Chimeric Antigen Receptor T Cell Therapies For Cancer

Chimeric Antigen Receptor T Cell Therapies For Cancer E Book Book PDF
✏Book Title : Chimeric Antigen Receptor T Cell Therapies for Cancer E Book
✏Author : Daniel W. Lee
✏Publisher : Elsevier Health Sciences
✏Release Date : 2019-11-30
✏Pages : 244
✏ISBN : 9780323755979
✏Available Language : English, Spanish, And French

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✏Chimeric Antigen Receptor T Cell Therapies for Cancer E Book Book Summary : From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Chimeric Antigen Receptor T Cell Therapies For Cancer Book PDF
✏Book Title : Chimeric Antigen Receptor T Cell Therapies for Cancer
✏Author : Daniel W. Lee
✏Publisher : Elsevier
✏Release Date : 2019-12-02
✏Pages : 244
✏ISBN : 0323661815
✏Available Language : English, Spanish, And French

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✏Chimeric Antigen Receptor T Cell Therapies for Cancer Book Summary : From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Cellular Therapies In Cancer Book PDF
✏Book Title : Cellular Therapies in Cancer
✏Author : Katy Rezvani
✏Publisher : Frontiers Media SA
✏Release Date : 2020-01-16
✏Pages :
✏ISBN : 9782889633784
✏Available Language : English, Spanish, And French

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✏Cellular Therapies in Cancer Book Summary :

Car T Cell Therapies For Non Hematopoietic Malignancies Taking Off The Training Wheels Book PDF
✏Book Title : CAR T Cell Therapies for Non Hematopoietic Malignancies Taking Off The Training Wheels
✏Author : Avery Dexter Posey, Jr.
✏Publisher : Frontiers Media SA
✏Release Date : 2020-04-24
✏Pages :
✏ISBN : 9782889636877
✏Available Language : English, Spanish, And French

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✏CAR T Cell Therapies for Non Hematopoietic Malignancies Taking Off The Training Wheels Book Summary : Chimeric antigen receptor (CAR) T cell therapies for leukemia (e.g. tisagenlecleucel) and lymphoma (e.g. axicabtagene ciloleucel) have recently received regulatory approval in the United States. Phase I/II trials have demonstrated complete remission of refractory or relapsed tumors in 50% - 94% patients. However, the clinical successes of engineered T cells for the treatment of solid malignancies have thus far been few and far between. Furthermore, several instances of severe and lethal toxicities have arisen due to on-target, off-tumor recognition of antigen by T cell products. Recent advances in phase I trials for solid tumors, as well as in pre-clinical models, have revealed several variables that will be important to consider for the successful use of CAR-T cells in treating solid tumors. These variables include (i) regional versus systemic delivery; (ii) scFv versus ligand interactions; (iii) antigen loss versus escape; (iv) epitope spreading and (v) checkpoint expression on immune cells or tumor cells. Also, there remains outstanding mechanistic questions related to why differences exist in the persistence and tonic signaling of second-generation CD28 versus 4-1BB co-stimulated CAR-T cells. In addition, we are now learning the roles of lympho-depleting regimens (and associated toxicities) in modifying the persistence of engineered T cell therapies. A more comprehensive view of CAR-T cell strategies and important advances, both of pre-clinical and clinical evaluations, in solid tumors is necessary to drive these therapies forward.

Part I Understanding Cancer Immunotherapy A Brief Review Part Ii What Is Chimeric Antigen Receptor Car T Cell Therapy An Emerging Cancer Treatment Modality  Book PDF
✏Book Title : Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality
✏Author : Dr. Hakim Saboowala
✏Publisher : Dr.Hakim Saboowala
✏Release Date : 2020-05-12
✏Pages :
✏ISBN :
✏Available Language : English, Spanish, And French

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✏Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality Book Summary : Part I- Understanding Cancer Immunotherapy: A brief Review. Immunotherapy, also called biologic therapy, is a type of cancer treatment that boosts the body's natural defenses to fight cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by: Stopping or slowing the growth of cancer cells Stopping cancer from spreading to other parts of the body Helping the immune system work better at destroying cancer cells There are several types of immunotherapy, including: Monoclonal antibodies and tumor-agnostic therapies Non-specific immunotherapies Oncolytic virus therapy T-cell therapy Cancer vaccines Part II- “What is Chimeric Antigen Receptor (CAR) T- Cell Therapy?” An Emerging Cancer Treatment Modality. Chimeric antigen receptor (CAR) T-cell therapy is an emerging cancer treatment modality in which the patients’ own immune cells are collected, genetically engineered to recognize a tumor-related target, expanded in vitro, and then reinfused to produce responses and prevent progression in a variety of malignancies (ie, adoptive cell transfer) Several types of adoptive cell transfer(ACT) are under investigation, but CAR T-cell therapy is the first to enter clinical practice. Like other technologies, CAR-T cell therapy has undergone a long development process in the past. Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. I have endeavored to compile this E- Booklet into Two Parts i.e. Part I & Part II for better understanding of Chimeric antigen receptor (CAR) T-cell therapy, an emerging cancer treatment modality. In Part I, an effort has been made to describe Cancer Immunotherapy briefly whereas in Part II know about of CAR T-Cell Therapy-the first to enter clinical practice- has been embodied. Further it is attempted to describe toxicity of CAR-T cell therapy briefly and future development and opportunities for immunotherapy. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Development Of Biomaterials For Chimeric Antigen Receptor Car T Cell Therapy Book PDF
✏Book Title : Development of Biomaterials for Chimeric Antigen Receptor CAR T Cell Therapy
✏Author : Brynn Riann Olden
✏Publisher :
✏Release Date : 2018
✏Pages : 115
✏ISBN : OCLC:1083532311
✏Available Language : English, Spanish, And French

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✏Development of Biomaterials for Chimeric Antigen Receptor CAR T Cell Therapy Book Summary : Chimeric antigen receptor (CAR) T cell therapy has emerged as an effective new cancer treatment that genetically reprograms a patient’s T cells to recognize an epitope specifically expressed on the surface of cancer cells and trigger cytotoxic action against those cancer cells. This therapy has been especially effective in the treatment of CD19+ hematologic malignancies. However, the manufacturing of these autologous cell therapies requires laborious processing steps that present multiple challenges and opportunities for innovation, described in Chapter 1. The current manufacturing system requires extensive use of biologic reagents including antibody-coated magnetic beads for manipulation and expansion, and retroviruses for genetic modification of ex vivo cultured T cells. In this work, three classes of synthetic biomaterials are developed to improve and study the ex vivo expansion and genetic modification of primary human T cells. In Chapter 2, we describe the development of cell-templated supported lipid bilayers as a platform for studying the effect of activation particle design on polyclonal T cell expansion and differentiation. Chapter 3 describes work towards identifying synthetic peptide and aptamer targeting ligands for T cell activation through library screening techniques. In Chapters 4 and 5, we report the use of cationic polymers of defined architecture for non-viral gene delivery to T cells and study the underlying barriers to improved gene delivery in T cells. The major findings from this work are summarized in Chapter 6 where we also make recommendations for future applications and directions of this work.

Cars On The Highway Chimeric Antigen Receptor Modified T Cells For The Adoptive Cell Therapy Of Malignant Diseases Book PDF
✏Book Title : CARs on the Highway Chimeric Antigen Receptor Modified T Cells for the Adoptive Cell Therapy of Malignant Diseases
✏Author : Astrid Holzinger
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1154264621
✏Available Language : English, Spanish, And French

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✏CARs on the Highway Chimeric Antigen Receptor Modified T Cells for the Adoptive Cell Therapy of Malignant Diseases Book Summary : Adoptive therapy of malignant diseases by chimeric antigen receptor (CAR) redirected T cells takes advantage of the patient's own immune system to recognize and destroy cancer cells. This is impressively demonstrated by the induction of complete and lasting remissions of leukemia with CAR-engineered T cells in early phase trials. Recent developments in optimizing the CAR design, in the recognition of target cells and the production of modified cells for clinical use, have paved the path for a broader application than currently explored. The chapter reviews the differences in CAR design, the success in the treatment of hematologic malignancies, the challenges in treating solid cancer, the treatment-related toxicities, and strategies to improve safety of CAR T cell therapy. Challenges for future applications are discussed.

Investigating The Efficacy Of Car T Cells Expressing Tqm 13 In Targeting Glioblastoma Book PDF
✏Book Title : Investigating the Efficacy of CAR T Cells Expressing TQM 13 in Targeting Glioblastoma
✏Author : Hali A Jiang
✏Publisher :
✏Release Date : 2019
✏Pages :
✏ISBN : OCLC:1107169324
✏Available Language : English, Spanish, And French

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✏Investigating the Efficacy of CAR T Cells Expressing TQM 13 in Targeting Glioblastoma Book Summary : Chimeric antigen receptor (CAR) modified T-cell therapy has proven to be an attractive immunotherapy that involves the genetic modification of T-lymphocytes to target specific antigens expressed by cancer cells. Recent research has shown promising results for CAR T-cells expressing Targeted Quadruple Mutant-13 (TQM-13), a mutant version of interleukin-13 (IL-13), in targeting and attacking glioblastoma multiforme (GBM). CAR T immunotherapy is able to utilize the inherent ability of T-lymphocyte cells to migrate across the blood-brain barrier (BBB), a specialized, highly selective, semipermeable membrane formed by neurovascular endothelial cells that restrict the substances that enter and exit the central nervous system. Additionally, the CAR modification leads to specialized targeting of a specific antigen displayed by the tumor of interest. Once attached and bound to the target, the CAR T-cell becomes activated leading to T-cell proliferation, secretion of apoptosis-inducing proteins, and subsequent destruction of the tumor cells. The present study examines the ability of CAR T-cells expressing TQM-13 to target GBM. The results indicate that CAR modification did not impede the cells natural ability to form intercellular gaps nor their ability to extravasate through an endothelial layer, both crucial steps in crossing the BBB. Additionally, it was found that CAR modification significantly increased both the total number of adhesions observed as well as the length of time the CAR T-cells adhered to GBM cells under flow conditions. These results imply that a TQM-13 directed CAR design has the potential to be a powerful therapeutic tool in the treatment of GBM.

Tumor Immunology And Immunotherapy Book PDF
✏Book Title : Tumor Immunology and Immunotherapy
✏Author : Robert C. Rees
✏Publisher : Oxford University Press, USA
✏Release Date : 2014-05-20
✏Pages : 442
✏ISBN : 9780199676866
✏Available Language : English, Spanish, And French

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✏Tumor Immunology and Immunotherapy Book Summary : Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting to show positive results. Following recent FDA approval for a vaccination against prostate cancer, and optimistic results in clinical trials for a vaccine targeting cancer antigens in lung cancer, cancer immunotherapy is now significantly impacting patient clinical management. Tumor Immunology and Immunotherapy provides an up-to-date and comprehensive account of cancer immunity and immunotherapy. It discusses our adaptive and innate immunity to cancer, the mechanisms underpinning our immune response, current approaches to cancer immunotherapy, and how tumour and host responses can circumvent effective anti-cancer immunity. The book examines recent results, publications and current areas of interest including 'immune editing' and the specific issues that are affecting the research and development of vaccines, providing insight into how these problems may be overcome, as viewed by world leaders in the field. Tumor Immunology and Immunotherapy will appeal to clinicians working in oncology and cancer immunotherapy, and research scientists including PhD and masters students, post-doctoral researchers and senior investigators.

Developments In T Cell Based Cancer Immunotherapies Book PDF
✏Book Title : Developments in T Cell Based Cancer Immunotherapies
✏Author : Paolo A. Ascierto
✏Publisher : Humana Press
✏Release Date : 2015-11-26
✏Pages : 305
✏ISBN : 9783319211671
✏Available Language : English, Spanish, And French

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✏Developments in T Cell Based Cancer Immunotherapies Book Summary : This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.

Current Perspectives Challenges And Advances In Cell Based Therapies Book PDF
✏Book Title : Current Perspectives Challenges and Advances in Cell Based Therapies
✏Author : Prashant Trikha
✏Publisher : Frontiers Media SA
✏Release Date : 2020-03-24
✏Pages :
✏ISBN : 9782889635641
✏Available Language : English, Spanish, And French

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✏Current Perspectives Challenges and Advances in Cell Based Therapies Book Summary :

Public Private Partnerships As Drivers Of Innovation In Healthcare 2nd Edition Book PDF
✏Book Title : Public Private Partnerships as Drivers of Innovation in Healthcare 2nd Edition
✏Author : Hilde Stevens
✏Publisher : Frontiers Media SA
✏Release Date : 2020-08-04
✏Pages : 107
✏ISBN : 9782889639458
✏Available Language : English, Spanish, And French

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✏Public Private Partnerships as Drivers of Innovation in Healthcare 2nd Edition Book Summary : Multi-stakeholder collaborations involving partners from public and private sectors are essential to address global health challenges and to move precision medicine forward. This eBook assembles a collection of papers which either illustrate recent achievements or discuss new perspectives offered by public-private partnerships in healthcare. Publisher’s note: In this 2nd edition, the following article has been added: Laverty H and Meulien P (2019) The Innovative Medicines Initiative −10 Years of Public-Private Collaboration. Front. Med. 6:275. doi: 10.3389/fmed.2019.00275

Immunologic Concepts In Transfusion Medicine E Book Book PDF
✏Book Title : Immunologic Concepts in Transfusion Medicine E Book
✏Author : Robert W Maitta
✏Publisher : Elsevier Health Sciences
✏Release Date : 2019-08-27
✏Pages : 380
✏ISBN : 9780323675109
✏Available Language : English, Spanish, And French

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✏Immunologic Concepts in Transfusion Medicine E Book Book Summary : Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. Consolidates today’s available information on this timely topic into a single, convenient resource.

📒Cell And Gene Therapies ✍ Miguel-Angel Perales

Cell And Gene Therapies Book PDF
✏Book Title : Cell and Gene Therapies
✏Author : Miguel-Angel Perales
✏Publisher : Springer
✏Release Date : 2018-11-27
✏Pages : 288
✏ISBN : 9783319543680
✏Available Language : English, Spanish, And French

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✏Cell and Gene Therapies Book Summary : In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee.

Overcoming Ovarian Cancer Chemoresistance Book PDF
✏Book Title : Overcoming Ovarian Cancer Chemoresistance
✏Author : Goli Samimi
✏Publisher : Academic Press
✏Release Date : 2020-11-19
✏Pages : 188
✏ISBN : 9780128198414
✏Available Language : English, Spanish, And French

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✏Overcoming Ovarian Cancer Chemoresistance Book Summary : Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Second Generation Cell And Gene Based Therapies Book PDF
✏Book Title : Second Generation Cell and Gene Based Therapies
✏Author : Alain Vertes
✏Publisher : Academic Press
✏Release Date : 2020-02-07
✏Pages : 846
✏ISBN : 9780128120330
✏Available Language : English, Spanish, And French

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✏Second Generation Cell and Gene Based Therapies Book Summary : Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products. The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals. Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization "Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies

Chimeric Antigen Receptor T Cell Therapy For The Community Oncologist Book PDF
✏Book Title : Chimeric Antigen Receptor T Cell Therapy for the Community Oncologist
✏Author :
✏Publisher :
✏Release Date : 2016
✏Pages :
✏ISBN : OCLC:1053694839
✏Available Language : English, Spanish, And French

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✏Chimeric Antigen Receptor T Cell Therapy for the Community Oncologist Book Summary : Abstract : The field of cancer immunotherapy has rapidly progressed in the past decade as several therapeutic modalities have entered into the clinic. One such immunotherapy that has shown promise in the treatment of cancer is the use of chimeric antigen receptor (CAR)‐modified T lymphocytes. CARs are engineered receptors constructed from antigen recognition regions of antibodies fused to T‐cell signaling and costimulatory domains that can be used to reprogram a patient's T cells to specifically target tumor cells. CAR T‐cell therapy has demonstrated sustained complete responses for some patients with advanced leukemia, and a number of CAR therapies are being evaluated in clinical studies. CAR T‐cell therapy‐associated toxicities, including cytokine release syndrome, macrophage activation syndrome, and tumor lysis syndrome, have been observed and effectively managed in the clinic. In patients with significant clinical responses, sustained B‐cell aplasia has also been observed and is a marker of CAR T‐cell persistence that might provide long‐term disease control. Education on CAR T‐cell therapy efficacy and safety management is critical for clinicians and patients who are considering this novel type of treatment. In the present report, the current landscape of CAR T‐cell therapy, the effective management of patients undergoing treatment, and which patients are the most suitable candidates for current trials are discussed. Implications for Practice: The present report describes the current status of chimeric antigen receptor (CAR) T lymphocytes as an immunotherapy for patients with relapsed or refractory B‐cell malignancies. CAR T cells targeting CD19, a protein expressed on many B‐cell malignancies, typically induce high complete response rates in patients with B‐cell leukemia or lymphoma who have very limited therapeutic options. Recent clinical trial results of CD19 CAR T‐cell therapies and the management of CAR T‐cell‐associated adverse events are discussed. The present report will therefore inform physicians regarding the efficacy and safety of CAR T cells as a therapy for B‐cell malignancies. Abstract : An immunotherapy that has shown promise in cancer treatment is chimeric antigen receptor‐modified (CAR‐modified) T lymphocytes. CARs are engineered receptors constructed from antigen recognition regions of antibodies fused to T‐cell signaling and costimulatory domains that reprogram a patient's T cells to specifically target tumor cells. The current landscape of CAR T‐cell therapy, effective management of patients undergoing treatment, and the most suitable candidates for current trials are discussed.

Basics Of Chimeric Antigen Receptor Car Immunotherapy Book PDF
✏Book Title : Basics of Chimeric Antigen Receptor CAR Immunotherapy
✏Author : Mumtaz Y. Balkhi
✏Publisher : Academic Press
✏Release Date : 2019-07-31
✏Pages : 92
✏ISBN : 9780128197479
✏Available Language : English, Spanish, And French

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✏Basics of Chimeric Antigen Receptor CAR Immunotherapy Book Summary : Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field. Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols Provides unique authority as the editor has worked directly with CARs Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field

Targeted Therapies In Cancer Book PDF
✏Book Title : Targeted Therapies in Cancer
✏Author : Marc Lacroix
✏Publisher :
✏Release Date : 2016
✏Pages :
✏ISBN : 1634846680
✏Available Language : English, Spanish, And French

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✏Targeted Therapies in Cancer Book Summary :

Current Strategies In Cancer Gene Therapy Book PDF
✏Book Title : Current Strategies in Cancer Gene Therapy
✏Author : Wolfgang Walther
✏Publisher : Springer
✏Release Date : 2017-01-17
✏Pages : 121
✏ISBN : 9783319429342
✏Available Language : English, Spanish, And French

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✏Current Strategies in Cancer Gene Therapy Book Summary : This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.

Designing Chimeric Antigen Receptors To Effectively And Safely Target Tumors Book PDF
✏Book Title : Designing Chimeric Antigen Receptors to Effectively and Safely Target Tumors
✏Author :
✏Publisher :
✏Release Date : 2015
✏Pages :
✏ISBN : OCLC:1052001211
✏Available Language : English, Spanish, And French

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✏Designing Chimeric Antigen Receptors to Effectively and Safely Target Tumors Book Summary : Highlights: Description of structural elements of chimeric antigen receptors used to engineer T cells. Differences between T cell receptor and chimeric antigen receptor recognition. Types of T cells that can be engineered to target tumor cells. Strategies for augmenting function and selectivity of chimeric antigen receptors. Strategies for improving safety of chimeric antigen receptor modified T cells. Abstract : The adoptive transfer of T cells engineered to express artificial chimeric antigen receptors CARs) that target a tumor cell surface molecule has emerged as an exciting new approach for cancer immunotherapy. Clinical trials in patients with advanced B cell malignancies treated with CD19-specific CAR-modified T cells (CAR-T) have shown impressive antitumor efficacy, leading to optimism that this approach will be useful for treating common solid tumors. Because CAR-T cells recognize tumor cells independent of their expression of human leukocyte antigen (HLA) molecules, tumors that escape conventional T cells by downregulating HLA and/or mutating components of the antigen processing machinery can be eliminated. The ability to introduce or delete additional genes in T cells has the potential to provide therapeutic cell products with novel attributes that overcome impediments to immune mediated tumor elimination in immunosuppressive tumor microenvironments. This review will discuss recent concepts in the development of effective and safe synthetic CARs for adoptive T cell therapy (ACT).

Oncology Of Infancy And Childhood E Book Book PDF
✏Book Title : Oncology of Infancy and Childhood E Book
✏Author : Stuart H. Orkin
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-06-09
✏Pages : 1392
✏ISBN : 9781437721386
✏Available Language : English, Spanish, And French

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✏Oncology of Infancy and Childhood E Book Book Summary : To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.

Novel Approaches And Strategies For Biologics Vaccines And Cancer Therapies Book PDF
✏Book Title : Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies
✏Author : Manmohan Singh
✏Publisher : Academic Press
✏Release Date : 2014-12-30
✏Pages : 520
✏ISBN : 9780124166615
✏Available Language : English, Spanish, And French

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✏Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies Book Summary : Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Cancer Immunotherapy And Biological Cancer Treatments Book PDF
✏Book Title : Cancer Immunotherapy and Biological Cancer Treatments
✏Author : Hilal Arnouk
✏Publisher : BoD – Books on Demand
✏Release Date : 2019-11-13
✏Pages : 112
✏ISBN : 9781789848625
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy and Biological Cancer Treatments Book Summary : In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or to bypass the tumor evasion of the immune system utilizing the latest advances in cancer vaccine development, formulation, and delivery. This book presents an up-to-date overview of novel cancer biological and immunotherapeutic approaches, including cancer vaccines, mimetic vaccines, monoclonal antibodies, adoptive T-cell transfer, chimeric antigen receptor T- cells, tumor infiltrating lymphocytes, dendritic cells, natural killer cells, immune checkpoint inhibitors, laser ablation, and immune stimulating interstitial laser thermotherapy.

Neuroblastomas New Insights For The Healthcare Professional 2011 Edition Book PDF
✏Book Title : Neuroblastomas New Insights for the Healthcare Professional 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 152
✏ISBN : 9781464901751
✏Available Language : English, Spanish, And French

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✏Neuroblastomas New Insights for the Healthcare Professional 2011 Edition Book Summary : Neuroblastomas: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroblastomas. The editors have built Neuroblastomas: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroblastomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neuroblastomas: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Current Immunotherapeutic Strategies In Cancer Book PDF
✏Book Title : Current Immunotherapeutic Strategies in Cancer
✏Author : Matthias Theobald
✏Publisher : Springer Nature
✏Release Date : 2019-08-31
✏Pages : 187
✏ISBN : 9783030237653
✏Available Language : English, Spanish, And French

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✏Current Immunotherapeutic Strategies in Cancer Book Summary : This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient’s cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.

Targeting The Disialoganglioside Gd2 With Chimeric Antigen Receptor T Cells For Immunotherapy In Diffuse Midline Gliomas And Exploration Of Neuron Opc Synaptic Connectivity In The Context Of Adaptive Myelination Book PDF
✏Book Title : Targeting the Disialoganglioside GD2 with Chimeric Antigen Receptor T Cells for Immunotherapy in Diffuse Midline Gliomas and Exploration of Neuron opc Synaptic Connectivity in the Context of Adaptive Myelination
✏Author : Christopher Mount
✏Publisher :
✏Release Date : 2020
✏Pages :
✏ISBN : OCLC:1155251341
✏Available Language : English, Spanish, And French

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✏Targeting the Disialoganglioside GD2 with Chimeric Antigen Receptor T Cells for Immunotherapy in Diffuse Midline Gliomas and Exploration of Neuron opc Synaptic Connectivity in the Context of Adaptive Myelination Book Summary : Histone 3 K27M mutated diffuse midline glioma (H3K27M DMG) is a universally fatal pediatric brain tumor. Despite improved understanding of the molecular origins of this disease, translations to improvement in clinical outcomes have yet to materialize. To date, there has been little target exploration for immunotherapy applications in H3K27M DMG. In this thesis, I describe my work that elucidated substantial preclinical efficacy of chimeric antigen receptor (CAR)-bearing T cells targeting the disialoganglioside GD2 as an immunotherapy regimen in patient-derived orthotopic xenograft models of H3K27M DMG. Single-dose systemic administration of GD2-4-1BB-CAR T cells in multiple orthotopic xenograft models of H3K27M DMG achieves potent and lasting antitumor efficacy, including tumor clearance by in vivo bioluminescence imaging and follow-up histology. Treatment-associated toxicity was transient and generally tolerated during the period of peak anti-tumor activity in brainstem orthotopic xenografts. If these results are predictive of human response, GD2-directed CAR T cell therapy in the setting of careful clinical management could have a transformative impact upon H3K27M DMG outcomes. In part two of this thesis, I present data revealing a brain-wide map of afferent neuronal connectivity to oligodendrocyte precursor cells (OPCs). Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC afferents, I identified extensive afferent synaptic inputs to OPCs residing in secondary motor cortex and underlying corpus callosum of adult mice. These inputs primarily arise from functionally-interconnecting cortical areas and thalamic nuclei, demonstrating that OPCs in motor-associated territories have synaptic access to brain-wide projection networks engaged in planning and execution of motor tasks. This circuit map is a foundational tool for future studies of context-specific neuron-OPC synapse function.

📒Gene Therapy Of Cancer ✍ Edmund C. Lattime

Gene Therapy Of Cancer Book PDF
✏Book Title : Gene Therapy of Cancer
✏Author : Edmund C. Lattime
✏Publisher : Academic Press
✏Release Date : 2013-08-28
✏Pages : 554
✏ISBN : 9780123946324
✏Available Language : English, Spanish, And French

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✏Gene Therapy of Cancer Book Summary : Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

15 Inpatient Cancer Rehabilitation In A Car T Cell Therapy Lymphoma Patient With Crs And Cres Toxicity Book PDF
✏Book Title : 15 INPATIENT CANCER REHABILITATION IN A CAR T CELL THERAPY LYMPHOMA PATIENT WITH CRS AND CRES TOXICITY
✏Author : Jack Fu
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1163824221
✏Available Language : English, Spanish, And French

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✏15 INPATIENT CANCER REHABILITATION IN A CAR T CELL THERAPY LYMPHOMA PATIENT WITH CRS AND CRES TOXICITY Book Summary : IntroductionCellular immunity using T-cells and their chimeric antigen receptors to redirect their cytotoxic specificity against tumor cells (CAR T-cell therapy) is a new and emerging treatment for a number of cancers. Cytokine Release Syndrome (CRS) and CAR T-cell related Encephalopathy Syndrome (CRES) are common toxicities and can cause significant medical and functional morbidity. Although not previously documented in CAR T-cell treated cancer patients, acute inpatient cancer rehabilitation has been shown to be effective in patients with neutropenic and thrombocytopenic precautions, requiring frequent transfusion support, and with significant neurologic deficits.ObjectiveTo describe the inpatient course including acute inpatient rehabilitation of a lymphoma patient status post CAR T-cell therapy with CRS and CRES toxicities.MethodsCase report from retrospective chart review.ResultsFrom initial hospitalization status post CAR T infusion until discharge from the inpatient rehabilitation unit (IRU) the patientu2019s CRS score improved from 3 (ICU) to 0 (IRU), CRES score improved from 4 (ICU) to 0 (IRU) and FIM mobility score improved from 1 (ICU) to 4 (IRU.)The patient required platelet transfusions 4 of 7 days and PRBC transfusion 3 of 7 days on the rehabilitation unit.He was safely discharged home with family assistance.ConclusionA CAR T-cell therapy patient after CRS and CRES toxicities was managed with comprehensive inpatient rehabilitation, medical and symptom management and discharged to the home setting.

Childhood Leukemia And Cancer An Issue Of Pediatric Clinics E Book Book PDF
✏Book Title : Childhood Leukemia and Cancer An Issue of Pediatric Clinics E Book
✏Author : Yaddanapudi Ravindranath
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-12-26
✏Pages : 353
✏ISBN : 9780323354660
✏Available Language : English, Spanish, And French

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✏Childhood Leukemia and Cancer An Issue of Pediatric Clinics E Book Book Summary : This issue concentrates on the current evidence and the collected experience of pediatric oncologists who care for cancer patients. The individual articles will provide the general pediatrician with a comprehensive primer on diagnosing and managing various types of cancers in the child with cancer. A cancer diagnosis is no longer a death sentence, so management and monitoring is very important and covered in every article.