Primary Structural Studies of Horse Carbonic Anhydrases

• Author : Robert Paul Bray
• Publisher : Unknown
• Release : 18 May 1977

• Author : N.D. Carter,S.J. Dodgson,G. Gros,R.E. Tashian
• Publisher : Springer Science & Business Media
• Release : 29 June 2013

As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant

• Author : Claudiu T. Supuran,Alessio Nocentini
• Publisher : Academic Press
• Release : 17 July 2019

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors

• Author : W.R. Chegwidden,N.D. Carter,Y.H. Edwards
• Publisher : Birkhäuser
• Release : 11 November 2013

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene

• Author : Claudiu T. Supuran
• Publisher : MDPI
• Release : 08 April 2019

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient

• Author : Susan C. Frost,Robert McKenna
• Publisher : Springer Science & Business Media
• Release : 22 October 2013

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic

• Author : Daumantas Matulis
• Publisher : Springer
• Release : 21 May 2019

This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular

• Author : Claudiu T Supuran,Giuseppina De Simone
• Publisher : Elsevier
• Release : 14 January 2015

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their

• Author : Robert W. Schrier
• Publisher : Lippincott Williams & Wilkins
• Release : 18 May 2022

The thoroughly updated Eighth Edition of this classic three-volume work provides the most comprehensive, current, and authoritative information on diseases of the kidney and urinary tract. This clinically oriented reference focuses on diagnosis and treatment of specific diseases, disorders, and complications and incorporates the basic science practicing physicians need to evaluate and manage the disease process. Each of the fourteen sections is written by internationally renowned contributors and provides coverage comparable to a complete book. The first two sections review

• Author : Claudiu T. Supuran,Andrea Scozzafava,Janet Conway
• Publisher : CRC Press
• Release : 27 May 2004

Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in

• Author : Francesco Botrè,Gerolf Gros,Bayard T. Storey
• Publisher : Unknown
• Release : 18 May 1991

Covers almost every aspect, from structure-function relationships and genetics to present biological and clinical implications. Topics include: Biochemistry, structure and mechanism; Genetics and molecular biology of isoenzymes; Secretory systems; Metabolism and hormonal control; Respiration and bone.

• Author : Maria Boulos Moubarak
• Publisher : Unknown
• Release : 18 May 1995

• Author : Penny Lee Kasch
• Publisher : Unknown
• Release : 18 May 1978

• Author : Lawrence Jay Edwards
• Publisher : Unknown
• Release : 18 May 1967

• Author : Corinne Misae Yoshihara
• Publisher : Unknown
• Release : 18 May 1986