Cellular Senescence in Disease

Produk Detail:
  • Author : Manuel Serrano
  • Publisher : Academic Press
  • Pages : 472 pages
  • ISBN : 0128225157
  • Rating : /5 from reviews
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Download or Read online Cellular Senescence in Disease full in PDF, ePub and kindle. this book written by Manuel Serrano and published by Academic Press which was released on 27 November 2021 with total page 472 pages. We cannot guarantee that Cellular Senescence in Disease book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities. Provides a thorough introduction to Cellular Senescence Covers all major pathologies for which cellular senescence has shown evidence of involvement Focuses on possible therapeutic pathways Edited and authored by worldwide experts

Cellular Senescence in Disease

Cellular Senescence in Disease
  • Author : Manuel Serrano,Daniel Munoz-Espin
  • Publisher : Academic Press
  • Release : 27 November 2021
GET THIS BOOK Cellular Senescence in Disease

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (

Senolytics in Disease Ageing and Longevity

Senolytics in Disease  Ageing and Longevity
  • Author : Daniel Muñoz-Espin,Marco Demaria
  • Publisher : Springer Nature
  • Release : 27 April 2020
GET THIS BOOK Senolytics in Disease Ageing and Longevity

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the

Cellular Senescence in Health Disease and Aging

Cellular Senescence in Health  Disease and Aging
  • Author : Markus Riessland
  • Publisher : Mdpi AG
  • Release : 08 November 2021
GET THIS BOOK Cellular Senescence in Health Disease and Aging

Dear Colleagues, When Hayflick and Moorhead coined the term "cellular senescence" (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial roles for CS have been identified, such as embryonic development and wound healing. The senescence associated secretory phenotype (SASP) activated in most senescent cells (SC) signals to the immune system "come here and remove me". In organisms with young and functional immune systems,

Characterization and Treatment of Cellular Senescence in Human Lung Fibroblasts

Characterization and Treatment of Cellular Senescence in Human Lung Fibroblasts
  • Author : Priscilla Tang
  • Publisher : Unknown
  • Release : 08 December 2021
GET THIS BOOK Characterization and Treatment of Cellular Senescence in Human Lung Fibroblasts

Cellular senescence is a state in which cells are arrested in the G1 phase of the cell cycle, but remain metabolically active. Senescent cell can secrete cytokines, chemokines, and proteases that contribute to development of age-related conditions such as osteoarthritis and Alzheimer's disease. Drugs able to selectively kill senescent cells termed senolytics , reduce multiple age-related symptoms in mouse models. To develop as assay to screen for senolytics likely to function in humans, senescence was induced in human lung IMR-90 cells

Tumor Dormancy Quiescence and Senescence Volume 2

Tumor Dormancy  Quiescence  and Senescence  Volume 2
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release : 29 November 2013
GET THIS BOOK Tumor Dormancy Quiescence and Senescence Volume 2

In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that

Aging and Age Related Disorders

Aging and Age Related Disorders
  • Author : Stephen Bondy,Kenneth Maiese
  • Publisher : Springer Science & Business Media
  • Release : 02 September 2010
GET THIS BOOK Aging and Age Related Disorders

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently

Autophagy and Senescence in Cancer Therapy

Autophagy and Senescence in Cancer Therapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 13 April 2021
GET THIS BOOK Autophagy and Senescence in Cancer Therapy

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for

Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases

Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases
  • Author : Ryusaku Matsumoto
  • Publisher : Unknown
  • Release : 08 December 2021
GET THIS BOOK Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases

A number of observations suggest a close connection between telomere length and mortality and age-related disease, suggesting that telomere length is a useful marker of individual biological aging and the shortening of telomere length is causally related with the pathogenesis in age-related diseases. To date, the significance of telomere length in metabolic and endocrine diseases has also been clarified. It has been reported that obesity, type 2 diabetes mellitus (T2DM), NAFLD, and hypertension were associated with shortened telomere length. In

Cellular Senescence and Their Role in Liver Metabolism in Health and Disease Overview and Future Directions

Cellular Senescence and Their Role in Liver Metabolism in Health and Disease  Overview and Future Directions
  • Author : Matthew Schade
  • Publisher : Unknown
  • Release : 08 December 2021
GET THIS BOOK Cellular Senescence and Their Role in Liver Metabolism in Health and Disease Overview and Future Directions

Chronic liver disease has globally risen mainly due to a prevalent hepatitis C virus (HCV) infection rate and an epidemic of obesity. It is estimated by the year 2030, 2.2 billion people around the world will be overweight and 1.1 billion people will be obese. Diabetes and obesity are the main risk factors for the development of the metabolic syndrome and in the liver of non-alcoholic fatty liver disease (NAFLD) which could progress to non-alcoholic fatty steatohepatitis (NASH) related cirrhosis and liver malignancy.

Frailty

Frailty
  • Author : R.A. Fielding
  • Publisher : Unknown
  • Release : 08 December 2021
GET THIS BOOK Frailty

Cover -- Contents -- Preface -- Foreword -- Contributors -- Connecting Age-Related Biological Decline to Frailty and Late-Life Vulnerability -- Abstract -- Introduction -- Frailty Conceptualization -- Frailty Measurement -- The Biology That Underlies Frailty -- Disease States and Frailty -- Physiological System Dysregulation and Frailty -- Age-Related Cellular and Molecular Changes and Frailty -- Disclosure Statement -- References -- Cellular Senescence and the Biology of Aging, Disease, and Frailty -- Abstract -- Introduction -- Cellular Senescence, the Senescence-Associated Secretory

Novel Insights Into the Contribution of Cellular Senescence to Cancer Therapy

Novel Insights Into the Contribution of Cellular Senescence to Cancer Therapy
  • Author : Tareq Saleh
  • Publisher : Unknown
  • Release : 08 December 2021
GET THIS BOOK Novel Insights Into the Contribution of Cellular Senescence to Cancer Therapy

Cellular senescence a specialized form of growth arrest that contributes to the pathogenesis of several aging-related disorders including cancer. While by definition tumor cells are considered immortalized, they can undergo senescence when exposed to conventional and targeted cancer therapy. Therapy-Induced Senescence (TIS) represents a fundamental response to therapy and impacts its outcomes. However, TIS has been considered a positive therapeutic goal since senescent tumor cells are expected to enter a state of permanent growth abrogation. In this work we examined