The Carbonic Anhydrases

• Author : W.R. Chegwidden,N.D. Carter,Y.H. Edwards
• Publisher : Birkhäuser
• Release : 11 November 2013

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene

• Author : Claudiu Supuran,Alessio Nocentini
• Publisher : Academic Press
• Release : 17 July 2019

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors

• Author : Claudiu T. Supuran,Giuseppina De Simone
• Publisher : Elsevier
• Release : 08 January 2015

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their

• Author : Richard E. Tashian,David Hewett-Emmett
• Publisher : Unknown
• Release : 15 June 1984

• Author : Robert Paul Bray
• Publisher : Unknown
• Release : 15 June 1977

• Author : Jan Lawrence Godoski
• Publisher : Unknown
• Release : 15 June 2021

• Author : W.R. Chegwidden,N.D. Carter,Y.H. Edwards
• Publisher : Springer Science & Business Media
• Release : 01 October 2000

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene

• Author : S.J. Dodgson,N.D. Carter,G. Gros,R.E. Tashian
• Publisher : Springer Science & Business Media
• Release : 31 May 1991

As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant

• Author : Francesco Botrè,Gerolf Gros,Bayard T. Storey
• Publisher : Unknown
• Release : 15 June 1991

Covers almost every aspect, from structure-function relationships and genetics to present biological and clinical implications. Topics include: Biochemistry, structure and mechanism; Genetics and molecular biology of isoenzymes; Secretory systems; Metabolism and hormonal control; Respiration and bone.

• Author : N.D. Carter,S.J. Dodgson,G. Gros,R.E. Tashian
• Publisher : Springer Science & Business Media
• Release : 29 June 2013

As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant

• Author : Claudiu T. Supuran
• Publisher : MDPI
• Release : 08 April 2019

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient

• Author : Ioan Puscas
• Publisher : Unknown
• Release : 15 June 1994

• Author : Michael Bruce Fairbanks
• Publisher : Unknown
• Release : 15 June 1970

• Author : Björn Elleby
• Publisher : Unknown
• Release : 15 June 2021

• Author : Joni Penttinen
• Publisher : Unknown
• Release : 15 June 2021