Cancer Stem Cells in Solid Tumors

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  • Author : Alison L. Allan
  • Publisher : Springer Science & Business Media
  • Pages : 478 pages
  • ISBN : 1617792462
  • Rating : 5/5 from 1 reviews
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Download or Read online Cancer Stem Cells in Solid Tumors full in PDF, ePub and kindle. this book written by Alison L. Allan and published by Springer Science & Business Media which was released on 12 August 2011 with total page 478 pages. We cannot guarantee that Cancer Stem Cells in Solid Tumors book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Cancer Stem Cells in Solid Tumors

Cancer Stem Cells in Solid Tumors
  • Author : Alison L. Allan
  • Publisher : Springer Science & Business Media
  • Release : 12 August 2011
GET THIS BOOK Cancer Stem Cells in Solid Tumors

The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have

Stem Cells and Cancer Stem Cells Volume 9

Stem Cells and Cancer Stem Cells  Volume 9
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release : 22 December 2012
GET THIS BOOK Stem Cells and Cancer Stem Cells Volume 9

This fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs. Showcasing the work of more than 80 contributors from 13 nations, it offers an unrivalled breadth of differing perspectives on the subject, with dedicated sections covering umbilical cord, induced pluripotent, embryonic, and hematopoietic stem cells, in addition to stem cells in

Role of Cancer Stem Cells in Cancer Biology and Therapy

Role of Cancer Stem Cells in Cancer Biology and Therapy
  • Author : Thomas Dittmar,Kurt S. Zänker
  • Publisher : CRC Press
  • Release : 01 March 2013
GET THIS BOOK Role of Cancer Stem Cells in Cancer Biology and Therapy

This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence

Prominin 1 CD133 New Insights on Stem Cancer Stem Cell Biology

Prominin 1  CD133   New Insights on Stem   Cancer Stem Cell Biology
  • Author : Denis Corbeil
  • Publisher : Springer Science & Business Media
  • Release : 19 November 2012
GET THIS BOOK Prominin 1 CD133 New Insights on Stem Cancer Stem Cell Biology

​​​​​​​Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection

Stem Cells and Cancer Stem Cells Volume 3

Stem Cells and Cancer Stem Cells Volume 3
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release : 22 November 2011
GET THIS BOOK Stem Cells and Cancer Stem Cells Volume 3

It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent

Advances in Cancer Stem Cell Biology

Advances in Cancer Stem Cell Biology
  • Author : Roberto Scatena,Alvaro Mordente,Bruno Giardina
  • Publisher : Springer Science & Business Media
  • Release : 06 October 2011
GET THIS BOOK Advances in Cancer Stem Cell Biology

In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours-

Cancer Stem Cells

Cancer Stem Cells
  • Author : Stanley Shostak
  • Publisher : BoD – Books on Demand
  • Release : 22 March 2011
GET THIS BOOK Cancer Stem Cells

Cancer Stem Cells Theories and Practice does not 'boldly go where no one has gone before!' Rather, Cancer Stem Cells Theories and Practice boldly goes where the cutting edge of research theory meets the concrete challenges of clinical practice. Cancer Stem Cells Theories and Practice is firmly grounded in the latest results on cancer stem cells (CSCs) from world-class cancer research laboratories, but its twenty-two chapters also tease apart cancer's vulnerabilities and identify opportunities for early detection, targeted therapy,

Cancer Stem Cells

Cancer Stem Cells
  • Author : Huiping Liu,Justin Durla Lathia
  • Publisher : Elsevier
  • Release : 16 August 2016
GET THIS BOOK Cancer Stem Cells

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. The book includes contributions from

Cancer Stem Cells

Cancer Stem Cells
  • Author : Sharmila A. Bapat
  • Publisher : John Wiley & Sons
  • Release : 03 October 2008
GET THIS BOOK Cancer Stem Cells

Because the concept and discoveries of cancer stem cells are relatively new, scientists and researchers need an introduction to this dynamic area. Cancer Stem Cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology - two fields that enhance, move, and evolve into each other continuously. It provides an informative study in

Stem Cells and Cancer Stem Cells Volume 12

Stem Cells and Cancer Stem Cells  Volume 12
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release : 20 February 2014
GET THIS BOOK Stem Cells and Cancer Stem Cells Volume 12

Volume 12 in this series explores the latest experimental and clinical uses of stem cells in the treatment of disease and of injuries and reviews methods for isolating multipotent endothelial-like cells from human adipose tissue and discusses clinical applications in cell therapy and regenerative medicine. The book is organized in five parts: Cancer Stem Cells, Pluripotent Stem Cells, Dendritic Stem Cells, Regenerative Medicine and General Applications. The first section includes chapters on histamine in the neural and cancer stem cell niches

Stem Cells and Cancer Stem Cells Volume 5

Stem Cells and Cancer Stem Cells  Volume 5
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release : 22 February 2012
GET THIS BOOK Stem Cells and Cancer Stem Cells Volume 5

It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although conventional chemotherapy kills most cells in a tumor, cancer stem cells remain intact. Vast applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem

Cancer Stem Cells

Cancer Stem Cells
  • Author : Otmar D. Wiestler,Bernhard Haendler,D. Mumberg
  • Publisher : Springer Science & Business Media
  • Release : 04 September 2007
GET THIS BOOK Cancer Stem Cells

Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book looks at recent developments in the field of cancer stem cells and the possible impact for the identification of novel treatment paradigms for cancer.

Stem Cells and Cancer Stem Cells Volume 11

Stem Cells and Cancer Stem Cells  Volume 11
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release : 21 October 2013
GET THIS BOOK Stem Cells and Cancer Stem Cells Volume 11

Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of

Stem Cells and Cancer Stem Cells Volume 6

Stem Cells and Cancer Stem Cells  Volume 6
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release : 29 February 2012
GET THIS BOOK Stem Cells and Cancer Stem Cells Volume 6

The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell

Breast Cancer Stem Cells Therapy Resistance

Breast Cancer Stem Cells   Therapy Resistance
  • Author : Phuc Van Pham
  • Publisher : Springer
  • Release : 26 November 2015
GET THIS BOOK Breast Cancer Stem Cells Therapy Resistance

This volume thoroughly examines breast cancer stem cells (BCSCs), from basic definitions to techniques for identifying, isolating, culturing, and targeting BCSCs for therapy; there is additional focus on pre-clinical and clinical results. The text begins with a discussion of breast cancer, focusing especially on the limitations of current therapies in its treatment. The subsequent chapters introduce and compare stem cells and cancer stem cells, describe properties and isolation techniques of BCSCs, and examine BCSC-targeting approaches. The text concludes with a