Computational and Experimental Design of Biopharmaceutical Formulations

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  • Author : Vladimir I. Razinkov
  • Publisher : Academic Press
  • Pages : 230 pages
  • ISBN : 9780128173480
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Computational and Experimental Design of Biopharmaceutical Formulations

Download or Read online Computational and Experimental Design of Biopharmaceutical Formulations full in PDF, ePub and kindle. this book written by Vladimir I. Razinkov and published by Academic Press which was released on 17 November 2021 with total page 230 pages. We cannot guarantee that Computational and Experimental Design of Biopharmaceutical Formulations book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Computational and Experimental Design of Biopharmaceutical Formulations outlines available experimental and computational tools. It describes a rational approach to formulation design not limited by experimental design that extends to modern methods of computational modeling. These methods include the modeling of protein structure and dynamics, and of solution properties in the presence of proteins and excipients. The chapters in this book consider computational modeling of protein-solution interactions, the design of early-stage formulation studies, the design of late-stage formulation studies, automation, high-throughput and control, design of lyophilized formulations, and emerging technologies in the future formulation development. Reviews methods for the design of biopharmaceutical formulations Considers both experimental and computational methods in concert Details design techniques specific to each step in protein formulation development Discusses the predictive power of methods used in formulation stability studies Describes and considers the potential of emerging models and experimental technologies

Computational and Experimental Design of Biopharmaceutical Formulations

Computational and Experimental Design of Biopharmaceutical Formulations
  • Author : Vladimir I. Razinkov,Arnold McAuley,Pavan Ghattyvenkatakrishna,Deirdre Piedmonte
  • Publisher : Academic Press
  • Release : 17 November 2021
GET THIS BOOK Computational and Experimental Design of Biopharmaceutical Formulations

Computational and Experimental Design of Biopharmaceutical Formulations outlines available experimental and computational tools. It describes a rational approach to formulation design not limited by experimental design that extends to modern methods of computational modeling. These methods include the modeling of protein structure and dynamics, and of solution properties in the presence of proteins and excipients. The chapters in this book consider computational modeling of protein-solution interactions, the design of early-stage formulation studies, the design of late-stage formulation studies, automation, high-throughput

Developability of Biotherapeutics

Developability of Biotherapeutics
  • Author : Sandeep Kumar,Satish Kumar Singh
  • Publisher : CRC Press
  • Release : 18 November 2015
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Biopharmaceuticals are emerging as frontline medicines to combat several life-threatening and chronic diseases. However, such medicines are expensive to develop and produce on a commercial scale, contributing to rising healthcare costs. Developability of Biotherapeutics: Computational Approaches describes applications of computational and molecular modeling techniques that improve the overall process of discovery and development by removing empiricism. The concept of developability involves making rational choices at the pre-clinical stages of biopharmaceutical drug development that could positively impact clinical outcomes. The book

Handbook of Preformulation

Handbook of Preformulation
  • Author : Sarfaraz K. Niazi
  • Publisher : CRC Press
  • Release : 22 March 2019
GET THIS BOOK Handbook of Preformulation

Preformulation studies are the physical, chemical, and biological studies needed to characterize a drug substance for enabling the proper design of a drug product, whereas the effectiveness of a drug product is determined during the formulation studies phase. Though the two disciplines overlap in practice, each is a significantly distinct phase of new drug development. Entirely focused on preformulation principles, this fully revised and updated Handbook of Preformulation: Chemical, Biological, and Botanical Drugs, Second Edition provides detailed descriptions of preformulation

Computer Aided Pharmaceutics and Drug Delivery

Computer Aided Pharmaceutics and Drug Delivery
  • Author : Vikas Anand Saharan
  • Publisher : Springer Nature
  • Release : 30 May 2022
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This book examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems.

Computer Aided Applications in Pharmaceutical Technology

Computer Aided Applications in Pharmaceutical Technology
  • Author : Jelena Djuris
  • Publisher : Elsevier
  • Release : 10 April 2013
GET THIS BOOK Computer Aided Applications in Pharmaceutical Technology

Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals

High Throughput Formulation Development of Biopharmaceuticals

High Throughput Formulation Development of Biopharmaceuticals
  • Author : Vladimir I. Razinkov,Gerd Kleemann
  • Publisher : Woodhead Publishing
  • Release : 29 September 2016
GET THIS BOOK High Throughput Formulation Development of Biopharmaceuticals

High Throughput Formulation Development of Biopharmaceuticals: Practical Guide to Methods and Applications provides the latest developments and information on the science of stable and safe drug product formulations, presenting a comprehensive review and detailed description of modern methodologies in the field of formulation development, a process starting with candidate and pre-formulation screening in its early development phase and then progressing to the refinement of robust formulations during commercialization in the later phases of development. The title covers topics such as

Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Biophysical Characterization of Proteins in Developing Biopharmaceuticals
  • Author : Damian J. Houde,Steven A. Berkowitz
  • Publisher : Elsevier
  • Release : 13 November 2019
GET THIS BOOK Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today’s industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been

Dosage Form Design Considerations

Dosage Form Design Considerations
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 28 July 2018
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Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies

Development of Biopharmaceutical Drug Device Products

Development of Biopharmaceutical Drug Device Products
  • Author : Feroz Jameel,John W. Skoug,Robert R. Nesbitt
  • Publisher : Springer Nature
  • Release : 13 March 2020
GET THIS BOOK Development of Biopharmaceutical Drug Device Products

The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T-cell engager (BITES), Dual Variable Domain (DVD) antibodies, and fusion proteins that are currently being used as therapeutic agents for immunology, oncology and other disease conditions. Regulatory agencies have raised the bar for the development and manufacture of antibody-based products, expecting to see the use of Quality by Design (QbD) elements demonstrating an in-depth understanding of product and

Virtual Drug Design

Virtual Drug Design
  • Author : Daniela Schuster,Honglin Li
  • Publisher : Frontiers Media SA
  • Release : 13 January 2020
GET THIS BOOK Virtual Drug Design

In the current drug research environment in academia and industry, cheminformatics and virtual screening methods are well established and integrated tools. Computational tools are used to predict a compound’s 3D structure, the 3D structure and function of a pharmacological target, ligand-target interactions, binding energies, and other factors essential for a successful drug. This includes molecular properties such as solubility, logP value, susceptibility to metabolism, cell permeation, blood brain barrier permeation, interaction with drug transporters and potential off-target effects. Given

FOCAPD 19 Proceedings of the 9th International Conference on Foundations of Computer Aided Process Design July 14 18 2019

FOCAPD 19 Proceedings of the 9th International Conference on Foundations of Computer Aided Process Design  July 14   18  2019
  • Author : Salvador Garcia Munoz,Carl D. Laird,Matthew J. Realff
  • Publisher : Elsevier
  • Release : 09 July 2019
GET THIS BOOK FOCAPD 19 Proceedings of the 9th International Conference on Foundations of Computer Aided Process Design July 14 18 2019

FOCAPD-19/Proceedings of the 9th International Conference on Foundations of Computer-Aided Process Design, July 14 - 18, 2019, compiles the presentations given at the Ninth International Conference on Foundations of Computer-Aided Process Design, FOCAPD-2019. It highlights the meetings held at this event that brings together researchers, educators and practitioners to identify new challenges and opportunities for process and product design. Combines presentations from the Ninth International Conference on Foundations of Computer-Aided Process Design, FOCAPD-2019

Synthesis Design and Resource Optimization in Batch Chemical Plants

Synthesis  Design  and Resource Optimization in Batch Chemical Plants
  • Author : Thokozani Majozi,Esmael Reshid Seid,Jui-Yuan Lee
  • Publisher : CRC Press
  • Release : 04 March 2015
GET THIS BOOK Synthesis Design and Resource Optimization in Batch Chemical Plants

The manner in which time is captured forms the foundation for synthesis, design, and optimization in batch chemical plants. However, there are still serious challenges with handling time in batch plants. Most techniques tend to assume either a fixed time dimension or adopt time average models to tame the time dimension, thereby simplifying the resu

Water Insoluble Drug Formulation

Water Insoluble Drug Formulation
  • Author : Ron Liu
  • Publisher : CRC Press
  • Release : 12 March 2018
GET THIS BOOK Water Insoluble Drug Formulation

Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds

Case Studies in Bayesian Methods for Biopharmaceutical CMC

Case Studies in Bayesian Methods for Biopharmaceutical CMC
  • Author : Paul Faya,Tony Pourmohamad
  • Publisher : CRC Press
  • Release : 15 December 2022
GET THIS BOOK Case Studies in Bayesian Methods for Biopharmaceutical CMC

The subject of this book is applied Bayesian methods for chemistry, manufacturing, and control (CMC) studies in the biopharmaceutical industry. The book has multiple authors from industry and academia, each contributing a case study (chapter). The collection of case studies covers a broad array of CMC topics, including stability analysis, analytical method development, specification setting, process development and optimization, process control, experimental design, dissolution testing, and comparability studies. The analysis of each case study includes a presentation of code and

Parenteral Medications Fourth Edition

Parenteral Medications  Fourth Edition
  • Author : Sandeep Nema,John D. Ludwig
  • Publisher : CRC Press
  • Release : 19 July 2019
GET THIS BOOK Parenteral Medications Fourth Edition

Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacturing of parenteral dosage forms, effectively balancing theoretical considerations with practical aspects of their development. Previously published as a three-volume set, all volumes have been combined into one comprehensive publication that addresses the plethora of changes in the science and considerable advances in the technology associated with these products and routes of administration. Key Features: Provides a comprehensive reference work on the formulation and manufacturing of parenteral dosage