Direct Nose to Brain Drug Delivery

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  • Author : Chandrakantsing Pardeshi
  • Publisher : Academic Press
  • Pages : 554 pages
  • ISBN : 0128225238
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Direct Nose to Brain Drug Delivery

Download or Read online Direct Nose to Brain Drug Delivery full in PDF, ePub and kindle. this book written by Chandrakantsing Pardeshi and published by Academic Press which was released on 16 June 2021 with total page 554 pages. We cannot guarantee that Direct Nose to Brain Drug Delivery book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals

Direct Nose to Brain Drug Delivery

Direct Nose to Brain Drug Delivery
  • Author : Chandrakantsing Pardeshi,Eliana Souto
  • Publisher : Academic Press
  • Release : 16 June 2021
GET THIS BOOK Direct Nose to Brain Drug Delivery

Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal

The Development and Application of Biological Models for Evaluation of Direct Nose to brain Drug Delivery Systems

The Development and Application of Biological Models for Evaluation of Direct Nose to brain Drug Delivery Systems
  • Author : Alpesh Mistry
  • Publisher : Unknown
  • Release : 22 January 2022
GET THIS BOOK The Development and Application of Biological Models for Evaluation of Direct Nose to brain Drug Delivery Systems

The olfactory neuroepithelium is the only part of the central nervous system that is exposed directly to the external environment. Therefore, it is the only non-invasive drug delivery route to the brain. Surface modification of PS nanoparticles with chitosan (C-PS), polysorbate 80 (P80-PS) and polysorbate 80+FCS (P80-FCS-PS) changed the toxicity and distribution of these nanoparticles in olfactory mucosae. In addition, a reduction in nanoparticle diameter from 200nm to 20nm increased nanoparticle mucosal penetration and possibly also their cellular toxicity.

Nasal Drug Delivery

Nasal Drug Delivery
  • Author : Mascha van den Berg
  • Publisher : Unknown
  • Release : 22 January 2022
GET THIS BOOK Nasal Drug Delivery

With the growing number of patients suffering from central nervous system (CNS) diseases a suitable approach for drug targeting to the brain becomes more and more important. This is a major problem in drug delivery research, due to the tight blood-brain barrier (BBB) that prevents the influx of xenobiotic compounds including drugs from the systemic circulation into the brain. The olfactory neurons, that allow humans and other species to smell, connect the brain and surrounding cerebrospinal fluid (CSF) with the

Numerical Simulation and Experimental Testing to Improve Olfactory Drug Delivery with Electric Field Guidance of Charged Particles

Numerical Simulation and Experimental Testing to Improve Olfactory Drug Delivery with Electric Field Guidance of Charged Particles
  • Author : Jinxiang Xi
  • Publisher : Unknown
  • Release : 22 January 2022
GET THIS BOOK Numerical Simulation and Experimental Testing to Improve Olfactory Drug Delivery with Electric Field Guidance of Charged Particles

Even though the direct nose-to-brain drug delivery has many clinical benefits, there are limited successes in delivering medication aerosols to the olfactory mucosa with standard inhalation devices. In this study, different delivery techniques were assessed in terms of their capacities to deliver drug aerosols to the olfactory epithelium. Specifically, the feasibility of electric field guidance of charged aerosols to the olfactory mucosa was evaluated in an image-based nose model both numerically and experimentally. Multi-sectional nasal cast replicas were fabricated using

Enhanced Intranasal Delivery of Gemcitabine to the Central Nervous System

Enhanced Intranasal Delivery of Gemcitabine to the Central Nervous System
  • Author : Mansi Krishan
  • Publisher : Unknown
  • Release : 22 January 2022
GET THIS BOOK Enhanced Intranasal Delivery of Gemcitabine to the Central Nervous System

Drug transport to the brain for the treatment of neurological diseases is a challenge due to impenetrable nature of the blood brain barrier (BBB). Intranasal (IN) drug administration is a non-invasive approach for rapid direct drug delivery from the nose to the central nervous system (CNS), thereby minimizing systemic exposure. The current study focuses on a strategy to enhance the delivery of the nucleoside drug gemcitabine (GEM) to the CNS via IN administration. Our approach took advantage of the fact

Nanoengineering of Biomaterials

Nanoengineering of Biomaterials
  • Author : Sougata Jana,Subrata Jana
  • Publisher : John Wiley & Sons
  • Release : 28 December 2021
GET THIS BOOK Nanoengineering of Biomaterials

A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for

Drug Delivery Systems

Drug Delivery Systems
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 23 October 2019
GET THIS BOOK Drug Delivery Systems

Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery

Drug Transporters in the Nasal Epithelia and Their Contribution in Drug Delivery

Drug Transporters in the Nasal Epithelia and Their Contribution in Drug Delivery
  • Author : Manar I. Al-Ghabeish
  • Publisher : Unknown
  • Release : 22 January 2022
GET THIS BOOK Drug Transporters in the Nasal Epithelia and Their Contribution in Drug Delivery

The nasal route has primarily been used to deliver drugs for the treatment of local diseases such as nasal infections, nasal congestion and allergies. The nasal route can also be used as a non-invasive alternative route to deliver drugs systemically when a rapid onset of action and/or avoidance of hepatic metabolism are desired. Moreover, there is a growing interest in the use of this route for direct transport of drugs from the nose to the brain. Most of the

Drug Delivery to the Brain

Drug Delivery to the Brain
  • Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
  • Publisher : Springer Science & Business Media
  • Release : 03 December 2013
GET THIS BOOK Drug Delivery to the Brain

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics

Theory and Applications of Nonparenteral Nanomedicines

Theory and Applications of Nonparenteral Nanomedicines
  • Author : Prashant Kesharwani,Sebastien Taurin,Khaled Greish
  • Publisher : Academic Press
  • Release : 12 September 2020
GET THIS BOOK Theory and Applications of Nonparenteral Nanomedicines

Theory and Applications of Nonparenteral Nanomedicines presents thoroughly analysed data and results regarding the potential of nanomedicines conceived by diverse non-parenteral routes. In the context of nanotechnology-based approaches, various routes such as oral, pulmonary, transdermal, delivery and local administration of nanomedicine have been utilized for the delivery of nanomedicine. This book discusses the non-parenteral application of nanomedicine, its regulatory implications, application of mucus penetrating nanocarrier, and detailed chapters on development of nanomedicines developed for drug delivery by various route. Beginning

Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems
  • Author : Huile Gao,Xiaoling Gao
  • Publisher : Academic Press
  • Release : 20 September 2018
GET THIS BOOK Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat

Parkinson s Disease Therapeutics

Parkinson   s Disease Therapeutics
  • Author : Magisetty Obulesu
  • Publisher : Academic Press
  • Release : 30 January 2020
GET THIS BOOK Parkinson s Disease Therapeutics

Parkinson’s Disease Therapeutics: Emphasis on Nanotechnological Advances presents the latest information on the second most common neurodegenerative disorder in the elderly. Despite remarkable progress in various PD therapeutics, such as microRNAs and brain drug delivery systems, a few limitations impede their success. This book sheds light on the pros and cons of recently developed novel therapeutics. Very few books have highlighted the protective efficacy of natural products, antioxidants, and biomaterial design for other diseases. Emphasizes novel therapeutics for Parkinson’

Nanobiotechnology in Neurodegenerative Diseases

Nanobiotechnology in Neurodegenerative Diseases
  • Author : Mahendra Rai,Alka Yadav
  • Publisher : Springer Nature
  • Release : 02 December 2019
GET THIS BOOK Nanobiotechnology in Neurodegenerative Diseases

This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including