Concepts and Models for Drug Permeability Studies

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  • Author : Bruno Filipe Carmelino Cardoso Sarmento
  • Publisher : Woodhead Publishing Limited
  • Pages : 408 pages
  • ISBN : 9780081000946
  • Rating : /5 from reviews
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Download or Read online Concepts and Models for Drug Permeability Studies full in PDF, ePub and kindle. this book written by Bruno Filipe Carmelino Cardoso Sarmento and published by Woodhead Publishing Limited which was released on 01 October 2015 with total page 408 pages. We cannot guarantee that Concepts and Models for Drug Permeability Studies book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route. Updated information regarding the most recent in vitro models to study the permeability of drugs Short and concise chapters covering all the biological barriers with interest in drug permeability A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models Simple and clear scientific content, adaptable for young scientists and experimented researchers

Concepts and Models for Drug Permeability Studies

Concepts and Models for Drug Permeability Studies
  • Author : Bruno Filipe Carmelino Cardoso Sarmento
  • Publisher : Woodhead Publishing Limited
  • Release : 01 October 2015
GET THIS BOOK Concepts and Models for Drug Permeability Studies

This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based

Concepts and Models for Drug Permeability Studies

Concepts and Models for Drug Permeability Studies
  • Author : Bruno Sarmento
  • Publisher : Woodhead Publishing
  • Release : 30 September 2015
GET THIS BOOK Concepts and Models for Drug Permeability Studies

This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based

Characterization of Pharmaceutical Nano and Microsystems

Characterization of Pharmaceutical Nano  and Microsystems
  • Author : Leena Peltonen
  • Publisher : John Wiley & Sons
  • Release : 27 October 2020
GET THIS BOOK Characterization of Pharmaceutical Nano and Microsystems

Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale. The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement

Nanotechnology for Oral Drug Delivery

Nanotechnology for Oral Drug Delivery
  • Author : João Pedro Martins,Hélder A. Santos
  • Publisher : Academic Press
  • Release : 30 July 2020
GET THIS BOOK Nanotechnology for Oral Drug Delivery

Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a

Drug Delivery Approaches

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  • Publisher : John Wiley & Sons
  • Release : 27 July 2021
GET THIS BOOK Drug Delivery Approaches

Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It

Nanoparticles in Life Sciences and Biomedicine

Nanoparticles in Life Sciences and Biomedicine
  • Author : Ana Rute Neves,Salette Reis
  • Publisher : CRC Press
  • Release : 13 February 2018
GET THIS BOOK Nanoparticles in Life Sciences and Biomedicine

The creation of new and more efficient therapies for improving human health greatly depends on drug delivery systems. Nanotechnology has emerged as a powerful strategy for the development of nanoparticles, such as nanoemulsions, liposomes, nanocrystals, and nanocomplexes, applied in the diagnosis, treatment, or theranostics of several pathologies and diseases. This book reviews the most recent research and development in nanotechnology and, following a multidisciplinary approach, presents new strategies for drug delivery, including aspects from chemistry, physics, biology, and imaging methodologies

The Theory of Endobiogeny

The Theory of Endobiogeny
  • Author : Kamyar M. Hedayat,Jean-Claude Lapraz
  • Publisher : Academic Press
  • Release : 18 June 2019
GET THIS BOOK The Theory of Endobiogeny

The Theory of Endobiogeny Volume 2: Foundational Concepts for Treatments of Common Clinical Conditions addresses the core elements of the adaptation response to stressors: autonomic nervous system (ANS), corticotropic axis, immunity and digestive tract function. The volume is oriented for clinical practice, offering clear discussions on treating the root cause of numerous common disorders, and symptomatically addressing the destabilizing factor in a vast number of disorders ranging from depression to irritable bowel, and from migraines to insomnia called spasmophilia. Extends the

A Practical Guide to Rational Drug Design

A Practical Guide to Rational Drug Design
  • Author : Sun Hongmao
  • Publisher : Woodhead Publishing
  • Release : 05 October 2015
GET THIS BOOK A Practical Guide to Rational Drug Design

This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors’ active compounds or from natural ligands of the targets; how to springboard from competitors’ SAR knowledge in lead

Transmucosal Absorption Enhancers in the Drug Delivery Field

Transmucosal Absorption Enhancers in the Drug Delivery Field
  • Author : Luca Casettari,Sam Maher,Lisbeth Illum
  • Publisher : MDPI
  • Release : 07 January 2020
GET THIS BOOK Transmucosal Absorption Enhancers in the Drug Delivery Field

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the

Absorption and Drug Development Solubility Permeability and Charge State

Absorption and Drug Development  Solubility  Permeability  and Charge State
  • Author : Alex Avdeef
  • Publisher : John Wiley & Sons
  • Release : 22 May 2012
GET THIS BOOK Absorption and Drug Development Solubility Permeability and Charge State

Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the

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Drug Like Properties
  • Author : Li Di,Edward H Kerns
  • Publisher : Academic Press
  • Release : 17 December 2015
GET THIS BOOK Drug Like Properties

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This

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Drug like Properties  Concepts  Structure Design and Methods
  • Author : Li Di,Edward H Kerns
  • Publisher : Elsevier
  • Release : 26 July 2010
GET THIS BOOK Drug like Properties Concepts Structure Design and Methods

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be

Drug Delivery to the Brain

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  • Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
  • Publisher : Springer Science & Business Media
  • Release : 03 December 2013
GET THIS BOOK Drug Delivery to the Brain

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics

Drug Targeting And Delivery

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  • Author : H.E. Junginger
  • Publisher : CRC Press
  • Release : 31 October 1992
GET THIS BOOK Drug Targeting And Delivery

This is a review of the structure and function of biological membranes and other cellular barriers used in drug transport. It discusses a range of concepts for drug delivery systems, treating the routes of drugs with regard to their characteristics: function, structure, uptake, mechanism and effect. The book also explores the interface between pharmaceutical technology and physiological principles in drug design, a field of increased importance to industry.