Fundamentals of Clinical Trials

Produk Detail:
  • Author : Lawrence M. Friedman
  • Publisher : Springer Science & Business Media
  • Pages : 361 pages
  • ISBN : 9780387985862
  • Rating : 4.5/5 from 2 reviews
CLICK HERE TO GET THIS BOOK >>>Fundamentals of Clinical Trials

Download or Read online Fundamentals of Clinical Trials full in PDF, ePub and kindle. this book written by Lawrence M. Friedman and published by Springer Science & Business Media which was released on 08 December 1998 with total page 361 pages. We cannot guarantee that Fundamentals of Clinical Trials book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. The randomized control clinical trial has become the gold standard scientific method for the evaluation of pharmaceuticals, biologics, devices, procedures and diagnostic tests. This trial design has been successfully used in both therapeutic and disease prevention trials. It is superior to alternative designs by eliminating several sources of bias which exist in those designs. This role has evolved over the past three decades in a number of disease areas including cardiology, opthalmology, cancer and AIDS. While the specifics of using the randomized control design for a specific intervention and disease may differ, the basic fundamentals still apply in developing the study protocol and operational procedures. These fundamentals still apply in developing the study protocol and operational procedures. These fundamentals include identifying the specific questions to be tested and appropriate outcome measures, determining an adequate sample size, specifying the randomization procedure, detailing the intervention with visit schedules for subject evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and determining the organizational structure.This text is structured to address the fundamentals as the protocol for a clinical trial is being developed. A chapter is devoted to each of the critical areas of a protocol to aid the clinical trial researcher. The fundamentals described in this text are based on sound scientific methodology, statistical principles and years of accumulated experience by the three authors. Collectively, the authors have been active researchers in a broad area of clinical trials including cardiology, cancer, opthalmology, diabetes, osteoporosis, AIDS, women's health and screening tests. In these studies, the authors have served as members of the steering committee responsible for developing the protocol and as members of data and safety monitoring committees. The fundamentals were proposed in the first edition published in 1981 and have not changed substantially in the later editions. However, the number of examples illustrating the fundamentals has greatly expanded base on the collective experience of the authors.This text is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The test uses numerous examples of published clinical trials from a variety of medical disciples to meaningfully illustrate the fundamentals. Technical design issues such as sample size are considered but the technical details have been suppressed as much as possible through the use of graphs and tables. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful both in a consulting and teaching capacity.The text assumes that the readers have only a modest formal statistical background. A basic introductory statistics course is helpful in maximizing the benefit of the text. However, a researcher or practitioner with no statistical background would still find most, if not all the chapters understandable and useful.

Fundamentals of Clinical Trials

Fundamentals of Clinical Trials
  • Author : Lawrence M. Friedman,Curt Furberg,David L. DeMets
  • Publisher : Springer Science & Business Media
  • Release : 08 December 1998
GET THIS BOOK Fundamentals of Clinical Trials

The randomized control clinical trial has become the gold standard scientific method for the evaluation of pharmaceuticals, biologics, devices, procedures and diagnostic tests. This trial design has been successfully used in both therapeutic and disease prevention trials. It is superior to alternative designs by eliminating several sources of bias which exist in those designs. This role has evolved over the past three decades in a number of disease areas including cardiology, opthalmology, cancer and AIDS. While the specifics of using

Clinical Trials

Clinical Trials
  • Author : Lorna Speid, Ph.D
  • Publisher : Oxford University Press
  • Release : 30 July 2010
GET THIS BOOK Clinical Trials

Every year, hundreds of thousands of healthy volunteers and patients worldwide undertake the journey through the maze that can be clinical trials. Research participants take part in clinical trials for a variety of reasons. The healthy volunteers may be seeking extra money to pay off college tuition, or they may know someone who is suffering and would potentially benefit from the results of the trial. The patient who is terminally ill might participate in a clinical trial simply as a

Fundamentals of Clinical Trials

Fundamentals of Clinical Trials
  • Author : Lawrence M. Friedman,Curt D. Furberg,David L. DeMets
  • Publisher : Springer Science & Business Media
  • Release : 09 September 2010
GET THIS BOOK Fundamentals of Clinical Trials

The clinical trial is “the most definitive tool for evaluation of the applicability of clinical research.” It represents “a key research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments” [1]. It has been called on many occasions, “the gold st- dard” against which all other clinical research is measured. Although many clinical trials are of high quality, a careful reader of the medical literature will notice that a large

Clinical Trials

Clinical Trials
  • Author : Stuart J. Pocock
  • Publisher : John Wiley & Sons
  • Release : 17 July 2013
GET THIS BOOK Clinical Trials

This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience.

Clinical Trials

Clinical Trials
  • Author : Tom Brody
  • Publisher : Academic Press
  • Release : 25 October 2011
GET THIS BOOK Clinical Trials

Clinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines is a practical guidebook for those engaged in clinical trial design. This book details the organizations and content of clinical trials, including trial design, safety, endpoints, subgroups, HRQoL, consent forms and package inserts. It provides extensive information on both US and international regulatory guidelines and features concrete examples of study design from the medical literature. This book is intended to orient those new to clinical trial

Design Execution and Management of Medical Device Clinical Trials

Design  Execution  and Management of Medical Device Clinical Trials
  • Author : Salah M. Abdel-aleem
  • Publisher : John Wiley & Sons
  • Release : 08 September 2009
GET THIS BOOK Design Execution and Management of Medical Device Clinical Trials

An essential introduction to conducting the various stages of medical device clinical trials Clinical research continues to be one of the most vital components of pharmaceutical, biostatistical, and medical studies. Design, Execution, and Management of Medical Device Clinical Trials provides a uniform methodology for conducting and managing clinical trials. Written in a style that is accessible to readers from diverse educational and professional backgrounds, this book provides an in-depth and broad overview for successfully performing clinical tasks and activities. Throughout

Global Clinical Trials

Global Clinical Trials
  • Author : Richard Chin,Menghis Bairu
  • Publisher : Academic Press
  • Release : 06 May 2011
GET THIS BOOK Global Clinical Trials

This book will explore the great opportunities and challenges which exist in conducting clinical trials in developing countries. By exploring the various regulations specific to the major players and providing insight into the logistical challenges including language barriers, this book provides a working tool for clinical researchers and administrators to navigate the intricacies of clinical trials in developing countries. Important topics such as ethical issues will be handled very carefully to highlight the significant differences of conducting this work in

The Design and Management of Medical Device Clinical Trials

The Design and Management of Medical Device Clinical Trials
  • Author : Salah M. Abdel-aleem
  • Publisher : John Wiley & Sons
  • Release : 09 September 2011
GET THIS BOOK The Design and Management of Medical Device Clinical Trials

Clinical trials tasks and activities are widely diverse and require certain skill sets to both plan and execute. This book provides professionals in the field of clinical research with valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It discusses key obstacles such as challenges to patient recruitment, investigator and study site selection, and dealing with compliance issues. Through practical examples, professionals working with medical device clinical

Clinical Trials Dictionary

Clinical Trials Dictionary
  • Author : Curtis L. Meinert
  • Publisher : John Wiley & Sons
  • Release : 15 August 2012
GET THIS BOOK Clinical Trials Dictionary

A thoroughly updated new edition of the essential reference on the design, practice, and analysis of clinical trials Clinical Trials Dictionary: Terminology and Usage Recommendations, Second Edition presents clear, precise, meticulously detailed entries on all aspects of modern-day clinical trials. Written and compiled by one of the world’s leading clinical trialists, this comprehensive volume incorporates areas of medicine, statistics, epidemiology, computer science, and bioethics—providing a treasure trove of key terms and ideas. This new edition continues to supply

Business Administration for Clinical Trials Managing Research Strategy Finance Regulation and Quality

Business Administration for Clinical Trials  Managing Research  Strategy  Finance  Regulation  and Quality
  • Author : R. Jennifer Cavalieri,Mark E. Rupp
  • Publisher : Sigma Theta Tau
  • Release : 19 November 2014
GET THIS BOOK Business Administration for Clinical Trials Managing Research Strategy Finance Regulation and Quality

This guidebook provides research professionals with a deeper understanding of strategic planning, financial management, and regulatory implementation. This book demonstrates a strategy for managing your portfolio of clinical trials, provides tactics and real-world examples, and helps the reader adapt them to their own research site.

Clinical Trials with Missing Data

Clinical Trials with Missing Data
  • Author : Michael O'Kelly,Bohdana Ratitch
  • Publisher : John Wiley & Sons
  • Release : 07 April 2014
GET THIS BOOK Clinical Trials with Missing Data

This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable. The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively. The

Clinical Trials

Clinical Trials
  • Author : Steven Piantadosi
  • Publisher : John Wiley & Sons
  • Release : 09 October 2017
GET THIS BOOK Clinical Trials

Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a

Bayesian Approaches to Clinical Trials and Health Care Evaluation

Bayesian Approaches to Clinical Trials and Health Care Evaluation
  • Author : David J. Spiegelhalter,Keith R. Abrams,Jonathan P. Myles
  • Publisher : John Wiley & Sons
  • Release : 16 January 2004
GET THIS BOOK Bayesian Approaches to Clinical Trials and Health Care Evaluation

READ ALL ABOUT IT! David Spiegelhalter has recently joined the ranks of Isaac Newton, Charles Darwin and Stephen Hawking by becoming a fellow of the Royal Society. Originating from the Medical Research Council’s biostatistics unit, David has played a leading role in the Bristol heart surgery and Harold Shipman inquiries. Order a copy of this author’s comprehensive text TODAY! The Bayesian approach involves synthesising data and judgement in order to reach conclusions about unknown quantities and make predictions.

Methods and Applications of Statistics in Clinical Trials Volume 1

Methods and Applications of Statistics in Clinical Trials  Volume 1
  • Author : N. Balakrishnan
  • Publisher : John Wiley & Sons
  • Release : 05 March 2014
GET THIS BOOK Methods and Applications of Statistics in Clinical Trials Volume 1

A complete guide to the key statistical concepts essential for the design and construction of clinical trials As the newest major resource in the field of medical research, Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs presents a timely and authoritative reviewof the central statistical concepts used to build clinical trials that obtain the best results. The referenceunveils modern approaches vital to understanding, creating, and evaluating data obtained throughoutthe various stages of clinical trial

Oncology Clinical Trials

Oncology Clinical Trials
  • Author : Susan Halabi, PhD,Wm. Kevin Kelly, DO
  • Publisher : Demos Medical Publishing
  • Release : 22 December 2009
GET THIS BOOK Oncology Clinical Trials

Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well conceived, carefully designed and efficiently conducted clinical trial can produce results that change clinical practice overnight, deliver new oncology drugs and diagnostics to the marketplace, and expand the horizon of contemporary thinking about cancer biology. A poorly done trial does little to advance the field or guide clinical practice, consumes precious clinical and financial