Chemical Biology of the Genome

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  • Author : Siddhartha Roy
  • Publisher : Academic Press
  • Pages : 350 pages
  • ISBN : 0128176458
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Chemical Biology of the Genome

Download or Read online Chemical Biology of the Genome full in PDF, ePub and kindle. this book written by Siddhartha Roy and published by Academic Press which was released on 14 May 2021 with total page 350 pages. We cannot guarantee that Chemical Biology of the Genome book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery

Chemical Biology of the Genome

Chemical Biology of the Genome
  • Author : Siddhartha Roy,Tapas K. Kundu
  • Publisher : Academic Press
  • Release : 14 May 2021
GET THIS BOOK Chemical Biology of the Genome

Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout,

Advancing Development of Synthetic Gene Regulators

Advancing Development of Synthetic Gene Regulators
  • Author : Anandhakumar Chandran
  • Publisher : Springer
  • Release : 19 September 2017
GET THIS BOOK Advancing Development of Synthetic Gene Regulators

This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates

Chemical Genomics

Chemical Genomics
  • Author : Haian Fu
  • Publisher : Cambridge University Press
  • Release : 13 February 2012
GET THIS BOOK Chemical Genomics

Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals;

Chemical Biology of Natural Products

Chemical Biology of Natural Products
  • Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
  • Publisher : CRC Press
  • Release : 22 September 2017
GET THIS BOOK Chemical Biology of Natural Products

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing

Chemical Genomics

Chemical Genomics
  • Author : Stefan Jaroch,Hilmar Weinmann
  • Publisher : Springer Science & Business Media
  • Release : 26 May 2007
GET THIS BOOK Chemical Genomics

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening

The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs
  • Author : Stefan Jurga,Jan Barciszewski
  • Publisher : Springer Nature
  • Release : 01 October 2020
GET THIS BOOK The Chemical Biology of Long Noncoding RNAs

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A

Chemogenomics and Chemical Genetics

Chemogenomics and Chemical Genetics
  • Author : ERIC MARECHAL,Sylvaine Roy,Laurence Lafanechère
  • Publisher : Springer Science & Business Media
  • Release : 21 June 2011
GET THIS BOOK Chemogenomics and Chemical Genetics

Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine
  • Author : Sheng Ding
  • Publisher : John Wiley & Sons
  • Release : 08 February 2008
GET THIS BOOK Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine

Scientists believe that stem cells have the potential to revolutionize the treatment of numerous diseases and conditions. This guide covers recent advances in technologies and their applications in stem cell biology, addressing the use of both embryonic and adult stem cells and discussing diverse technologies, including genome-wide expression analysis, informatics, chemical genomics, and more. Applications covered encompass self-renewal, differentiation, reprogramming, and regeneration in model organisms. This is a premier reference for practicing professionals involved in stem cell research and students.

Data Mining in Drug Discovery

Data Mining in Drug Discovery
  • Author : Rémy D. Hoffmann,Arnaud Gohier,Pavel Pospisil
  • Publisher : John Wiley & Sons
  • Release : 25 September 2013
GET THIS BOOK Data Mining in Drug Discovery

Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine. Clearly divided into four sections, the first part discusses the different data sources available, both commercial and non-commercial, while the next section looks at the role and value of data mining in drug discovery. The third part compares the most common applications

Chemogenomics and Chemical Genetics

Chemogenomics and Chemical Genetics
  • Author : ERIC MARECHAL,Sylvaine Roy,Laurence Lafanechère
  • Publisher : Springer
  • Release : 17 June 2011
GET THIS BOOK Chemogenomics and Chemical Genetics

Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently

Mass Spectrometry in Chemical Biology

Mass Spectrometry in Chemical Biology
  • Author : Norberto Peporine Lopes,Ricardo Roberto da Silva
  • Publisher : Royal Society of Chemistry
  • Release : 22 November 2017
GET THIS BOOK Mass Spectrometry in Chemical Biology

Introduction; Introduction to mass spectrometry instrumentation and methods used in chemical biology; Metabolomics; Proteomics; Mass spectrometry to discover natural products; Applications of mass spectrometry in synthetic biology; Studying enzyme mechanisms using mass spectrometry: Introduction; Studying enzyme mechanisms using mass spectrometry: Applications; Databases; Future perspectives;

Computational Chemogenomics

Computational Chemogenomics
  • Author : Edgar Jacoby
  • Publisher : CRC Press
  • Release : 03 December 2013
GET THIS BOOK Computational Chemogenomics

This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity

Computational Genome Analysis

Computational Genome Analysis
  • Author : Richard C. Deonier,Simon Tavaré,Michael Waterman
  • Publisher : Springer Science & Business Media
  • Release : 13 August 2007
GET THIS BOOK Computational Genome Analysis

This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key

From Biotechnology to Genomes

From Biotechnology to Genomes
  • Author : Ph Goujon
  • Publisher : World Scientific
  • Release : 27 January 2022
GET THIS BOOK From Biotechnology to Genomes

Aimed at scientists and non-specialised readers alike, this book retraces the source of national and international biotechnology programmes by examining the origins of biotechnology and its political and economic interpretation by large nations. With a foreword by Andr‚ Goffeau, who initiated the European Yeast Genome Project, the book describes the achievements of the first genetic and physical maps, as well as the political and scientific genesis of the American Human Genome Project. Following these advances, the author discusses the European