DNA Repair in Cancer Therapy

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  • Author : Mark R. Kelley
  • Publisher : Academic Press
  • Pages : 464 pages
  • ISBN : 0128035994
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>DNA Repair in Cancer Therapy

Download or Read online DNA Repair in Cancer Therapy full in PDF, ePub and kindle. this book written by Mark R. Kelley and published by Academic Press which was released on 07 June 2016 with total page 464 pages. We cannot guarantee that DNA Repair in Cancer Therapy book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy
  • Author : Mark R. Kelley,Melissa L. Fishel
  • Publisher : Academic Press
  • Release : 07 June 2016
GET THIS BOOK DNA Repair in Cancer Therapy

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the

Advances in DNA Repair in Cancer Therapy

Advances in DNA Repair in Cancer Therapy
  • Author : Lawrence Panasci,Raquel Aloyz,Moulay Alaoui-Jamali
  • Publisher : Springer Science & Business Media
  • Release : 09 December 2012
GET THIS BOOK Advances in DNA Repair in Cancer Therapy

​A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy
  • Author : Lawrence C. Panasci,Moulay A. Alaoui-Jamali
  • Publisher : Springer Science & Business Media
  • Release : 19 March 2004
GET THIS BOOK DNA Repair in Cancer Therapy

A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book

DNA Repair and Cancer

DNA Repair and Cancer
  • Author : Srinivasan Madhusudan,David M. Wilson III
  • Publisher : CRC Press
  • Release : 22 January 2013
GET THIS BOOK DNA Repair and Cancer

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators,

Targeting the DNA Damage Response for Anti Cancer Therapy

Targeting the DNA Damage Response for Anti Cancer Therapy
  • Author : John Pollard,Nicola Curtin
  • Publisher : Springer
  • Release : 26 May 2018
GET THIS BOOK Targeting the DNA Damage Response for Anti Cancer Therapy

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such

PARP Inhibitors for Cancer Therapy

PARP Inhibitors for Cancer Therapy
  • Author : Nicola J. Curtin,Ricky A. Sharma
  • Publisher : Humana Press
  • Release : 13 June 2015
GET THIS BOOK PARP Inhibitors for Cancer Therapy

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are

Cancer Associated Defects in the DNA Damage Response Drivers for Malignant Transformation and Potential Therapeutic Targets

Cancer Associated Defects in the DNA Damage Response  Drivers for Malignant Transformation and Potential Therapeutic Targets
  • Author : Marcel van Vugt,H. Christian Reinhardt
  • Publisher : Frontiers Media SA
  • Release : 17 October 2016
GET THIS BOOK Cancer Associated Defects in the DNA Damage Response Drivers for Malignant Transformation and Potential Therapeutic Targets

For this eBook, and the associated Research Topic in Frontiers in Genetics, entitled: ‘Cancer-associated defects in the DNA damage response: drivers for malignant transformation and potential therapeutic targets’ we have selected 10 papers that each discusses important, yet distinct aspects of the response to DNA damage in normal cells and cancer cells. Using an evolutionary conserved signaling network called the ‘DNA damage response (DDR)’ cells maintain the integrity of their genome, and thus safeguard cellular functioning and the ability to create

System Biology Analysis of the Role of DNA Repair in Cancer Treatment Outcome

System Biology Analysis of the Role of DNA Repair in Cancer Treatment Outcome
  • Author : Mengdi Qian
  • Publisher : Unknown
  • Release : 21 May 2022
GET THIS BOOK System Biology Analysis of the Role of DNA Repair in Cancer Treatment Outcome

Cancer is one of the most lethal and hard to cure diseases. The common treatments for cancer include surgery, radiation therapy, chemotherapy, immunotherapy and hormone therapy. Ionizing radiation (IR) is one of the main clinical treatments for cancer and it works by inducing DNA double strand breaks (DSBs), which are the most toxic DNA lesions that lead to cell death. The effectiveness of IR treatment depends on the amount of induced damage and the DNA damage repair status of the

DNA Repair Genetic Instability and Cancer

DNA Repair  Genetic Instability  and Cancer
  • Author : Qingyi Wei,Dr. Lei Li,Dr. David Chen
  • Publisher : World Scientific
  • Release : 21 May 2022
GET THIS BOOK DNA Repair Genetic Instability and Cancer

This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy
  • Author : Mark R. Kelley
  • Publisher : Academic Press
  • Release : 20 October 2011
GET THIS BOOK DNA Repair in Cancer Therapy

Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus. Additionally, increasing discussion and research is centering on