Clinical Genome Sequencing

Clinical Genome Sequencing Book PDF
✏Book Title : Clinical Genome Sequencing
✏Author : Aad Tibben
✏Publisher : Academic Press
✏Release Date : 2019-03-30
✏Pages : 258
✏ISBN : 9780128133361
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Clinical Genome Sequencing Book Summary : Clinical Genome Sequencing: Psychological Aspects thoroughly details key psychological factors to consider while implementing genome sequencing in clinical practice, taking into account the subtleties of genetic risk assessment, patient consent and best practices for sharing genomic findings. Chapter contributions from leading international researchers and practitioners cover topics ranging from the current state of genomic testing, to patient consent, patient responses to sequencing data, common uncertainties, direct-to-consumer genomics, the role of genome sequencing in precision medicine, genetic counseling and genome sequencing, genome sequencing in pediatrics, genome sequencing in prenatal testing, and ethical issues in genome sequencing. Applied clinical case studies support concept illustration, making this an invaluable, practical reference for this important and multifaceted topic area within genomic medicine. Features contributions from leading international researchers and practitioners versed in the psychosocial dimensions of genomic medicine implementation Presents clinical case studies that support concept illustration, making this an invaluable reference for students, researchers, and clinicians looking for practical guidance in this important and multifaceted topic area Details the current state of genomic testing, expectations of genome sequencing, patient consent, patient responses to sequencing data, uncertainties in genome sequencing, direct-to-consumer genome sequencing, and more

📒Clinical Genomics ✍ Shashikant Kulkarni

Clinical Genomics Book PDF
✏Book Title : Clinical Genomics
✏Author : Shashikant Kulkarni
✏Publisher : Academic Press
✏Release Date : 2014-11-10
✏Pages : 488
✏ISBN : 9780124051737
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Clinical Genomics Book Summary : Clinical Genomics provides an overview of the various next-generation sequencing (NGS) technologies that are currently used in clinical diagnostic laboratories. It presents key bioinformatic challenges and the solutions that must be addressed by clinical genomicists and genomic pathologists, such as specific pipelines for identification of the full range of variants that are clinically important. This book is also focused on the challenges of diagnostic interpretation of NGS results in a clinical setting. Its final sections are devoted to the emerging regulatory issues that will govern clinical use of NGS, and reimbursement paradigms that will affect the way in which laboratory professionals get paid for the testing. Simplifies complexities of NGS technologies for rapid education of clinical genomicists and genomic pathologists towards genomic medicine paradigm Tried and tested practice-based analysis for precision diagnosis and treatment plans Specific pipelines and meta-analysis for full range of clinically important variants

Oxford Desk Reference Clinical Genetics And Genomics Book PDF
✏Book Title : Oxford Desk Reference Clinical Genetics and Genomics
✏Author : Helen V. Firth
✏Publisher : Oxford University Press
✏Release Date : 2017
✏Pages : 877
✏ISBN : 9780199557509
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Oxford Desk Reference Clinical Genetics and Genomics Book Summary : Preceded by Oxford desk reference. Clinical genetics / Helen V. Firth, Jane A. Hurst, with Judith G. Hall (consulting editor). 2005.

Exome Sequence Analysis And Interpretation Book PDF
✏Book Title : Exome Sequence Analysis and Interpretation
✏Author : Vinod Scaria
✏Publisher : Research in Genomics
✏Release Date : 2015-02-11
✏Pages : 124
✏ISBN :
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Exome Sequence Analysis and Interpretation Book Summary : A concise handbook on exome sequencing for clinicians and clinical geneticists.

Whole Genome Sequencing And Clinical Drug Response Data Of 142 Ovarian Cancer Samples Book PDF
✏Book Title : Whole Genome Sequencing and Clinical Drug Response Data of 142 Ovarian Cancer Samples
✏Author : Els Witteveen
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1163828404
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Whole Genome Sequencing and Clinical Drug Response Data of 142 Ovarian Cancer Samples Book Summary : Introduction - While most patients with ovarian cancer are initially sensitive to chemotherapy, approximately 75% will develop recurrent disease and become resistant. Predicted response to platinum is considered important in deciding on the best treatment upon recurrence. Often a disease-free interval of 6 months is considered the threshold between predicted resistance and sensitivity. In this study we compare clinical response to predicted response, and aim to identify mechanisms of chemotherapy resistance through whole genome sequencing (WGS) of matched pre-treatment biopsies.Methodology - Tissue biopsies were obtained in patients with advanced or metastatic ovarian carcinoma. Samples with minimally 30% tumour purity were characterized by WGS to a coverage of ~100X (and 35X for corresponding germline samples). Predicted response to platinum, based on disease-free interval (6-month threshold) was compared to clinical response as measured according to the RECIST criteria on CT imaging.Results - In total, 137 patients were included and 142 ovarian cancer tissue biopsy samples were obtained, mainly of recurrent disease (111/142, 78%). Up to now, in 49 cases platinum (combination) treatment was given and response was assessed. Predicted response only correlated with measured response in 51% of patients. In the predicted sensitive group 11/29 patients (38%) were sensitive and experienced partial or complete response. In the group with predicted resistance 14/20 patients (70%) had progressive or stable disease. WGS data is being analysed to identify better prognostic criteria. Furthermore, we have started analysing copy number variation profiles of five patients for whom two subsequent biopsies were available. Evolution over time at copy number level did not seem to result from prolonged biopsy intervals or differences in tumour purity, but could be related to the number of previous treatment cycles.Conclusion - WGS augmented with detailed clinical data can potentially increase knowledge on the development of resistance and aid clinical decision making. Disclosures:No competing interests.Applicable funding sources: KWF Kankerbestrijding (Dutch Cancer Society) - UU2015-7743 [de Witte, Witteveen, Zweemer, Kloosterman].

Clinical Applications For Next Generation Sequencing Book PDF
✏Book Title : Clinical Applications for Next Generation Sequencing
✏Author : Urszula Demkow
✏Publisher : Academic Press
✏Release Date : 2015-09-10
✏Pages : 334
✏ISBN : 9780128018415
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Clinical Applications for Next Generation Sequencing Book Summary : Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments. Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients. The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia. Fills the gap between state-of-the-art technology and evidence-based practice Provides an educational opportunity which advances patient care through the transfer of NGS to real-world patient assessment Promotes a practical tool that clinicians can apply directly to patient care Includes a systematic framework for understanding the role of NGS testing in many common and rare diseases Presents evidence regarding the important role of NGS in current diagnostic strategies

📒Genomic And Precision Medicine ✍ Geoffrey S. Ginsburg

Genomic And Precision Medicine Book PDF
✏Book Title : Genomic and Precision Medicine
✏Author : Geoffrey S. Ginsburg
✏Publisher : Academic Press
✏Release Date : 2016-11-22
✏Pages : 398
✏ISBN : 9780128006566
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Genomic and Precision Medicine Book Summary : Genomic and Precision Medicine: Translation and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care. Provides a comprehensive volume on the translation and implementation of biology into health care provision Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation Includes an up-to-date overview on major ‘translational events’ in genomic and personalized medicine, along with lessons learned

Bioinformatics Tools For Detection And Clinical Interpretation Of Genomic Variations Book PDF
✏Book Title : Bioinformatics Tools for Detection and Clinical Interpretation of Genomic Variations
✏Author : Ali Samadikuchaksaraei
✏Publisher : BoD – Books on Demand
✏Release Date : 2019-09-04
✏Pages : 100
✏ISBN : 9781789237993
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Bioinformatics Tools for Detection and Clinical Interpretation of Genomic Variations Book Summary : Genomic variations and phenotypic diversity are closely linked and form the underlying mechanism for development of many human diseases. This book addresses the methods of detection, analysis, and interpretation of genomic variations in clinically relevant scenarios. If your research or clinical practice involves handling of genomic sequencing data, this book is for you. Topics covered include: methods for identifying genetic diversity, the workflow for analyzing whole exome and whole genome sequencing data, local ancestry deconvolution models, the value of molecular patterns and pattern biomarkers in cancer diagnosis and prognosis, and genotyping and profiling resistance-associated variants of hepatitis C. If your research or clinical practice involves handling of genomic sequencing data, this book is for you.

Next Generation Sequencing Based Clinical Molecular Diagnosis Of Human Genetic Disorders Book PDF
✏Book Title : Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders
✏Author : Lee-Jun C. Wong
✏Publisher : Springer
✏Release Date : 2017-05-15
✏Pages : 364
✏ISBN : 9783319564180
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders Book Summary : Next Generation Sequencing technology has been applied to clinical diagnoses in the past three to five years using various approaches, including target gene panels and whole exomes. The purpose of this book is to summarize the experiences, the results, advantages and disadvantages, along with future development in the area of NGS-based molecular diagnosis. This up-to-date volume will not only provide the readers working with Next Generation Sequencing the basics on how to apply the technology to molecular diagnosis, but will present the results and experience of practical application.

Clinical Genomics Practical Applications For Adult Patient Care Book PDF
✏Book Title : Clinical Genomics Practical Applications for Adult Patient Care
✏Author : Michael T. Murray
✏Publisher : McGraw Hill Professional
✏Release Date : 2013-10-22
✏Pages : 608
✏ISBN : 9780071810593
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Clinical Genomics Practical Applications for Adult Patient Care Book Summary : Convert the latest genomic data to the most effective patient management and treatment approaches Clinical Genomics helps healthcare providers translate the vast amount of new genomic data into successful clinical application. It is a comprehensive textbook and practical guide to the use of this information across a broad spectrum of adult diseases – from individual differences in drug responses, cardiac and cancer risks to Alzheimer's and other neurological and psychiatric disorders. While traditional textbooks on medical genetics focus on classic Mendelian disorders, Clinical Genomics discusses the everyday application of genetic assessment and the diagnostic, therapeutic, and preventive implications to the most common adult diseases that healthcare providers encounter. Covering approximately 200 conditions, it is a true clinical text for use across all of internal medicine. Coverage of each condition is presented in a consistent, clinically relevant manner and includes: Key Points Diagnostic Criteria and Clinical Characteristics Screening and C ounseling Management and Treatment Molecular Genetics and Molecular Mechanism Supplementary Information More than ten valuable appendices, include Genetic Privacy; Race, Ancestry, and Genetics; Personalized Medicine in Clinical Practice; Clinical Interpretation of Genomic Data; and Genetic Risk Profiling in the Genomics Era. Clinical Genomics is essential for internists, primary care physicians, and other healthcare providers who wish to increase their knowledge of the gene-and-protein level care of patients in a clinical setting.

Clinical Pharmacogenomics Testing In The Era Of Next Generation Sequencing Challenges And Opportunities For Precision Medicine Book PDF
✏Book Title : Clinical Pharmacogenomics Testing in the Era of Next Generation Sequencing Challenges and Opportunities for Precision Medicine
✏Author :
✏Publisher :
✏Release Date : 2018
✏Pages :
✏ISBN : OCLC:1053732124
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Clinical Pharmacogenomics Testing in the Era of Next Generation Sequencing Challenges and Opportunities for Precision Medicine Book Summary : ABSTRACT: Introduction : The rapid development and dramatic decrease in cost of sequencing techniques have ushered the implementation of genomic testing in patient care. Next generation DNA sequencing (NGS) techniques have been used increasingly in clinical laboratories to scan the whole or part of the human genome in order to facilitate diagnosis and/or prognostics of genetic disease. Despite many hurdles and debates, pharmacogenomics (PGx) is believed to be an area of genomic medicine where precision medicine could have immediate impact in the near future. Areas covered : This review focuses on lessons learned through early attempts of clinically implementing PGx testing; the challenges and opportunities that PGx testing brings to precision medicine in the era of NGS. Expert commentary : Replacing targeted analysis approach with NGS for PGx testing is neither technically feasible nor necessary currently due to several technical limitations and uncertainty involved in interpreting variants of uncertain significance for PGx variants. However, reporting PGx variants out of clinical whole exome or whole genome sequencing (WES/WGS) might represent additional benefits for patients who are tested by WES/WGS.

Next Generation Information Technologies And Systems Book PDF
✏Book Title : Next Generation Information Technologies and Systems
✏Author : Yishai Feldman
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-09-29
✏Pages : 169
✏ISBN : 9783642049408
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Next Generation Information Technologies and Systems Book Summary : This book constitutes the refereed post-conference proceedings of the 7th International Conference on Next Generation Information Technologies and Systems, NGITS 2009, held in Haifa, Israel, in June 2009. The 14 revised full papers presented together with two keynote lectures and one invited paper were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on middleware and integration, modeling, healthcare/biomedical, service and information management, and applications.

Cardiovascular Genetics And Genomics In Clinical Practice Book PDF
✏Book Title : Cardiovascular Genetics and Genomics in Clinical Practice
✏Author : Donna K. Arnett, PhD
✏Publisher : Demos Medical Publishing
✏Release Date : 2014-11-10
✏Pages : 246
✏ISBN : 9781617051784
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Cardiovascular Genetics and Genomics in Clinical Practice Book Summary : Weighted Numerical Score: 100 - 5 Stars! This is a systematic guide to cardiovascular genetics and genomics from basic concepts to clinical application. It organizes a large volume of information from an active area of research, which holds promise for future discovery. --Doody's Reviews Cardiovascular Genetics and Genomics in Clinical Practice presents clinical cases to illuminate basic concepts of cardiovascular genetics and genomics as practitioners encounter them in day-to-day practice. The unique use of real-world case discussions facilitates the memorization and understanding of basic principles, which can be more readily applied to actual cases. Cardiovascular Genetics and Genomics in Clinical Practice features a step-by-step learning process that begins with an easy-to-understand "primer" of basic scientific concepts regarding cardiovascular genetics and genomics followed by state-of-the-art research and applications for treatment of cardiovascular disorders. Expert clinicians and researchers describe illustrative cases for each topic along with detailed discussions of current scientific understanding and its application in current disease management and treatment. Summaries, key teaching points, and illustrations are highlighted to facilitate quick recall and review. The book will be useful for cardiovascular clinicians in training, board preparation, or as a review for those already in clinical practice. Cardiovascular Genetics and Genomics in Clinical Practice features: Clinical case scenarios to illuminate the basic concepts of cardiovascular genetics and genomics as they are used in daily practice Explanation of fundamental concepts as a foundation for more in-depth understanding Detailed discussions of current scientific knowledge and clinical management The expertise of renowned clinician-scientists in the field Real practical insight for practice

📒The Biologist S Imagination ✍ William Hoffman

The Biologist S Imagination Book PDF
✏Book Title : The Biologist s Imagination
✏Author : William Hoffman
✏Publisher : Oxford University Press
✏Release Date : 2014-05-01
✏Pages : 296
✏ISBN : 9780199361328
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏The Biologist s Imagination Book Summary : Scholars and policymakers alike agree that innovation in the biosciences is key to future growth. The field continues to shift and expand, and it is certainly changing the way people live their lives in a variety of ways. With a large share of federal research dollars devoted to the biosciences, the field is just beginning to live up to its billing as a source of innovation, economic productivity and growth. Vast untapped potential to imagine and innovate exists in the biosciences given new tools now widely available. In The Biologist's Imagination, William Hoffman and Leo Furcht examine the history of innovation in the biosciences, tracing technological innovation from the late eighteenth century to the present and placing special emphasis on how and where technology evolves. Place is often key to innovation, from the early industrial age to the rise of the biotechnology industry in the second half of the twentieth century. The book uses the distinct history of bioinnovation to discuss current trends as they relate to medicine, agriculture, energy, industry, ecosystems, and climate. Fast-moving research fields like genomics, synthetic biology, stem cell research, neuroscience, bioautomation and bioprinting are accelerating these trends. Hoffman and Furcht argue that our system of bioscience innovation is itself in need of innovation. It needs to adapt to the massive changes brought about by converging technologies and the globalization of higher education, workforce skills, and entrepreneurship. The Biologist's Imagination is both a review of past models for bioscience innovation and a forward-looking, original argument for what future models should take into account.

📒The Drama Of Dna ✍ Karen H. Rothenberg

The Drama Of Dna Book PDF
✏Book Title : The Drama of DNA
✏Author : Karen H. Rothenberg
✏Publisher : Oxford University Press, USA
✏Release Date : 2014
✏Pages : 211
✏ISBN : 9780199309351
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏The Drama of DNA Book Summary : Through the use of dramatic narratives, The Drama of DNA brings to life the complexities raised by the application of genomic technologies to health care and diagnosis. This creative, pedagogical approach shines a unique light on the ethical, psychosocial, and policy challenges that emerge as comprehensive sequencing of the human genome transitions from research to clinical medicine. Narrative genomics aims to enhance understanding of how we evaluate, process, and share genomic information, and to cultivate a deeper appreciation for difficult decisions encountered by health care professionals, bioethicists, families, and society as this technology reaches the bedside. This innovative book includes both original genomic plays and theatrical excerpts that illuminate the implications of genomic information and emerging technologies for physicians, scientists, counselors, patients, blood relatives, and society. In addition to the plays, the authors provide an analytical foundation to frame the many challenges that often arise.

Genomics And Clinical Medicine Book PDF
✏Book Title : Genomics and Clinical Medicine
✏Author : Dhavendra Kumar
✏Publisher : Oxford University Press
✏Release Date : 2008-02-15
✏Pages : 672
✏ISBN : 0199720053
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Genomics and Clinical Medicine Book Summary : An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.

Clinical Biochemistry Of Domestic Animals Book PDF
✏Book Title : Clinical Biochemistry of Domestic Animals
✏Author : Jiro Jerry Kaneko
✏Publisher : Academic Press
✏Release Date : 2008-09-04
✏Pages : 928
✏ISBN : 0080568823
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Clinical Biochemistry of Domestic Animals Book Summary : The 6th edition of a well-known and much used standard text in the field. This book covers all aspects of the biochemical abnormalities caused by various diseases and how they relate to the biochemical changes in the blood, urine, cerebrospinal fluid, joint fluids, other body fluids and in cells. The purpose is to provide the fundamental bases for understanding the biochemical changes that occur in disease processes and in turn to provide the rationale for applying this understanding to the diagnosis of the disease process. A substantial appendix is provided so that the user can quickly identify the reference ranges for a large number of animal species. * An appendix is provided in the book so that the user can quickly identify the reference ranges for a large number of animal species * Explains what biochemical changes occur in disease processes and provides the rationale for applying this understanding to the diagnosis of the disease process

Omics In Clinical Practice Book PDF
✏Book Title : Omics in Clinical Practice
✏Author : Yu Liu
✏Publisher : CRC Press
✏Release Date : 2014-06-20
✏Pages : 464
✏ISBN : 9781771880602
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Omics in Clinical Practice Book Summary : This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered. The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized medicine. Part III focuses on molecular and genetic markers. Part IV describes the use of omics while studying pathogens, and Part V examines the applications for companion diagnostics. The book: • Introduces genomics, proteomics, and transcriptomics in relation to human disease and ailments • Considers the role of translation and personalized medicine in relation to genomics, proteomics, and transcriptomics • Covers molecular and genetic markers • Considers the role of genomics, proteomics, and transcriptomics in relation to pathogen detection, evolution, and infection • Covers companion diagnostics in relation to genomics, proteomics, and transcriptomics clinical applications and research

📒The Drama Of Dna ✍ Karen H. Rothenberg JD, MPA

The Drama Of Dna Book PDF
✏Book Title : The Drama of DNA
✏Author : Karen H. Rothenberg JD, MPA
✏Publisher : Oxford University Press
✏Release Date : 2014-03-14
✏Pages : 224
✏ISBN : 9780199373154
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏The Drama of DNA Book Summary : Through the use of dramatic narratives, The Drama of DNA brings to life the complexities raised by the application of genomic technologies to health care and diagnosis. This creative, pedagogical approach shines a unique light on the ethical, psychosocial, and policy challenges that emerge as comprehensive sequencing of the human genome transitions from research to clinical medicine. Narrative genomics aims to enhance understanding of how we evaluate, process, and share genomic information, and to cultivate a deeper appreciation for difficult decisions encountered by health care professionals, bioethicists, families, and society as this technology reaches the bedside. This innovative book includes both original genomic plays and theatrical excerpts that illuminate the implications of genomic information and emerging technologies for physicians, scientists, counselors, patients, blood relatives, and society. In addition to the plays, the authors provide an analytical foundation to frame the many challenges that often arise.

Genomics Proteomics And Clinical Bacteriology Book PDF
✏Book Title : Genomics Proteomics and Clinical Bacteriology
✏Author : Neil Woodford
✏Publisher : Springer Science & Business Media
✏Release Date : 2004
✏Pages : 395
✏ISBN : 9781592597635
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Genomics Proteomics and Clinical Bacteriology Book Summary : This review of the application of proteomic and genomic advances in clinical biology covers principles such as the application of genomics to diagnostic bacteriology and protocols for interrogating bacterial genomes. It also provides updates on all the significant advances of genome sequencing.

Emery And Rimoin S Principles And Practice Of Medical Genetics And Genomics Book PDF
✏Book Title : Emery and Rimoin s Principles and Practice of Medical Genetics and Genomics
✏Author : Reed E. Pyeritz
✏Publisher : Academic Press
✏Release Date : 2018-11-20
✏Pages : 412
✏ISBN : 9780128126844
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Emery and Rimoin s Principles and Practice of Medical Genetics and Genomics Book Summary : For decades, Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics into medical practice. With detailed coverage in contributions from over 250 of the world’s most trusted authorities in medical genetics and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for medical students, residents, physicians, and researchers involved in the care of patients with genetic conditions. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly. Clinical Principles and Applications thoroughly addresses general methods and approaches to genetic counseling, genetic diagnostics, treatment pathways, and drug discovery. Additionally, new and updated chapters explore the clinical implementation of genomic technologies, analytics, and therapeutics, with special attention paid to developing technologies, common challenges, patient care, and ethical and legal aspects. With regular advances in genomic technologies propelling precision medicine into the clinic, the seventh edition of Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for the health professionals and researchers. Fully revised and up-to-date, this new edition introduces genetic researchers, students, and health professionals to general principles of genetic counseling, genetic and genomic diagnostics, treatment pathways, drug discovery, and the application of genomic technologies, analytics, and therapeutics in clinical practice Examines key topics and developing areas within clinical genomics, including genetic evaluation of patients, clinical trials and drug discovery, genetic health records, cytogenetic analysis, diagnostic molecular genetics, small molecule genetic therapeutics, gene product replacement, clinical teratology, transplantation genetics, and ethical and legal aspects of genomic medicine Includes color images supporting identification, concept illustration, and method processing Features contributions by leading international researchers and practitioners of medical genetics

📒Clinical Applications Of Pcr ✍ Y. M. Dennis Lo

Clinical Applications Of Pcr Book PDF
✏Book Title : Clinical Applications of PCR
✏Author : Y. M. Dennis Lo
✏Publisher : Springer Science & Business Media
✏Release Date : 2006
✏Pages : 200
✏ISBN : 9781597450744
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Clinical Applications of PCR Book Summary : In this updated second edition of the much praised Clinical Applications of PCR, leading researchers apply molecular diagnostics to the many recent advances that have occurred in polymerase chain reaction (PCR)-based technologies. Highlights include real-time PCR, which allows the technique to be performed in a quantitative manner with improved sensitivity, robustness, and resilience to carryover contamination, mass spectrometric analysis of nucleic acids, and circulating cell-free nucleic acids in plasma. The authors apply these innovations to a broad spectrum of applications, including gene expression, methylation, trace molecule, gene dosage, and single cell analysis. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and highly practical, Clinical Applications of PCR, Second Edition, will help today's laboratorians and researchers working in molecular diagnostics harness the power of these techniques with unprecedented sensitivity and ease.

Current Controversies In Perinatology An Issue Of Clinics In Perinatology  Book PDF
✏Book Title : Current Controversies in Perinatology An Issue of Clinics in Perinatology
✏Author : Robert H. Lane
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-11-20
✏Pages : 321
✏ISBN : 9780323326735
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Current Controversies in Perinatology An Issue of Clinics in Perinatology Book Summary : Neonatal-perinatal medicine has a strong history of evidence based practice but unfortunately there remain many areas of uncertainty and unproven hypotheses and treatments that may harm our highly vulnerable patients. When new ideas are introduced into the labor and delivery room or the NICU we have to evaluate these procedures and therapies before they become accepted as standards of care. We need to learn from the past lessons of grey baby syndrome and chloramphenicol and of kernicterus and sulfonamide antibiotics where therapeutic good intentions actually did more harm than good and increased the mortality rate of premature babies in the NICU.This proposed edition addresses a broad range of current topics in perinatal neonatal practice. The AAP has just issued new guidelines for the approach to a neonate exposed to maternal genital herpes virus infection. The recommendations were not evidence based and are highly controversial as well as confusing. These topics are addressed in a scholarly and objective manner to both address the controversy and help the practitioner make informed decisions.

Massachusetts General Hospital Comprehensive Clinical Psychiatry Book PDF
✏Book Title : Massachusetts General Hospital Comprehensive Clinical Psychiatry
✏Author : Theodore A. Stern
✏Publisher : Elsevier Health Sciences
✏Release Date : 2015-03-23
✏Pages : 1060
✏ISBN : 9780323295079
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Massachusetts General Hospital Comprehensive Clinical Psychiatry Book Summary : The Massachusetts General Hospital is widely respected as one of the world's premier psychiatric institutions. Now, preeminent authorities from MGH present the newly updated edition of Massachusetts General Hospital Comprehensive Clinical Psychiatry, a unique medical reference book that continues to simplify your access to the current clinical knowledge you need - both in print and online! It provides practical approaches to a wide variety of clinical syndromes and settings, aided by stunning graphics and hundreds of questions and answers geared to each chapter. You'll have convenient access to all the authoritative answers necessary to overcome any clinical challenge. User-friendly, highly templated organization with abundant boxed summaries, bulleted points, case histories, algorithms, references, and suggested readings. Peerless, hands-on advice from members of the esteemed MGH Department of Psychiatry helps you put today's best approaches to work for your patients. Interactive and downloadable Q&As for each chapter allow you to test your retention of the material covered. In-depth coverage of many unique areas, including Psychiatric and Substance Use Disorders in Transitioning Adolescents and Young Adults; Neuroanatomical Systems Relevant to Neuropsychiatric Disorders; Legal and Ethical Issues in Psychiatry; Military Psychiatry; and Approaches to Collaborative Care and Primary Care Psychiatry. Features full, new DSM-5 criteria; new art, tables, and key points; and new Alzheimer's Disease guidelines. Highlights recent developments in the field, such as neurotherapeutics, new psychotropics, military psychiatry, collaborative care, ensuring your knowledge is thoroughly up to date. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

📒Clinical Dermatology ✍ Richard B. Weller

Clinical Dermatology Book PDF
✏Book Title : Clinical Dermatology
✏Author : Richard B. Weller
✏Publisher : John Wiley & Sons
✏Release Date : 2014-11-19
✏Pages : 456
✏ISBN : 9781118851029
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Clinical Dermatology Book Summary : The best-selling text has been completely revised and revitalised in this fifth edition, with the authors once again encouraging general practitioners, medical students, general physicians and early stage dermatology specialist trainees and interns to relish the unique challenge of diagnosing and treating skin conditions. Clinical Dermatology, 5th edition contains over 400 high quality pictures and diagrams combined with colourful phrases to illustrate and entertain as it teaches. The book has established a reputation as a ‘way of learning’ and as an accessible guide to the subject for the aspiring specialist. Readers are guided through the maze that too often lies between the presenting skin complaint and its final diagnosis and treatment. The authors have skilfully crafted an easily read text with enough detail to clarify the subject, but not enough to obscure it. This fifth edition contains new chapters on non-invasive physical treatment and dermoscopy, and new material on cosmetic dermatology, surgical dermatology, the skin and the psyche, and dermatoses of non-Caucasian skin. The text throughout the book has been updated in line with developments in the science and practice of dermatology. “... brilliantly succeeds in enticing you to look further. The writing is clear, and the joint British-American authorship avoids any parochial views.” From a review of a previous edition in BMJ “...a very well-presented book...an excellent aid for teaching. I recommend this book highly to individuals and departments.” From a review of a previous edition in J Derm Treatment “... provides a good overview of the structure and function of the skin as well as a good foundation for learning dermatology...well organized and includes a chapter dedicated to skin signs of systemic disease which is not covered in the other dermatology primers.” From a review of a previous edition in JAMA

📒Exploring Personal Genomics ✍ Joel T. Dudley

Exploring Personal Genomics Book PDF
✏Book Title : Exploring Personal Genomics
✏Author : Joel T. Dudley
✏Publisher : OUP Oxford
✏Release Date : 2013-01-04
✏Pages : 256
✏ISBN : 9780191663765
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Exploring Personal Genomics Book Summary : Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to offer unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we begin our lives, how we develop and grow, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is an essential component of the inevitable transition towards personalized health and medicine. As the medical establishment begins to explore and evaluate the role of personal genomics in health and medicine, both clinicians and patients alike will gain from becoming well versed in both the power and the pitfalls of personal genomic information. Furthermore, it is likely that all students of the biomedical sciences will soon be required to gain crucial understanding in the emerging field of personal genomics. Exploring Personal Genomics provides a novel, inquiry-based approach to the understanding and interpretation of the practical, medical, physiological, and societal aspects of personal genomic information. The material is presented in two parts: the first provides readers of all backgrounds with a fundamental understanding of the biology of human genomes, information on how to obtain and understand digital representations of personal genomic data, tools and techniques for exploring the personal genomics of ancestry and genealogy, discovery and interpretation of genetic trait associations, and the role of personal genomics in drug response. The second part offers more advanced readers an understanding of the science, tools, and techniques for investigating interactions between a personal genome and the environment, connecting DNA to physiology, and assessing rare variants and structural variation. This book aims to support undergraduate and graduate studies in medicine, genetics, molecular biology, and bioinformatics. Additionally, the design of the content is such that medical practitioners, professionals working in the biomedical sciences or related fields, and motivated lay individuals interested in exploring their personal genetic data should find it relevant and approachable.

Challenges And Opportunities Of Next Generation Sequencing For Biomedical Research Book PDF
✏Book Title : Challenges and Opportunities of Next generation Sequencing for Biomedical Research
✏Author : Mark I. Rees
✏Publisher : Academic Press
✏Release Date : 2012
✏Pages : 196
✏ISBN : 9780123942876
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Challenges and Opportunities of Next generation Sequencing for Biomedical Research Book Summary : Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Human Genetics And Genomics Book PDF
✏Book Title : Human Genetics and Genomics
✏Author : Bruce R. Korf
✏Publisher : John Wiley & Sons
✏Release Date : 2012-11-19
✏Pages : 280
✏ISBN : 9781118537664
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Human Genetics and Genomics Book Summary : This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today’s genetics teaching, and includes updated discussion of genetic risk assessment, “single gene” disorders and therapeutics. Key learning features include: Clinical snapshots to help relate science to practice ‘Hot topics’ boxes that focus on the latest developments in testing, assessment and treatment ‘Ethical issues’ boxes to prompt further thought and discussion on the implications of genetic developments ‘Sources of information’ boxes to assist with the practicalities of clinical research and information provision Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: Factsheets on 100 genetic disorders, ideal for study and exam preparation Interactive Multiple Choice Questions (MCQs) with feedback on all answers Links to online resources for further study Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.

Tietz Textbook Of Clinical Chemistry And Molecular Diagnostics E Book Book PDF
✏Book Title : Tietz Textbook of Clinical Chemistry and Molecular Diagnostics E Book
✏Author : Carl A. Burtis
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-10-14
✏Pages : 2256
✏ISBN : 9781455759422
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Tietz Textbook of Clinical Chemistry and Molecular Diagnostics E Book Book Summary : As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors, Ann Gronowski, W. Greg Miller, Michael Oellerich, Francois Rousseau, Mitchell Scott, and Karl Voelkerding, lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.

Henry S Clinical Diagnosis And Management By Laboratory Methods E Book Book PDF
✏Book Title : Henry s Clinical Diagnosis and Management by Laboratory Methods E Book
✏Author : Richard A. McPherson
✏Publisher : Elsevier Health Sciences
✏Release Date : 2011-09-06
✏Pages : 1568
✏ISBN : 9781455726844
✏Available Language : English, Spanish, And French

Click Here To Get Book

✏Henry s Clinical Diagnosis and Management by Laboratory Methods E Book Book Summary : Recognized as the definitive book in laboratory medicine since 1908, Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard A. McPherson, MD and Matthew R. Pincus, MD, PhD, is a comprehensive, multidisciplinary pathology reference that gives you state-of-the-art guidance on lab test selection and interpretation of results. Revisions throughout keep you current on the latest topics in the field, such as biochemical markers of bone metabolism, clinical enzymology, pharmacogenomics, and more! A user-friendly full-color layout puts all the latest, most essential knowledge at your fingertips. Update your understanding of the scientific foundation and clinical application of today's complete range of laboratory tests. Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. Reference the information you need quickly and easily thanks to a full-color layout, many new color illustrations and visual aids, and an organization by organ system. Master all the latest approaches in clinical laboratory medicine with new and updated coverage of: the chemical basis for analyte assays and common interferences; lipids and dyslipoproteinemia; markers in the blood for cardiac injury evaluation and related stroke disorders; coagulation testing for antiplatelet drugs such as aspirin and clopidogrel; biochemical markers of bone metabolism; clinical enzymology; hematology and transfusion medicine; medical microbiology; body fluid analysis; and many other rapidly evolving frontiers in the field. Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. Apply the latest best practices in clinical laboratory management with special chapters on organization, work flow, quality control, interpretation of results, informatics, financial management, and establishing a molecular diagnostics laboratory. Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.