Design of Hybrid Molecules for Drug Development

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  • Author : Michael Decker
  • Publisher : Elsevier
  • Pages : 352 pages
  • ISBN : 0081011180
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Design of Hybrid Molecules for Drug Development

Download or Read online Design of Hybrid Molecules for Drug Development full in PDF, ePub and kindle. this book written by Michael Decker and published by Elsevier which was released on 05 April 2017 with total page 352 pages. We cannot guarantee that Design of Hybrid Molecules for Drug Development book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs

Design of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development
  • Author : Michael Decker
  • Publisher : Elsevier
  • Release : 05 April 2017
GET THIS BOOK Design of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery
  • Author : Jens-Uwe Peters
  • Publisher : John Wiley & Sons
  • Release : 20 January 2012
GET THIS BOOK Polypharmacology in Drug Discovery

An essential outline of the main facets of polypharmacology indrug discovery research Extending drug discovery opportunities beyond the "one drug, onetarget" philosophy, a polypharmacological approach to the treatmentof complex diseases is emerging as a hot topic in both industry andacademic research. Polypharmacology in Drug Discovery presents anoverview of the various facets of polypharmacology and how it canbe applied as an innovative concept for developing medicines fortreating bacterial infections, epilepsy, cancer, psychiatricdisorders, and more. Filled with a collection of instructive casestudies

Design Synthesis and Biological Evaluation of Selective Estrogen Receptor Modulator histone Deacetylase Inhibitor Hybrid Molecules

Design  Synthesis  and Biological Evaluation of Selective Estrogen Receptor Modulator histone Deacetylase Inhibitor Hybrid Molecules
  • Author : Anthony Palermo
  • Publisher : Unknown
  • Release : 19 June 2021
GET THIS BOOK Design Synthesis and Biological Evaluation of Selective Estrogen Receptor Modulator histone Deacetylase Inhibitor Hybrid Molecules

"Therapeutic options for the treatment of breast cancer have long been limited to invasive surgical procedures, or chemo- and radiotherapies that are plagued with detrimental side-effects. Selective estrogen receptor modulators (SERMs), such as tamoxifen and raloxifene, are a large subclass of molecules that have been used in adjuvant therapies and have provided substantial clinical benefits as preventative and long-term treatment options. Despite their success, endocrine therapies face several challenges including the development of endocrine resistance and, in the case of

Chemical Drug Design

Chemical Drug Design
  • Author : Girish Kumar Gupta,Vinod Kumar
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 10 October 2016
GET THIS BOOK Chemical Drug Design

Chemical Drug Design provides a compact overview on recent advances in this rapidly developing field. With contributions on in silico drug design, natural product based compounds, as well as on ligand- and structure-based approaches, the authors present innovative methods and techniques for identifying and synthetically designing novel drugs.

Applied Case Studies and Solutions in Molecular Docking Based Drug Design

Applied Case Studies and Solutions in Molecular Docking Based Drug Design
  • Author : Dastmalchi, Siavoush
  • Publisher : IGI Global
  • Release : 11 May 2016
GET THIS BOOK Applied Case Studies and Solutions in Molecular Docking Based Drug Design

As the pharmaceutical industry continues to advance, new techniques in drug design are emerging. In order to deliver optimum care to patients, the development of innovative pharmacological techniques has become a widely studied topic. Applied Case Studies and Solutions in Molecular Docking-Based Drug Design is a pivotal reference source for the latest scholarly research on the progress of pharmaceutical design and computational approaches in the field of molecular docking. Highlighting innovative research perspectives and real-world applications, this book is ideally

Methods and Algorithms for Molecular Docking Based Drug Design and Discovery

Methods and Algorithms for Molecular Docking Based Drug Design and Discovery
  • Author : Dastmalchi, Siavoush
  • Publisher : IGI Global
  • Release : 03 May 2016
GET THIS BOOK Methods and Algorithms for Molecular Docking Based Drug Design and Discovery

The role of technology in the medical field has resulted in significant developments within the pharmaceutical industry. Computational approaches have emerged as a crucial method in further advancing drug design and development. Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery presents emerging research on the application of computer-assisted design methods for drugs, emphasizing the benefits and improvements that molecular docking has caused within the pharmaceutical industry. Focusing on validation methods, search algorithms, and scoring functions, this book is

Key Heterocycle Cores for Designing Multitargeting Molecules

Key Heterocycle Cores for Designing Multitargeting Molecules
  • Author : Om Silakari
  • Publisher : Elsevier
  • Release : 11 June 2018
GET THIS BOOK Key Heterocycle Cores for Designing Multitargeting Molecules

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of

Drug Discovery Handbook

Drug Discovery Handbook
  • Author : Shayne C. Gad
  • Publisher : Wiley-Interscience
  • Release : 11 July 2005
GET THIS BOOK Drug Discovery Handbook

THE FIRST COMPREHENSIVE GUIDE TO THE METHODS AND TECHNIQUES OF DRUG DISCOVERY The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods

Medicinal Chemistry of Neglected and Tropical Diseases

Medicinal Chemistry of Neglected and Tropical Diseases
  • Author : Venkatesan Jayaprakash,Daniele Castagnolo,Yusuf Özkay
  • Publisher : CRC Press
  • Release : 15 August 2019
GET THIS BOOK Medicinal Chemistry of Neglected and Tropical Diseases

Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this