Clinical Studies and Therapies in Parkinson s Disease

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  • Author : Juan Segura-Aguilar
  • Publisher : Academic Press
  • Pages : 306 pages
  • ISBN : 0128221585
  • Rating : /5 from reviews
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Download or Read online Clinical Studies and Therapies in Parkinson s Disease full in PDF, ePub and kindle. this book written by Juan Segura-Aguilar and published by Academic Press which was released on 12 June 2021 with total page 306 pages. We cannot guarantee that Clinical Studies and Therapies in Parkinson s Disease book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease. Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms Analyzes preclinical models of Parkinson’s disease therapies based on exogenous neurotoxins and why they have failed Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins Proposes a more physiological model directly related to the metabolism of dopaminergic neurons Provides the basic concepts and mechanisms of dopamine metabolism

Clinical Studies and Therapies in Parkinson s Disease

Clinical Studies and Therapies in Parkinson s Disease
  • Author : Juan Segura-Aguilar
  • Publisher : Academic Press
  • Release : 12 June 2021
GET THIS BOOK Clinical Studies and Therapies in Parkinson s Disease

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains

Restorative Therapies in Parkinson s Disease

Restorative Therapies in Parkinson s Disease
  • Author : Patrik Brundin,C. Warren Olanow
  • Publisher : Springer Science & Business Media
  • Release : 31 August 2006
GET THIS BOOK Restorative Therapies in Parkinson s Disease

In this exciting and timely book new approaches to repairing the parkinsonian brain are described by leading experts. Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease. The comprehensive chapters are geared to an audience

Recent Advances in Parkinson s Disease

Recent Advances in Parkinson s Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 02 April 2020
GET THIS BOOK Recent Advances in Parkinson s Disease

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?,

Therapeutics of Parkinson s Disease and Other Movement Disorders

Therapeutics of Parkinson s Disease and Other Movement Disorders
  • Author : Mark Hallett,Werner Poewe
  • Publisher : John Wiley & Sons
  • Release : 13 October 2008
GET THIS BOOK Therapeutics of Parkinson s Disease and Other Movement Disorders

Provides a comprehensive update on therapies for Parkinson’s disease and other movement disorders Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions The expert guidance of recognised authorities will enable readers of this book to plan their patients’ care with greater confidence

Balance Dysfunction in Parkinson s Disease

Balance Dysfunction in Parkinson   s Disease
  • Author : Martina Mancini,John G. Nutt,Fay B. Horak
  • Publisher : Academic Press
  • Release : 14 September 2019
GET THIS BOOK Balance Dysfunction in Parkinson s Disease

Balance Dysfunction in Parkinson’s Disease: Basic Mechanisms to Clinical Management presents the most updated information on a variety of topics. Sections help clinicians evaluate the types of balance control issues, dynamic balance dysfunction during turning, and the effects of medication, deep brain stimulation, and rehabilitation intervention on balance control. This book is the first to review the four main postural control systems and how they are affected, including balance during quiet stance, reactive postural adjustments to external perturbations, anticipatory

Parkinson s Disease

Parkinson s Disease
  • Author : Hirotaro Narabayashi,Toshiharu Nagatsu,Nobuo Yanagisawa,Yoshikuni Mizuno
  • Publisher : Lippincott Williams & Wilkins
  • Release : 18 January 1993
GET THIS BOOK Parkinson s Disease

This volume contains the edited proceedings of the Tenth International Symposium on Parkinson's Disease, and provides a comprehensive account of the latest advances worldwide in the study and treatment of parkinsonian syndromes. With contributions from more than 400 leading international authorities, the book presents an overview of the wide spectrum of current basic and clinical research and therapy - from studies using the most advanced neurochemical and molecular biological techniques, to new insights into the clinical picture of the parkinsonian patient

Recent Advances in Parkinsons Disease

Recent Advances in Parkinsons Disease
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 20 August 2010
GET THIS BOOK Recent Advances in Parkinsons Disease

This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide

Towards New Therapies for Parkinson s Disease

Towards New Therapies for Parkinson s Disease
  • Author : David Finkelstein
  • Publisher : BoD – Books on Demand
  • Release : 02 November 2011
GET THIS BOOK Towards New Therapies for Parkinson s Disease

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The

Clinical Trials In Parkinson s Disease

Clinical Trials In Parkinson s Disease
  • Author : Santiago Perez-Lloret
  • Publisher : Humana
  • Release : 02 September 2021
GET THIS BOOK Clinical Trials In Parkinson s Disease

This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the

Early Diagnosis and Preventive Therapy in Parkinson s Disease

Early Diagnosis and Preventive Therapy in Parkinson   s Disease
  • Author : Horst Przuntek,Peter Riederer
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOK Early Diagnosis and Preventive Therapy in Parkinson s Disease

At the time when "Parkinson's Disease" is diagnosed in a patient, roughly two thirds of dopaminergic neurons of substantia nigra are already degenerated. The onset of the disease must, therefore, be much earlier. This book deals with early diagnosis and early preventive treatment which may sustain the process underlying the disease. By use of psychometric, kinesiologic, physiologic, histologic, biochemical, endocrinologic, pharmacologic and imaging techniques, including positron-emission tomography and brain mapping, specialists tried to focus on new diagnostic criteria. New methods

Gene Therapy of the Central Nervous System From Bench to Bedside

Gene Therapy of the Central Nervous System  From Bench to Bedside
  • Author : Michael G. Kaplitt,Matthew During
  • Publisher : Gulf Professional Publishing
  • Release : 18 January 2022
GET THIS BOOK Gene Therapy of the Central Nervous System From Bench to Bedside

Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two

Parkinson s Disease and the Family

Parkinson s Disease and the Family
  • Author : Nutan Sharma,Elaine Richman
  • Publisher : Harvard University Press
  • Release : 30 June 2009
GET THIS BOOK Parkinson s Disease and the Family

Too often, with Parkinson's disease, a loved one serves as medical interpreter, patient advocate, and caregiver. Sharma and Richman draw on the latest research and clinical practice techniques to offer valuable suggestions for managing patient care and, perhaps more important, for healing the family unit.