Carbonic Anhydrases as Biocatalysts

• Author : Claudiu T Supuran,Giuseppina De Simone
• Publisher : Elsevier
• Release : 14 January 2015

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their

• Author : Claudiu T. Supuran,Alessio Nocentini
• Publisher : Academic Press
• Release : 17 July 2019

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors

• Author : Claudiu T. Supuran
• Publisher : MDPI
• Release : 08 April 2019

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient

• Author : W. Richard Chegwidden,Nicholas D. Carter
• Publisher : Springer Nature
• Release : 01 December 2021

This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians

• Author : Alane Beatriz Vermelho,Claudiu T. Supuran
• Publisher : Springer Nature
• Release : 24 June 2022

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The

• Author : Junpei Zhou,Massimiliano Fenice,Sunil Khare
• Publisher : Frontiers Media SA
• Release : 29 December 2021

• Author : Anonim
• Publisher : Academic Press
• Release : 22 February 2020

Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current

• Author : Gonzalo de Gonzalo,Iván Lavandera
• Publisher : John Wiley & Sons
• Release : 13 April 2021

This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined

• Author : Peter Grunwald
• Publisher : MDPI
• Release : 14 November 2018

This book is a printed edition of the Special Issue "Immobilized Biocatalysts" that was published in Catalysts

• Author : Peter Grunwald
• Publisher : CRC Press
• Release : 11 December 2014

Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the

• Author : Gavin Williams,Mélanie Hall
• Publisher : Royal Society of Chemistry
• Release : 31 May 2018

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current 'hot' topics

• Author : Bryan Morreale,Fan Shi
• Publisher : Elsevier
• Release : 01 June 2015

Materials for Carbon Dioxide Mitigation Technology offers expert insight and experience from recognized authorities in advanced material development in carbon mitigation technology and constitutes a comprehensive guide to the selection and design of a wide range of solvent/sorbent/catalyst used by scientists globally. It appeals to chemical scientists, material scientists and engineers, energy researchers, and environmental scientists from academia, industry, and government in their research directed toward greener, more efficient carbon mitigation processes. Emphasizes material development for carbon mitigation

• Author : Gonzalo de Gonzalo,Pablo Domínguez de María
• Publisher : Royal Society of Chemistry
• Release : 02 November 2017

Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by

• Author : Antonio Cuesta
• Publisher : Unknown
• Release : 27 March 2023

Adsorbent-based carbon capture is only feasible if adsorption-desorption cycles are both fully regenerating and economical. A potentially energy-saving and regenerating pH swing system is currently utilized by biocatalysts. The main objective is to develop, test and analyze a synthetic pH Swing Adsorption (pHSA) system as well as a pHSA compatible solid adsorbent to capture CO2 from a simulated ambient air gas stream. Furthermore, comparing its performance to other CO2 sorbent systems is necessary to determine the feasibility of pHSA implementation.

• Author : Andrew D. Miller,Julian Tanner
• Publisher : John Wiley & Sons
• Release : 03 May 2013

“This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules... This reviewer showed [the book] to several of his senior graduate students, and they unanimously gave the book rave reviews. Summing Up: Highly recommended...” CHOICE Chemical biology is a rapidly developing branch of chemistry, which sets out to understand the way biology works at the molecular level. Fundamental to