DNA Methylation and Complex Human Disease

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  • Author : Michel Neidhart
  • Publisher : Academic Press
  • Pages : 552 pages
  • ISBN : 0127999205
  • Rating : /5 from reviews
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Download or Read online DNA Methylation and Complex Human Disease full in PDF, ePub and kindle. this book written by Michel Neidhart and published by Academic Press which was released on 11 August 2015 with total page 552 pages. We cannot guarantee that DNA Methylation and Complex Human Disease book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease
  • Author : Michel Neidhart
  • Publisher : Academic Press
  • Release : 11 August 2015
GET THIS BOOK DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as

Epigenetics in Human Disease

Epigenetics in Human Disease
  • Author : Trygve O. Tollefsbol
  • Publisher : Academic Press
  • Release : 19 June 2021
GET THIS BOOK Epigenetics in Human Disease

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable,

Epigenetics and Complex Traits

Epigenetics and Complex Traits
  • Author : Anna K. Naumova,Celia M.T. Greenwood
  • Publisher : Springer Science & Business Media
  • Release : 17 September 2013
GET THIS BOOK Epigenetics and Complex Traits

This book will provide an overview of basic epigenetic phenomena; interaction between epigenetic and genetic factors; and the influence of epigenetic factors on inheritance. Epigenetic states may contribute to the penetrance of genetic polymorphisms or mutations and thereby modify inheritance patterns. This may result in non‐Mendelian inheritance of genetic traits such as observed in common human disease. The relationship between epigenetics and genetics, however, has not been comprehensively summarized yet. The topic is being more and more appreciated lately

Mitochondrial Diseases

Mitochondrial Diseases
  • Author : Eylem Taskin,Celal Guven,Yusuf Sevgiler
  • Publisher : BoD – Books on Demand
  • Release : 29 August 2018
GET THIS BOOK Mitochondrial Diseases

Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such

Beyond Our Genes

Beyond Our Genes
  • Author : Raffaele Teperino
  • Publisher : Springer Nature
  • Release : 24 January 2020
GET THIS BOOK Beyond Our Genes

The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has

Non coding RNAs in Complex Diseases

Non coding RNAs in Complex Diseases
  • Author : Xia Li,Juan Xu,Yun Xiao,Shangwei Ning,Yunpeng Zhang
  • Publisher : Springer
  • Release : 06 September 2018
GET THIS BOOK Non coding RNAs in Complex Diseases

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across

Epigenetic Approaches in Drug Discovery Development and Treatment

Epigenetic Approaches in Drug Discovery  Development and Treatment
  • Author : Shibashish Giri,Chandravanu Dash
  • Publisher : Frontiers Media SA
  • Release : 07 August 2020
GET THIS BOOK Epigenetic Approaches in Drug Discovery Development and Treatment

Establishment of a normal phenotype involves dynamic epigenetic regulation of gene expression that when affected contributes to human diseases. On a molecular level, epigenetic regulation is marked by specific covalent modifications (acetylation, methylation, phosphorylation, sumoylation, PARylation and ubiquitylation) of DNA and its associated histones. Studies also suggest the influence of such epigenetic modifications on non-coding RNA expression implicated in normal and diseased phenotypes. Epigenetic control of genetic expression is a reversible process essential for normal development and function of an

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease
  • Author : Randy L. Jirtle,Frederick L. Tyson
  • Publisher : Springer Science & Business Media
  • Release : 13 May 2013
GET THIS BOOK Environmental Epigenomics in Health and Disease

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem

Stress Genetics Epigenetics and Genomics

Stress  Genetics  Epigenetics and Genomics
  • Author : George Fink
  • Publisher : Academic Press
  • Release : 24 October 2020
GET THIS BOOK Stress Genetics Epigenetics and Genomics

This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases. The Handbook of Stress

Human Epigenomics

Human Epigenomics
  • Author : Carsten Carlberg,Ferdinand Molnár
  • Publisher : Springer
  • Release : 01 February 2018
GET THIS BOOK Human Epigenomics

The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the

The Use of DNA Methylation Assays for Epidemiological Studies

The Use of DNA Methylation Assays for Epidemiological Studies
  • Author : Florence Katharine Crary-Dooley
  • Publisher : Unknown
  • Release : 19 June 2021
GET THIS BOOK The Use of DNA Methylation Assays for Epidemiological Studies

DNA methylation is an epigenetic mark at the interface of genetic and environmental factors relevant to human disease. Quantitative assessments of gene specific and global DNA methylation levels are thus important tools in epidemiology research, particularly for understanding the effects of environmental exposures in complex diseases. Among the available methods of quantitative DNA methylation measurements, bisulfite sequencing is considered the gold standard, but whole genome bisulfite sequencing (WGBS) has previously been considered too costly for epidemiology studies with large sample

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Leonid Padyukov
  • Publisher : Academic Press
  • Release : 28 September 2013
GET THIS BOOK Between the Lines of Genetic Code

Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current

Dynamic regulation of DNA methylation in human T cell biology

Dynamic regulation of DNA methylation in human T cell biology
  • Author : Antonio Lentini
  • Publisher : Linköping University Electronic Press
  • Release : 19 March 2019
GET THIS BOOK Dynamic regulation of DNA methylation in human T cell biology

T helper cells play a central role in orchestrating immune responses in humans. Upon encountering a foreign antigen, T helper cells are activated followed by a differentiation process where the cells are specialised to help combating the infection. Dysregulation of T helper cell activation, differentiation and function has been implicated in numerous diseases, including autoimmunity and cancer. Whereas gene-regulatory networks help drive T-cell differentiation, acquisition of stable cell states require heritable epigenetic signals, such as DNA methylation. Indeed, the establishment

Patho Epigenetics of Disease

Patho Epigenetics of Disease
  • Author : Janos Minarovits,Hans Helmut Niller
  • Publisher : Springer Science & Business Media
  • Release : 14 June 2012
GET THIS BOOK Patho Epigenetics of Disease

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance

Pathobiology of Human Disease

Pathobiology of Human Disease
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 01 August 2014
GET THIS BOOK Pathobiology of Human Disease

Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human Organ Systems Molecular Pathology/Basic Mechanisms of Diseases Animal Models/Other Model Systems Experimental Pathology Clinical Pathology Each article provides a