversity Oriented Synthesis
  • Author : Andrea Trabocchi
  • Publisher : John Wiley & Sons
  • Release : 17 June 2013
GET THIS BOOK Diversity Oriented Synthesis

Discover an enhanced synthetic approach to developing andscreening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developinglarge collections of structurally diverse small molecules as probesto investigate biological pathways. This book presents the mosteffective methods in diversity-oriented synthesis for creatingsmall molecule collections. It offers tested and proven strategiesfor developing diversity-oriented synthetic libraries and screeningmethods for identifying ligands. Lastly, it explores some promisingnew applications based on diversity-oriented synthesis that havethe potential to dramatically advance studies in drug discovery andchemical biology.

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience
  • Author : Zbigniew J. Witczak,Roman Bielski
  • Publisher : John Wiley & Sons
  • Release : 14 January 2016
GET THIS BOOK Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

The book consists of a brief introduction, a foreward provided byprofessor Danishefsky of Columbia University, and about 14 –16 chapters, each written by one or two eminent scholars/authorsdescribing their recent research in the area of either dominoreactions or intramolecular rearrangements in carbohydratechemistry. Three or four chapters will be reviews. The domino (cascade, tandem)reactions are always intramolecular. They are usually very fast,clean and offer highly complex structures in a one pot process.Intramolecular rearrangements offer very similar advantages andoften lead

Drug Discovery and Development

Drug Discovery and Development
  • Author : Ramarao Poduri
  • Publisher : Springer Nature
  • Release : 18 January 2022
GET THIS BOOK Drug Discovery and Development

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable