Genome Editing

• Author : Kursad Turksen
• Publisher : Springer
• Release : 09 August 2016

This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of

• Author : Kiran Musunuru
• Publisher : Academic Press
• Release : 05 March 2021

Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as

• Author : Minh Duc Hoang
• Publisher : Unknown
• Release : 18 May 2021

• Author : Krishnarao Appasani
• Publisher : Cambridge University Press
• Release : 31 July 2018

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

• Author : Kenneth R. Chien,Eugene Braunwald
• Publisher : Unknown
• Release : 18 May 1999

Covering the molecular basis of heart disease, this text evaluates topics such as genetic mapping approaches in inherited cardiovascular disorders, and driving mechanisms in the transition from cardiac hypertrophy to heart failure.

• Author : Shu Liu
• Publisher : McGraw Hill Professional
• Release : 12 June 2020

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Cardiovascular engineering principles and practices with a focus on disease prevention Aimed at advanced students taking cardiovascular, regenerative, and tissue engineering courses, Cardiovascular Engineering: A Protective Approach explores applications of protective engineering strategies and technologies to common cardiovascular disorders. A protective approach to cardiovascular engineering involves studying the naturally occurring mechanisms that protect

• Author : Qinbo Xu
• Publisher : John Wiley & Sons Incorporated
• Release : 18 May 2021

The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is

• Author : Anonim
• Publisher : Unknown
• Release : 18 May 2021

• Author : Kewal K. Jain
• Publisher : Seattle ; Toronto : Hogrefe & Huber
• Release : 18 May 1998

During the past eight years following initial gene therapy experiments, more than 200 clinical protocols have been submitted worldwide and more than 2000 patients have been treated. Although a lot remains to be accomplished before gene therapy becomes a standard medical practice, enough information has accumulated to justify a textbook on the subject. Some of the procedures and products are expected to enter the marketplace and medical practice by the year 2000. The public is very much aware of the potential of gene

• Author : William DeTurk,Lawerence Cahalin
• Publisher : McGraw Hill Professional
• Release : 12 January 2018

A comprehensive, up-to-date textbook spanning the entire scope of cardiovascular and pulmonary practice A Doody’s Core Title for 2019! Cardiovascular and Pulmonary Physical Therapy, Third Edition reflects the broadest possible spectrum of cardiovascular and pulmonary practice and draws upon the expertise of a carefully selected team of world-renowned contributors. This internationally acclaimed text reviews must-know background knowledge, thoroughly explains exercise principles, cites the best evidence, and integrates the American Physical Therapy Association’s approved practice patterns into the chapter content.

• Author : Anonim
• Publisher : Unknown
• Release : 18 May 2021

Abstract: PRKAG2 cardiac syndrome is a distinct form of human cardiomyopathy characterized by cardiac hypertrophy, ventricular pre-excitation and progressive cardiac conduction disorder. However, it remains unclear how mutations in the PRKAG2 gene give rise to such a complicated disease. To investigate the underlying molecular mechanisms, we generated disease-specific hiPSC-derived cardiomyocytes from two brothers both carrying a heterozygous missense mutation c.905G>A (R302Q) in the PRKAG2 gene and further corrected the R302Q mutation with CRISPR-Cas9 mediated genome editing.

• Author : Daphna Weissglas
• Publisher : Unknown
• Release : 18 May 2021

• Author : Giuseppe Ippolito
• Publisher : Unknown
• Release : 18 May 2021

International specialists examine therapeutic choices for the treatment of myocardial cell dysfunction in HIV disease, with a focus on knowledge in both clinical and biological aspects of HIV-associated cardiovascular disease. Topics covered include research findings from experimental work on transgenic mice; the role of cytokines in the development of HIV-associated cardiomyopathy and pulmonary hypertension (with related diagnostic and therapeutic implications); and the relationship between dilated cardiomyopathy and encephalopathy in HIV-infected adults and children.

• Author : T. Hagen
• Publisher : Elsevier Science Limited
• Release : 03 December 2002

This volume of Advances in Cell Aging and Gerontology provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading

• Author : Xiaojun Liu
• Publisher : BoD – Books on Demand
• Release : 05 September 2018

Genetics and genomics in poultry have been the most rapidly advancing subjects since the completion of the chicken genome sequence in 2004 and have been extensively used to understand the genetic determinants of complex traits. This book intends to provide readers with a comprehensive overview of the current progress in the application of genetic and genomic science in the poultry field. The contents cover genetic variation detection, selection methods for breeding, transgenesis and genome editing, genetic basis of disease resistance, control