Cellular Senescence In Disease

Telomeres And Cellular Senescence In Metabolic And Endocrine Diseases Book PDF
✏Book Title : Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases
✏Author : Ryusaku Matsumoto
✏Publisher :
✏Release Date : 2016
✏Pages :
✏ISBN : OCLC:1154231748
✏Available Language : English, Spanish, And French

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✏Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases Book Summary : A number of observations suggest a close connection between telomere length and mortality and age-related disease, suggesting that telomere length is a useful marker of individual biological aging and the shortening of telomere length is causally related with the pathogenesis in age-related diseases. To date, the significance of telomere length in metabolic and endocrine diseases has also been clarified. It has been reported that obesity, type 2 diabetes mellitus (T2DM), NAFLD, and hypertension were associated with shortened telomere length. In endocrine diseases, polycystic ovary syndrome (PCOS), Cushing's syndrome, and acromegaly were associated with shortened telomere length. In these conditions, an increased oxidative stress associated with the metabolic and hormonal abnormalities appears to play a pivotal role in the shortened telomere length. Recently, a large population-based study demonstrated that shortened telomeres at baseline were associated with an increased risk of metabolic diseases, suggesting that the shortened telomere itself plays a causal role for the onset or development of the metabolic diseases. In this chapter, the pathophysiological role of shortened telomere length in metabolic and endocrine diseases and the significance of cellular senescence are discussed.

Senolytics In Disease Ageing And Longevity Book PDF
✏Book Title : Senolytics in Disease Ageing and Longevity
✏Author : Daniel Muñoz-Espin
✏Publisher : Springer Nature
✏Release Date : 2020-04-27
✏Pages : 222
✏ISBN : 9783030449032
✏Available Language : English, Spanish, And French

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✏Senolytics in Disease Ageing and Longevity Book Summary : This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Cellular Senescence Exacerbates Injury And Impairs Regeneration In Biliary Disease Book PDF
✏Book Title : Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease
✏Author : Sofía Ferreira-González
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1064656338
✏Available Language : English, Spanish, And French

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✏Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease Book Summary :

📒Cellular Aging And Cell Death ✍ Nikki J. Holbrook

Cellular Aging And Cell Death Book PDF
✏Book Title : Cellular Aging and Cell Death
✏Author : Nikki J. Holbrook
✏Publisher : John Wiley & Sons
✏Release Date : 1995-12-20
✏Pages : 336
✏ISBN : 0471121231
✏Available Language : English, Spanish, And French

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✏Cellular Aging and Cell Death Book Summary : Cellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext. Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence. Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases. One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging. Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.

Novel Insights Into The Contribution Of Cellular Senescence To Cancer Therapy Book PDF
✏Book Title : Novel Insights Into the Contribution of Cellular Senescence to Cancer Therapy
✏Author : Tareq Saleh
✏Publisher :
✏Release Date : 2018
✏Pages :
✏ISBN : OCLC:1103925031
✏Available Language : English, Spanish, And French

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✏Novel Insights Into the Contribution of Cellular Senescence to Cancer Therapy Book Summary : Cellular senescence a specialized form of growth arrest that contributes to the pathogenesis of several aging-related disorders including cancer. While by definition tumor cells are considered immortalized, they can undergo senescence when exposed to conventional and targeted cancer therapy. Therapy-Induced Senescence (TIS) represents a fundamental response to therapy and impacts its outcomes. However, TIS has been considered a positive therapeutic goal since senescent tumor cells are expected to enter a state of permanent growth abrogation. In this work we examined the hypothesis that a subpopulation of senescent cells can re-acquire proliferative potential after a state of senescent dormancy, indicating that senescence is not obligatorily an irreversible process. Our observations indicate that H460 non-small cell lung cancer cells induced into senescence by exposure to etoposide, and enriched based on Îø-galactosidase staining and size, were shown to recover reproductive capacity, which was accompanied by resolution of the DNA-damage-response (downregulation of p53 and p21Cip1 induction), attenuation of the Senescence-associated Secretory Phenotype (SASP). To overcome the reservation that the newly dividing cells may not have been derived from the senescent population and in an effort to establish that escape from TIS is feasible, tumor cells induced into senescence by chemotherapy were enriched for senescence by flow cytometry; the subsequent division of senescent cells was demonstrable utilizing both real-time, live microscopy and High Speed Live Cell Interferometry (HSLCI). Furthermore, sorted senescent cells were observed to form tumors when implanted in immune deficient mice and with a significant delay in immunecompetent mice. As chemotherapy induced senescent cells have been identified in patient tumors, it is reasonable to propose that tumor cells that escape from senescence could contribute to disease recurrence. In addition, therapy-induced senescence could prove to reflect one form of tumor dormancy. Recently, ABT263 has been used as a senolytic drug, effectively eliminating senescent cells from aging-related animal models. Here, we utilize ABT263 in a two-hit approach to eliminate senescent tumor cells that persistent after exposure to chemotherapy. ABT263 results in the killing of senescent tumor cells in a concentration-dependent manner and shifts the response towards apoptotic cell death. Furthermore, sequential administration of ABT263 interferes with the ability of senescent tumor cells to recover growth potential. These results indicate that senescent tumor cells can contribute to cancer relapse by acquiring proliferative properties and that senolytic therapy allows for the clearance of dormant senescent tumor cells and will potentially decrease cancer recurrence rates.

Cellular Senescence And Tumor Suppression Book PDF
✏Book Title : Cellular Senescence and Tumor Suppression
✏Author : Peter D. Adams
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-01-23
✏Pages : 272
✏ISBN : 1441910751
✏Available Language : English, Spanish, And French

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✏Cellular Senescence and Tumor Suppression Book Summary : As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

Intra Extracellular Dynamics Of The Respiratory System And Global Airway Disease Book PDF
✏Book Title : Intra Extracellular Dynamics of the Respiratory System and Global Airway Disease
✏Author : De Yun Wang
✏Publisher : Frontiers Media SA
✏Release Date : 2020-09-02
✏Pages :
✏ISBN : 9782889639731
✏Available Language : English, Spanish, And French

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✏Intra Extracellular Dynamics of the Respiratory System and Global Airway Disease Book Summary :

The Role Of Ribosomal Protein S6 Kinases In Cellular Senescence Ageing And Fatty Liver Disease Book PDF
✏Book Title : The Role of Ribosomal Protein S6 Kinases in Cellular Senescence Ageing and Fatty Liver Disease
✏Author : Suchira Upeksha Gallage
✏Publisher :
✏Release Date : 2017
✏Pages :
✏ISBN : OCLC:1144798440
✏Available Language : English, Spanish, And French

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✏The Role of Ribosomal Protein S6 Kinases in Cellular Senescence Ageing and Fatty Liver Disease Book Summary :

Senescence And Senescence Related Disorders Book PDF
✏Book Title : Senescence and Senescence Related Disorders
✏Author : Wang Zhiwei
✏Publisher : BoD – Books on Demand
✏Release Date : 2013-02-20
✏Pages : 160
✏ISBN : 9789535109976
✏Available Language : English, Spanish, And French

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✏Senescence and Senescence Related Disorders Book Summary : Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions.

Metabolic And Bioenergetic Drivers Of Neurodegenerative Disease Treating Neurodegenerative Diseases As Metabolic Diseases Book PDF
✏Book Title : Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases
✏Author :
✏Publisher : Academic Press
✏Release Date : 2020-09-01
✏Pages : 322
✏ISBN : 9780128231227
✏Available Language : English, Spanish, And French

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✏Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases Book Summary : Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more. Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases.

📒A Means To An End ✍ William R. Clark

A Means To An End Book PDF
✏Book Title : A Means to an End
✏Author : William R. Clark
✏Publisher : Oxford University Press
✏Release Date : 2002-02-28
✏Pages : 256
✏ISBN : 0195348397
✏Available Language : English, Spanish, And French

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✏A Means to an End Book Summary : Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control. With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders--such as Werner's syndrome--that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning. This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.

Hiv And Respiratory Disease An Issue Of Clinics In Chest Medicine E Book Book PDF
✏Book Title : HIV and Respiratory Disease An Issue of Clinics in Chest Medicine E Book
✏Author : Kristina Crothers
✏Publisher : Elsevier Health Sciences
✏Release Date : 2013-05-29
✏Pages : 214
✏ISBN : 9781455771493
✏Available Language : English, Spanish, And French

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✏HIV and Respiratory Disease An Issue of Clinics in Chest Medicine E Book Book Summary : This issue of Clinics in Chest Medicine is Guest Edited by Kristina Crothers, MD from the University of Washington and will focus on HIV and Respiratory Disease. Article topics include Abnormalities in Host Defense, Antiretroviral Therapy and Lung Immunology, HIV associated Pneumonia, HIV associated Tuberculosis, HIV associated lung malignancies, and HIV associated COPD.

Biomedical Index To Phs Supported Research Book PDF
✏Book Title : Biomedical Index to PHS supported Research
✏Author :
✏Publisher :
✏Release Date : 1994
✏Pages :
✏ISBN : MINN:31951P003778514
✏Available Language : English, Spanish, And French

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✏Biomedical Index to PHS supported Research Book Summary :

📒Coronary Vasculature ✍ Robert J. Tomanek

Coronary Vasculature Book PDF
✏Book Title : Coronary Vasculature
✏Author : Robert J. Tomanek
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-10-19
✏Pages : 278
✏ISBN : 9781461448877
✏Available Language : English, Spanish, And French

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✏Coronary Vasculature Book Summary : Ischemic heart disease is the leading cause of morbidity and mortality in the developed world. The high metabolism and oxygen demand of the cardiac myocardium depends on both a high blood flow and a rich capillary density. For this reason, the growth of the coronary vasculature is vital, not only in early development, but also in the adult faced with various stresses. Novel technologies have enabled the discovery of the molecular mechanisms underlying the growth and assembly coronary vessels, and this volume covers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood, and senescence. Chapters address normal coronary development, coronary anomalies and their possible underlying developmental errors, coronary vessel adaptations to exercise training, aging, hypoxia, myocardial ischemia, and cardiac hypertrophy. This comprehensive overview of current research in coronary vessels and myocardial perfusion was written by Dr. Robert J. Tomanek, Emeritus Professor of Anatomy and Cell Biology at the University of Iowa. The book reviews, discusses, and integrates findings from various areas of coronary vasculature research, and as a result, will be a valuable reference source for cardiovascular scientists and physicians for many years to come.

Tumor Dormancy Quiescence And Senescence Volume 2 Book PDF
✏Book Title : Tumor Dormancy Quiescence and Senescence Volume 2
✏Author : M.A. Hayat
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-11-29
✏Pages : 320
✏ISBN : 9789400777262
✏Available Language : English, Spanish, And French

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✏Tumor Dormancy Quiescence and Senescence Volume 2 Book Summary : In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.

📒Cells Aging And Human Disease ✍ Michael B. Fossel M.D.

Cells Aging And Human Disease Book PDF
✏Book Title : Cells Aging and Human Disease
✏Author : Michael B. Fossel M.D.
✏Publisher : Oxford University Press
✏Release Date : 2004-06-10
✏Pages : 504
✏ISBN : 0198032196
✏Available Language : English, Spanish, And French

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✏Cells Aging and Human Disease Book Summary : Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

Aging And Age Related Disorders Book PDF
✏Book Title : Aging and Age Related Disorders
✏Author : Stephen Bondy
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-09-02
✏Pages : 472
✏ISBN : 1607616025
✏Available Language : English, Spanish, And French

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✏Aging and Age Related Disorders Book Summary : Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.

Diet And Exercise In Cognitive Function And Neurological Diseases Book PDF
✏Book Title : Diet and Exercise in Cognitive Function and Neurological Diseases
✏Author : Akhlaq A. Farooqui
✏Publisher : John Wiley & Sons
✏Release Date : 2015-02-06
✏Pages : 384
✏ISBN : 9781118840566
✏Available Language : English, Spanish, And French

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✏Diet and Exercise in Cognitive Function and Neurological Diseases Book Summary : Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.

Inflammation Aging And Oxidative Stress Book PDF
✏Book Title : Inflammation Aging and Oxidative Stress
✏Author : Stephen C. Bondy
✏Publisher : Springer
✏Release Date : 2016-12-14
✏Pages : 405
✏ISBN : 9783319334868
✏Available Language : English, Spanish, And French

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✏Inflammation Aging and Oxidative Stress Book Summary : The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

Telomeres And Telomerase In Aging Disease And Cancer Book PDF
✏Book Title : Telomeres and Telomerase in Aging Disease and Cancer
✏Author : K. Lenhard Rudolph
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-11-07
✏Pages : 330
✏ISBN : 9783540737094
✏Available Language : English, Spanish, And French

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✏Telomeres and Telomerase in Aging Disease and Cancer Book Summary : Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Robbins Cotran Pathologic Basis Of Disease E Book Book PDF
✏Book Title : Robbins Cotran Pathologic Basis of Disease E Book
✏Author : Vinay Kumar
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-06-10
✏Pages : 1464
✏ISBN : 9781437720150
✏Available Language : English, Spanish, And French

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✏Robbins Cotran Pathologic Basis of Disease E Book Book Summary : One of the best-selling medical textbooks of all time, Robbins and Cotran Pathologic Basis of Disease is the one book that nearly all medical students purchase, and is also widely used by physicians worldwide. A "who's who" of pathology experts delivers the most dependable, current, and complete coverage of today's essential pathology knowledge. At the same time, masterful editing and a practical organization make mastering every concept remarkably easy. The result remains the ideal source for an optimal understanding of pathology. Offers the most authoritative and comprehensive, yet readable coverage available in any pathology textbook, making it ideal for USMLE or specialty board preparation as well as for course work. Delivers a state-of-the-art understanding of the pathologic basis of disease through completely updated coverage, including the latest cellular and molecular biology. Demonstrates every concept visually with over 1,600 full-color photomicrographs and conceptual diagrams - many revised for even better quality. Facilitates learning with an outstanding full-color, highly user-friendly design.

Robbins Cotran Pathologic Basis Of Disease E Book Book PDF
✏Book Title : Robbins Cotran Pathologic Basis of Disease E Book
✏Author : Vinay Kumar
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-06-10
✏Pages : 1464
✏ISBN : 9781437721829
✏Available Language : English, Spanish, And French

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✏Robbins Cotran Pathologic Basis of Disease E Book Book Summary : One of the best-selling medical textbooks of all time, Robbins and Cotran Pathologic Basis of Disease is the one book you likely purchased as a medical student that still provides answers now that you're in practice. The new PROFESSIONAL EDITION is the same "who's who" of pathology experts that delivers the most dependable, current, and complete coverage of today's essential pathology knowledge, now enhanced with PERKS DESIGNED SPECIALLY FOR YOU AS A PRACTITIONER. Masterful editing and a practical organization make learning or reinforcing every concept remarkably easy. The result remains the ideal source for an optimal understanding of pathology at its core. Offers the most authoritative and comprehensive, yet readable coverage available in any pathology textbook, making it ideal for USMLE or specialty board preparation as well as for course work

Inflammation Advancing Age And Nutrition Book PDF
✏Book Title : Inflammation Advancing Age and Nutrition
✏Author : Irfan Rahman
✏Publisher : Academic Press
✏Release Date : 2013-09-03
✏Pages : 394
✏ISBN : 9780123978073
✏Available Language : English, Spanish, And French

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✏Inflammation Advancing Age and Nutrition Book Summary : The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field. Includes models of aging, including worm, mouse and human Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition Includes suggested nutritional interventions

📒Frailty ✍ R.A. Fielding

Frailty Book PDF
✏Book Title : Frailty
✏Author : R.A. Fielding
✏Publisher :
✏Release Date : 2015
✏Pages : 124
✏ISBN : 3318054771
✏Available Language : English, Spanish, And French

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✏Frailty Book Summary : Cover -- Contents -- Preface -- Foreword -- Contributors -- Connecting Age-Related Biological Decline to Frailty and Late-Life Vulnerability -- Abstract -- Introduction -- Frailty Conceptualization -- Frailty Measurement -- The Biology That Underlies Frailty -- Disease States and Frailty -- Physiological System Dysregulation and Frailty -- Age-Related Cellular and Molecular Changes and Frailty -- Disclosure Statement -- References -- Cellular Senescence and the Biology of Aging, Disease, and Frailty -- Abstract -- Introduction -- Cellular Senescence, the Senescence-Associated Secretory Phenotype, and Aging -- Cellular Senescence and Age-Related Disease and Frailty -- Interventions Targeting Senescent Cells and the Senescence-Associated Secretory Phenotype -- Conclusions -- Acknowledgments -- Disclosure Statement -- References -- The Role of Genome Instability in Frailty: Mitochondria versus Nucleus -- Abstract -- Introduction -- Cellular and Mitochondrial Mechanisms of Nuclear Genome Instability -- Mitochondrial Quality Control and Nuclear Genome Stability -- Concluding Remarks -- Acknowledgments -- Disclosure Statement -- References -- Determinants of Frailty and Longevity: Are They the Same Ones? -- Abstract -- Introduction -- Longevity and Functional Reserve -- Disease, Functional Reserve, and Frailty -- Longevity and Frailty: Biological Background -- Disclosure Statement -- References -- Psychological Frailty in the Aging Patient -- Abstract -- Introduction -- Frailty -- Psychological Frailty -- Disclosure Statement -- References -- Frailty Clinical Phenotype: A Physical and Cognitive Point of View -- Abstract -- Introduction -- Physical Frailty: From Concept to Clinical Practice -- Cognitive Frailty: From Concept to Operational Definition -- Redefining Frailty: Emerging Definitions -- Conclusion -- Acknowledgments -- Disclosure Statement.

📒Human Biology ✍ Sara Stinson

Human Biology Book PDF
✏Book Title : Human Biology
✏Author : Sara Stinson
✏Publisher : John Wiley & Sons
✏Release Date : 2012-03-19
✏Pages : 780
✏ISBN : 9781118108048
✏Available Language : English, Spanish, And French

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✏Human Biology Book Summary : This comprehensive introduction to the field of human biology covers all the major areas of the field: genetic variation, variation related to climate, infectious and non-infectious diseases, aging, growth, nutrition, and demography. Written by four expert authors working in close collaboration, this second edition has been thoroughly updated to provide undergraduate and graduate students with two new chapters: one on race and culture and their ties to human biology, and the other a concluding summary chapter highlighting the integration and intersection of the topics covered in the book.

Treating Autoimmune Disease With Chinese Medicine E Book Book PDF
✏Book Title : Treating Autoimmune Disease with Chinese Medicine E Book
✏Author : Wanzhu Hou
✏Publisher : Elsevier Health Sciences
✏Release Date : 2009-07-21
✏Pages : 320
✏ISBN : 9780702036248
✏Available Language : English, Spanish, And French

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✏Treating Autoimmune Disease with Chinese Medicine E Book Book Summary : TREATING AUTOIMMUNE DISEASES WITH CHINESE MEDICINE clearly describes the integration of Chinese and Western medicine in the treatment of autoimmune diseases. This book clearly describes how Chinese medicine can treat autoimmune diseases by clearly presenting recommendations for acupuncture point and herbal treatment when the patient presents with different symptoms, different blood results and may be taking different medications. Written by highly qualified, American-based practitioners with long experience of working in both Chinese and Western medical environments Addresses the use of Chinese medicine in a wide range of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, and psoriasis Includes treatments using both acupuncture and Chinese herbs

The Role Of Bile Pigments In Health And Disease Effects On Cell Signaling Cytotoxicity And Cytoprotection Book PDF
✏Book Title : The role of bile pigments in health and disease effects on cell signaling cytotoxicity and cytoprotection
✏Author : Jaime Kapitulnik
✏Publisher : Frontiers E-books
✏Release Date :
✏Pages :
✏ISBN : 9782889190447
✏Available Language : English, Spanish, And French

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✏The role of bile pigments in health and disease effects on cell signaling cytotoxicity and cytoprotection Book Summary : Degradation of heme involves its conversion to biliverdin by heme oxygenase followed by reduction of biliverdin to bilirubin by biliverdin reductase. There is ample evidence for the pleiotropic functions of biliverdin reductase in cell signaling and regulation of gene expression. This enzyme plays a major role in glucose uptake and the stress response. Bilirubin has been shown to behave as a "double-edged sword". It can exert either cytotoxic or cytoprotective effects, depending on the blood and/or tissue concentration of its free fraction, the nature of the target cell or tissue, and the cellular redox state. Its antioxidant effect is the basis for the proposed cardioprotective effect of relatively low blood concentrations of bilirubin in humans with moderate hyperbilirubinemia. This Special Topic forum is intended to serve as a platform for updating information and presenting advances in basic and clinical research in the above and related subjects.

Prevention And Treatment Of Age Related Diseases Book PDF
✏Book Title : Prevention and Treatment of Age related Diseases
✏Author : Suresh I.S. Rattan
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-05-09
✏Pages : 364
✏ISBN : 9781402050589
✏Available Language : English, Spanish, And French

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✏Prevention and Treatment of Age related Diseases Book Summary : This book offers a broad-ranging assessment of current efforts of the molecular, cellular, hormonal, nutritional and lifestyle strategies being tested and applied by biogerontologists in the search for effective means of intervention, prevention and treatment of age-related diseases, and for achieving healthy old age. Employing a semi-academic style, the book presents data from experimental systems, while focusing primarily on their applications to humans in the prevention and treatment of age-related impairments.

The Impact Of Obesity And Nutrition On Chronic Liver Diseases An Issue Of Clinics In Liver Disease E Book Book PDF
✏Book Title : The Impact of Obesity and Nutrition on Chronic Liver Diseases An Issue of Clinics in Liver Disease E Book
✏Author : Zobair Younossi
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-02-07
✏Pages : 707
✏ISBN : 9780323266659
✏Available Language : English, Spanish, And French

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✏The Impact of Obesity and Nutrition on Chronic Liver Diseases An Issue of Clinics in Liver Disease E Book Book Summary : Internationally renowned experts present topics related to obesity, nutrition, and liver disease in this issue. In the first article, the epidemiology of obesity and its association with liver disease are covered. The following two articles focus on the roles that visceral adipose tissue and microbiota potentially play in the pathogenesis of obesity-related liver disease. The next article focuses on the hepatic pathology seen in patients with obesity-related liver disease and those with malnutrition. The next five articles are focused on NAFLD and provide in-depth data on the natural history and treatment strategies for patients with NAFLD. The next six articles deal with the impact of obesity on other liver diseases and on special populations including children and liver-transplant recipients. The final article provides the most updated information regarding genomics and genetic targets that may provide better prognostic and diagnostic biomarkers and more personalized treatment targets for patients with NAFLD. Cutting-edge information in this issue will help readers gain better understanding of the natural history and pathogenesis of primary and secondary liver diseases associated with obesity. As the information about obesity-related liver disease expands, clinicians will be able to provide more targeted therapeutic options for these patients and develop more accurate diagnostic and prognostic biomarkers.

Brocklehurst S Textbook Of Geriatric Medicine And Gerontology Book PDF
✏Book Title : Brocklehurst s Textbook of Geriatric Medicine and Gerontology
✏Author : Howard M. Fillit
✏Publisher : Elsevier Health Sciences
✏Release Date : 2010-05-10
✏Pages : 1152
✏ISBN : 9781437720754
✏Available Language : English, Spanish, And French

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✏Brocklehurst s Textbook of Geriatric Medicine and Gerontology Book Summary : Popular with generations of practitioners, Brocklehurst's Textbook of Geriatric Medicine and Gerontology has been the definitive reference of choice in the field of geriatric care. The new 7th Edition, by Howard M. Fillit, MD, Kenneth Rockwood, MD, and Kenneth Woodhouse, carries on this tradition with an increased clinical focus and updated coverage to help you meet the unique challenges posed by this growing patient population. Consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more make reference quick and easy, while over 255 illustrations compliment the text to help you find what you need on a given condition. Examples of the latest imaging studies depict the effects of aging on the brain, and new algorithms further streamline decision making. Emphasizes the clinical relevance of the latest scientific findings to help you easily apply the material to everyday practice. Features consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more that make reference quick and easy. Includes over 255 illustrations—including algorithms, photographs, and tables—that compliment the text to help you find what you need on a given condition. Provides summary boxes at the end of each chapter that highlight important points. Features the work of an expert author team, now led by Dr. Howard M. Fillit who provides an American perspective to complement the book’s traditional wealth of British expertise. Includes an expanded use of algorithms to streamline decision making. Presents more color images in the section on aging skin, offering a real-life perspective of conditions for enhanced diagnostic accuracy. Includes examples of the latest imaging studies to help you detect and classify changes to the brain during aging. Offers Grade A evidence-based references keyed to the relevant text.