Chromatin Readers In Health And Disease

Environmental Epigenomics In Health And Disease Book PDF
✏Book Title : Environmental Epigenomics in Health and Disease
✏Author : Randy L Jirtle
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-05-16
✏Pages : 302
✏ISBN : 9783642233807
✏Available Language : English, Spanish, And French

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✏Environmental Epigenomics in Health and Disease Book Summary : There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Epigenetics In Health And Disease Book PDF
✏Book Title : Epigenetics in Health and Disease
✏Author : Igor Kovalchuk
✏Publisher : FT Press
✏Release Date : 2012
✏Pages : 598
✏ISBN : 9780132597081
✏Available Language : English, Spanish, And French

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✏Epigenetics in Health and Disease Book Summary : "After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Cover, p. [4].

Epigenomics In Health And Disease Book PDF
✏Book Title : Epigenomics in Health and Disease
✏Author : Mario Fraga
✏Publisher : Academic Press
✏Release Date : 2015-10-12
✏Pages : 328
✏ISBN : 9780128004968
✏Available Language : English, Spanish, And French

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✏Epigenomics in Health and Disease Book Summary : Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging

Transcriptional Gene Regulation In Health And Disease Book PDF
✏Book Title : Transcriptional Gene Regulation in Health and Disease
✏Author :
✏Publisher : Academic Press
✏Release Date : 2018-01-15
✏Pages : 254
✏ISBN : 9780128123409
✏Available Language : English, Spanish, And French

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✏Transcriptional Gene Regulation in Health and Disease Book Summary : Transcriptional Gene Regulation in Health and Disease, Volume 335, the latest release in the International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists drawn from international sources Offers a wide range of perspectives on specific subjects

Epigenetics In Cardiac Disease Book PDF
✏Book Title : Epigenetics in Cardiac Disease
✏Author : Johannes Backs
✏Publisher : Springer
✏Release Date : 2016-11-21
✏Pages : 316
✏ISBN : 9783319414577
✏Available Language : English, Spanish, And French

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✏Epigenetics in Cardiac Disease Book Summary : This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.

Cellular Signaling In Health And Disease Book PDF
✏Book Title : Cellular Signaling in Health and Disease
✏Author : Martin Beckerman
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-05-28
✏Pages : 470
✏ISBN : 038798173X
✏Available Language : English, Spanish, And French

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✏Cellular Signaling in Health and Disease Book Summary : In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

Chromatin Signaling And Diseases Book PDF
✏Book Title : Chromatin Signaling and Diseases
✏Author : Olivier Binda
✏Publisher : Academic Press
✏Release Date : 2016-08-06
✏Pages : 466
✏ISBN : 9780128026090
✏Available Language : English, Spanish, And French

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✏Chromatin Signaling and Diseases Book Summary : Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling

Health And Disease A Reader Book PDF
✏Book Title : Health And Disease A Reader
✏Author : Basiro Davey
✏Publisher : Open University Press
✏Release Date : 2001
✏Pages : 458
✏ISBN : UOM:49015002767672
✏Available Language : English, Spanish, And French

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✏Health And Disease A Reader Book Summary : Health and disease have become major subjects for investigation, comment and debate. This text is a collection of articles which reflect the varied and sometimes controversial perspectives within these debates.

📒Health And Disease ✍ Basiro Davey

Health And Disease Book PDF
✏Book Title : Health and Disease
✏Author : Basiro Davey
✏Publisher :
✏Release Date : 1995
✏Pages : 436
✏ISBN : STANFORD:36105009828331
✏Available Language : English, Spanish, And French

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✏Health and Disease Book Summary : "Health and disease have become major subjects for investigation, comment and debate. Health and Disease: A Reader is an interdisciplinary collection of articles which reflect the varied and sometimes controversial perspectives within these debates. Drawn from a wide range of sources, including the biomedical and social sciences, history, literature and lay accounts, these articles address all aspects of health and disease." "Health and Disease: A Reader will be essential reading for all students and teachers of health studies, nursing, medicine, social policy, social work and sociology. It will also be of interest to researchers in the natural and social sciences, health care professionals, policy makers and analysts, and anyone interested in health, disease and health care."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved

Steroid Receptors In Health And Disease Book PDF
✏Book Title : Steroid Receptors in Health and Disease
✏Author : Virinder Moudgil
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-03-09
✏Pages : 334
✏ISBN : 9781468455410
✏Available Language : English, Spanish, And French

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✏Steroid Receptors in Health and Disease Book Summary : During the last two decades, progress in steroid hormone research has resulted in the development of new approaches to contraception as well as diagnosis and treatment of endocrine disorders and cancers. Although significant advances have been made in the purification, characterization, immunochemistry and molecular biology of steroid receptors, the precise molecular mechanism of steroid hormone action has remained obscure. This book captures the detailed presentations made at the first conference on Steroid Receptors in Health and Disease held at Meadow Brook Hall, Oakland University in the fall of 1987. The purpose of this international con ference was to facilitate scientific exchange toward a better understand ing of the mode of action of steroid hormones. The scientific sessions consisted of poster presentations and state-of-the-art lectures, the latter of which make up this volume. The first chapter is meant to provide the reader with a more general background of the topics covered in the book, as well as to discuss certain theme-related issues that are either not yet well-established or accepted or are in the stage of infancy. It is hoped that this volume will serve as a useful treatise for students and investigators interested in basic and clinical aspects of biological regulation by steroid hormones. A task of this magnitude could not have been undertaken without the encouragement, advice and continued generous assistance of the members of the scientific committee. I am gratefully indebted to Drs.

📒The Health And Society Reader ✍ Fernando Rivera

The Health And Society Reader Book PDF
✏Book Title : The Health and Society Reader
✏Author : Fernando Rivera
✏Publisher :
✏Release Date : 2018-12-31
✏Pages : 372
✏ISBN : 1516542436
✏Available Language : English, Spanish, And French

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✏The Health and Society Reader Book Summary : The Health and Society Reader: Health and Disease in a Changing Environment provides students with both an introduction to the sociological study of health and disease and a contemporary view of critical issues in the field. The anthology is divided into seven sections. Sections I and II contain engaging, thought-provoking readings on medical sociology and the social causes of health disparities, including inequality, gender, and veteran status. Section III examines demographic shifts and health, helping readers better understand the relationship between aging and health and migration and healthcare access. In Sections IV and V, students read about family support and mental health, the correlation between religion, stress, and health, doctor-patient interactions, and social capital and health. Closing sections address the impact of neighborhoods on health, medical tourism, global health, and environment, risk, and health. Featuring informative and accessible articles, The Health and Society Reader is an ideal resource for undergraduate and graduate courses in medical sociology, sociology of health and illness, and social determinants of health. It can be also be used as a supplemental text for courses in psychology, anthropology, nursing, social work, and other health-related fields. Fernando I. Rivera is a professor of sociology at the University of Central Florida. He holds a Ph.D. and a M.A. in sociology from the University of Nebraska-Lincoln. Dr. Rivera has established an ongoing research program in the fields of medical sociology/sociology of health, race and ethnicity, and the sociology of disasters. Hyung Sam Park is an associate lecturer in the Department of Sociology at the University of Central Florida. He holds a Ph.D. in sociology from the University of Pittsburgh, PA. He has taught courses on health and illness, the environment, social problems, social networks, and quantitative methods.

Post Translational Modifications In Health And Disease Book PDF
✏Book Title : Post Translational Modifications in Health and Disease
✏Author : Cecilio J. Vidal
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-10-13
✏Pages : 490
✏ISBN : 1441963820
✏Available Language : English, Spanish, And French

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✏Post Translational Modifications in Health and Disease Book Summary : Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.

Effect Of Bioactive Nutriments In Health And Disease The Role Of Epigenetic Modifications Book PDF
✏Book Title : Effect of Bioactive Nutriments in Health and Disease The Role of Epigenetic Modifications
✏Author : Pablo Bautista-García
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1154227423
✏Available Language : English, Spanish, And French

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✏Effect of Bioactive Nutriments in Health and Disease The Role of Epigenetic Modifications Book Summary : Recently, a list of clinical, physiopathological, and epidemiological studies has underlined the detrimental or beneficial role of nutritional factors in some chronic diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer. It has been described that lifestyle, environmental conditions, and nutritional compounds influence gene expression. In the last instance, it has been demonstrated that bioactive nutrimental components are important signal molecules that carry information from the external environment and could affect in biological terms, processes related to gene expression. Bioactive nutriments can work in different ways: regulating the chromatin structure or factors that directly regulate the activity of nuclear receptors. The relevance of the changes in the chromatin structure has been demonstrated by the fact that many chronic diseases and metabolic disorders are related with changes in DNA methylation patterns. For this reason, recently, the bioactive food nutriments have been investigated to characterize the molecular mechanism involved in changes of the chromatin structure, such as acetylation and methylation, and their potential benefit on chronic diseases. The dietary compounds intake involved in the regulation of epigenetic modifications can provide significant health effects and may prevent various pathological processes involved in the development of cancer and other serious diseases.

📒Human Epigenomics ✍ Carsten Carlberg

Human Epigenomics Book PDF
✏Book Title : Human Epigenomics
✏Author : Carsten Carlberg
✏Publisher : Springer
✏Release Date : 2018-02-01
✏Pages : 223
✏ISBN : 9789811076145
✏Available Language : English, Spanish, And French

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✏Human Epigenomics Book Summary : The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a useful reference for individuals working in biomedicine.

📒Epigenetics In Human Disease ✍ Trygve O. Tollefsbol

Epigenetics In Human Disease Book PDF
✏Book Title : Epigenetics in Human Disease
✏Author : Trygve O. Tollefsbol
✏Publisher : Academic Press
✏Release Date : 2012
✏Pages : 577
✏ISBN : 9780123884152
✏Available Language : English, Spanish, And French

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✏Epigenetics in Human Disease Book Summary : Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

📒Genome Stability And Human Diseases ✍ Heinz-Peter Nasheuer

Genome Stability And Human Diseases Book PDF
✏Book Title : Genome Stability and Human Diseases
✏Author : Heinz-Peter Nasheuer
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-12-11
✏Pages : 340
✏ISBN : 9048134714
✏Available Language : English, Spanish, And French

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✏Genome Stability and Human Diseases Book Summary : Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Ubiquitination Governing Dna Repair Book PDF
✏Book Title : Ubiquitination Governing DNA Repair
✏Author : Effrossyni Boutou
✏Publisher : BoD – Books on Demand
✏Release Date : 2018-08-01
✏Pages : 220
✏ISBN : 9781789235845
✏Available Language : English, Spanish, And French

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✏Ubiquitination Governing DNA Repair Book Summary : DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

Nutrition Epigenetics And Health Book PDF
✏Book Title : Nutrition Epigenetics and Health
✏Author : Burdge Graham
✏Publisher : World Scientific
✏Release Date : 2016-10-07
✏Pages : 236
✏ISBN : 9789813143326
✏Available Language : English, Spanish, And French

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✏Nutrition Epigenetics and Health Book Summary : Epigenetics is emerging as an important factor in risk of diseases of global importance including obesity, cardiovascular disease and cancer. Unlike gene polymorphisms which have been the focus of understanding the role of inherited disease susceptibility for some time, epigenetic can be modified by environmental factors, in particular nutrition. Thus research into the role of epigenetics in disease has substantial potential for explaining the impact of the environmental factors such as diet on disease risk. Since epigenetic processes can be modified by nutrition, it may be possible to modify inappropriate epigenetic marks by nutritional interventions to reduce disease risk. This book will explore current understanding of the interaction between nutrition, epigenetics and disease risk, will place this knowledge in the context of global health and discuss the ethical implications of this research.

Nf Kb In Health And Disease Book PDF
✏Book Title : NF kB in Health and Disease
✏Author : Michael Karin
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-04-26
✏Pages : 268
✏ISBN : 3642160174
✏Available Language : English, Spanish, And French

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✏NF kB in Health and Disease Book Summary : Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation

The Medical News Book PDF
✏Book Title : The Medical News
✏Author :
✏Publisher :
✏Release Date : 1891
✏Pages :
✏ISBN : MSU:31293017659933
✏Available Language : English, Spanish, And French

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✏The Medical News Book Summary :

Gene Regulation Epigenetics And Hormone Signaling Book PDF
✏Book Title : Gene Regulation Epigenetics and Hormone Signaling
✏Author : Subhrangsu S. Mandal
✏Publisher : John Wiley & Sons
✏Release Date : 2017-10-23
✏Pages : 668
✏ISBN : 9783527322817
✏Available Language : English, Spanish, And French

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✏Gene Regulation Epigenetics and Hormone Signaling Book Summary : The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

📒Register Of Research ✍ Great Britain. Department of the Environment

Register Of Research Book PDF
✏Book Title : Register of Research
✏Author : Great Britain. Department of the Environment
✏Publisher :
✏Release Date : 1975
✏Pages : 258
✏ISBN : 0903197499
✏Available Language : English, Spanish, And French

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✏Register of Research Book Summary :

Protein Deimination In Human Health And Disease Book PDF
✏Book Title : Protein Deimination in Human Health and Disease
✏Author : Anthony P. Nicholas
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-12-03
✏Pages : 433
✏ISBN : 9781461483175
✏Available Language : English, Spanish, And French

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✏Protein Deimination in Human Health and Disease Book Summary : Deimination is a relatively new post-translational modification of proteins, whose recognition is ever-increasing. First linked to the pathology of rheumatoid arthritis (RA), deimination is a process by which selected positively charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl arginine deiminase (PAD) family of enzymes. Although the medical literature is rich with articles about the possible significance of deiminated proteins in RA, Protein Deimination in Human Health and Disease is the first publication to compile this knowledge and the growing amount of new information now known about the presence of deiminated proteins in the eye, skin, hair, gums, lung and nervous system, as well. As a result, this process has now been linked to numerous additional conditions besides RA, including cancer, glaucoma, Alzheimer's disease, Parkinson's disease, multiple sclerosis, spinal cord and peripheral nerve injury, Creutzfeldt-Jakob disease, among many others. Chronicling the earliest studies of deimination up to the present, this volume distills what is currently known about citrullination of proteins in the human body and is the first book of its kind on the topic.

📒Gene Control ✍ David Latchman

Gene Control Book PDF
✏Book Title : Gene Control
✏Author : David Latchman
✏Publisher : Garland Science
✏Release Date : 2018-03-29
✏Pages : 448
✏ISBN : 9781136844201
✏Available Language : English, Spanish, And French

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✏Gene Control Book Summary : Gene Control offers a current description of how gene expression is controlled in eukaryotes, reviewing and summarizing the extensive primary literature into an easily accessible format. Gene Control is a comprehensively restructured and expanded edition of Latchman’s Gene Regulation: A Eukaryotic Perspective, Fifth Edition. The first part of the book deals with the fundamental processes of gene control at the levels of chromatin structure, transcription, and post-transcriptional processes. Three pairs of chapters deal with each of these aspects, first describing the basic process itself, followed by the manner in which it is involved in controlling gene expression. The second part of the book deals with the role of gene control in specific biological processes. Certain chapters deal with the importance of gene control in cellular signaling processes and for normal development of the embryo. Another chapter discusses the key roles played by gene-regulatory processes in the specification of differentiated cell types such as muscle cells and neurons. The final chapters discuss the consequences of errors in gene control; the relationship between gene misregulation and human diseases, especially cancer; and potential therapies designed specifically to target particular levels of gene control. Gene Control will be of value to students in biological sciences, as well as to scientists and clinicians interested in how genes are regulated in health and disease.

Human Epigenetics How Science Works Book PDF
✏Book Title : Human Epigenetics How Science Works
✏Author : Carsten Carlberg
✏Publisher : Springer Nature
✏Release Date : 2019-09-24
✏Pages : 153
✏ISBN : 9783030229078
✏Available Language : English, Spanish, And French

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✏Human Epigenetics How Science Works Book Summary : The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

📒Epigenomics ✍ Anne C. Ferguson-Smith

Epigenomics Book PDF
✏Book Title : Epigenomics
✏Author : Anne C. Ferguson-Smith
✏Publisher : Springer Science & Business Media
✏Release Date : 2008-12-05
✏Pages : 438
✏ISBN : 9781402091872
✏Available Language : English, Spanish, And French

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✏Epigenomics Book Summary : Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times. The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease. The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum.

📒Nutrition In Epigenetics ✍ Mihai D. Niculescu

Nutrition In Epigenetics Book PDF
✏Book Title : Nutrition in Epigenetics
✏Author : Mihai D. Niculescu
✏Publisher : John Wiley & Sons
✏Release Date : 2011-03-25
✏Pages : 332
✏ISBN : 0470959800
✏Available Language : English, Spanish, And French

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✏Nutrition in Epigenetics Book Summary : The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.

Epigenetic Aspects Of Chronic Diseases Book PDF
✏Book Title : Epigenetic Aspects of Chronic Diseases
✏Author : Helmtrud I. Roach
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-04-01
✏Pages : 236
✏ISBN : 1848826443
✏Available Language : English, Spanish, And French

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✏Epigenetic Aspects of Chronic Diseases Book Summary : Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.

A Clinician S Guide To Sperm Dna And Chromatin Damage Book PDF
✏Book Title : A Clinician s Guide to Sperm DNA and Chromatin Damage
✏Author : Armand Zini
✏Publisher : Springer
✏Release Date : 2018-03-05
✏Pages : 605
✏ISBN : 9783319718156
✏Available Language : English, Spanish, And French

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✏A Clinician s Guide to Sperm DNA and Chromatin Damage Book Summary : This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.

📒Adolescents In Health And Disease ✍ William Andrew Daniel

Adolescents In Health And Disease Book PDF
✏Book Title : Adolescents in Health and Disease
✏Author : William Andrew Daniel
✏Publisher :
✏Release Date : 1977
✏Pages : 392
✏ISBN : UOM:39015003229344
✏Available Language : English, Spanish, And French

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✏Adolescents in Health and Disease Book Summary :